A nine letter word for hope
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MacuScopeTM
Accurately measures a patient’s Macular Protective Pigment Density (MPPD)
Low MPPD is a major risk factor for Macular Degeneration and is modifiable
Pigment deficiency can NOW be identified and monitored decades before clinical signs and/or symptoms appear
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The FactsOverwhelming body of evidence that:
Yellow MPP blocks high energy blue light – has strong antioxidative properties
– resides anterior to the RPE layer and photoreceptors
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Concentration of Macular Pigments
Consists solely of 3 carotenoids:
Lutein (L), Meso-zeaxanthin (MZ) & Zeaxanthin (Z) MZ is the dominant carotenoid at the fovea and is the most
potent antioxidant in the macula
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Link to AMD
AMD Patients have low MPPD - a major risk factor
Reasons for low MPPD include:– Genetics– Smoking– Dietary insufficiency– Obesity– Inability to absorb– Lack of ability to convert L to MZ
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Nutraceutical Supplementation Repigmentation of the macula reduces the risk of
developing AMD– Objective: prevent future permanent and cumulative
damage
Appropriate nutraceutical supplementation can rebuild Macular Pigment– a formulary containing all 3 carotenoids as found in
LMZ3: 10mg Lutein: 10 mg Meso-zeaxanthin: 2 mg Zeaxanthin
Measurable repigmentation can occur in as little as 6 months and usually plateaus in 2 years
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AREDS Report 22
Archives of Ophthalmology, Sept. ’07
Evaluated dietary intake of carotenoids, vitamins A, C and E and their relationship to the progression of AMD
Conclusion: Only dietary intake of carotenoids correlated with a decreased rate of progression for any of the four stages of AMD
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Leading Expert John Nolan BSc, PhD
– Fulbright Scholar @ University of Georgia– Deputy Director & Post Doctoral Research Fellow, Waterford
Institute of Technology
PhD thesis "Determinants of Macular Pigment in Healthy Subjects" was the largest cross-sectional study of its type in the world
Significant findings from his thesis:– Healthy middle-aged offspring of patients with age-related macular
degeneration (AMD) have a significant lack of macular pigment– This finding suggests that the observed lack of pigment may predispose
the sons and daughters of AMD sufferers to this disease– Appropriate dietary modification may delay, or even prevent the onset
of disease
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Leading Expert Richard A. Bone PhD, Professor, Dept. of Physics, Florida
International University Research Interests: Experimental Biophysics - Physics of
the eye and visual system: MP and its possible relationship with AMD; non-invasive measurement of the MP; Cumulative light distribution on the human retina.
Recent Publications:– Bone, Landrum, Guerra, and Ruiz. (2003) Lutein and zeaxanthin dietary supplements raise macular pigment… J. Nutr.
133, 992-998.
– Krinsky, Landrum, Bone. (2003) Biologic mechanisms of the protective role of lutein… Annu. Rev. Nutr. 23, 171-201.
– Bone, Landrum (2004) Heterochromatic flicker photometery. Arch. Biochem. Biophys. 430, 137-142.
– Bone, Landrum, Gibert. (2004) Macular pigment and the edge hypothesis of flicker photometry. Vision Res. 44, 3045-3051.
– Rosenthal, Kim, de Monastario, Thompson, Bone et al (2006) Dose-ranging study of lutein…Invest. Ophthalmol. Vis. Sci. 47, 5227-5233.
–Bone, Landrum, Cao, Howard, Alvarez-Calderon. (2006) Macular pigment response…Nutr. Metab. 4:12.
– Bone, Brener, Gibert (2007) Macular pigment, photopigments, and melanin…Vision Res. 47, 3259-3268.
Bone and Draper (2007) Optical anisotropy of the human cornea…Applied Optics 46, 8351-8357.
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“It’s a great tool for identifying patients at risk for AMD. There is great relief on their faces when they get the results and find out they are not at risk. The thing patients fear most is going blind. For those who are at risk, they’re thrilled that there is something that can be done about it through supplementation and re-testing six months later.”
“We are seen as the technological leader in the community because no one else has this. We’re getting patients from across the state wanting to take the test.”
Elaine Happ OD, Monticello, MN
Testimonials on Technology
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“The MacuScope uses technology that needs to be available in every practice. It allows doctors to provide preventative eye care which may be vital to keeping quality vision for our patients. Our MacuScope raises the standard of care we provide and has been a welcome addition to our practice.”
Wes Kemp, O.D., Bolivar, MO
Testimonials on Technology
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“Trying to prevent blindness is a big part of what we do. You feel good about being an O.D. when a patient returns for their six month re-check, their macular protective pigment has increased, and you get a great big thank you! It’s wonderful to give patients hope”
Harriet Pelton, O.D., Bloomfield Twp, MI
Testimonials on Technology