Advancement in Aerosols
Embed Size (px)
Transcript of Advancement in Aerosols
ADVANCEMENT IN AEROSOLSDharamjit PattanayakPharmaceutical Technology M.Pharm 2nd Sem Jeypore College of Pharmacy
have been defined as colloidal system consisting of very finely subdivided liquid or solid particles dispersed in and surrounded by gas.
A system that depends on the power of a compressed or liquefied gas to expel the contents from the container.
Rapid action. Avoidance of degradation in GI tract. Directly applied to the affected area. Prevents Oxidation Easier application Sterility can be maintained Avoid the Manual contact Not affected by Moisture
Preparation Volatile propellant cause discount to skin. Difficult formulation
COMPONENTS OF AEROSOLS PROPELLENT
Propellant is responsible for developing the proper pressure within the container and it expels the product when the valve is opened and aids in atomization or foam production of the product.
PHYSICOCHEMICAL PROPERTIES OF FLUROCARBON AND HYDROCARBON Pollo Liquid Vapour pressance Boiling Chemical NameNumeri cal Design ation
pair 700 1300F0
Trichloromono fluoromethane Dichloro difluoromethane Dichloro tetrafluoro ethane Difluoroethane Butane Isobutane Propane
11 12 114 152a A-17 A-31
13.4 84.9 27.6 76.4 31.6 45.8
39.0 196.0 63.5 191.0 82.0 111.0 270.7
74.7 -21.6 38.4 -11.2 31.1 10.9 -43.7
23.7 -29.8 3.6 -24.0 -0.6 -11.6 -44.6
1.49 1.33 1.47 0.91 0.58 0.56 0.50
PHYSICOCHEMICAL PRPERTIES OF FLUROCARBON AND HYDROCARBON Containers A Metal
1. Tin plated sheet 2. Aluminum 3. Stainless steelC.
Glass1. Uncoated glass 2. Plastic coated glass
Continuous spray valveMounting Cup Valve body or Housing Stem Gasket Spring Dip Tube
2. Metering valves
Spray Actuators Foam Actuators Solid Stream Actuators Special Actuators Metered dose inhaler
FORMULATION OF PHARMACEUTICAL AEROSOLS
TYPES OF SYSTEMSolution system Water based system Suspension or dispersion system Foam systemAqueous stable foam Non-Aqueous stable foam Quick Breaking Foam Thermal foam
- Intranasal foam
STEBILITY TESTING OF PHARMACEUTICAL AIROSOL Concentration Container Valve
Filling Apparatus Cold Filling Apparatus Compressed Gas Filling Apparatus
QUALITY CONTROL FOR PHARMACEUTICAL AEROSOLS Propellant Valve,
Actuators, Dip tube Container Weight checking Leak testing Spray testing
NEWER DEVELOPMENTSAt present there is much interest in developing MDIs for a variety of conditions including asthma, diabetes, AIDs, Cancer, heart, many of these compound have been developed by using biotechnology process and their delivery to the respiratory system via MDI is an extremely challenging undertaking.
REFERENCE1. 2. 3.
4. 5. 6.
The theory and Practical of Industrial Pharmacy, By L.Lachman, H.a.Liberman, J.L.Kaning. Remington : The Science and Practice of Pharmacy vol-I. Pharmaceutical Dosage Forms and Drug Delivery System By: H.C. Ansel, L.V.Allen, NG Popovich. Pharmaceutics: The Science of Dosage Form Design By : Michael E.Aulton. Pharmaceutics I by: R.M.Meheta www.pharma.edu.com