Accord and Advance

8/19/2019 Accord and Advance

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ACCORD

Action to ControlCardiovascular Risk in

Diabetes Trial

Reference:1) https://www.accordtrial.org/public/index.cfm?

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#) http://www.nhlbi.nih.go2/health/prof/heart/other/accord/34a.htm

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8hat is ;CC&RD stud


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• %he stud< began enrollingparticipants in #1 and too> placein -- clinical sites across the @nitedtates and Canada.

• ; total of 1#,1 adults withestablished t


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ACCORD study seek to

answer$

• to determine if a strateg< ofintensi2e lowering of blood sugarle2els intensi2e lowering of bloodpressure or treatment of blood lipidswith a Abrate drug plus a statin drugcan reduce the ris> of maBor CD

e2ents in patients with t of CD.


5/16

5owe2er

• no pre2ious clinical trial had testedthe eects of lowering blood sugaror blood pressure to near%nor&allevels in patients with t


6/16

"hat is the status of theACCORD study$

• ;ll three ;CC&RD clinical trials ha2eended. %he ational 5eart Eung and0lood Institute =5E0I) stopped the

intensi2e blood sugar loweringstrateg< on Februar< + #! due tosafet< concerns.

• %he blood pressure and lipid treatmenttrials continued until the planned endof the stud< in une #.


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1) ACCORD lood )ugarClinical Trial

• ;CC&RD Data and afet< 9onitoring0oard =D90) noticed that there is astatisticall< signiAcant ##G higherrate of death in the intensi2e=5b;1CH +."G) than the standardgroup=5b;1CH-.,G).


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ACCORD lood *ressureClinical Trial

• In the intensive group an a2erage s


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ACCORD 1ipid ClinicalTrial

• Jeople with t


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• statins lowers the rates of heartattac>s and cardio2ascular death

•

Abrate medications are used toincrease the blood le2els of theKgoodL 5DE cholesterol as well asreduce trigl


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ADVAC3

Action in Diabetes andVascular DiseaseReference:http://www.ad2ancetrial.com

http://www.medicalnewstoda


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;D;C(

• ;D;C( is the largest clinical trialon diabetes e2er conducted o2er11 patients

• %hese patients ha2e come from #dierent countries.

4l l i


14/16

4lucose lowering ar&results

• intensi2e blood glucose control usingDiamicron 9R =gliclaMide modiAed release)and other drugs as re3uired protectspatients against serious complications of

the disease.

• Reduces the o2erall ris> of seriousdiabetes complications b< 1G with a

#1G reduction in >idne< disease and *Greduction in the de2elopment ofmacroalbuminuria=a well establishedmar>er of increased cardio2ascular ris>)

l d l i


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lood pressure loweringar& results

• Jreterax=perindopril and indapamide)signi5cantly reduces total&ortality by +/6 and the ris> of

cardiovacular death by +76.

• In absolute terms one death wouldbe a2oided for e2er< - patients

treated with Jreterax for A2e


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%han>

Accord and Advance

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