A New Combination Formula for Treatment of Fungal Keratitis
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Transcript of A New Combination Formula for Treatment of Fungal Keratitis
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Pembimbing: dr. Rinanto Prabowo, Sp.M
BRIANATA SUSANTO UTOMO
KEPANITERAAN KLINIK MATA FK UKDWRS MATA DR YAP
Journal Reading
A New Combination Formula for Treatment of fungal Keratitis:An Experimental Study
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Pendahuluan
Absorbsi terbatasNatamycin eyedrop infeksi superfisial Ketokonazol antifungal +antibakteri Ketorolac efektif dan amanMucoadesive polymer memperpanjang
durasi
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Metode Penelitian
Evaluasi obatStudi antimikrobial in vitroStudi antimikrobial in vivo
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Evaluasi Obat
Mucoadhesive (ketokonazol dan ketorolac)CarbopolMethylcelulloseHydroxypropyl methylcellulose
pH, mukoadhesi, sterilisasi dan stabilitas
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Studi antimikrobial in vitro
Candida saburoud dextrose agar steril saline
Studi evaluasi aktifitas antifungalStudi drug release formula antifungal Membandingkan dengan “Nizoral cream”
(ketokonazol 2%)
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Studi antimikrobial in vivo
PF44(rapid release) 2% ketokonazol 0.5% ketorolac 1% carbopol
PF51 (slow release) 2% ketokonazol 0.5% ketorolac 4% hydroxyl-propyl-methylcellulose
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Studi antimikrobial in vivo
24 kelinci (tanpa riwayat lesi mata, 1,5-2,5kg)Grup 1 (12 kelinci)
OD PF 44 OS kontrol (6 ketokonazol, 6 placebo)
Grup 2 (12 kelinci) OD PF 51 OS kontrol (6 ketokonazol, 6 placebo)
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Studi antimikrobial in vivo
Ketamine – scraping – tobramicin – inokulasi pada stroma 100µL
Rapid release (PF 44) diberikan 6x sehariSlow release (PF 51) diberikan 3x sehariDimulai 48 jam setelah inokulasi selama 10
hariEvaluasi PA
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Hasil
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Hasil
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Hasil
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Hasil
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Hasil
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Hasil
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Hasil
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Hasil
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Kesimpulan
Slow release formula menyembuhkan lebih baik
pertumbuhan jamur (-)Sel radang ringan (-)
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Saran
Slow release formula untuk keratitis pada manusia
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Terima Kasih