Adsorption in Physical Pharmacy

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1. It is a surface phenomenon and refers to the uniform distribution of a substance through another at the surface e.g. solution of H2 in Pd. 2. It is the phenomenon in which a layer of ions, molecules or aggregates of molecules condense upon the surface with which they come in contact. 3. It is defined as the concentration of a substance at

Transcript of Adsorption in Physical Pharmacy

Page 1: Adsorption in Physical Pharmacy

1. It is a surface phenomenon and refers to the uniform distribution of a substance through another at the surface e.g. solution of H2 in Pd.

2. It is the phenomenon in which a layer of ions, molecules or aggregates of molecules condense upon the surface with which they come in contact.

3. It is defined as the concentration of a substance at the interface or boundary between heterogeneous phases e.g. solid/ gas or two immisci.ble liquids

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Adsorbate

It is the substance which is adsorbed at the surface of another substance

Examples are: gases, dyes, water vapors etc.

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Adsorbent

It is the substance which adsorbs the other substance at its surface.

Examples are: activated charcoal, bone charcoal, alumina, silica gel, kaolin and filler’s earth.

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Order Of Adsorption

I. Liquid/ Solid adsorptionII. Solid/ Gas adsorptionIII.Liquid/ Gas adsorptionIV.Liquid/ Liquid adsorption

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Positive adsorption

Negative adsorption

Sorption

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How adsorption occurs

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Types of Adsorption

Vander walls or physical adsorption

Chemisorption

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Factors effecting the adsorption

Solubility of adsorptionNature of AdsorbateNature of adsorbentConcentration of adsorbentPressureTemperaturepHAffinity between adsorbent and adsorbateStirring

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Pharmaceutical Applications of adsorption

1. Activated charcoal2. Physiological Importance3. Purification4. Preparation of Vitamin B1

5. Gas masks6. Heterogeneous Catalysts7. Bacterial filtration8. Solid-liquid chromatography9. Emulsification10.Decolonization11.Adsorption of water vapors