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Pearcy, Mark, Woodruff, Mia, Xiao, Yin, Klein, Travis, Crawford, Ross, Izatt,Maree, Langton, Christian, Hutmacher, Dietmar, & Schuetz, Michael(2013)Orthopaedics and Trauma Queensland Annual Report 2012.

Orthopaedics and Trauma Queensland, Australia.

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http://www.ihbi.qut.edu.au/about/researchover/medicaldevice/orthopaedicsTrauma.jsp

Orthopaedics and Trauma QueenslandA Centre for reseArCh And eduCAtion in MusCuloskeletAl disorders

IncorporatIng:

› BIomaterIals and tIssue morphology group

› Bone group

› cartIlage regeneratIon laBoratory

› northsIde spIne research group

› orthopaedIc research group

› paedIatrIc spIne research group

› QuantItatIve BIomedIcal ImagIng and characterIsatIon research group

› regeneratIve medIcIne group

› trauma research group

A N N U A L R E P O R T 2 0 1 2

HeadingContents

inTrOducTiOn inside front

direcTOr’s message inside front

research Overview 1

selecTed PrOjecT highlighTs 1

research FaciliTies 9›› institute of health and Biomedical

innovation (ihBi) 9›› science and engineering Faculty 9›› medical engineering research

Facility (merF) 9

FacTs and Figures 9

naTiOnal cOmPeTiTive granTs 10

OTher granTs 11

PuBlicaTiOns 13›› Books 13›› Book chapters 13›› journal articles 13

sTaFF 17

adjuncT PrOFessOrial sTaFF 19

higher degree research sTudenTs 20›› new students 20›› continuing students 20›› completions 22›› Overseas visiting students 22

awards, Prizes and cOmmuniTy service 23

acknOwledgemenTs 24

for further inforMAtion PhOne +61 7 3138 6000 Fax +61 7 3138 6030 email orthotraumaqld@qut.edu.auwww.ihbi.qut.edu.au/research/medical_device.jsp

introduCtion

Orthopaedics and Trauma Queensland, the centre for research and education in

musculoskeletal disorders, is an internationally recognised research group that continues

to develop its reputation as an international leader in research and education. it provides a

stimulus for research, education and clinical application within the international orthopaedic

and trauma communities.

Orthopaedics and Trauma Queensland develops and promotes the innovative use of

engineering and technology, in collaboration with surgeons, to provide new techniques,

materials, procedures and medical devices. its integration with clinical practice and strong

links with hospitals ensure that the research will be translated into practical outcomes

for patients.

The group undertakes clinical practice in orthopaedics and trauma and applies core

engineering skills to challenges in medicine. The research is built on a strong foundation

of knowledge in biomedical engineering, and incorporates expertise in cell biology,

mathematical modelling, human anatomy and physiology and clinical medicine in

orthopaedics and trauma. new knowledge is being developed and applied to the full range

of orthopaedic diseases and injuries, such as knee and hip replacements, fractures and

spinal deformities.

doMAin leAder’s MessAge

welcome to the 2012 Orthopaedics and Trauma Queensland (O&TQ) annual report.

The review of QuT’s institute of health and Biomedical innovation (ihBi) conducted in 2012 is

leading to a re-organisation of the structure of research groups in ihBi. The completion of the

restructure was delayed with the executive director, Professor ross young, leaving to take

on the role of executive dean in the Faculty of health at QuT. a new executive director is

expected to begin in september 2013 with the new structure commencing in 2014.

Orthopaedics and Trauma Queensland is taking the opportunity of this delay to develop a

more comprehensive strategy for its transition into a centre recognised internationally for its

leadership in the area of the group’s central theme of advancing orthopaedic and trauma

surgery for improved treatment of musculoskeletal disorders and disease. Because of the

restructuring of ihBi for 2014 i have included a summary in the Facts and Figures section

of our performance from 2006 showing that over the seven years we have graduated 44

Postgraduate students, received $23.27million in research funding and published 387

journal papers; all significant achievements.

This year our research in orthopaedic implants, biomaterials and innovative scaffold

development, bone biology, spinal deformity and other spinal disorders has continued

to develop and provide clinically relevant outcomes. Our international links continue to

develop with Professor yin xiao cementing a formal link with chinese colleagues while our

other international links continue to flourish.

Please enjoy this report of our activities in 2012.

Professor Mark Pearcy Bsc, Phd, deng, fieAust, CPeng (Biomed)medical device domain leader, institute of health and Biomedical innovation, QuT

R e s e a R C h O v e R v i e w [ 1 ]

Research Overview

reseArCh overview

The research of Orthopaedics and Trauma

Queensland seeks to solve problems in a

broad range of areas focussed on issues

encountered in clinical practice, including:

›› Biomaterials and bone substitutes

›› cartilage biomechanics

›› cell biology›› cell biomechanics›› clinical research›› epidemiology›› Fracture healing›› lubrication›› mathematical

modelling›› mechanical

testing

›› Osteoarthritis›› Osteoporosis›› regenerative

medicine›› spinal deformity›› spinal disease›› surgical

complications›› surgical implants›› Tissue engineering›› Tissue mechanics›› wound healing

seleCted ProjeCt highlights

1. Biomaterials and tissue Morphology group

The Biomaterials and Tissue morphology

(BTm) group at ihBi, led by associate

Professor mia woodruff has taken on

several new members during 2012,

including the recruitment of research

associate dr giles kirby from the uk,

who undertook his Phd with collaborator

Professor kevin shakesheff at the

university of nottingham, and research

assistants kristofor Bogoevski and Flavia

savi. several publications arose during

the year including a Materials Today article

detailing histological assessment of long-

term bone regeneration using resorbable

scaffolds plus progenitor cells, in a pre-

clinical model (Figure 1).

Figure 1. Resorbable medical grade polycaprolactone scaffolds with and without the addition of bone marrow stromal cells implanted within a critical-sized porcine cranial defect for two years (Woodruff et al, publication: 74).

The BTm group continues to work closely

with the medical engineering research

Facility (merF) where several large

animal models are underway testing

new scaffolds in bone repair including

bioactive composites and novel growth

factor delivery strategies. The histology

capacity at ihBi continues to grow via

income from several equipment grants

and, with the resin embedding techniques

enabling large bone defect analysis, is

strengthening to become one of the

most equipped in the country. The BTm

group and the regenerative medicine

group, led by Professor hutmacher,

are also building capacity in the area of

biofabrication with a focus on custom

made, bioactive resorbable scaffolds for

patient specific implantation. we are also

developing growth factor delivery strategies

aimed at reducing clinical doses and

associated costs, (Figure 2); (which shows

microspheres containing growth factors

immobilised onto electrospun meshes

and demonstrates excellent bone-cell

interactions with the particles).

Figure 2. a) Electrospun porous meshes immobilized with protein eluting biodegradable particles. b) Precursor osteoblasts attaching and spreading on microparticles (Bock et al, publication: 8).

The paraffin and resin histology laboratory,

housed at ihBi , provides both QuT

academic project support and contract-

research services to external industry

[ 2 ] R e s e a R C h O v e R v i e w

clients and universities (Figure 3). services

include tissue processing, embedding

(paraffin and resin), sectioning, staining,

imaging/scanning and histomorphometrical

analysis – please contact us if you would

like further information on using these

services: mia.woodruff@qut.edu.au

Figure 3. Histology service provision at IHBI. For information please contact mia.woodruff@qut.edu.au.

2. Bone groupThe research of this group focuses on the

changes that osteocytes exhibit in osteo-

arthritis (Figure 4).

Figure 4. Pathological changes of osteocytes in osteoarthritis (OA).

Developing novel bone substitute

materials for bone repair and regeneration

low oxygen tension (hypoxia) plays a

pivotal role in the body by coupling blood

vessel and bone formation. it does this

by triggering a process of progenitor cell

recruitment and differentiation. The aim

of this project involves using materials-

based strategies to design scaffolds,

which activate the hypoxia pathway for the

purpose of developing and regenerating

skeletal tissue. This project will be a

catalyst to develope new treatment

strategies for large bone defects and has

the potential greatly to improve clinical

outcomes for patients. currently the market

for bone substitutes in australia alone is

estimated at a$400 million per annum.

Titanium implants and bone integration

Titanium implants are widely used in

dentistry and orthopaedics to replace

teeth and joints. modifying the implant

surface has been shown to improve

bone formation around titanium implants

under ‘normal’ conditions. however, their

success is reduced in compromised bone

such as that encountered in osteoporosis.

This study investigates the effect of

surface roughness and chemistry on bone

integration in osteoporotic conditions

and determine the associated biological

mechanisms. The determination of the

biological mechanisms will improve our

understanding of bone-implant interaction,

especially in difficult clinical situations such

as osteoporosis. This will lead to improved

outcomes of implants in osteoporotic

conditions.

Mesenchymal stem cell characterization

and tissue forming capacity

cell-based therapy has emerged as

one of the most promising therapeutic

approaches for tissue repair and

regeneration due to the inherent

characteristics of mesenchymal stromal

cells (mscs) in respect to their self-renewal

capacity and multipotent differentiation

potential. however, there has not been

a universal understanding of which

expansion conditions are optimal for the

manufacture of mscs intended for bone

repair and regeneration. more interestingly,

recent experimental evidence suggests

that implanted mscs have a close

communication with host cells, and the

contribution of donor cells is beyond their

direct conversion into bone forming cells.

The group is working on the molecular and

cellular interactions during the process

of new bone formation. The knowledge

developed will provide a scientific rationale

for the development of novel therapeutic

strategies in the treatment of bone defects.

3. Cartilage regeneration laboratoryThe cartilage regeneration laboratory

(crl) is led by associate Professor

Travis klein. The goal of the crl is to

develop long-term regenerative therapies

for treating cartilage defects, including

osteoarthritis. To help understand the

processes of cartilage formation and joint

pathologies, the group is developing model

systems combining human cells with

functionalised biomaterials and mechanical

stimulation techniques. The crl is

also working in the emerging area of

biofabrication, where biomaterials and cells

are combined in a computer-controlled

manner to form three-dimensional

structures suitable for in-vitro or in-vivo

studies.

crl research is funded by the australian

research council (arc) through the

Future Fellowship and discovery Project

schemes, as well as the national health

and medical research council (nhmrc)

through a Project grant (in collaboration

with associate Professor yin xiao and

Professor ross crawford). associate

Professor klein and Professor dietmar w

hutmacher are also named investigators

on a large european union grant that

was awarded in 2012. This project,

hydrozOnes, is a major collaborative

effort with 16 partners from around europe

that aims to develop tissue-engineered

cartilage constructs using advanced

biomaterial and biofabrication technologies

over the next five years. additionally, the

crl was successful in its bid for an ihBi

collaboration grant with dr Tony Parker

from ihBi and the Faculty of health. This

grant aims to help our understanding of

the interactions between the angiogenic

system and loading in osteoarthritis.

Heading

R e s e a R C h O v e R v i e w [ 3 ]

The crl currently consists of one

postdoctoral researcher, dr karsten

schrobback, 3 Phd students, and several

additional higher degree research (hdr)

students who are co-supervised in the

group. One of the major developments of

the year was june jeon’s completion of

her Phd, entitled ‘development of zonal

cartilage constructs: effects of chondrocyte

subpopulation, compressive stimulation,

and culture models.’ dr jeon did an

excellent job during her Phd and continues

to play a role in the crl as a post-doc in

the regenerative medicine group. daniela

Paul, and christoph meinert completed

their master’s and Bachelor’s degrees,

respectively, at the university of applied

sciences darmstadt (germany) after

successful research projects in the crl.

christoph has decided to re-join the crl

for a Phd at QuT, starting in 2013.

in 2012, the crl published work in leading

journals including Osteoarthritis and

Cartilage, Tissue Engineering –

Part A, the Journal of Tissue Engineering

and Regenerative Medicine, Cell

and Tissue Research, the Journal of

Biophotonics, and Progress in Polymer

Science. The article in the Journal of

Biophotonics describes novel imaging

techniques for cartilage, which were

developed during marieke Pudlas’ (first

author) research visit to the crl, and

was chosen as the cover article.

The group presented their work in 2012

at the world Biomaterials congress

(chengdu, china), including a special

symposium on zonal cartilage tissue

engineering chaired by associate

Professor klein; the world congress of

the international cartilage repair society

(montreal, canada); the Tissue engineering

and regenerative medicine international

society world congress (vienna, austria);

and annual meetings of the matrix

Biology society of australia and new

zealand. They further took part in the first

australian Osteoarthritis summit, in which

stakeholders including research leaders,

funding bodies and people suffering

from Oa discussed the priorities for

osteoarthritis research.

4. northside spine research groupThis group bases its activities around

the clinical practice of dr Paul licina and

examines the outcomes of surgery for

degenerative spinal disorders. in particular

the group is looking at comparison

of fusion rates with bone substitute.

investigations into anterior alone anterior

lumber interbody fusion with plate and

rhBPm-2 were completed and material

is being prepared for publication.

Presentation of ‘actifuse is comparable

with infuse in achieving fusion’ at the

spine society of australia annual scientific

meeting 2013 was well received with an

aim of future publication of these results.

Presentation of ‘Patient expectations,

outcomes and satisfaction: related, relevant

or redundant?’, at the international society

for the study of the lumbar spine (issls)

spine week meeting in amsterdam 2012

was followed by publication in the evidence

Based spine journal (eBsj). Future

collaboration with ihBi and the centre

for accident research and road safety,

Queensland (carrs-Q) investigating

fitness to drive following spinal surgery is

in progress.

5. orthopaedic research groupThe Orthopaedic research group directed

by Professor ross crawford is directly

involved in the supervision and training

of the next generation of doctors and

surgeons. each year medical students from

around the world participate in traineeships

with the group’s post-doctoral researchers

who try to impart research skills to further

the students’ careers. The projects that the

students participate in are part of the larger

research program that the Orthopaedic

group is involved in. an overseas

orthopaedic surgeon spends

12 months with the group developing

surgical and research skills. To date

fourteen surgeons, from countries as

diverse as india, canada, The netherlands

and the uk, have completed this training.

Professor crawford is involved in clinical

research at The Prince charles hospital

including research projects exploring the

relationship between obesity and outcome

following total joint replacement; minimising

complications post surgery; the efficacy

of new techniques and instrumentation;

economic evaluation of infection prevention

in total hip replacement; and risk factors

and outcome following hip fracture.

Professor crawford and his team also

have strong collaborative links with the

exeter hip unit in exeter, uk and liaise on

many clinical and developmental projects

surrounding hip replacement.

Professor crawford and dr lance wilson

have been investigating the causes and

clinical treatment of periprosthetic femoral

fractures. These fractures, that directly

involve the existing femoral implant, are

rare and difficult to treat. Our team of

orthopaedic surgeons, engineers and

students approached the problem with

two aims: to generate the same type of

fractures seen clinically in the laboratory

and to assess the performance of different

fracture repair techniques. The study has

generated two additions to the field of

orthopaedic research: an in-vitro model for

periprosthetic fracture generation and the

validation of cement-in-cement revisions

for periprosthetic fractures.

Biomechanical studies into the design and

behaviour of femoral stems used in total hip

replacement have been instrumental in the

development of a new design of implant

that will be released globally in 2014. in

Heading

[ 4 ] R e s e a R C h O v e R v i e w

addition to the scientific achievements,

the team has trained medical students

and orthopaedic surgeons in the use of

biomechanics as related to orthopaedics.

On the reverse side biomedical engineering

students are able to work with surgeons on

projects that are clinically applicable.

6. Paediatric spine research groupThe QuT/mater Paediatric spine research

group (Psrg) is a collaboration between

QuT Biomedical engineering researchers

and spinal Orthopaedic surgeons at the

mater children’s hospital in Brisbane,

australia. The group was established in

2002 to undertake research into spinal

deformities and other spine disorders to

improve the understanding and treatment

of these conditions. scoliosis, the most

common spinal deformity affecting children

and adolescents, results in the spine

curving sideways and twisting, leading to

an obvious hump on one side of the back

(Figure 5).

Figure 5. A 13-year-old girl suffering from progressive scoliosis requiring surgical stabilization.

scoliosis affects 2–4% of the population

and can appear during infancy, childhood

or the teenage years. The cause remains

unknown. about 500 australian children

each year require surgical correction and

stabilisation of their progressing scoliosis

using screws and rods. a world first study,

currently underway by Psrg researchers,

involves the sampling of vertebral bone

from the spinal column of adolescents with

scoliosis. The bone samples are taken by

the Orthopaedic spinal surgeon during

anterior scoliosis correction surgery in the

operating theatres at the mater children’s

hospital (Figures 6 and 7).

Figure 6. Fluoroscope image taken as the sample of vertebral bone is collected prior to the insertion of the vertebral body screw.

Figure 7. Spinal Orthopaedic Surgeons performing surgical stabilisation of progressive idiopathic scoliosis.

several recent studies have established

that teenagers with idiopathic scoliosis

have generalised lower bone mineral

density than their peers without scoliosis,

when measured by conventional imaging

techniques. it is also now understood

that low bone mineral density is a primary

problem of idiopathic scoliosis rather than

secondary to the spinal deformity as it is

present before the deformity develops and

also persists into maturity.

The vertebral bone samples taken in

this study will be analysed for their bone

mineral density as well as the quality of

the bone to see if there are abnormalities

in either bony architecture or the material

mechanical properties of scoliotic bone.

nanoindentation and Quantitative

Backscattered electron imaging (Figure 8)

will be used to analyse the vertebral bone

samples as well as complementary tests

on a sample of the patient’s blood for bone

turnover markers and vitamin d status.

Figure 8. Example of a Quantitative Backscattered Electron image showing mineral variations within adult trabecular bone in a femoral head sample from previous work by Victoria Toal as part of her PhD studies. The current study will analyse adolescent scoliotic vertebral bone for the first time.

This research project will make a

considerable contribution towards an

improved understanding of the quality of

bone in scoliosis sufferers. The findings

will potentially be used as a factor in the

prediction of scoliotic curve progression,

and the treatment approaches employed

for children and adolescents with

scoliosis. as this study is the first ever

to examine scoliotic vertebral bone

using nanoindentation and Quantitative

Backscattered electron imaging, it is

anticipated that there will be significant

international and national interest from both

the scientific and medical community in the

outcomes of this research.

Heading

R e s e a R C h O v e R v i e w [ 5 ]

a novel and topical research project

deviation for the Psrg in 2012 found that

the iPhone is a useful clinical device that

can assist medical staff in the surveillance

and management of young patients

with spinal deformity. The worsening

of spinal deformities in young children

and adolescents has been traditionally

monitored by spinal Orthopaedic surgeons

by measurement of the angles of deformity

on hardcopy x-rays with a protractor

and pencil. The rotation deformity of the

scoliotic spine and ribcage (rib hump)

was measured with a simple hand-held

scoliometer tool (similar to a carpenter’s

level). The iPhone and other smart phones

have the capability to accurately sense

inclination, and can therefore be used to

measure scoliosis deformity angles on

x-rays (or computer screens for digital

x-rays) and the twisting of the patient’s

ribcage (rib hump) (Figures 9 and 10).

Figure 9. iPhone measuring the angle of vertebral tilt on an X-Ray of a patient with scoliosis.

Figure 10. iPhone measuring the angle of trunk rotation (rib hump) on a scoliosis patient.

The research project aimed to quantify

the performance of the iPhone compared

to a standard protractor (scoliosis angles)

and scoliometer (rib humps) to ensure

medical staff could rely on their phones to

provide accurate readings and therefore

make appropriate clinical management

decisions. The x-ray measurement study

and the rib hump measurement study both

confirmed that the iPhone has the potential

to make a significant impact on efficiency

in busy city spinal clinics as well as remote

areas where digital x-ray systems are not

always available. The iPhone was found to

be a clinically equivalent measuring tool to

the traditional protractor and scoliometer

devices, with inter and intra-observer

variability similar to the traditional devices

and also similar to previous studies of

the traditional measurement techniques.

This work resulted in two internationally

peer-reviewed journal papers published

in 2012 as well as an award for the Best

Presentation at the annual scientific

meeting of the spine society of australia

conference and continues to attract

interest from researchers and clinicians

internationally.

7. Quantitative Biomedical imaging and Characterisation research group (Q-BiC)

The Q-Bic research group now

concentrates almost exclusively on

Quantitative ultrasound imaging and

characterisation.

3D/4D Quantitative Ultrasound Imaging

‘flat-Bed’ scanner: although

mammography is an effective way to

detect breast cancer, it is a 2d modality

used to image a 3d structure. image

co-registration with mri of a commercial

phantom is currently being investigated.

we have developed a twin-compartment

scanning tank facilitated via an ultrasonically

transparent membrane. in the lower

compartment a phased-array transducer is

scanned and the subject positioned in the

upper compartment.

robotic tumour targeting: successful

tracking of a tumour volume during

radiation delivery will provide a permanent

record of movement and may serve as

an interrupt. we have developed a twin-

robot dynamic phantom that will enable

the dosimetric consequences of tumour

movement to be quantified.

ultrasound Computed tomography:

utilising two co-axial phased-array

ultrasound transducers with a robotic arm

to facilitate translation and rotation, we

aim to determine both attenuation and

velocity maps for implementation within a

finite element model to predict mechanical

integrity. Potential applications include

paediatric skeletal assessment, bone

fatigue fracture risk in elite athletes, armed

forces personnel and equine laminitis.

another application is characterisation of

radiation dosimetry gels, to be validated

against conventional mri and optical cT.

Tissue Characterisation

langton theory and ultrasound transit

time spectroscopy (utts): langton

has recently proposed that the primary

ultrasound attenuation mechanism in

complex porous composite media such as

cancellous bone is due to phase interference

resulting from variations in propagation transit

time through the test sample as detected

over the phase-sensitive surface of the

receive ultrasound transducer. a Transit Time

spectrum, ranging from tmin to tmax, describing

propagation through entire solid and liquid

respectively, may be defined, from which it is

hypothesised that uTTs will provide accurate

assessment of both the volume fraction and

structure of complex porous composites.

it is envisaged that uTTs will, for the first

time, enable whO osteoporosis criteria to

be applied to ultrasound bone densitometry

Heading

[ 6 ] R e s e a R C h O v e R v i e w

measurements, thereby significantly

increasing both the utility and acceptance.

8. regenerative Medicine groupThe Overarching Philosophy of the

Regenerative Medicine Group:

BiOengineers embrace complexity

BiOengineers design modularity/versatility

and BiOengineers deliver simplicity

The translational pathways for clinical

testing and therapeutic use and the

complexity of engineered tissue constructs,

often containing a combination of scaffolds,

cells, and/or growth factors, creates

challenges not only from a basic science

point of view but also from a translational

research angle. hence, it is necessary to

develop a much more iterative style of

research with low and permeable barriers

and a great deal of interaction between

academic research and industry. Based on

this background the regenerative medicine

group focuses on three major themes:

Biofabrication Technology Platform

The anatomical, physiological and

physiochemical aspects of regenerating or,

as an engineer would define it, rebuilding

tissues from cells in orchestration with

a scaffold and/or matrix are immensely

complicated. we must embrace this

biological complexity, but it cannot

dominate the design of a scaffold-

based concept in the process of clinical

translation. moreover, one size or

formulation cannot fulfill every need, from

cell expansion and delivery of growth

factors for muscle regeneration to creating

a structurally sound and slow degrading

scaffold for large-scale bone defect repair.

we should engineer flexibility, so that a

single suite of approvable materials can be

exploited for multiple physician uses in a

variety of clinical niches.

For regenerative medicine to succeed

as a reality, we must deliver simplicity.

The penetration of new technology into

any market is not determined only by

improvement in patient outcome — the true

limiting factors are cost, familiarity, and ease

of use. we believe that our biofabrication

technology platform technology addresses a

balance between the physiological and the

practical requirement, and that its uses for

clinical, veterinary, and laboratory research

needs will continue to expand in the

decades to come.

additive manufacturing techniques offer

the potential to fabricate tissue constructs

to repair or replace damaged or diseased

human tissues and organs. using these

techniques, spatial variations along multiple

axes with high geometric complexity in

combination with different biomaterials can

be obtained. The level of control offered by

these computer-controlled technologies

to design and fabricate tissues will allow

tissue engineers to better study factors that

modulate tissue formation and function,

yet most importantly discuss which

biomaterials properties are needed to move

the current concepts to practical solutions

and ultimately from bench to bedside.

The current limitations of the classical

tissue and organ printing techniques allow

the rm group to make a strong case that

the field needs to move towards exploring

and applying the full spectrum and the

combination of additive manufacturing

techniques and biomaterials for engineering

of tissues and organs. especially we

advocate that tissue engineers in our group

working on this concept need to interface

and learn from other areas such as material

science, mechatronics, bioengineering and

digital printing.

Bone Tissue Engineering

commonly applied therapies to achieve

bone reconstruction or function

are restricted to the transplantation

of autografts and allografts, or the

implantation of metal devices or

ceramic-based implants. Bone grafts

generally possess osteoconductive and

osteoinductive properties. They are,

however, limited in access and availability

and harvest is associated with donor site

morbidity, hemorrhage, risk of infection,

insufficient transplant integration, and graft

devitalisation. as a result, recent research

focuses on the development of alternative

therapeutic concepts.

available literature indicates that bone

regeneration has become a focus area in

the field of tissue engineering. hence, a

considerable number of research groups

including our own and commercial

entities work on the development of

tissue engineered constructs to aid

bone regeneration. however, bench to

bedside translations are still infrequent

as the process towards approval by

regulatory bodies is protracted and

cost-intensive. approval requires both

comprehensive in-vitro and in-vivo studies

necessitating the utilisation of large

preclinical animal models. consequently,

to allow comparison between different

studies and their outcomes, our group

focuses on the standardization of large

preclincial animal models, fixation devices,

surgical procedures and methods of

taking measurements to produce reliable

data pools as a base for further research

directions in the area of bone tissue

engineering.

Development of 3D disease models

in the future, animal and human donor

cell models may not be the first choice for

understanding mechanisms of disease,

cancer and their treatments. a main factor

is the poor evidence for efficacy of animal

models in humans. in addition, ethical

issues limit the applicability of animal

models due to increasing restrictions

in animal transport from overseas and

cost of higher developed animals such

as primates that would provide in-vivo

resemblance of human tissues. human

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R e s e a R C h O v e R v i e w [ 7 ]

donor tissues are of limited availability and

certain genetic predispositions that remain

undetected impact on the interpretability

of the outcome. In-vitro models, on the

other hand allow systematic repetitive,

in-depth and quantitative studies of

physiological and pathophysiological

processes without having to deal with

complications that are associated with

animal and donor tissues such as keeping

cells in viable conditions for a long period

of time. while most in-vitro models have

been successfully created in the two-

dimensional (2d) ‘monolayer’ medium,

2d models for studying for example

tumour cell growth in plastic dishes have

been compared to “...training for a desert

war in the arctic”. a more complex and

purer approach is to provide a three

dimensional (3d) ‘microenvironment’ to

the cells studied, by resembling the cells’

interstitial fluid and extracellular matrix

(ecm) as they experience these under

in-vivo conditions. The logic behind this

3d approach is that this model allows cells

to crosstalk with their microenvironment,

which may initiate events at cellular and

molecular levels including changes in cell

differentiation, morphogenesis, motility,

secretory function and gene expression.

in a 3d structure, cells can recapitulate

their original structure similar to in-vivo

conditions. it is believed that those ‘cues’

from the microenvironment are necessary

for the cells to differentiate and thus such

3d conditions allow the study of in-vivo

cellular events.

Functional features of ecm-cell niches

arise from the dynamic modulation of

the interplay of specific binding and

physical constraints of different cells.

in consequence, projects within this

programme will have to systematically

study different interactions according to

their relevance for various disease-tissue-

specific niche types. These interactions,

or categories of signals, define the general

outline for experimental approaches to

mimic signals related to disease related cell

microenvironments by using bioengineering

tools and innovative biomaterials.

accordingly, surface and matrix engineering

approaches are employed by the rm

group for the preparation of scaffold

surfaces and matrices with gradated

biochemical and physical characteristics.

as a major challenge of such a research

programme, surfaces and matrices have

to combine several of the above-listed

features according to the hypothesis on

the structural and functional properties

of the particular disease cell niche under

investigation. we envision that experiments

using advanced biomimetic materials

together with progress in modeling of

cellular interactions within the niche

microenvironment will substantially

contribute to the refinement of the

hypotheses on exogenous signals of

the disease cell niche which, in turn, will

provide a base for the development of next

generation of biomaterials research for

disease model bioengineering.

currently, several research groups including

ours have begun to adapt more advanced

3d culture techniques adapted from the

tissue engineering field to create not

only more physiological but also more

clinically relevant disease models; e.g.

tumour biology. in the context of what is

defined today as ‘tumour engineering’,

that is, the construction of complex cell

culture models that recapitulate aspects

of the in-vivo tumour microenvironment

to study the dynamics of tumour

development, progression, and therapy

on multiple scales. Our group provides

examples of fundamental questions that

could be answered by developing such

models, and encourages the continued

collaboration between bioengineers,

physical scientists and life scientists not

only for regenerative purposes, but also to

unravel the complexity that is the tumour

microenvironment.

9. trauma research groupThe Trauma research group brings

together clinical and engineering expertise

to tackle emerging issues in relation to the

management of orthopaedic trauma.

Optimizing the timing of mechanical

stimulation for fracture healing

Building on the adjunct appointment

of Professor claes, 2012 saw the

commencement of the first collaborative

research project between the Trauma

research group and the institute for

Orthopaedic research and Biomechanics

(university of ulm, germany). This project,

supported by an arbeitsgemeinschaft fur

ostesynthesis (aO) Trauma asia Pacific

grant, investigates the influence of the

temporal application of load on the process

of fracture healing.

The study question could be best

addressed using an experimental model

developed by Professor claes’ group. in

February dr ronny Bindl joined dr devakar

epari to complete the first experiments,

and train local students nicole loechel

(Phd) and lidia koval (masters) in the

procedures for ongoing work towards this

project. Preliminary results demonstrating

the benefits of early mechanical stimulation

followed by rigid fixation were presented at

the 1st aO Trauma asia Pacific scientific

congress in hong kong.

Mechanobiology of Bone Healing

dr Tim wehner, from the university of

ulm and known for his expertise in the

numerical modelling of fracture healing,

joined the Trauma research group on a

sixth month visit funded by the german

research council (dFg). dr wehner

is collaborating with dr epari on the

development of a novel experimental

model to investigate the mechanobiology

[ 8 ] R e s e a R C h O v e R v i e w

of bone healing. The experimental

model is intended to provide precise

control of the mechanical environment

thereby providing a platform for further

development and validation of algorithms

for the simulation of bone healing and

regeneration. dr wehner’s visit was timely,

coinciding with the 2012 conference and

workshop on modelling and computation

in musculoskeletal engineering, which

featured plenary lecturers from Professor

lutz claes (ulm), Professor georg duda

(Berlin), dr alf gerisch (darmstadt), and

dr richard weinkamer (Potsdam).

dr vaida glatt joined our Trauma research

group in mid 2012 via the julius wolff

institute in Berlin, germany, where she

undertook a post-doctoral fellowship with

Professor georg duda. dr glatt received

her Phd under the supervision of Professor

chris evans at the center for advanced

Orthopaedic studies, harvard medical

school. dr glatt’s research focus is the

regeneration and repair of orthopaedic

tissues. specifically, her interest lies in the

interaction of biological and mechanical

factors in the healing of large segmental

bone defects. her work is focused on

maximising the regenerative capacity of

bone healing while minimising the dose

of BmP-2 required clinically through

manipulation of the implant stability. soon

after arriving, dr glatt was awarded a

vice-chancellor’s research Fellowship in

recognition of her research achievements.

The Trauma research group has

expanded its presence outside the institute

of health and Biomedical innovation.

dr roland steck took on the additional

role of deputy director of the medical

engineering research Facility on The

Prince charles hospital campus.

dr steck has been invaluable in ensuring

the needs of researchers are being met at

this world-class facility. The Trauma group

also moved into the newly completed

Translational research institute (Tri) on the

Princess alexandra hospital campus. maja

schlittler and esther jacobson are the first

of our group to enjoy the new facilities,

which have become a home for the spinal

Trauma registry and the Trauma database.

in 2012, we celebrated the successful

completion of Phd degrees by two of

our group members. congratulations

dr Pushpanjali krishnakanth and

dr caroline grant. we are pleased that

dr caroline grant will continue her work

and support of the group’s activities as a

post-doctoral researcher.

in addition to visits by Professor claes and

Professor Perren we were fortunate to host

for the first time mr ruebi Frigg. mr Frigg is

the chief development Officer at synthes

and has been responsible for many of

the innovations in trauma implants on the

market today. mr Frigg took time out from

a busy world tour to share his knowledge

and experience with members of the

Trauma research group.

2012 ended with the establishment of the

integrated Trauma centre led by Professor

schuetz as part of the newly formed

diamantina health Partners, Queensland’s

first academic health science centre. with

a holistic view of trauma, the centre brings

together Queensland’s brightest and best

covering pre-hospital and hospital care,

allied health, rehabilitation and prevention.

The goal of the centre is to improve care

for patients in our community by integrating

clinical practice, research and education.

Heading

R e s e a R C h f a C i l i t i e s [ 9 ]

Research facilities

institute of heAlth And BioMediCAl innovAtion (ihBi)

QuT kelvin grove campus

›› laboratories for cell culture, mechanical and materials Testing, Polymer chemistry, Tissue mechanics, instrumentation and histology

›› mechanical and electronics workshop

sCienCe And engineering fACultY

Qut gardens Point Campus›› cell culture and mechanical Testing

laboratories›› rapid Prototyping Facility›› six axis spine Testing robot›› nanoindentation (umis 2000)

MediCAl engineering reseArCh fACilitY (Merf)

the Prince Charles hospital›› Operating Theatres›› anatomical and surgical skills

laboratory›› laboratories for materials Testing,

cell culture and Other Projects›› seminar room

The medical engineering research Facility

(merF) at The Prince charles hospital,

chermside was opened in 2008, and

was built by QuT with assistance from

the Queensland government smart

state Facilities Fund, the industry

partners medtronic and stryker, and

The Prince charles hospital. in 2012 merF

transitioned to a new reporting structure

under the umbrella of the institute of health

and Biomedical innovation (ihBi) within the

QuT organisational chart.

merF has become renowned for providing

the very best in theatres, equipment,

amenities and support to accommodate

surgical skills and allied health training and

education. in addition, merF is one of a few

preclinical research facilities worldwide that

is capable of providing the entire process

chain from concept to completion for the

evaluation of new biomaterials, implants,

medical devices

and surgical techniques at a single site.

facts and figures 2012›› 82 staff ›› 56 postgraduate students (20 commencements and 11 completions)›› $4.31 million research income ›› 83 journal papers, 2 books, 7 book chapters

suMMArY of fACts And figures 2006 - 2012

Orthopaedics and Trauma Queensland - facts and figures for 2006 to 2012

data from the O&TQ annual reports that are available on QuT ePrints

year staff number* staff academic and research**

hdr student number enrolled

hdr student commencing

hdr student completions

income au$ journal Publications

2006 45 22 23 4 5 $2.60m 232007 53 25 31 8 2 $2.30m 452008 86 26 40 10 6 $3.00m 422009 90 28 34 10 6 $3.16m 532010 85 27 54 20 8 $3.80m 752011 83 33 59 16 6 $4.10m 632012 82 36 56 20 11 $4.31m 83

totals 44 $23.27m 384* staff number includes academics, research Only staff, Professional staff, adjunct appointments and clinical Fellows associated

with O&TQ** staff number includes academics, research Only staff, Post-doctoral fellows and research Fellows (but not including

research assistants)

Heading

[ 1 0 ] N a t i O N a l C O m p e t i t i v e g R a N t s

grAnt national health and medical research council

title Bioactive and biodegradable scaffold and novel graft source for the repair of large segmental bone defects

Chief investigAtors dw hutmacher, m schuetz, d epari, m woodruff, r steck

funding $448 838

grAnt national health and medical research council

title a novel mesenchymal stromal cell and biomaterial for corneal reconstruction

Chief investigAtors dw hutmacher

funding $498 799

grAnt australian research council

title Optimisation of functional mesoporous materials for low-abundance biomarkers quantification towards biodiagnostic applications

Chief investigAtors i Prasadam

funding $45 000

grAnt national health and medical research council

title stem cells for periodontal regeneration

Chief investigAtors dw hutmacher

funding $200 617

grAnt australian research council Future Fellowship

title Frontiers in bone and joint regeneration

Chief investigAtors dw hutmacher

funding $931 168

grAnt australian research council Future Fellowship

title regenerating articular cartilage with smart hydrogels and fabrication technologies

Chief investigAtors Tj klein

funding $639 288

National competitive grants

Heading

O t h e R g R a N t s [ 1 1 ]

Other grants

grAnt Queensland government

title smart Futures Phd scholarship: robotic extrusion of intelligent tissue engineering scaffolds

Chief investigAtors m woodruff

funding $36 000

grAnt medtronic australasia Pty ltd

title Biomechanical assessment of a new growth modulation staple for fusionless scoliosis correction

Chief investigAtors c adam

funding $39 198

grAnt Queensland Orthopaedic research Trust – Queensland community Foundation Funds

title student research support

Chief investigAtors mj Pearcy

funding $7200

grAnt The Prince charles hospital Foundation research grant

title developing an injectable drug containing hyaluronic acid (ha) and erk signaling pathway modulators for osteoarthritis treatment.

Chief investigAtors r crawford, y xiao, i Prasadam

funding $73 250

grAnt australian dental research Foundation inc

title investigation of hedgehog signalling pathway during cementum regeneration in rat root wound healing model

Chief investigAtors y xiao

funding $9994

grAnt aO Foundation

title regenerative potential of osteoblasts and mesenchymal stem cells for bone tissue engineering

Chief investigAtors dw hutmacher, a Berner, a anthon

funding $122 743

grAnt mater Foundation

title Psrg synthes research activity support

Chief investigAtors c adam, m Pearcy

funding $475 000

grAnt human health and wellbeing collaborative research development grant scheme (hhwB) – ihBi

title Obesity and bone health: molecular links between obesity and osteoarthristis and therapeutic implications

Chief investigAtors r crawford, y xiao

funding $30 000

grAnt The wesley research institute lTd

title The reconstruction of large segmental bone defects using patient-specific tissue engineered constructs

Chief investigAtors m schuetz, dw hutmacher

funding $89 600

grAnt urB – aTn-daad joint research co-operation scheme

title Osteochondral defect regeneration using novel hybrid scaffolds

Chief investigAtors m woodruff

funding $24 000

[ 1 2 ] O t h e R g R a N t s

grAnt ihBi collaborative research development grant

title chondrocyte production and mechanoregulation of anti-aginogenic factors

Chief investigAtors T klein

funding $29 124

grAnt ihBi collaborative research development grant

title an innovative biomemetic model for studying the pathomechanisms of aging and age-related macular degeneration

Chief investigAtors B Feigl, d harkin, dw hutmacher

funding $30 000

grAnt cells and Tissue collaborative research development grant scheme – ihBi

title The expression and release of damage-associated molecular patterns (damps) following skeletal muscle injury

Chief investigAtors r steck, m woodruff, j Peake

funding $15 000

grAnt ihBi collaborative research development grant

title a novel bioengineered 3d model to study ovarian cancer progression in-vivo

Chief investigAtors F melchels, d loessner, dw hutmacher

funding $19 987

grAnt ihBi collaborative research development grant

title deciphering molecular interactions between prostate cancer cells and bone microenvironment

Chief investigAtors a Taubenberger, dw hutmacher,

funding $10 000

grAnt ihBi collaborative research development grant

title customized polycaprolactone melt electrospun scaffold for periodical regeneration

Chief investigAtors c vaquette, dw hutmacher

funding $10 000

grAnt arthritis australia

title Therapeutic targeting of microrna-23 in osteoarthritis

Chief investigAtors r crawford, y xiao, i Prasadam

funding $30 000

grAnt human health and wellbeing collaborative research development grant scheme (hhwB) – ihBi

title developing intelligent biodegradable polymer micro/nanoparticles encapsulating nicotinic receptor modulator drugs for pulmonary delivery for the treatment of nicotine and alcohol dependancy

Chief investigAtors B goss

funding $29 824

Heading

p u b l i C a t i O N s [ 1 3 ]

Books

1. afara iO, Oloyede a (2012) near infrared spectroscopy evaluation of articular cartilage: decision-making in arthroplasty: real-time assessment of articular cartilage. Lambert Academic Publishing.

2. xiao y. (ed) (2012) Mesenchymal stem cells; Cell Biology research Progress. Nova Science Publishers, New York.

Book ChAPters

1. irawan d, hutmacher dw, kleinTj (2012) Matrices for zonal cartilage tissue engineering. In Khang, G. (Ed.) Handbook of Intelligent Scaffold For Tissue Engineering And Regenerative Medicine. singapore, (p 733–756).

2. little P, adam c (2012) Patient-specific modeling of scoliosis. In Gefen, A. (Ed) Studies in Mechanobiology, Tissue Engineering and Biomaterials Vol 9; Part II Spine, Springer, Berlin, (p 103–131).

3. Prasadam i, chakravorty n, crawford rw, xiao y (2012) Mesenchymal stem cells in osteoarthritis therapy:current status of theory, technology and applications. In Xiao Y (Ed) Mesenchymal Stem Cells. nova science Publishers, new york, (p 163–176).

4. schuetz ma, Berner a, richards rg (2012) implant removal. in Babst, reto, Bavonratanavech, southern, &Pesantez, rodrigo (eds.) Minimally invasive plate osteosynthesis [2nd. Ed.]. aO Publishing, davos, (p 757–767).

5. schuetz ma, kääb mj (2012) distale femurfrakturen. In Haas, Norbert P, Krettek C (Eds). Tscherne unfallchirurgie: Hüfte und Oberschenkel. springer verlag.

6. xiao y, kaur n (2012) overview of mesenchymal stem cells. In Xiao Y (Ed) Mesenchymal Stem Cells. nova science Publishers, new york, (p1–14).

7. yan F, lin m, xiao y (2012) Periodontal regeneration and mesenchymal stem cells. in Xiao Y (Ed) Mesenchymal Stem Cells. nova science Publishers, new york, (p177–196).

journAl ArtiCles

1. adam cj (2012) endogenous musculoskeletal tissue engineering – a focussed perspective. Cell and Tissue Research, 347(3):489–99.

2. afara i, Prasadam i, crawford r, xiao y, Oloyede a (2012) non-destructive evaluation of carticular cartilage defects using near-infrared (nir) spectroscopy in osteoarthritic rat model and its direct relation to Mankin score. Osteoarthritis and Cartilage, 20(11):1367–1373.

3. an s, gao y, ling j, wei x, xiao y (2012) Calcium ions promote osteogenic differentiation and mineralization of human dental pulp cells: implications for pulp capping materials. Journal of Materials Science: Materials in Medicine, 23(3):789–795.

4. an s, ling j, gao y, xiao y (2012) effects of varied ionic calcium and phosphate on the proliferation, osteogenic differentiation and mineralization of human periodontal ligament cells in vitr. Journal of Periodontal Research, 47(3):374–382.

5. Balogh zj, reumann mk., gruen rl, mayer-kuckuk P, schuetz ma, harris ia, gabbe Bj, Bhandari m (2012) Advances and future directions for management of trauma patients with musculoskeletal injuries. The Lancet, 380(958):1109–1119.

6. Berner a, Boerckel jd, saifzadeh s, steck r, ren j, vaquette c, zhang jQ, nerlich m, guldberg re, hutmacher dw, woodruff ma (2012) Biomimetic tubular nanofiber mesh and latelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration. Cell and Tissue Research, 347(3):603–612.

7. Blackwood ka, Bock n, dargavilleTr, woodruff ma (2012) scaffolds for growth factor delivery as applied to bone tissue engineering. International Journal of Polymer Science: 1–25.

8. Bock n, dargavilleTr, woodruff ma (2012) electrospraying of polymers with therapeutic molecules: state of the art. Progress in Polymer Science, 37(11):1510–1551.

9. Bolland Bj, whitehouse sl, Timperley aj. (2012) indications for early hip revision surgery in the uk - a re-analysis of njr data. Hip International, 22 (2):145–52.

10. Bray lj, george ka, hutmacher dw, chirilaTv, harkin dg (2012) A dual-layer silk fibroin scaffold for reconstructing the human corneal limbus. Biomaterials, 33(13):3529–3538.

11. Bray lj, heazlewood cF, atkinson k, hutmacher dw, harkin dg (2012) evaluation of methods for cultivating limbal mesenchymal stromal cells. Cytotherapy, 14(8):936–947.

12. Brew cj, simpson Pm, whitehouse sl, donnelly w, crawford r, hubble mjw (2012) scaling digital radiographs for templating in total hip arthroplasty using conventional acetate templates independent of calibration marker. Journal of Arthroplasty, 27(4):643–647.

13. Brogan k, charity j, sheeraz a, whitehouse sl, Timperley aj, howell jr (2012) revision total hip replacement using the cement-in-cement technique for the acetabular component: technique and results for 60 hips. The Journal of Bone and Joint Surgery; British volume, 94(11):1482–6.

14. Brown cP, Oloyede a, crawford rw, Thomas ger, Price aj, gill hs (2012) Acoustic, mechanical and near-infrared profiling of osteoarthritic progression in bovine joints. Physics in Medicine and Biology, 57(2):547–559.

15. Brown Td, slotosch a, Thibaudeau l, Taubenberger a, loessner d, vaquette c, dalton Pd, hutmacher

publications

Heading

[ 1 4 ] p u b l i C a t i O N s

dw (2012) design and fabrication of tubular scaffolds via direct writing in a melt electrospinning mode. Biointerphases, 7(april):13.

16. cao z, zhang h, zhou x, han x, ren y, gao T, xiao y, de crombrugghe B, somerman mj, Feng jQ (2012) genetic evidence for the vital function of osterix in cementogenesis. Journal of Bone and Mineral Research, 27(5):1080–1092.

17. chakravorty n, ivanovski s, Prasadam i, crawford r, Oloyede a, xiao y (2012) the micrornA expression signature on modified titanium implant surfaces influences genetic mechanisms leading to osteogenic differentiation. Acta Biomaterialia, 8(9):3516–3523.

18. chen g, Fan w, mishra s, el-atem a, schuetz ma, xiaoy (2012) tooth fracture risk analysis based on a new finite element dental structure models using micro-ct data. Computers in Biology and Medicine, 42(10):957–963.

19. chen j, crawford r, xiao y (2012) vertical inhibition of the Pi3k/Akt/mtor pathway for the treatment of osteoarthritis. Journal of Cellular Biochemistry, 114(2):245–9.

20. cipitria a, lange c, schell h, wagermaier w, reichert jc, hutmacher dw, Fratzl P, duda gn (2012) Porous scaffold architecture guides tissue formation. Journal of Bone and Mineral Research, 27(6):1275–1288.

21. darmanis sn, hubble mj, howell jr, whitehouse sl, Timperley aj (2012) Benefits of using modern cementing techniques in the acetabulum: the rim cutter. Journal of Orthopaedic Surgery, hong kong, 20 (3):316–321.

22. doan n, du z, crawford r, reher P, xiao y (2012) is flapless implant surgery a viable option in posterior maxilla? A review. International Journal of Oral and Maxillofacial Surgery, 41(9):1064–1071.

23. drobetz h, weninger O, grant c, heal c, muller r, schuetz ma, steck r (2012) More is not necessarily better. A Biomechanical study on distal screw numbers in volar locking distal radius plates. Injury 44:535–539.

24. Fan w, wu c, han P, zhou y, xiao y (2012) Porous Ca-si-based nanospheres: a potential intra-canal disinfectant-carrier for infected canal treatment. Materials Letters, 81(8):16–19.

25. Fu x, chen j, wu d, du z, lei Q, cai z, schultze-mosgau s (2012) effects of ovariectomy on rat mandibular cortical bone: a study using raman spectroscopy and multivariate analysis. Anayltcal Chemistry, 84(7):3318–23.

26. govaert g, schuetz ma, Peters P (2012) rib fixation for a traumatic ‘stove-in chest’: an option to consider. Anz Journal of Surgery, 82(4):276–277.

27. govaert g, siriwardhane m, hatzifotis m, malisano l, schuetz ma (2012) Prevention of pelvic sepsis in major open pelviperineal injury. Injury, 43(4):533–536.

28. han P, wu c, chang j, xiao y (2012) the cementogenic differentiation of periodontal ligament cells via the activation of wnt/ß-catenin signalling pathway by li + ions released from bioactive scaffolds. Biomaterials, 33(27):6370–6379.

29. heljak mk, wieszkowski w, lam cxF, hutmacher dw, kurzydlowski kj (2012) evolutionary design of bone scaffolds with reference to material selection. International Journal for Numerical Methods in Biomedical Engineering, 28(july):789–800.

30. histing T, klein m, stieger a, stenger d, steck r, matthys r, holstein jh, garcia P, Pohlemann T, menger md (2012) A new model to analyze metaphyseal bone healing in mice. Journal of Surgical Research, 178(2):715–721.

31. hutmacher dw, duda g, guldberg re (2012) endogenous musculoskeletal tissue regeneration. Cell and Tissue Research, 347(3):485–488.

32. hutmacher dw, woodruff ma, shakesheff k, guldberg re (2012) direct fabrication as a patient- targeted therapeutic in a clinical environment. Methods in Molecular Biology, 868:327–340.

33. izatt mT, adam cj, verzin ej, labrom rd, askin gn (2012) Ct and radiographic analysis of sagittal profile changes following thoracoscopic anterior scoliosis surgery. Scoliosis, 7(1):15.

34. izatt mT, Bateman gr, adam cj (2012) evaluation of the iPhone with an acrylic sleeve versus the scoliometer for rib hump measurement in scoliosis. Scoliosis, 7(1):14.

35. jaiprakash a, Prasadam i, Feng jQ, liu y, crawford r, xiao y (2012) Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: A possible pathological role in subchondral bone sclerosis. International Journal of Biological Sciences, 8(3):406–417.

36. jeon j.e, schrobback k, hutmacher dw, klein Tj (2012) dynamic compression improves biosynthesis of human zonal chondrocytes from osteoarthritis patients. Osteoarthritis and Cartilage, 20(8):906–915.

37. leong dT, abraham mc, gupta a, lim Tc, chew FT, hutmacher dw (2012) atf5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells. Journal of Cellular Biochemistry, 113(8):2744–2753.

38. licina P, johnston m, ewing l, Pearcy mj (2012) Patient expectations, outcomes and satisfaction: related, relevant or redundant? Evidence-Based Spinecare Journal, 3(4):13–19.

39. little jP, adam cj (2012) towards determining soft tissue properties

Heading

p u b l i C a t i O N s [ 1 5 ]

for modelling spine surgery: current progress and challenges. Medical and Biological Engineering and Computing, 50(2):199–209.

40. little jP, izatt mT, labrom rd, askin gn, adam cj (2012) investigating the change in three dimenstional deformity for idiopathic scoliosis patients using axially loaded Mri. Clinical Biomechanics, 27(5):415–421.

41. loessner d, Quent vmc, kraemer j, weber ec, hutmacher dw, magdolen v, clements ja (2012) Combined expression of klk4, klk5, klk6, and klk7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance. Gynecologic Oncology, 127(3):569–578

42. lutton c, young yw, williams r, meedeniya acB, mackay-sim a, goss B (2012) Combined vegf and Pdgf treatment reduces secondary degeneration after spinal cord injury. Journal of Neurotrauma, 29(5):957–970.

43. malda j, Benders kem., kleinTj, de grauw jc, kik mjl, hutmacher dw, saris dBF, van weeren Pr, dhert wja. (2012) Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles. Osteoarthritis and Cartilage, 20(10):1147–1151.

44. malekani j, schmutz B, gu y, schuetz ma, yarlagadda Pk (2012) orthopedic bone plates: evolution in structure implementation technique and biomaterial. GSTF Journal of Engineering Technology (JET), 1(1): 135–140.

45. mao x, Tay gh, godbolt Bd, crawford rw (2012) Pseudotumour in a well-fixed Metal-on-Polyethylene uncemented hip Arthroplasty. Journal of Arthroplasty, 27(3):493.e13–493.e17.

46. melchels FPw, domingos man, klein Tj., malda j, Bartolo Pj, hutmacher dw (2012) Additive manufacturing of tissues and organs. Progress in Polymer Science, 37(8):1079–1104.

47. momot, k (2012) Microstructural magnetic resonance imaging of articular cartilage. Biomedical Spectroscopy and Imaging, 1(1): 27–37.

48. momot k i, Takegoshi k (2012) sensitivity of the nMr density matrix to pulse sequence parameters: a simplified analytic approach. Journal of Magnetic Resonance, 221 (1):57–68.

49. moody h, heard c, Frank c, shrive n, Oloyede a (2012) investigating the potential value of individual Parameters of histological grading systems in a sheep model of cartilage damage: the Modified Mankin Method. Journal of Anatomy, 221 (9):47–54.

50. Pawlak z, urbaniak w, gadomski a, yusuf kQ, afara iO, Oloyede a (2012) the role of lamellate phospholipid bilayers in lubrication of joints. Acta of Bioengineering and Biomechanics/Wroclaw University of Tecnology, 14(4):101–106.

51. Pfeifer c, müller m, Prantl l, Berner a, dendorfer s, englert c (2012) Cartilage labelling for mechanical testing in t-peel configuration. International Orthopaedics, 36 (7): 1493–1499.

52. Poole cm, cornelius i, Trapp jv, langton cm (2012) fast tessellated solid navigation in geAnt4. Australasian Physical and Engineering Sciences in Medicine, 35(3): 329–334.

53. Poole c, cornelius i, Trapp jv, langton cm (2012) A CAd interface for geAnt4. Australasian Physical and Engineering Sciences in Medicine, 35(3): 329–334.

54. Poole cm, cornelius i, Trapp jv, langton cm (2012) radiotherapy Monte Carlo simulation using cloud computing technology. Australasian Physical and Engineering Sciences in Medicine, 35(4):497–502.

55. Prasadam i, crawford r, xiao y (2012) Aggravation of AdAMts and matrix metalloproteinase production and role of erk1/2 pathway in the interaction of

osteoarthritic subchondral bone osteoblasts and articular cartilage chondrocytes – Possible pathogenic role in osteoarthritis. Journal of Rheumatology, 39(3):621–634.

56. Prasadam i, mao x, wang y, shi w, crawford r, xiao y (2012) inhibition of p38 pathway leads tooA-like changes in a rat animal model. Rheumatology, 51(5):813–823.

57. Pull Ter gunne aF, hosman ajF, cohen dB, schuetz ma, habil d, van laarhoven cjhm, van middendorp jj.(2012) A methodological systematic review on surgical site infections following spinal surgery. Part 1: risk factors. Spine, 37(24):2017–2033.

58. rath sn, arkudas a, lam cx, Olkowski r, Polykandroitis e, chró cicka a, Beier jP, horch re, hutmacher dw, kneser u (2012) development of a pre-vascularized 3d scaffold-hydrogel composite graft using an arterio-venous loop for tissue engineering applications. Journal of Biomaterials Applications, 27(3):277–289.

59. reichert jc, epari dr, wullschleger me, Berner a, saifzadeh s, nöth u, dickinson ic, schuetz ma, hutmacher dw (2012) Bone tissue engineering. reconstruction of critical sized segmental bone defects in the ovine tibia. Knochen-tissue-engineering Rekonstruktion segmentaler knochendefekte kritischer größe in der schafstibia, 41(4):280–287.

60. ruutu m, Thomas g, steck r, degli-esposti ma, zinkernagel ms, alexander k, velasco j, strutton g, Tran a, Benham h, rehaume l, wilson rj, kikly k, davies j, Pettit ar, Brown ma, mcguckin ma, Thomas r (2012) glucan triggers spondylarthritis and Crohn’s disease-like ileitis in skg mice. Arthritis and Rheumatism, 64(7):2211–2222.

61. schantz jT, woodruff ma, lam cxF, lim Tc, machens hg, Teoh sh, hutmacher dw (2012) differentiation

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potential of mesenchymal progenitor cells following transplantation into calvarial defects. Journal of the Mechanical Behavior of Biomedical Materials, 11(jul):132–142.

62. schon B, schrobback k, van der ven m, stroebel s, hooper gj, woodfield TB (2012) validation of a high-throughput microtissue fabrication process for 3d assembly of tissue engineered cartilage constructs. Cell and Tissue Research, 347( 3): 629–642.

63. schrobback k, klein Tj, crawford r, upton z, malda j leavesley di (2012) effects of oxygen and culture system on in-vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes. Cell and Tissue Research, 347(3):649–663.

64. schrobback k, malda j, crawford rw, upton z, leavesley di, klein Tj (2012) effects of oxygen on zonal marker expression in human articular chondrocytes. Tissue Engineering, 18(Oct):920–933.

65. shaw m, adam cj, izatt mT, licina P, askin gn (2012) use of the iPhone for Cobb angle measurement in scoliosis. European Spine Journal, 21(6):1062–1068.

66. sieh s, Taubenberger av, rizzi sc, sadowski m, lehman ml, rockstroh a, an j, clements ja, nelson cc, hutmacher dw (2012) Phenotypic Characterization of Prostate Cancer lnCaP Cells Cultured within a Bioengineered Microenvironment. PLoS ONE, 7(9).

67. sugiyama s, wullschleger m, wilson k, williams r, goss B (2012) reliability of clinical measurement for assessing spinal fusion: An experimental sheep study. Spine, 37(9):763–768.

68. van middendorp jj, Barbagallo g, schuetz ma, hosman ajF (2012) design and rationale of a Prospective, observational european Multicenter study on the efficacy of acute surgical decompression after traumatic

spinal Cord injury: the sCi-PoeM study. Spinal Cord, 50(9):686–694.

69. van middendorp jj, Pull Ter gunne aF, schuetz ma, habil d, cohen dB, hosman ajF, van laarhoven cjhm (2012) A methodological systematic review on surgical site infections following spinal surgery: Part 2: Prophylactic treatments. Spine, 37(24):2034–2045.

70. van middendorp jj, schuetz ma (2012) likelihood of tetraplegia after Ct clearance of the cervical spine in obtunded blunt trauma patients. Journal of Neurotrauma, 29(8):1714–1715.

71. vaquette c, Fan w, xiao y, hamlet s, hutmacher dw, ivanovski s (2012) A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone/periodontal ligament complex. Biomaterials, 33(22):5560–5573.

72. vijaysegaran P, coulter sa, coulter c, crawford rw (2012) Blood Cultures for Assessment of Postoperative fever in Arthroplasty Patients. journal of Arthroplasty, 27(3):375–377.

73. wilson lj, roe ja, Pearcy mj, crawford rw (2012) shortening cemented femoral implants. An in-vitro investigation to quantify exeter femoral implant rotational stability vs simulated implant length. Journal of Arthroplasty, 27(6):934–939.

74. woodruff ma, lange c, reichert j, Berner a, chen F, Fratzl P, schantz jT, hutmacher dw (2012) Bone tissue engineering: from bench to bedside. Materials Today, 15(10):430–435.

75. wu c, Fan w, zhou y, luo y, gelinsky m, chang j, xiao y (2012) 3d-printing of highly uniform Casio 3 ceramic scaffolds: Preparation, characterization and in-vivo osteogenesis. Journal of Materials Chemistry, 22(24):12288–12295.

76. wu c, zhou y, Fan w, han P, chang j, yuen j, zhang m, xiao y (2012) hypoxia-mimicking mesoporous

bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterial, 33(7):2076–2085.

77. wu c, Fan w, chang j, xiao y (2012) Mesoporous bioactive glass scaffolds for efficient delivery of vascular endothelial growth factor. Journal of Biomaterials Applications, 28(3) pp367–374.

78. wu c, zhou y, lin c, chang j, xiao y (2012) strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering. Acta Biomaterialia, 8(10): 3805–3815.

79. yao jw, xiao y, lin F (2012) effect of various ph values, ionic strength, and temperature on papain hydrolysis of salivary film. European Journal of Oral Sciences, 120(2):140–146.

80. yong mrnO, izatt mT, adam cj, labrom rd, askin gn (2012) secondary curve behavior in lenke type 1C adolescent idiopathic scoliosis after thoracoscopic selective anterior thoracic fusion. spine, 37(23):1965–1974.

81. zhang m, wu c, li h, yuen j, chang j, xiao y (2012) Preparation, characterization and in-vitro angiogenic capacity of cobalt substituted -tricalcium phosphate ceramics. Journal of Materials Chemistry, 22(40):21686–21694.

82. zhang m, wu c, lin k, Fan w, chen l, xiao y, chang j (2012) Biological responses of human bone marrow mesenchymal stem cells to sr-M-si (M 5 Zn, Mg) silicate bioceramics. Journal of Biomedical Materials Research Part A, 100a(11):2979–2990.

83. zhou y, wu c, xiao y (2012) the stimulation of proliferation and differentiation of periodontal ligament cells by the ionic products from Ca 7si 2P 2o 16 bioceramics. Acta Biomaterialia, 8(6):2307–2316.

s t a f f [ 1 7 ]

nAMe title

BrisBAne sPine grouP

dr richard williams centre director

dr Ben goss research Fellow

dr Fatemeh chehrehasa lecturer, human anatomy

dr alexander gibson spinal Fellow

dr hamish deverall spinal Fellow

dr stephen morris spinal Fellow

mrs rachel luton-goggins administration Officer

BioMAteriAls And tissue MorPhologY grouP

associate Professor maria woodruff leader, Biomaterials and Tissue morphology group

dr keith Blackwood Postdoctoral research Fellow

miss alyssa morris research assistant

mr kristofor Bogoevski research assistant

ms Flavia medeiros savi research assistant

mr edward ren research assistant

Bone BiologY grouP

Professor yin xiao leader, Bone research group

dr chengtie wu Postdoctoral Fellow

dr indira Prasadam Postdoctoral research Fellow

dr jiezhong chen Postdoctoral research Fellow

mr samuel Perry research assistant

ms wei shi research assistant

dr kai luo visiting Fellow

dr zhibin du visiting Fellow

CArtilAge regenerAtion lABorAtorY

associate Professor Travis klein vice-chancellor’s research Fellow

dr karsten schrobback Postdoctoral research Fellow

northside sPinAl reseArCh grouP

dr Paul licina spinal Orthopaedic surgeon

Professor mark Pearcy Professor of Biomedical engineering

ms michelle johnston clinical research nurse

orthoPAediC reseArCh grouP

Professor ross crawford chair in Orthopaedic research, director merF

Professor kunle Oloyede leader, cartilage Biomechanics group

dr yufeng zhang Postdoctoral Fellow

dr lance wilson research Fellow

dr sarah whitehouse research Fellow

dr david Farr navigation & arthroplasty Fellow

dr craig hughes navigation & arthroplasty Fellow

ms louise Tuppin clinical data manager

ms sue grice clinical research nurse

dr Takkan morishima visiting Fellow

mr Thor Friis research assistant

miss jessica Thompson research assistant

miss jenna lyon research assistant

miss monica warzywoda administration coordinator

staff

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[ 1 8 ] s t a f f

PAediAtriC sPine reseArCh grouP

dr geoff askin spinal Orthopaedic surgeon

associate Professor clayton adam Principal research Fellow

dr robert labrom spinal Orthopaedic surgeon

mrs maree izatt Project coordinator

Professor mark Pearcy Professor of Biomedical engineering

dr Paige little Postdoctoral research Fellow

dr alan carstens clinical spinal Fellow

dr mark Quick clinical Fellow

dr nabeel sunni clinical Fellow

dr mostyn yong clinical researcher

mr Brendon evans research assistant

mr Beau Brooker research assistant

QuAntAtive BioMediCAl iMAging And ChArACterisAtion reseArCh grouP And MediCAl PhYsiCs

Professor christian langton leader, Quantative Biomedical imaging and characterisation research group

dr konstantin momot senior lecturer, experimental Physics

dr mark wellard magnetic resonance Facility coordinator

regenerAtive MediCine grouP

Professor dietmar w hutmacher chair in regenerative medicine

dr anna Taubenberger visiting Fellow

dr Ferry melchels visiting Fellow

ms stephanie alexander visiting Fellow

dr cedryck vaquette research Fellow

mr Tobias Fuhrmann Postdoctoral research Fellow

dr siamak saifzadeh veterinary research scientist

dr christina Theodoropoulos senior research assistant

mrs nicole Benson labratory Technician

trAuMA reseArCh grouP

Professor michael schuetz chair in Trauma

dr devakar epari leader, Trauma research group

dr roland steck deputy director merF, senior research Fellow

dr Beat schmutz senior research Fellow

dr vaida glatt Postdoctoral research Fellow

dr joost van middendorp Postdoctoral research Fellow

ms maya schlittler Postdoctoral research Fellow

dr caroline grant research Fellow

dr david Theile senior research Fellow

ms esther jacobson spinal database manager

dr ronny Bindl visiting Fellow

dr Timothy wehner visiting Fellow

mrs nadine krueger research assistant

mrs rebecca Bibby administration coordinator

MediCAl deviCe doMAin of ihBi inCorPorAting o&tQ

Professor mark Percy leader

mrs joanne richardson administration Officer

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a d j u N C t p R O f e s s O R i a l s t a f f [ 1 9 ]

MediCAl PhYsiCs›› PrOFessOr james POPe

northside sPinAl reseArCh grouP›› dr Paul licina

PAediAtriC sPinAl reseArCh grouP›› dr geOFFrey askin ›› dr jOhn earwaker ›› PrOFessOr jOhn evans ›› dr rOBerT laBrOm›› dr PeTer BOys

regenerAtive MediCine grouP›› PrOFessOr rOBerT e guldBerg ›› dr Paul dalTOn ›› dr sasO ivanOvski›› dr anThOny lynham›› dr Tim wOOdField›› dr jOhannes malda›› PrOFessOr geOrg duda›› dr PaOlO BarTOlO

trAuMA›› PrOFessOr luTz claes ›› PrOFessOr nOrBerT haas ›› dr herwig drOBerTz›› PrOFessOr sTePhan Perren

Finite element simulations: (top) of a rat ulna compression model, which is used for studying stress fracture healing; (bottom) to predict correctly the location of the stress fracture.

adjunct professorial staff

[ 2 0 ] h i g h e R d e g R e e R e s e a R C h s t u d e N t s

new students

doctor of Philosophy

nAMe ProjeCt

Bartnikowski, michal development and optimisation of scaffolds for Osteochondral regeneration

chen, zetao regulating the immune response to bone substitute materials to improve osteogenesis

chhaya, mohit additive tissue manufacturing for breast reconstruction; combining computer aided design and manufacturing with adipose tissue engineering

du, zhibin Osseointergration in osteoporosis subject using ovariectomized rat model

Farnaghi, saba Obesity and osteoarthritis: a new insight in understanding the role of leptin-induced osteocytes in osteoarthritis pathogenesis.

henkel, jan evaluation of the efficacy of a novel ria/mPcl-TcP scaffold system in repairing ciritical-sized segmental bone defects compared to the gold standard autograft treatment in an ovine large animal model.

kashani, jamal an innovative computational framework for simulating articular cartilage biomechanics and degeneration

keenan, Bethany mechanobiology of growth in the scoliotic spine

loechel, nicole The effect of inverse dynamization on bone healing: a mechanobiological investigation

refshauge, sacha augmented reality taining tool for a c-arm fluoroscopy unit

ren, jiongyu use of strontium subsituted bioactive glass (srBg) and Polycaprolactone (Pcl) to develop melt electrospun scaffolds for bone repair

Tadimalla, sirisha mr micro-imaging of articular cartilage: studies based on T1ρ and T2 relaxation

Tourell, monique a magnetic resonance investigation into articular cartilage fibre microstructure.

Tufekci, Pelin development of a novel experimental model to investigate the influence of mechanics on bone healing

Master of engineering

nAMe ProjeCt

afrin, sadia a novel 3-dimensional in-vitro model to study immune cell-renal cell interactions

Fountain, stephanie characterising the mechanical conditions within a critical size bone defect when treated with a tissue engineered bone scaffold.

koval, lidia relationship between the stiffness of the internal fixation and metaphyseal fracture healing in mice.

ikin, nicole Finite element modelling of self-expanding abdominal aortic stents

meek, john racial difference in morphology of the distal humerus

mark, Quick multi-segmental analysis of growth modulation implants

Continuing students

doctor of Philosophy

nAMe ProjeCt

alsulami, abdullah ali Quantitative 3d ultrasound characterisation of tissues

amarathunga arachchige, jayani P Quantitative fit assessment of tibial nail designs during the insertion

Barani lonbani, zohreh characterising closed soft tissue trauma to investigate the reciprocal healing effects with bone fractures

Berner, arne Quantitative and qualitative assessment of the regenerative potential of osteoblasts versus bone marrow derived mesenchymal stem cells in the reconstruction of critical sized segmental tibial bone defects in a large animal model

Bock, nathalie combining electrospun scaffolds with biodegradable microspheres for sustained delivery of growth factors

Brown, Toby melt electrospinning writing

chakravorty, nishant role of micro-rnas in improved osteogenicity of modified titanium implant surfaces

higher degree research students

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h i g h e R d e g R e e R e s e a R C h s t u d e N t s [ 2 1 ]

clarke, amy w an investigation of tooth impact biomechanics to develop a test methodology for mouthguard effectiveness

couzens, greg The role of wrist motors in carpal stability

doan, nghiem v an evaluation of clinical procedures used in dental implant treatment in posterior maxilla using flapless technique

Fairhurst, helen an experimental and finite element investigation of the biomechanical outcomes of scoliosis correction surgery

Friis, Thor-einar The OP1 implant device – a study of osteogenic induction and bone formation in an orthotopic implant model in sheep

han, Pingping The regulation of wnt canonical signalling pathway during cementum regeneration

harith, hazreen haizi The automation of implant fitting for a distal tibial plate

heidarkhan Tehrani, ashkan Biomechanical and structural investigation of collagenous membranes: creating transplantable bioinspired scaffod for cartilage regeneration.

khoei, shadi multi-modality 3d quantitative imaging of radiation dosimetry gels

kuaha, kunnika driving zonal chondrogenesis of mesenchymal stem cells

levett, Peter a development of novel hydrogels and hydrogel constructs for repair of articular cartilage

malekani, javad a novel and innovative technique for deformation of pre-contoured fracture fixation plates in orthopaedic surgery

markwell, Timothy s 3d reconstruction from limited 2d data sets in radiotherapy

mcmeniman, Timothy j Fixation methods in impaction bone grafting of the acetabulum in revision total hip arthroplasty: an in-vitro study

mohd radzi, shairah development of a method to assess the quality of ankle joint reduction in 3d

moody, hayley r using near infrared spectroscopy to adapt histopathology ranking for surgical assessment of articular cartilage

Poh, su Ping Patrina melt extrusion of bioactive scaffolds comprising polycaprolactone (Pcl) and strontium-substituted bioactive glass (srBg) for bone regeneration

Powell, sean k investigations of water dynamics in anisotropic biophysical structures

Thibaudeau, laure Tissue engineered bone construct applied to an in-vivo breast cancer bone metastasis model

Toal, victoria r The mechanics of microdamage and microfracture in trabaecular bone

Tumkur jaiprakash, anjali Osteocytes in the development and progression of osteoarthritis

wille, marie luise ultrasound transit time spectral analysis of complex porous media

zhang, xufang Pro-angiogenic and anti-angiogenic factors in the degeneration of osteoarthritic cartilage

zhou, yinghong interactions between undifferentiated and osteogenic differentiated mesenchymal stromal cells during osteogenesis

Master of engineering

nAMe ProjeCt

calabro, lorenzo improving in-vivo models of fracture fixation associated osteomyelitis

jones, Brendan establishment of ovine model for tissue engineering constructs in critical sized mandibular defects

kim, margaret experimental and clinical evaluation of a tissue engineering strategy in the reconstruction of critical sized mandibular bony defects

sunni, nabeel a biomechanical investigation of fusionless growth modulation implants for spinal scoliosis treatment

vijaysegaran, Praveen an analysis of variables affecting the quality of orthopaedic laminar airflow systems

mostyn yong Polycaprolactone-based scaffold plus rhBmP-2 versus autograft in an ovine model of thoracoscopic anterior spinal fusion

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[ 2 2 ] h i g h e R d e g R e e R e s e a R C h s t u d e N t s

CoMPletions

doctor of Philosophy

name PrOjecT

afara, isaac Oluwaseun near infrared spectroscopy for non-destructive evaluation of articular cartilage

grant, caroline a mechanical testing and modelling of bone-implant construct

jeon, june evelyn development of zonal cartilage constructs: effects of chondrocyte subpopulation, compressive stimulation, and culture models

Poole, christopher m Faster monte carlo simulation of radiotherapy geometries

reichert, verena maria charlotte application of a human bone engineering platform to an in-vitro and in-vivo breast cancer metastasis model

roe, john a how important is length?: mechanical testing and measurement of a cemented, polished, tapered femoral implant

young, yun wai Pro-inflammatory growth factors reduce secondary degeneration after traumatic spinal cord injury

yusuf, kehinde Quasim an exploratory study of the potential of resurfacing articular cartilage with synthetic phospholipids

Master of engineering

nAMe ProjeCt

asgarifar, hajarossadat application of high voltage, high frequency pulsed electromagnetic field on cortical bone tissue

kalhor, ali effects of hyperbaric oxygen and inducible nitric oxide inhibitor treatment on femoral head osteonecrosis in a rat model

yuen, jones Preparation, characterisation and in-vivo osteogenesis of mesoporous bioactive glasses

overseAs visiting students

nAMe universitY

antille, melanie swiss Federal institute of Technology, lausanne

Boom, koen eindhoven university of Technology

chan, kai university of Otago, new zealand

dunker, urip rwTh aachen university, germany

jungst, Thomas julius-maximilians university, wϋrzburg

kammerer, elke university of darmstadt, germany

kirby, giles university of nottingham, uk

standfest, marco university of applied sciences regensburg, germany

Taher, amad radbound university nijmegen medical centre, The netherlands

wang, jun The second xiangya hospital of central south university, china

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a w a R d s , p R i z e s a N d C O m m u N i t y s e R v i C e [ 2 3 ]

awards, prizes and community service

›› Professor dietmar hutmacher received the 2012 australasian society for Biomaterials and Tissue engineering (asBTe) award for research excellence, and made Fellow of the international union of societies for Biomaterials science and engineering. he was also awarded a Founding Fellowship (FTerm) by the Tissue engineering and regenerative medicine society, which recognises Professor hutmacher as a distinguished global leader within the tissue engineering and regenerative medicine field

›› QuT Biomedical engineering graduate michal Bartnikowski was awarded a smart state Phd scholarship to develop robotically extruded intelligent scaffolds for osteochondral defect repair

›› dr mia woodruff received a highly commended 2012 Biotech rising star award at the 2012 women in Technology awards

›› Professor yin xiao was invited to give an expert opinion on a nature paper about a protein with dual benefits for bone health

[ 2 4 ] a C K N O w l e d g e m e N t s

› acknOwledgemenTs

orthopaedics and trauma Queensland gratefully

acknowledges the significant financial and

collaborative support of:

›› aO Foundation

›› australian research council

›› depuy synthes spine

›› golden casket research Foundation

›› holy spirit northside hospital

›› institute of health and Biomedical innovation

›› mater Foundation

›› mater health services Brisbane ltd

›› medtronic sofamor danek

›› national health and medical research council

›› Osteosynthesis and Trauma care (OTc) Foundation, switzerland

›› Princess alexandra hospital

›› Queensland health

›› Queensland Orthopaedic research Trust

›› Queensland university of Technology

›› Queensland x-ray

›› royal australasian college of surgeons

›› stryker

›› The Prince charles hospital

›› The Prince charles hospital Foundation

›› The wesley research institute

© QuT 2013 19870 cricOs no. 00213j