Advancement in Aerosols

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ADVANCEMENT IN AEROSOLSDharamjit PattanayakPharmaceutical Technology M.Pharm 2nd Sem Jeypore College of Pharmacy

DEFINITION Aerosols

have been defined as colloidal system consisting of very finely subdivided liquid or solid particles dispersed in and surrounded by gas.

A system that depends on the power of a compressed or liquefied gas to expel the contents from the container.

ADVANTAGES

Rapid action. Avoidance of degradation in GI tract. Directly applied to the affected area. Prevents Oxidation Easier application Sterility can be maintained Avoid the Manual contact Not affected by Moisture

DISADVANTAGE Costly

Preparation Volatile propellant cause discount to skin. Difficult formulation

COMPONENTS OF AEROSOLS PROPELLENT

Propellant is responsible for developing the proper pressure within the container and it expels the product when the valve is opened and aids in atomization or foam production of the product.

PHYSICOCHEMICAL PROPERTIES OF FLUROCARBON AND HYDROCARBON Pollo Liquid Vapour pressance Boiling Chemical NameNumeri cal Design ation

pair 700 1300F0

Density F0

C

70F

Trichloromono fluoromethane Dichloro difluoromethane Dichloro tetrafluoro ethane Difluoroethane Butane Isobutane Propane

11 12 114 152a A-17 A-31

13.4 84.9 27.6 76.4 31.6 45.8

39.0 196.0 63.5 191.0 82.0 111.0 270.7

74.7 -21.6 38.4 -11.2 31.1 10.9 -43.7

23.7 -29.8 3.6 -24.0 -0.6 -11.6 -44.6

1.49 1.33 1.47 0.91 0.58 0.56 0.50

A-108 122.8

PHYSICOCHEMICAL PRPERTIES OF FLUROCARBON AND HYDROCARBON Containers A Metal

1. Tin plated sheet 2. Aluminum 3. Stainless steelC.

Glass1. Uncoated glass 2. Plastic coated glass

VALVES1.

Continuous spray valveMounting Cup Valve body or Housing Stem Gasket Spring Dip Tube

2. Metering valves

ACTUATORS-

Spray Actuators Foam Actuators Solid Stream Actuators Special Actuators Metered dose inhaler

FORMULATION OF PHARMACEUTICAL AEROSOLS

TYPES OF SYSTEMSolution system Water based system Suspension or dispersion system Foam systemAqueous stable foam Non-Aqueous stable foam Quick Breaking Foam Thermal foam

- Intranasal foam

STEBILITY TESTING OF PHARMACEUTICAL AIROSOL Concentration Container Valve

and Propellant

MANUFACTURE Pressure

Filling Apparatus Cold Filling Apparatus Compressed Gas Filling Apparatus

QUALITY CONTROL FOR PHARMACEUTICAL AEROSOLS Propellant Valve,

Actuators, Dip tube Container Weight checking Leak testing Spray testing

NEWER DEVELOPMENTSAt present there is much interest in developing MDIs for a variety of conditions including asthma, diabetes, AIDs, Cancer, heart, many of these compound have been developed by using biotechnology process and their delivery to the respiratory system via MDI is an extremely challenging undertaking.

REFERENCE1. 2. 3.

4. 5. 6.

The theory and Practical of Industrial Pharmacy, By L.Lachman, H.a.Liberman, J.L.Kaning. Remington : The Science and Practice of Pharmacy vol-I. Pharmaceutical Dosage Forms and Drug Delivery System By: H.C. Ansel, L.V.Allen, NG Popovich. Pharmaceutics: The Science of Dosage Form Design By : Michael E.Aulton. Pharmaceutics I by: R.M.Meheta www.pharma.edu.com

Thank You