Acutely Toxic Gases (ATGs) · the specific ATG. General guidance (unless otherwise specified in the...
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Acutely Toxic Gases Chemical Class Standard Operating Procedure Rev. Date: 2017-03-28 Acutely Toxic Gases (ATGs) H280 H330 H331 H332 H333 This SOP is not a substitute for hands-on training. Print a copy and insert into your laboratory SOP binder. Department: Chemistry Date SOP was written: Thursday, March 23, 2017 Date SOP was approved by PI/lab supervisor: Friday, March 24, 2017 Principal Investigator: Name: F. Fischer Signature: ______________________________ Internal Lab Safety Coordinator or Lab Manager: Name: Stephen von Kugelgen Lab Phone: 510.301.1058 Office Phone: 510.642.8252 Emergency Contact: Name: Stephen von Kugelgen Phone Number: 510.301.1058 Location(s) covered by this SOP: Tan Hall 674, 675, 676, 679, 680, 683, 684 1. Purpose This SOP covers the precautions and safe handling procedures for the use of Acutely Toxic Gases (ATGs). For a list of ATGs covered by this SOP and their use(s), see the “List of Chemicals”. Procedures described in Section 12 apply to all materials covered in this SOP. A change to the “List of Chemicals” does not constitute a change in the SOP requiring review or retraining. If you have questions concerning the applicability of any recommendation or requirement listed in this procedure, contact the Principal Investigator/Laboratory Supervisor or the campus Chemical Hygiene Officer at [email protected]. 2. Acutely Toxic Gases Information Before working with any Acutely Toxic Gases (ATGs), review the UC-Berkeley EH&S publication Toxic Gas Program on the EH&S website. If you have questions about Toxic Gas Program requirements, contact EH&S at 642-3073. 3. Potential Hazards/Toxicity
Transcript of Acutely Toxic Gases (ATGs) · the specific ATG. General guidance (unless otherwise specified in the...
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AcutelyToxicGasesChemicalClassStandardOperatingProcedure
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AcutelyToxicGases(ATGs)H280H330H331H332H333
ThisSOPisnotasubstituteforhands-ontraining.PrintacopyandinsertintoyourlaboratorySOPbinder.
Department: Chemistry
DateSOPwaswritten: Thursday,March23,2017
DateSOPwasapprovedbyPI/labsupervisor: Friday,March24,2017
PrincipalInvestigator:Name:F.Fischer
Signature:______________________________
InternalLabSafetyCoordinatororLabManager:Name:StephenvonKugelgen
LabPhone:510.301.1058
OfficePhone:510.642.8252
EmergencyContact: Name:StephenvonKugelgen
PhoneNumber:510.301.1058Location(s)coveredbythisSOP: TanHall674,675,676,679,680,683,684
1. PurposeThisSOPcoverstheprecautionsandsafehandlingproceduresfortheuseofAcutelyToxicGases(ATGs).ForalistofATGscoveredbythisSOPandtheiruse(s),seethe“ListofChemicals”.ProceduresdescribedinSection12applytoallmaterialscoveredinthisSOP.Achangetothe“ListofChemicals”doesnotconstituteachangeintheSOPrequiringrevieworretraining.Ifyouhavequestionsconcerningtheapplicabilityofanyrecommendationorrequirementlistedinthisprocedure,contactthePrincipalInvestigator/LaboratorySupervisororthecampusChemicalHygieneOfficeratucbcho@berkeley.edu.
2. AcutelyToxicGasesInformationBeforeworkingwithanyAcutelyToxicGases(ATGs),reviewtheUC-BerkeleyEH&SpublicationToxicGasProgramontheEH&Swebsite.IfyouhavequestionsaboutToxicGasProgramrequirements,contactEH&Sat642-3073.
3. PotentialHazards/Toxicity
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Toxicgasesaregasesthatmaycausesignificantacutehealtheffectsatlowconcentrations.Healtheffectsmayincludesevereskinoreyeirritation,pulmonaryedema,neurotoxicity,orotherpotentiallyfatalconditions.TheGloballyHarmonizedSystemofClassificationandLabelingofChemicals(GHS)designatesATGsbyoneormoreofthefollowingHcodes:
H280Containsgasunderpressure;mayexplodeifheatedH330FatalifinhaledH331ToxicifinhaledH332HarmfulifinhaledH333Maybeharmfulifinhaled
ATGsmayalsohaveotherhazardouspropertiesinadditiontoacutetoxicity(e.g.corrositivity,pyrophoricity).Safeuserequiresassessingallpotentialhazards.
ItisthePrincipal Investigator’s responsibility toensureactivity-specific laboratoryproceduresand/orprocessesaretakenintoaccountwhenusingthisChemicalClassSOP.
Please,reviewtheSDSofanychemicalbeforeuse(seeSection11–SDSLocation).
4. EngineeringControlsUsetheengineeringcontrolslistedbelowunlessotherlab-specificinformationisincludedintheProtocol/Proceduresection.
• WorkwithATGsmustbeconductedinafumehoodunlessothercontrolsaredesignatedinthelab-specificProtocol/Proceduresection.Sashheightmustbekeptlowtoavoidescapingfumesandprovideaphysicalbarrier.
• Indoorstorageofallgascylindersinthisprogrammustbeinamechanicallyventilated,lockablearea.Examplesofmechanicalventilatedareasincludeexhaustedgascabinets,fumehoods,andspecialfirecodecompliantgasstoragerooms.
• Allcylindersandgascabinetsmustbeclearlylabeledwithcontentandhazardinformation.• Allregulators,valves,piping,tubingandfittingsmustbechemicallycompatiblewiththegases
beingused.Regulatorsmustbecompatiblewiththesizeandtypeofgascylinderbeingusedandratedforfullcylinderpressure.Consultyourgassupplierforapprovedregulators,valves,piping,tubing,andfittings.
• Cylindersmustbestoredupright,withtankvalvessecurelyclosedandvalveprotectioncapinplace,andfirmlysecuredtopreventfallingorbeingknockedover.
• SomeATGshavepoorwarningproperties.IfaparticularATGfallsintothiscategoryandworkwiththisgaswillbedoneroutinelyorlargerquantitieswillbeemployed,installacontinuouselectronicwarningsensorwithalarmifavailable.Insurethatthefumehoodisoperatingproperlyandkeepthesashaslowaspossibleatalltimes.Aventilationmonitorisrequiredonthehood.
5. PersonalProtectiveEquipmentAtaminimum,thefollowingPPEmustbewornatalltimes.
EyeandFaceProtection
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A. ANSIZ87.1-compliantsafetyglasseswithsideshields,orchemicalsplashgoggles.
• Ordinary prescription glasses will NOT provide adequate protection unless they alsomeetANSIstandardandhavecompliantsideshields.
B. Ifthepotentialforexplosion/splashingexists,andadequatecoverageisnotprovidedbythehoodsash,afaceshieldmustbeworn.
SkinandBodyProtection1. Glovesarerequiredwhenhandlinghazardouschemicals.
• RefertospecificchemicalSDSforinformationongloveselection.• Foradditionalinformationongloveselection,goto:
http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-and-usage.html2. Labcoatsarerequiredwhenhandlinghazardouschemicalsinthelab.Selectthetypeoflabcoat
accordingtothehazardsatthespecificworkplace.3. Longpants,closed-toe/closed-heelshoes,coveredlegs,andankles.
RespiratoryProtectionRespiratoryprotectionisnormallynotrequiredforUCBerkeleylaboratoryactivities.AnylabpersonnelconsideringtheuseofarespiratormustcontactEH&Sforaworkplaceassessment.
6. FirstAidProceduresandMedicalEmergenciesIntheeventofaninjury,notifyyoursupervisorimmediatelyandEH&Swithin8hours.
GototheOccupationalHealthFacility(TangHealthCenter,oncampus); ifafterhours,gotothenearestemergencyroom(AltaBates,2450AshbyAveinBerkeley);or
Call911(fromacellphone:510-642-3333)if:
• itisalifethreateningemergency;or
• younotareconfidentinyourabilitytofullyassesstheconditionsoftheenvironmentand/orthe condition of the contaminated/injured person, or you cannot be assured of your ownsafety;or
• thecontaminated/injuredpersonisnotbreathingorisunconscious.
Please remember to provide a copy of the appropriate manufacturer SDS (if available) to theemergency responders or physician. At a minimum, be ready to provide the identity/name of anyhazardousmaterialsinvolved.
IncaseofskincontactIfskincontactoccurs,and/orskinorclothingareonfire,immediatelydrenchinthesafetyshowerwithcopiousamountsofwaterfornolessthan15minutestoremoveanyremainingcontaminants.Ifpossibletodosowithoutfurtherinjury,removeanyremainingjewelryorclothing.IncaseofeyecontactRinsethoroughlywithplentyofwaterusinganeyewashstationforatleast15minutes,occasionallyliftingtheupperandlowereyelids.Removecontactlensesifpossible.Ifinhaled
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Moveintofreshair.
7. SpecialHandling,Storage,andDisposalRequirementsLab-specificinformationonhandlingandstoragemaybeincludedintheProtocol/Proceduresection.Precautionsforsafehandling
• Donotdrag,roll,slideordropcylinders.Asuitablehandtruck,towhichthecylinderissecured,mustbeusedforcylindermovement.
• Whentransportinggasesoutsidethelab,theprotectivecapmustbeinplaceandmustcoverthevalve.
• Neverattempttoliftacylinderbyitscap.• Securecylindersatalltimeswhileinuseandduringtransport.• Oncecylinderhasbeenconnectedtoprocess,openvalveslowlyandcarefully.Ifexperiencing
difficultyopeningcylindervalve,discontinueuseandcontactsupplier.Donotattempttoforcefreeing“frozen”orcorrodedvalves.
• Regulatorsandvalvesmustbekeptfreeofmoisture.Systemsmustbepurgedwithdryinertgas(e.g.helium,nitrogen,argon,etc.)beforetheproductisintroducedandwhensystemisoutofservice.
Conditionsforsafestorage• ItisessentialthatallATGsbestoredseparatelyfromallchemicalswithwhichtheymayreact.
EnsuresegregationofincompatiblechemicalsperguidancewithinEH&Sguidelines.Also,followanysubstance-specificstorageguidanceprovidedinSafetyDataSheet(SDS)documentation.
• Allcompressedgascylindersmustbestoreduprightwithvalvecovercapsinplace.Damagetoavalvecancausethecylindertobecomeadangerousprojectile.Cylindersmustbeproperlysecuredwithtwonon-combustiblerestraintstopreventthemfromfallingatalltimes.
Disposal• Allemptygascylindersmustbelabeledasempty;however,emptycylindersmaystillcontain
sometoxicgas,somustremaininexhaustedenclosuresorfirecodecompliantgasstoragerooms.Depletedgascylindersmustbereturnabletothevendoraccordingtotheirguidelines.
8. ChemicalReleaseChemicalReleaseDial911
• AccidentalRelease–Helpcontaminatedorinjuredpersons.Ifconditionsandtimepermit,closeanyopenvalve.Evacuatethereleasearea.Avoidbreathingvapors.Eliminatesourcesofignition.Keepothersfromenteringthisarea(e.g.,usecautiontape,barriers,etc.).NotifysupervisorandEH&Simmediately.
• Contactwithbodyorclothes–Removeclothingandrinsebodythoroughlyinemergencyshowerforatleast15minutes.Seekmedicalattention.NotifysupervisorandEH&Simmediately.
• ContactwithEyes–Immediatelyrinseeyeballsandinnersurfaceofeyelidwithwaterfor15minutesusinganeyewashstationbyforciblyholdingtheeyeopen.Seekmedicalattention.NotifysupervisorandEH&Simmediately.
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9. CleaningandDecontaminationLab-specificinformationondecontaminationmaybeincludedintheProtocol/Proceduresection.Alllinesorductscarryingpurgedorexhaustedemissionsofgasesmustbeconnectedtoamechanicalexhaustsystemthatdischargestoasafelocation(i.e.,presentsnopotentialforre-entrainmentintoanybuildingsupplyairintakeoroccupiedarea).Constructionoftheexhaustductsmustbechemicallyresistanttodegradationbythegasinuse.Significantemissionsofcorrosiveortoxicgasesrequireanemissioncontroldevice(e.g.,scrubber,flaredevice,adsorbent)beforethepurgedgascanbeventedintotheexhaustductsystem.RefertoToxicGasProgram.
10. HazardousWasteDisposalLabelWaste
• AllemptygascylindersshallbelabeledasemptyDisposeofWaste
• Depletedgascylindersshouldbereturnabletothevendoraccordingtotheirguidelines.• ContactEH&Sat642-3073ifyouneedassistance.
11. SafetyDataSheet(SDS)LocationSDScanbeaccessedonlineathttp://ucsds.com
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12.Protocol/Procedure–AcutelyToxicGases(ATGs)
Procedure/Use Scale EngineeringControls/Equipment
PPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions
1.Useasa
reagent.
Upto200mLof
gas(at25ºC,1
atm,approx.10-2
mol)froma
lecturebottle.
Largerquantities
requirea
compound-
specificSOP.
SpeaktoyourPI
andLabSafety
Coordinator
abouthowto
establishanew
procedureforan
AcutelyToxic
Gas.
Allreactionsusingthese
materialsmustbe
performedinaproperly
operatingfumehood
withthesashaslowas
possible.
Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafety
glasseswithsideshields.
Faceprotection:Faceshieldsaretobeusedwhenthereisnoprotectionfrom
thehoodsash.
Handprotection:Confirmthecompatibilityoftheglovesyouusewith
thespecificATG.General
guidance(unlessotherwisespecifiedin
thespecificSDS):ataminimum,8mil
minimumnitrileglovesmustbeusedto
preventincidentalcontact.Forgas
releaseorforpotentialcontactwith
largerquantities,usedoublenitrileor
heaviergaugenitrileorneoprene
gloves.Glovesmustbeinspectedpriorto
use.Removeglovesimmediatelyupon
contamination.Washanddryhandsafter
use.
Clothing:Wearlabcoat;fulllengthpantsorequivalent;andclose-toed,close-
heeledshoes.
Avoidinhalationofthesematerials.
BesurethatthedeliverypressureoftheATG
iscompatiblewiththereactionapparatus.
Useacompatiblegasregulator.Insurethat
thegasbeingpassedthroughthereactoris
properlyventedintothefumehoodandthat
anyventedgasesdonotconstituteahealth
threattocoworkersornearbypopulations.
Extremecareshouldbetakennottoover
pressurizeglassreactors.
Notes AnydeviationfromthisSOPrequiresapprovalfromPI.
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13-DocumentationofTraining(signatureofallusersisrequired)
• PriortoconductinganyworkwithATGs,designatedpersonnelmustprovidetrainingtohis/herlaboratorypersonnelspecifictothehazardsinvolvedinworkingwiththissubstance,workarea
decontamination,andemergencyprocedures.
• ThePrincipalInvestigatormustprovidehis/herlaboratorypersonnelwithacopyofthisSOPandacopyoftherelevantSDSsprovidedbythemanufacturer.
IhavereadandunderstandthecontentofthisSOP:
Name Signature Identifier Date
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Appendix–ListofAcutelyToxicGases(non-exhaustivelist)
ChemicalName/Formula CAS# ChemicalName/Formula CAS#AmmoniaNH3 7664-41-7 ArsenicpentafluorideAsF5 7784-36-3
ArsineAsH3 7784-42-1 BorontrichlorideBCl3 10294-34-5
BorontrifluorideBF3 7637-07-2 CarbonmonoxideCO 630-08-0
CyanogenC2N2 460-19-5 CyanogenchlorideNCCl 506-77-4
ChlorineCl2 7782-50-5 DiazomethaneH2CN2 334-88-3
DiboraneB2H6 19287-45-7 FluorineF2 7782-41-4
GermaneGeH4 7782-65-2 Hexaethyltetraphosphate
C12H30O13P4
757-58-4
HydrogenbromideHBr 10035-10-6 HydrogenChlorideHCl 7647-01-0
HydrogenfluorideHF 7664-39-3 HydrogensulfideH2S 7783-06-4
HydrogenselenideH2Se 7783-07-5 MethylmercaptanCH3SH 74-93-1
NitricoxideNO 10102-43-9 NitrogendioxideNO2 10102-44-0
NitrogentetroxideN2O4 10544-72-6 OxygendifluorideOF2 7783-41-7
PhosgeneCOCl2 75-44-5 PhosphinePH3 75-45-5
PhosphorouspentafluoridePF5 7641-19-0 SeleniumhexafluorideSeF6 7783-79-1
StibineSbH3 7803-52-3 SulfurtetrafluorideSF4 7783-60-0
Trimethylsilyldiazomethane(CH3)3SiCHN2 18107-18-1
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ListofChemicals
Chemical(s) Chemical(s) Chemical(s)
Hexafluoroacetone(seespecificSOP) Ammonia Arsenicpentafluoride
Arsine Borontrichloride Borontrifluoride
Carbonmonoxide(seespecificSOP) Chlorine Cyanogen
Cyanogenchloride Diazomethane Diborane
Fluorine Germane Hexaethyltetraphosphate
Hydrogenbromide Hydrogenchloride Hydrogenfluoride
Hydrogenselenide Hydrogensulfide Methanethiol
Nitricoxide Nitrogendioxide Nitrogentetroxide
Oxygendifluoride Phosgene Phosphine
Phosphorouspentafluoride Stibine Sulfurtetrafluoride
