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Background

Parenteral: injected through skin or otherexternal boundary tissue, alongside of small

intestine Uses:

NPOnothing by mouth

Unstable in GI, 1stpass metabolism

Immediate action needed

Delivery to specific site

Depot form

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Definitions

LVP-large volume parenteral (>100 ml)

piggy back smaller volume (may be up

to 250 ml)

D5W (5% dextrose in water)

NS (normal saline) 0.9%NaCl

Compounded Sterile Preparation (CSP)

Continuous infusion vs. intermittent dosing

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Definitions

HEPA filter- High Efficiency Particulate Air

0.3 micron, 99.97%

ISO: International Organization forStandardization

ISO 5: Clean room standards based on

particles for cubic meter by particle size Class 100: number of particles 5 m per

cubic foot

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Hood types

Horizontal LaminarAirflow Workbench

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Hood Types

Vertical LaminarAirflow Workbench

(Biosafety)

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Hood Types

Barrier Isolator

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USP 797 Risk Levels

High (3) Nonsterile ingredients

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Clean room

Video

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Syringes and Needles

Parts of syringe (32.12) Barrel

Plunger Tip

Parts of needle (32.12)

Bevel Shaft

Hub

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Injection technique

Critical sites

Swabbing

Bevel up, angle

Equalize pressure

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IV Preparation

Preparation Calculations Assembly

Cleaning Inspection

Expiration dates Quality

Manipulation Inspection

Quality

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References and Resources

USP, Proposed Revisions to USP Chapter http://www.usp.org/healthcareInfo/pharmInfo/revisions797.html

ASHP Self Assessment Tool for Compounding Sterile Preparationshttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdf

Ockerman AV, U.S. Pharmacist, Compounded Sterile Preparations:An Overview of the New Standards USP http://www.uspharmacist.com/index.asp?show=article&page=8_1252.htm

ASHP Guidelines on Quality Assurance for Pharmacy-PreparedSterile Products, Am J Health-Syst Pharm, 2000;57:1150-69

http://www.usp.org/healthcareInfo/pharmInfo/revisions797.htmlhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.usp.org/healthcareInfo/pharmInfo/revisions797.html