Collaborative Program In Neuroscience

2016 CPIN RESEARCH DAY

Meeting Program May 19, 2016

Medical Sciences Building, University of Toronto http://www.neuroscience.utoronto.ca/events/CPIN_Research_Day.htm

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2016 Collaborative Program In Neuroscience (CPIN) Research Day University of Toronto, May 19, 2016

Schedule

8:30 a.m. Registration Opens (MSB Student Commons)

Section I Trainee Oral Presentations 9:00 a.m. Oral Presentations and Evaluation (MSB 2173, MSB 3227, MSB 4171, MSB 4279)

10:30 a.m. Poster Set-up (MSB Student Commons)

10:50 a.m. Research Day Opening Remarks (MSB 2158, JJR Macleod Auditorium)

Announcement: Jonathan Dostrovsky Award in Neuroscience

Section II Distinguished Neuroscience Lectures (JJR Macleod Auditorium) 11:10 a.m. Dr. Sandra Black Professor & Brill Chair in Neurology, Department of Medicine; Professor, Institutes of Medical Science, of Rehabilitation Sciences, and of Biomaterials and Biomedical Engineering; Executive Director, Toronto Dementia Research Alliance; Director, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute “Brain Networks and Network Science”

11:40 a.m. Dr. John S. Floras Professor, Division of Cardiology, Department of Medicine and Institute of Medical Science; Canada Research Chair Tier 1 in Integrative Cardiovascular Biology; Senior Clinical Scientist, Lunenfeld-Tanenbaum Research Institute “Disturbances of neurogenic control of the human heart and circulation in heart failure and sleep apnea”

Section III Lunch and Trainee Poster Presentations (MSB Student Commons) 12:10 p.m. Lunch and Poster viewing 12:30 p.m. Poster evaluation

2:30 p.m. CPIN Activity Summary (JJR Macleod Auditorium)

Section IV Distinguished Neuroscience Lectures (JJR Macleod Auditorium) 2:40 p.m. Dr. Michael H. Thaut Professor & Director of the Music and Health Research Collaboratory (MaHRC), Faculty of Music “Music and rhythm based interventions for neurorehabilitation – research translations from the basic neuroscience of music perception and music performance”

3:10 p.m. Dr. Janice Robertson Associate Professor, Department of Laboratory Medicine and Pathobiology; Tanz Centre for Research in Neurodegenerative Diseases “Uncovering Disease Mechanisms in Amyotrophic Lateral Sclerosis”

3:40 p.m. Dr. Graham Collingridge Professor & Chair, Department of Physiology; Senior Scientist, Lunenfeld-Tanenbaum Research Institute “Is Alzheimer’s caused by LTD gone awry”

Section V Awards Ceremony and Closing Remarks (JJR Macleod Auditorium) 4:10 p.m. Awards Announcements & Presentations

4:30 p.m. Closing Remarks

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Event Organizers

CPIN Research Day Organizing Committee Vladislav Sekulic (Student Organizer) Ekaterina Turlova (Student Organizer) Zhong-Ping Feng (CPIN Director) Jeffrey Henderson Amy Ramsey Suhail Asrar (CPIN Office)

Event Program Design Alexandre Guet-McCreight (Cover Art) Vladislav Sekulic (Abstracts)

Administration Suhail Asrar

Trainee Presentation Judges Ana Cristina Andreazza Deryk Beal Robert Bonin Colleen Dosckstader Jonathan Downar Zhong-Ping Feng Leon French Karen A. Gordon Ariel Graff Anne-Marie Guerguerian Lili-Naz Hazrati Jeffrey Henderson Paul Hwang Zhengping Jia Bill Ju Jeremie Lefebvre Julie Lefebvre Donald Mabbott Kei Masani Jose Nobrega Mohan Pabba John Peever Peter Pennefather Stephen Perry Amy Ramsey Ali Salahpour Iman Sarvastani Gerold Schmitt-Ulms Ze'ev Seltzer Etienne Sibille Frances Skinner Shuzo Sugita Hong-Shuo Sun Kaori Takehara-Nishiuchi Anurag Tandon Vincent Tropepe Lu-Yang Wang Carol Westall

CPIN Academic/Executive Committees; Board of Directors Applied Psychology and Human Development | Kang Lee; Earl Woodruff Biochemistry | Angus McQuibban/Oliver Ernst; Justin Nodwell Institute of Biomaterials & Biomedical Engineering | Julie Audet/Ofer Levi; Christopher Yip Cell And Systems Biology | Melanie Woodin/John Peever; Les Buck Computer Science | Richard Zemel; Ravin Balakrishnan Dalla Lana School of Public Health | Geoff Anderson; Howard Hu Dentistry | Ze'ev Seltzer; Morris Manolson Laboratory Medicine and Pathobiology | Janice Robertson/Lili-Naz Hazrati; Harry Elsholtz Institute of Medical Science | Cindi Morshead/Albert Wong; Mingyao Liu Medical Biophysics | Bojana Stefanovic; Peter Burns Music | Lee Bartel Pharmaceutical Sciences | Jeffrey Henderson/David R. Hampson (Honorary member); Heather Boon Pharmacology | Amy J. Ramsey; Ruth Ross Physiology | Jonathan Dostrovsky (Honorary member)/Lu-Yang Wang; Graham Collingridge Physiology | Zhong-Ping Feng (CPN Director; Chair of Committees) Psychology | John S. Yeomans; Morris Moscovitch Rehabilitation Science Institute | Karl Zabjek; Angela Colantonio

Distinguished Speakers Sandra Black Graham Collingridge John S. Floras Janice Robertson Michael H. Thaut

Trainee Volunteers Julianne Baarbe Alexandra Chatzikalymniou Ayda Ghahremani Alexandre Guet-McCreight Yi (Bonny) Hou Sammen Huang Kirusanthy Kaneshwaran Feiya Li Maria Marano Tsukiko Miyata Sarah Peters Sofia Raitsin Emily Underwood Raymond Wong Kristiana Xhima Frances Xia Yohan Yee

Special Acknowledgements Artur Cane Angela Colantonio Jonathan Dostrovsky Michael Farkouh Karen A. Gordon Lili-Naz Hazrati Zhengping Jia Allan Kaplan Darina Landa Mingyao Liu Tom Schweizer Kaori Takehara-Nishiuchi Vincent Tropepe Lu-Yang Wang Donald Weaver Jim Woodgett Melanie Woodin Julie Wysocki

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ORAL PRESENTATIONS 1. Robert Chen; Physiology; Krembil Research Institute Supervisor: Dr. Elise F. Stanley ELECTRON MICROSCOPY ANALYSIS OF SYNAPTIC VESICLE TETHERING BY CALCIUM CHANNELS AT PRESYNAPTIC ACTIVE ZONES Chen RHC 1,2; Nath AR 1,2; Stanley EF 1,2 1 Krembil Research Institute, Toronto Western Hospital; 2 Department of Physiology, U of T 2. Zoey Wei-Chih Cheng; Institute of Medical Science Supervisor: Dr. Shun Wong RADIATION-INDUCED SENESCENCE IN HIPPOCAMPAL NEURONS AND NEURAL PROGENITOR CELLS AND THE ROLE OF p53 AND p21 Cheng Z, 1,2;, Zheng YZ, 1; Li Y-Q, 1; Wong CS, 1,2. 1. Sunnybrook Health Sciences Centre 2. Institute of Medical Science, U of T 3. Andrea Constantinof; Physiology Supervisor: Dr. Stephen Matthews TRANSGENERATIONAL PROGRAMMING OF TRANSCRIPTION IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS (PVN) BY GLUCOCORTICOIDS Constantinof A, MSc 1; Moisiadis VG, 1; Matthews SG Phd, 1,2,3,4. 1 Physiology, U of T, Ontario, Canada; 2OBGYN, U of T, Ontario, Canada; 3 Medicine, U of T, Ontario, Canada; 4 Fraser Mustard Research Institute, Ontario, Canada. 4. Alexandra Decker; Psychology Supervisor: Dr. Donald Mabbott HIPPOCAMPAL SUBFIELD VOLUME LOSS AND VERBAL ASSOCIATIVE MEMORY IN SURVIVORS OF PEDAITRIC BRAIN TUMORS Decker AL, 1,2; Szulc KU, 1; Skocic J, 1; de Medeiros CB, 1; Riggs, L 1; Bouffet, E, 3; Dockstader C, 1,2; Laughlin, S, 4; Chakravarty, MM, 5,6; Mabbott DJ, 1,2,7 1 Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Canada; 2 Psychology, U of T, Toronto, Canada; 3 Hematology/Oncology, Hospital for Sick Children, Toronto, Canada; 4 Diagnositic Imaging, The Hospital for Sick Children, Toronto, Canada; 5 Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Quebec; 6 Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Quebec; 7 Department of Psychology, Hospital for Sick Children, Toronto, Ontario 5. Ayda Ghahremani; Institute of Medical Science Supervisor: Dr. Robert Chen SUBTHALAMIC BETA BAND POWER IS RELATED TO GLOBAL SUPPRESSION Ghahremani, A, 1., Wessel, JR, 2., Udupa, K, 3., Saha, U, 3., Kalia, SK, 3., Hodaie, M, 3., Lozano, AM, 3., Aron, AR, 4., & Chen, R, 3. 1 Institute of Medical Science; 2 University of Iowa, Iowa; 3 Krembil Research Centre; 4 University of San Diego, San Diego

6. Colleen Gillon; Physiology Supervisor: Dr. Sheena Josselyn INVESTIGATING THE ROLE OF M6A MRNA METHYLATION IN MEMORY FORMATION Gillon CJ, 1,2; Walters BJ, 1; Mercaldo V, 1; Yipp M, 1; Neve RL, 3; Frankland PW, 1,2,4,5; Josselyn SA, 1,2,4,5 1 Program in Neurosciences & Mental Health, Hospital for Sick Children; 2 Department of Physiology, U of T; 3 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, USA; 4 Department of Psychology, U of T; 5 Institute of Medical Science, U of T 7. Alexandre Guet-McCreight; Physiology Supervisor: Dr. Frances K Skinner PREDICTING CELL-TYPE SPECIFIC ACTIVE PROPERTIES BY DEVELOPING MULTI-COMPARTMENT MODELS USING DATABASES AND ELECTROPHYSIOLOGICAL FEATURE CONSTRAINTS: APPLICATION TO INTERNEURON SPECIFIC 3 (IS3) CELLS IN THE HIPPOCAMPUS Guet-McCreight A 1,2; Camiré O 3,4; Topolnik L 3,4; Skinner FK 1,5,2 1 Krembil Research Institute, University Health Network; 2 Department of Physiology, U of T; 3 Centre de recherche du CHU de Québec, Université Laval; 4 Department of Biochemistry, Microbiology and Bioinformatics, Université Laval; 5 Department of Medicine (Neurology), U of T 8. Erika Harding; Physiology Supervisor: Dr. Michael Salter CALCIUM RESPONSES TO SINGLE ACTION POTENTIALS IN SPINAL CORD LAMINA I NEURONS Harding, EK, 1,2; Salter, MW 1,2 1. Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto; 2. Department of Physiology, U of T 9. Alicia Hilderley; Rehabilitation Sciences Institute Supervisor: Virginia Wright/Darcy Fehlings CORTICAL ACTIVITY DURING LOWER LIMB MOVEMENTS IN CHILDREN WITH HEMIPLEGIC CEREBRAL PALSY: AN FMRI STUDY Hilderley AJ 1,2; Morgan BR 3; Lee W 3; Fehlings D 1,2; Taylor MJ 3,5; Wright FV 1,2 1 Holland Bloorview Kids Rehabilitation Hospital, Toronto Canada; 2 Rehabilitation Sciences Institute, U of T; 3 Department of Diagnostic Imaging, Hospital for Sick Children, Toronto Canada; 4 Department of Paediatrics, U of T; 5 Department of Psychology, U of T. 10. Megan Hird; Institute of Medical Science Supervisor: Dr. Tom Schweizer INVESTIGATING DRIVING ERRORS AND BRAIN ACTIVATION IN MILD COGNITIVE IMPAIRMENT Hird MA, 1,2; Vesely KA, 1,2; Churchill NW, 1; Fischer CE, 1,3; Naglie G, 4,5,6; Graham SJ, 7,8; Schweizer TA, 1,9,10 1 Neuroscience Research Program, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital; 2 Institute of Medical Science, U of T; 3 Department of Psychiatry, Division of Geriatric Psychiatry, St. Michael's Hospital, U of T; 4 Department of Medicine and Rotman Research Institute, Baycrest Health Sciences; 5 Department of Medicine and Institute of Health Policy, Management

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and Evaluation, U of T; 6 Research Department, Toronto Rehabilitation Institute - University Health Network; 7 Physical Sciences Platform, Sunnybrook Research Institute; 8 Department of Medical Biophysics, U of T; 9 Department of Surgery, Neurosurgery Division, U of T; 10 Institute of Biomaterials and Biomedical Engineering, U of T 11. Yi Bo Hou; Physiology Supervisor: Dr. Paul Frankland NEURONAL REACTIVATION CHANGES DUE TO NEUROGENESIS-MEDIATED FORGETTING Y. Hou1,2; J. Epp2; P. Frankland1,2. 1 Department of Physiology, Faculty of Medicine, U of T; 2 Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8. 12. Vincent Man; Psychology Supervisor: Dr. William Cunningham COMPUTATIONAL AND NEURAL MECHANISMS UNDERLYING REWARD–CONTEXT INTEGRATION Man V, 1; Cunningham WA 1,2 1 Department of Psychology, U of T; 2 Rotman Research Institute, Baycrest Hospital 13. Julie Marocha; Molecular Genetics Supervisor: Dr. Julie Lefebvre THE FUNCTIONAL REQUIREMENT FOR cLUSTERED PROTOCADHERIN DIVERSITY IN DENDRITE SELF-AVOIDANCE Marocha, J, 1,2; Lefebvre, JL, 1,2 1 Program for Neuroscience and Mental Health, Hospital for Sick Children; 2 Department of Molecular Genetics, U of T 14. Amy Miles; Institute of Medical Science Supervisor: Dr. Allan S Kaplan A PILOT STUDY OF DIFFUSION TENSOR IMAGING IN ANOREXIA NERVOSA: COMPARISON OF UNDERWEIGHT AND WEIGHT-RECOVERED SUBJECTS, THEIR UNAFFECTED SISTERS, AND UNRELATED CONTROLS Miles AM 1,3; Kaplan AS 1,2,3; Voineskos AV 1,2,3; Chakravarty MM 4,5 1 Institute of Medical Science, U of T; 2 Department of Psychiatry, U of T; 3 Centre for Addiction and Mental Health; 4 Brain Imaging Centre, Douglas Institute; 5 Department of Psychiatry, McGill University 15. Amy Hyemin Oh; Institute of Medical Science Supervisor: Dr. Lucy Osborne EFFECTS OF ALTERED GTF2I COPY NUMBER ON THE NEURAL STEM CELL PHYSIOLOGY IN WILLIAMS SYNDROME AND 7Q11.23 DUPLICATION SYNDROME Oh AH 1; Miller F 1,2,3; Osborne L 1,2 1 Institute of Medical Sciences, U of T; 2 Department of Molecular Genetics, Uof T; 3 Developmental and Stem Cell Biology, Hospital for Sick Children, ON

16. Charissa Poon; Institute of Biomaterials and Biomedical Engineering Supervisor: Dr. Kullervo Hynynen LIFESPAN OF ONE FOCUSED ULTRASOUND MEDIATED BLOOD-BRAIN BARRIER OPENING TREATMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE Poon C, 1,2; Hynynen K, 1,2,3 1 Institute of Biomaterials and Biomedical Engineering, U of T; 2 Sunnybrook Research Institute; 3 Medical Biophysics, U of T 17. Sofia Raitsin; Institute of Medical Science Supervisor: Dr. Jeffrey Meyer EFFECTS OF GLUCOCORTICOIDS AND OXIDATIVE STRESS ON MONOAMINE OXIDASE A (MAO-A) ACTIVITY IN THE PREFRONTAL CORTEX IN RODENTS: IMPLICATIONS FOR MAJOR DEPRESSIVE DISORDER (MDD) Raitsin S, 1,2; Tong J, 1,3; Kish S, 1,4; Xu X, 2; Magomedova L, 5; Cummins C, 5; Meyer J, 1,2,3,4 1 Institute of Medical Science, U of T; 2 Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health; 3 Department of Psychiatry, U of T; 4 Department of Pharmacology, U of T; 5 Leslie Dan Faculty of Pharmacy, U of T 18. Tian Renton; The Rehabilitation Sciences Institute Supervisor: Dr. Jane Topolovec-Vranic ASSESSING SYMPTOMS OF DEPRESSION AND CONCUSSION IN ADOLESCENT ATHLETES DEVOID OF CONCUSSION INJURY. Renton T 1,2; Colantonio A 1,3; Reed N 1,4; Topolovec-Vranic J 1,2. 1 The Rehabilitation Sciences Institute, U of T; 2 St.Michael's Hospital, Trauma & Neurosurgery Program; 3 Toronto Rehabilitation Institute, 4 Holland Bloorview Rehabilitation Hospital 19. Husain Shakil; Physiology Supervisor: Dr. Steven A. Prescott PAIN PROCESSING BY SPINAL DORSAL HORN CIRCUITS IS DISRUPTED IN DISTINCT WAYS BY DIFFERENT FORMS OF DISINHIBITION Shakil H, 1,2; Lee KY, 1,2; Prescott SA, 1,2 1 Neurosciences and Mental Health, The Hospital for Sick Children; 2 Department of Physiology, U of T 20. Alana Tibbles; Rehabilitation Sciences Institute Supervisor: Dr. Robin Green ELEVATED SUBSTANCE USE IMPEDES RECOVERY OF TIMED ATTENTION AFTER MODERATE-SEVERE TRAUMATIC BRAIN INJURY Tibbles A, 1,2; Green R, 1,2 1 Rehabilitation Sciences Institute, U of T; 2 Toronto Rehab, UHN 21. Michael Tso; Institute of Medical Science Supervisor: Dr. R. Loch Macdonald WHOLE GENOME EXPRESSION PROFILING OF BLOOD-BRAIN BARRIER ENDOTHELIAL CELLS AFTER SUBARACHNOID HEMORRHAGE Tso MK, 1,2; Turgeon P, 3; Bosche B, 1; Ai J, 1; Marsden, PA, 2,3; Macdonald RL, 1,2 1 Division of Neurosurgery, St. Michael’s Hospital; 2 Institute of Medical Science, U of T; 3 Department of Laboratory Medicine & Pathobiology, U of T

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22. Xinzhu Wang; Laboratory Medicine & Pathobiology Supervisor: Dr. Gerold Schmitt-Ulms INTERACTING WITH THE WRONG CROWD: HOW TAU MEDIATES TOXICITY VIA ABERRANT PROTEIN BINDING IN A CRISPR-EDITIED INDUCIBLE CELL SYSTEM Xinzhu Louisa Wang 1,2; Gerold Schmitt-Ulms 1,2 1 Laboratory Medicine & Pathobiology, U of T; 2 Tanz Centre for Research in Neurodegenerative Diseases 23. Danielle Weber-Adrian; Laboratory Medicine and Pathobiology Supervisor: Dr. Isabelle Aubert NON-SURGICAL GENE DELIVERY TO THE BRAIN Weber-Adrian, 1,2; Silburt J, 1,2; Noroozian Z, 1,2; Shah K 3; Burgess A, 4; Kuegler S, 5; Hynynen K 4,6; Aubert I, 1,2 1 Laboratory Medicine & Pathobiology, U of T; 2 Biological Sciences, Sunnybrook Research Institute; 3 Institute of Medical Science, U of T; 4 Physical Sciences, Sunnybrook Research Institute; 5 Neurology, University of Medicine Goettingen; 6 Medical Biophysics, U of T 24. Yohan Yee; Medical Biophysics Supervisor: Dr. Jason Lerch COVARIANCE OF BRAIN REGION VOLUMES CAN BE EXPLAINED BY GENE EXPRESSION Yee Y, 1,2; Fernandes DJ, 1,2; Ellegood J, 1; Vousden DA, 1,2; Spencer-Noakes L, 1; Cahill LS, 1; Lerch JP, 1,2 1 Mouse Imaging Centre, The Hospital for Sick Children; 2 Department of Medical Biophysics, U of T

POSTER PRESENTATIONS 25. Dhekra Al-Basha; Physiology Supervisor: Dr. Steven Prescott USING OPTOGENETICS TO PROBE NEURONAL EXCITABILITY Al-Basha D, 1,2; Prescott SA, 1,2 1 The Department of Physiology, U of T; 2 The Hospital for Sick Children 26. Ina Anreiter; Ecology and Evolutionary Biology Supervisor: Dr. Marla Sokolowski HISTONE METHILATION OF THE FORAGING GENE PLAYS A ROLE IN BEHAVIOURAL VARIABILITY IN DROSOPHILA MELANOGASTER Anreiter I, 1; Allen AM, 2; Kramer JM,3; Sokolowski MB,1 1- Department of Ecology and Evolutionary Biology, U of T; 2- Department of Cell and Systems Biology, U of T; 3- Department of Physiology and Pharmacology, University of Western Ontario 27. Patrick Antonio; Rehabilitation Sciences Institute Supervisor: Dr. Stephen Perry INVESTIGATING BALANCE, PLANTAR PRESSURE, AND FOOT SENSITIVITY IN INDIVIDUALS WITH DIABETES DURING STAIR GAIT Antonio PJ, 1; Perry SD 1,2 1 Rehabilitation Sciences Institute, U of T, Toronto, ON; 2 Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON

28. Jessica Arsenault; Psychology Supervisor: Dr. Bradley Buchsbaum FAILURE TO REPLICATE: DOES MOTOR CORTEX MAP SPEECH SOUNDS? Arsenault JS, 1,2; Buchsbaum BR, 1,2 1 Rotman Research Institute, Baycrest Health Sciences; 2 Department of Psychology, U of T 29. Hamza Arshad; Biochemistry Supervisor: Dr. Joel Watts Utilizing the Bank Vole Prion Protein to Decipher the Species Barrier in Prion Disease Arshad H, 1,2; Watts J 2,1 1. Department of Biochemistry, U of T; 2 Tanz Centre for Research in Neurodegenerative Diseases 30. Jermeen Baddour; Human Biology Program Supervisor: Dr. Vincenzo De Luca AN ASSOCIATION BETWEEN LIFETIME VIOLENCE AND ANTIPSYCHOTIC MEDICATION IN SCHIZOPHRENIA PATIENTS Baddour J, 1,2; De Luca V 1,2 1 U of T; 2 Centre of Addiction & Mental Health 31. Kiran Beera; Medical Biophysics Supervisor: Dr. Brian Nieman MOUSE BRAIN DEVELOPMENTAL OUTCOMES AFTER WHOLE-BRAIN VS. FOCAL IRRADIATION Beera KG 1,2; Dazai J 2; Jaffray DA 1,3; Nieman BJ 1,2 1 Department of Medical Biophysics, U of T; 2 Mouse Imaging Centre, Toronto; 3 Princess Margaret Cancer Centre, University Health Network, Toronto; Techna Institute, University Health Network, Toronto 32. Pieter Beerepoot; Pharmacology & Toxicology Supervisor: Dr. Ali Salahpour PHARMACOLOGICAL CHAPERONES OF THE DOPAMINE TRANSPORTER RESCUE DOPAMINE TRANSPORTER DEFICIENCY SYNDROME MUTATIONS Beerepoot, P 1; Lam, VM 1; Salahpour, A 1; 1 Pharmacology & Toxicology, U of T 33. Marie Kristel Bermejo; Pharmacology & Toxicology Supervisor: Dr. Ali Salahpour SELECTIVE RESCUE OF NMDA RECEPTORS IN DOPAMINE NEURONS OF NR1 INDUCIBLE-RESCUE KNOCKDOWN MICE Bermejo MK, 1; Mielnik CA, 1; Raymond R, 2; Nobrega J, 2; Ramsey AJ, 1, 3; Salahpour A, 1 1 Pharmacology & Toxicology, U of T; 2 Centre for Addiction and Mental Health; 3 Physiology, U of T 34. Iva Brunec; Psychology Supervisor: Dr. Morris Moscovitch and Dr. Morgan Barense ENHANCED TEMPORAL ORDER MEMORY FOR SPATIAL CONTEXTS PRECEDING EVENT BOUNDARIES IN SPATIAL NAVIGATION Brunec IK, 1,2,; Ozubko JD, 3; Barense MD, 1,2; Moscovitch M, 1,2

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1 Department of Psychology, U of T; 2 Rotman Research Institute, Baycrest; 3 Department of Psychology, SUNY Geneseo 35. Andrew Burke; Pharmaceutical Sciences Supervisor: Dr. David R. Hampson A NEURODEVELOPMENTAL AND BEHAVIOURAL STUDY OF MICE FOLLOWING IN UTERO AND EARLY POSTNATAL EXPOSURE TO IMIDACLOPRID, A NEONICOTINOID PESTICIDE Burke AP, 1; Hampson DR, 1,2 1 Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, U of T; 2 Department of Pharmacology, Faculty of Medicine, U of T 36. Feng Cao; Physiology Supervisor: Dr. Zhengping Jia THE ROLE OF NEUROLIGIN 2 AND INHIBITORY TRANSMISSION IN THE FUNCTION OF THALAMIC CIRCUITRY DURING EPILEPSY Cao F 1,2; Liu J 1,2; Jia ZP 1,2 1 Department of Physiology, Faculty of Medicine, U of T; 2 Neuroscience & Mental Health, The Hospital of Sick Children 37. Jasmine Carter; Pharmacology and Toxicology Supervisor: Dr. Walter Swardfager VALIDITY OF THE CENTER OF EPIDEMIOLOGICAL STUDIES DEPRESSION SCALE IN TYPE 2 DIABETES Carter J 1,2,3; Cogo-Moreira H, 4; Hermann N 1,2; Merino D, 1; Yang P 1,2; Shah BR 1,2; Kiss A 1,2; Reitav J, 3; Oh PI 1,2,3; Swardfager W 1,2,3 1 U of T; 2 Sunnybrook Research Institute; 3 University Health Network; 4 Universidade Federal de São Paulo 38. Amanda Ceniti; Institute of Medical Science Supervisor: Dr. Sidney Kennedy IDENTIFYING REWARD-BASED MARKERS OF RISK FOR DEPRESSION AND SUICIDALITY FOLLOWING MILD TRAUMATIC BRAIN INJURY Ceniti AK, 1,2,3; Rizvi SJ, 1,2,3; Schweizer TA, 1,2; Baker AJ, 1,2; Bhalerao S, 1,2; Kennedy SH, 1,2,3 1 St. Michael's Hospital, Toronto, Ontario; 2 U of T, Toronto, Ontario; 3 University Health Network, Toronto, Ontario 39. Priscilla Chan; Human Biology Program Supervisor: Dr. Michael Fehlings TNFAIP6 AS A CANDIDATE ANTI-INFLAMMATORY PROTEIN IN SPINAL CORD INJURY Chan P, 1,2; Chamankhah M, 2; Wang J, 2; Fehlings MG, 2,3,4 1 Department of Human Biology, Faculty of Arts & Science, U of T; 2 Department of Genetics and Development, Krembil Research Institute, University Health Network; 3 Department of Surgery, U of T; 4 Institute of Medical Science, U of T 40. Alexandra Chatzikalymniou; Physiology Supervisor: Dr. Frances Skinner THE EFFECT OF INHIBITORY CELL NETWORK INTERACTIONS DURING THETA RHYTHMS ON EXTRACELLULAR FIELD POTENTIALS IN CA1 HIPPOCAMPUS A. Pierri Chatzikalymniou1,2; K. Ferguson1,4; F. K. Skinner1,3,2

1 Krembil Research Institute, University Health Network, Toronto ON, CA; 2 Department of Physiology, U of T, Toronto ON, CA; 3 Department of Medicine (Neurology), U of T, Toronto ON, CA; 4 Department of Neuroscience, Yale School of Medicine, New Haven, CT, US 41. Yuxiao Chen; Pharmacology and Toxicology Supervisor: Dr. Amy J. Ramsey NMDA RECEPTOR SIGNALING AND MOLECULAR DETERMINANTS OF SYNAPTIC DYNAMICS AND COGNITION Chen Y, 1; Milenkovic M, 1; Ramsey AJ, 1 1 Pharmacology and Toxicology, U of T 42. Brian Kyung An Choi; Rehabilitation Sciences Institute Supervisor: Dr. Paulo Koeberle INHIBITION OF PRIMARY CILIA RESORPTION REDUCES RETINAL GANGLION CELL DEGENERATION AFTER AXOTOMY Choi BK, 1; Shabanzadeh A, 2; D'Onofrio PM, 1; Koeberle PD, 3 1 Rehabilitation Sciences Institute, U of T; 2 Toronto Western Hospital; 3 Department of Surgery, U of T 43. Jun Ku Chung; Institute of Medical Science Supervisor: Dr. Ariel Graff-Guerrero DEPRESSIVE SYMPTOMS AND SMALL HIPPOCAMPAL VOLUME ACCELERATE THE PROGRESSION TO DEMENTIA FROM MILD COGNITIVE IMPAIRMENT Chung JK, 1,2; Plitman E, 1,2; Nakajima S, 2,3,4,5; Chakravarty MM, 6,7; Caravaggio F, 1,2; Takeuchi H, 3,4; Gerretsen P, 2,3,5; Iwata Y, 2,4; Patel R, 6; Mulsant B, 3 and Graff-Guerrero A, 1,2,3,4,5 1 Institute of Medical Science, Faculty of Medicine, U of T; 2 Multimodal Imaging Group - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada; 3 Department of Psychiatry, U of T, Toronto, Canada; 4 Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan; 5 Geriatric Mental Health Division, Centre for Addiction and Mental Health, Toronto, Canada; 6 Cerebral Imaging Centre, Douglas Mental Health Institute, McGill University, Montreal, Quebec, Canada; 7 Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada

44. Sarah Coakeley; Institute of Medical Science Supervisor: Dr. Antonio Strafella PET IMAGING OF TAU PATHOLOGY IN PROGRESSIVE SUPRANUCLEAR PALSY Coakeley S, 1,2,3; Cho SS, 1,2,3; Rusjan P, 3; Graff-Guerrero A, 3; Chen R, 1,2; Lang AE, 1,2; Kalia L, 1,2; Slow E,1; Houle S,3; Strafella AP, 1,2,3 1 Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, U of T; 2 Krembil Research Institute, UHN, U of T ; 3 Research Imaging Centre, Centre for Addiction and Mental Health, U of T 45. Susana Da Silva; Institute of Medical Science; Centre for Addiction and Mental Health Supervisor: Dr. George Foussias DECONSTRUCTING THE MOTIVATIONAL SYSTEM IN SCHIZOPHRENIA Da Silva S 1,2; Saperia S 1; Fervaha G 1,2; Siddiqui I 1,2; Agid O 1,2,3; Ravindran A 1,2,3; Zakzanis K 4; Remington G 1,2,3; Foussias G 1,2,3

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1 Centre for Addiction and Mental Health; 2 Institute of Medical Science, U of T; 3 Department of Psychiatry, U of T; 4 Department of Psychology, U of T Scarborough 46. Tania Da Silva; Institute of Medical Science Supervisor: Dr. Romina Mizrahi IMAGING NEUROINFLAMMATION IN CLINICAL HIGH RISK FOR PSYCHOSIS WITH CONCURRENT CANNABIS USE: AN IN-VIVO PET STUDY WITH [18F]-FEPPA Da Silva T 1,2; Hafizi S, 1; Watts JJ 1,2; Navas E, 1; Wilson AA 1,2; Houle S 1,2; Le Foll B 1,2; Rusjan PM 1,2; Mizrahi R 1,2 1 Centre for Addiction and Mental Health; 2 Institute of Medical Science, U of T 47. Chesarahmia Dojo Soeandy; Pharmaceutical Sciences Supervisor: Dr. Jeffrey Henderson CELL DEATH ANALYSIS OF MURINE ENDOTHELIN-1 MODEL OF CEREBRAL ISCHEMIA Dojo Soeandy, C 1; Salmasi, F 1; and Henderson, JT 1 1 Pharmaceutical Sciences, U of T 48. Philippe D'Onofrio; Rehabilitation Science Institute Supervisor: Dr. Paulo Koeberle ERK1/2 Contributes to Necroptosis in Neurons After Optic Nerve Transection D'Onofrio PM, 1; Choi BK, 1; Shabanzadeh A, 2; Koeberle PD, 1,3 1 Rehabilitation Science Institute; 2 Toronto Western Hospital; 3 Department of Surgery, U of T 49. Rachel Downey; Rehabilitation Sciences Institute Supervisor: Dr. Paul Comper AN EVALUATION OF THE CLINICAL UTILITY OF THE SPORT CONCUSSION ASSESSMENT TOOL-3 (SCAT3) IN VARSITY ATHLETES Downey R 1; Hutchison M 3; Richards D 3; Comper P 1,2,3 1 Rehabilitation Sciences Institute, U of T; 2 Toronto Rehabilitation Institute; 3 Faculty of Kinesiology and Physical Education, U of T 50. Rachel Dragas; Institute of Medical Science Supervisor: Dr. Michael Fehlings COMBINATORY TREATMENT WITH HEPATOCYTE GROWTH FACTOR AND NEURAL PROGENITOR CELLS REDUCES ASTROGLIOSIS AND PRO-INFLAMMATORY MICROGLIAL ACTIVATION IN VITRO Dragas R, 1,2; Siddiqui AM, 1; Chamankhah M, 1; Hong J, 1,2; Fehlings MG, 1-3 1 Department of Genetics and Development, Krembil Research Institute, Toronto, Canada; 2 Institute of Medical Science, Faculty of Medicine, U of T, Canada; 3 Division of Neurosurgery and Spinal Program, U of T, Canada 51. Abigail D'Souza; Pharmaceutical Sciences Supervisor: Dr. Robert Bonin HANGING BEHAVIOR IN MICE IS A SENSITIVE MARKER OF ANIMAL WELFARE D’Souza AJ1 ; Lecker I, 1;Bonin RP, 1 1. Pharmaceutical Sciences, U of T

52. Brittany Elliott; Physiology/Krembil Research Institute Supervisor: Dr. Elise Stanley CLONING OF THE CHICK CAV2.1 VOLTAGE-GATED CALCIUM CHANNEL Elliott, BB 1,2; Li, Q 1; Stanley, EF 1,2 1 Laboratory of Synaptic Transmission, Krembil Research Institute; 2 Physiology, U of T 53. Zahra Emami; Institute of Biomaterials and Biomedical Engineering Supervisor: Dr. Tom Chau QUANTIFYING AND OVERCOMING THE EFFECT OF DISTRACTORS ON COGNITIVE LOAD IN A BRAIN-COMPUTER INTERFACE Emami Z, 1; Chau T, 1,2 1 Institute of Biomaterials and Biomedical Engineering, U of T; 2 Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital 54. Majid Gasim; Human Biology Program; Physiology Supervisor: Dr. William Hutchison MICROELECTRODE RECORDINGS OF THE GLOBUS PALLIDUS INTERNUS (GPI) IN CEREBRAL PALSY PATIENTS Gasim M,1; Lopez Rios AL,2; Botero Posada LF,2; Hutchison WD, 1,3 1 Physiology, U of T, Toronto, Ontario Canada; 2 Hospital Universitario San Vicente de Paul, Rionegro, Medellin, Colombia; 3 Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada 55. Samantha Gauvreau; Psychology Supervisor: Dr. Donald Mabbott NEURAL NETWORK DISTURBANCES IN CHILDREN TREATED FOR BRAIN TUMOURS Gauvreau S, 1,8; Dockstader C, 9; Harasym D, 1; Piscione J, 3,4; Laughlin S, 5; Timmons B, 6; Bartels U, 3,7; Skocic J, 1; de Medeiros C, 1; Scheinemann K, 6; Bouffet E, 3,7; Doesburg S, 10; Mabbott D, 1,2,8 1 Neurosciences and Mental Health, Hospital for Sick Children; 2 Department of Psychology, Hospital for Sick Children; 3 Division of Haematology/Oncology, Hospital for Sick Children; 4 Department of Rehabilitation Services, Hospital for Sick Children; 5 Diagnostic Imaging, Hospital for Sick Children; 6 Department of Paediatrics, McMaster University; 7 Department of Paediatrics, U of T; 8 Department of Psychology, U of T; 9 Human Biology Program, U of T; 10 Biomedical Physiology and Kinesiology, Simon Fraser University 56. Torin Glass; Institute of Medical Science Supervisor: Dr. Steven Miller SEVERE RETINOPATHY OF PREMATURITY OF EXTREME PRETERM NEWBORNS PREDICTS DELAY IN POSTERIOR WHITE MATTER AND OPTIC RADIATION MYELINATION WITH POOR NEURODEVELOPMENTAL OUTCOMES Glass TJA 1,2; Chau V 1,2,8; Gardiner J 3,8; Foong J 2; Vinall J 4; Zwicker JG 4b,5,7,8; Grunau RE 4,7; Synnes A 4b,7; Poskitt KJ 4a,6,7; Miller SP 1,2,8 1 Department of Pediatrics (Neurology), U of T and the Hospital for Sick Children, Toronto, Ontario, Canada; 2 Neurosciences & Mental Health Research Institute, Toronto, Ontario, Canada; 3 Department of Ophthalmology, University of

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British Columbia and BC Children’s Hospital, Vancouver, British Columbia, Canada; 4 Department of Pediatrics (a Neurology, b Neonatology and c Developmental Pediatrics), University of British Columbia and BC Children’s Hospital, Vancouver, British Columbia, Canada; 5 Department of Occupational Science and Occupational Therapy, Vancouver, British Columbia, Canada; 6 Department of Radiology, University of British Columbia and BC Children’s Hospital, Vancouver, British Columbia, Canada; 7 Sunny Hill Health Centre for Children, Vancouver, British Columbia, Canada; 8 Child and Family Research Institute, Vancouver, British Columbia, Canada 57. Kevin Grykuliak; Medical Biophysics Supervisor: Dr. Kullervo Hynynen DUAL FREQUENCY ULTRASOUND APPLICATIONS FOR MICROBUBBLE MEDIATED BLOOD BRAIN BARRIER DISRUPTION Grykuliak KJ 1,2; Hynynen K 1,2: 1 Sunnybrook Research Institute; 2 Department of Medical Biophysics, U of T 58. Shih-Ping Hung; Institute of Medical Science Supervisor: Dr. Mojgan Hodaie NOVEL PRE-SURGICAL TRIGEMINAL NERVE MICROSTRUCTURAL SIGNATURES OF LONG-TERM RESPONSE TO SURGERY FOR TRIGEMINAL NEURALGIA Hung PS 1,2; Chen DQ 1,2; Behan BT 1; Hodaie M 1,3 1 Krembil Research Institute; 2 Institute of Medical Science, U of T; 3 Division of Neurosurgery, Toronto Western Hospital 59. Cheryl Jones; Music Supervisor: Dr. Michael Thaut MUSIC-BASED COGNITIVE REHABILITATION INTERVENTIONS FOLLOWING ABI Jones, C 1 1 Music and Health Sciences, U of T. 60. Kirusanthy Kanehwaran; Physiology Supervisor: Dr. Beverley A Orser PROBING THE UNDERLYING MECHANISMS OF POSTANESTHETIC MEMORY DEFICITS Kaneshwaran K, 1; Haffey SC, 1; Lei G, 1; Avramescu S 2,3; Lecker I, 1; Wang DS, 1; Mostafa F, 1; Orser BA 1,2,3 1 Physiology, U of T; 2 Anesthesia, U of T; 3 Anesthesia, Sunnybrook Health Sciences Centre 61. Fenika Kapadia; Pharmacology and Toxicology Supervisor: Dr. Etienne Sibille HIGH-THROUGHPUT ANALYSIS OF AGE-DEPENDENT PROTEIN CHANGES IN LAYER 2/3 OF THE ORTIBOFRONTAL CORTEX. Kapadia, FK, 1; Pabba MP, 2; Scifo ES, 3 1 Pharmacology and Toxicology, U of T; 2 Campbell Family Research Institute at Center for Addiction & Mental Health 62. Dunja Knezevic; Institute of Medical Science Supervisor: Dr. Romina Mizrahi IMAGING NEUROINFLAMMATION IN AMNESTIC MILD COGNITIVE IMPAIRMENT (aMCI) USING A NOVEL PET RADIOLIGAND: [18F]-FEPPA

Knezevic D 1,2; Verhoeff NPLG 2,3,4; Hafizi S 1; Voineskos AN 1,2,3; Rajji T 1,2,3; Pollock BG 2,3; Houle S 2,3; Rusjan PM 1; Mizrahi R 1,2,3. 1 Centre for Addiction and Mental Health; 2 Institute of Medical Science, U of T; 3 Department of Psychiatry, U of T; 4 Centre for Mental Health, Baycrest Health Sciences 63. Chantel Kowalchuk; Institute of Medical Science Supervisor: Dr. Margaret Hahn OLANZAPINE ABOLISHES THE ABILITY OF CENTRAL INSULIN TO SUPPRESS HEPATIC GLUCOSE PRODUCTION Teo, C, 1; Kowalchuk, C, 1,2; Wilson, V, 1; Chintoh, A, 1,3; Lam, Loretta Lam, 4; Giacca, Adria, 4; Remington, Gary, 1,2,3; Hahn, Margaret, 1,2,3 1 Centre for Addiction & Mental health; 2 Institute of Medical Science, U of T; 3 Department of Psychiatry, U of T; 4 Department of Physiology, U of T 64. Timothy Lam; Rehabilitation Sciences Institute Supervisor: Dr. Joyce Chen MOVERS AND THINKERS: EXPLORING THE RELATIONSHIP BETWEEN MOTOR AND COGNITIVE BRAIN NETWORKS IN UPPER LIMB RECOVERY POST-STROKE Lam TK, 1,2,3,4; Dawson DR, 1,2,4; Chen JJ, 4,5; Levine B, 2,4,6; Chen JL, 1,2,3,7 1 Rehabilitation Sciences Institute, U of T; 2 Canadian Partnership for Stroke Recovery; 3 Sunnybrook Research Institute; 4 Rotman Research Institute; 5 Department of Medical Biophysics, U of T; 6 Department of Psychology, U of T; 7 Department of Physical Therapy, U of T 65. Vincent Lam; Pharmacology & Toxicology Supervisor: Dr. Ali Salahpour THE DISCOVERY OF NOVEL TAAR1 LIGANDS THROUGH THE USE OF A HOMOLOGY MODEL AND IN SILICO SCREENING Lam VM 1; Rodriguez D 2; Zhang T 1; Koh EJ 1; Carlsson J 3; and Salahpour A 1 1 Department of Pharmacology and Toxicology, U of T ;2 Science for Life Laboratory, Department of Biochemistry and Biophysics and Center for Biomembrane Research, Stockholm University; 3 Science for Life Laboratory, Department of Medicinal Chemistry, BMC, Uppsala University 66. Angus Lau; Biochemistry Supervisor: Dr. Joel Watts BIOCHEMICAL ANALYSIS OF STRAINS OF ALPHA-SYNUCLEIN AGGREGATES Lau A, 1; Watts JC 1,2 1 Biochemistry, U of T; 2 Tanz Centre for Research in Neurodegenerative Diseases 67. Celeste Leung; Physiology Supervisor: Dr. Zhengping Jia THE ROLE OF PAK SIGNALING WITHIN THE ENTORHINAL CORTEX IN THE REGULATION OF SYNAPTIC PLASTICITY AND SOCIAL MEMORY Leung C, 1,2; Cao F, 1,2; and Jia ZP, 1,2 1 Department of Physiology, Faculty of Medicine, U of T; 2

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Department of Neurosciences and Mental Health, Hospital for Sick Children

68. Rachel Leung; Psychology Supervisor: Dr. Margot Taylor NEURAL SUBSTRATES OF EMOTIONAL FACE PROCESSING IN CHILDREN WITH AUTISM SPECTRUM DISORDER Leung RC 1, 2; Taylor MJ 1, 2, 3 1 Diagnostic Imaging, Hospital for Sick Children; 2 Department of Psychology, U of T; 3 Department of Paediatrics, U of T 69. Josiane Mapplebeck; Physiology Supervisor: Dr. Michael Salter SEX DIFFERENCES IN MICROGLIA AND P2X4 RECEPTOR MEDIATION OF NEUROPATHIC PAIN IN RATS Mapplebeck JCS, 1-3; Moriarty O, 1,4; Beggs S 1-3; Tu T, 1; Mogil JS, 5,6; Salter MW, 1-3 1 Program in Neuroscience; Mental Health, Hospital for Sick Children; 2 Department of Physiology, U of T; 3 U of T Centre for the Study of Pain; 4 Department of Neuroscience, Physiology & Pharmacology, University College London; 5 Department of Psychology, McGill University; 6 Alan Edwards Centre for Research on Pain, McGill University 70. Maria Marano; Institute of Medical Science Supervisor: Dr. Anurag Tandon UPTAKE AND SEQUESTRATION OF α-SYNUCLEIN IN A PRION-LIKE PROPAGATION MODEL Marano MM,1; Sri Renganathan SD,1; Tandon A,1 Tanz Centre for Research in Neurodegenerative Diseases, U of T 71. Karen Misquitta; Institute of Medical Science Supervisor: Dr. Carmela Tartaglia ASSESSING THE RELATIONSHIP OF WHITE MATTER HYPERINTENSITIES AND NEUROPSYCHIATRIC SYMPTOMS IN ALZHEIMER’S DISEASE Misquitta KM, 1,2; Dadar M, 3; Anor CJ, 2; Collins DL, 3; Tartaglia MC, 1,2 1 Institute of Medical Science, U of T; 2 Tanz Centre for Research in Neurodegenerative Diseases, U of T; 3 McConnell Brain Imaging Center, Montreal Neurological Institute 72. Keith Misquitta; Pharmacology and Toxicology Supervisor: Dr. Etienne Sibille LIGHT-INDUCED ANXIETY-LIKE BEHAVIOR IN THE UNPREDICTABLE CHRONIC MILD STRESS MODEL IN MICE: A TIME-DEPENDENT TRAJECTORY BASED APPROACH Misquitta K 1,2; Banasr M 1; Nikolova Y 1; Sibille E 1,2 1 Campbell Family Mental Health Research Institute of CAMH, Toronto, Canada;2 Departments of Psychiatry, Pharmacology and Toxicology, U of T 73. Tsukiko Miyata; Medical Biophysics Supervisor: Dr. Jim Woodgett THE ROLE OF GSK3 IN SYNAPTIC PLASTICITY

Miyata T, 1,2; Avila A, 2; Woodgett J, 1,2 1 Department of Medical Biophysics, U of T; 2 Lunenfeld Tanenbaum Research Institute

74. Zainab Moazzam; Institute of Biomaterials and Biomedical Engineering Supervisor: Dr. Paul Yoo SAPHENOUS NERVE STIMULATION: EXPANDING THE ALGORITHM OF INCONTINENCE CARE Moazzam Z, 1; Yoo PB, 1,2 1. Institute of Biomaterials and Biomedical Engineering, U of T; 2 Department of Electrical and Computer Engineering, U of T 75. Jabir Mohamed; Institute of Medical Science Supervisor: Dr. McIntyre Burnham THE ROLE OF SUBCORTICAL INHIBITORY STRUCTURES IN COMPLEX PARTIAL SEIZURES Mohamed, J, 1; Scott, BW, 2; Burnham, WM, 1,3 1 Institute of Medical Science, U of T; 2 SickKids Research Institute, Hospital for Sick Children; 3 Pharmacology & Toxicology, U of T 76. Negar Mohammadi; Human Biology Program; Physiology Supervisor: Dr. William Hutchison THE ROLE OF THE SUBTHALAMIC NUCLEUS IN RESPONSE INHIBITION: EVIDENCE FROM SINGLE-CELL LEVEL AND LOCAL FIELD POTENTIALS IN THE HUMANS WITH PARKINSON'S DISEASE Mohammadi N, 1,2,3; Botero Posada LF, 4; Lopez Rios AL, 4; Hutchison WD, 1,2,3 1 Department of Physiology, U of T; 2 Department of Human Biology, U of T; 3 Division of Neurosurgery, Toronto Western Hospital; 4 Hospital Universitario De San Vicente Fundación, Medellín, Antioquia, Colombia 77. Cindy Narinesingh; Institute of Medical Science Supervisor: Dr. Agnes Wong TEMPORAL CHARACTERISTICS OF THE AUDIOVISUAL INTEGRATION WINDOW IN AMBLYOPIA Narinesingh C, 1; Goltz HC, 2,4; Wong AMF, 2,3,4 1 Institute of Medical Science, U of T; 2 Program in Neurosciences and Mental Health, The Hospital for Sick Children; 3 Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children; 4 Department of Ophthalmology and Vision Sciences, U of T 78. Wanida Nuwisait; Physiology Supervisor: Dr. Peter Carlen ELECTROGRAPHIC AND BEHAVIORAL ANALYSIS OF SECONDARILY GENERALIZED TONIC-CLONIC SEIZURES INDUCED BY INTRAHIPPOCAMPAL 4-AP APPLICATION IN RATS Nuwisait WN, 1,2; Salam MTS 1,3,4; Del Campo MDC 1; Carlen PC 1,2 1 Toronto Western Research Institute; 2 Department of Physiology, U of T; 3 Departments of Electrical and Computer Engineering, U of T; 4 Hospital for Sick Children 79. Temitope Olanbiwonnu; Pharmacology and Toxicology Supervisor: Dr. Laurie Zawertailo

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THE EFFECTS OF SMOKING CESSATION TREATMENT ON SMOKING CUE REACTIVITY: AN FMRI STUDY *Olanbiwonnu T 1,3; Wannas P 1,3; Payer D; Selby P 1,2; Zawertailo L 1,3 1 Dept. of Pharmacology and Toxicology, 2 Dept. of Psychiatry, U of T, 3 Centre for Addiction and Mental Health 80. Zihang Pan; Human Biology Program Supervisor: Dr. Roger McIntyre ANHEDONIA SCORES POSITIVELY CO-VARY WITH WAIST CIRCUMFERENCE IN ADULTS WITH MDD AND BD: RESULTS FROM THE INTERNATIONAL MOOD DISORDERS COLLABORATIVE PROJECT Pan Z, 1; Mansur RB, 1; Cha DS 1,2; McIntyre RS, 1,2,3 1 Mood Disorders Psychopharmacology Unit, U of T, University Health Network; 2 Institute of Medical Science, U of T; 3 Department of Psychiatry and Pharmacology, U of T 81. Alicia Paniccia; Rehabilitation Science Institute Supervisor: Dr. Sally Lindsay EXPLORING THE EXPERIENCES OF YOUTH AND YOUNG ADULTS WITH ABI AS THEY TRANSITION TOWARDS WORK-RELATED ROLES Paniccia A, 1,3; Stergiou-Kita M, 2; Kirsh B, 2; Lindsay S, 2,3 1 Rehabilitation Science Institute, U of T; 2 Department of Occupational Science and Occupational Therapy, University to Toronto; 3 Holland Bloorview Kids Rehabilitation Hospital 82. Melissa Paniccia; Rehabilitation Sciences Institute Supervisor: Dr. Nick Reed and Dr. Scott Thomas AGE, SEX AND BASELINE CONCUSSION SYMPTOMS IN HEALTHY YOUTH ATHLETES: AN EXPLORATION OF HEART RATE VARIABILITY Paniccia M, 1,2; Verweel L, 2; Taha T, 1,3; Keightley M, 1,2; Thomas S, 1,3; Reed N, 1,2,4 1 Rehabilitation Science Institute, U of T; 2 Concussion Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital; 3 Faculty of Physical Education and Kinesiology, U of T; 4 Department of Occupational Science and Occupational Therapy, U of T 83. Albert Park; Human Biology Program; The Hospital for Sick Children, Program In Neurosciences & Mental Health Supervisor: Dr. Sheena Josselyn OPTOGENETIC SUPPRESSION OF A COCAINE-PLACE MEMORY IN THE MOUSE LATERAL AMYGDALA Hsiang H-L 1,2,3; Park A 1,2,3; Howland JG, 4; Frankland PW 1,2,3; Josselyn SA 1,2,3 1 Program in Neurosciences and Mental Health, Hospital for Sick Children; 2 Institute of Medical Sciences; 3 Department of Psychology, Department of Physiology, U of T; 4 Department of Physiology, University of Saskatchewan 84. Eric Plitman; Institute of Medical Science Supervisor: Dr. Ariel Graff-Guerrero GLUTAMATE+GLUTAMINE LEVELS IN THE PRECOMMISSURAL DORSAL CAUDATE ARE ASSOCIATED WITH LOCAL VOLUME DEFICITS IN ANTIPSYCHOTIC-NAÏVE PATIENTS WITH FIRST-EPISODE PSYCHOSIS Plitman E, 1,2; Patel R, 3,4; Chung JK, 1,2; Pipitone J, 5; Chavez S, 1,6; Reyes-Madrigal F, 7; Gómez-Cruz G, 7; León-Ortiz P, 7,8; Chakravarty MM, 3,4; de la Fuente-Sandoval C, 7,9; Graff-Guerrero A, 1,2,6,10,11

1 Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, U of T; 2 Institute of Medical Science, U of T; 3 Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University; 4 Departments of Psychiatry and Biomedical Engineering, McGill University; 5 Kimel Family Translational Imaging-Genetics Research Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, U of T; 6 Department of Psychiatry, U of T; 7 Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico; 8 Department of Education, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico; 9 Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico; 10 Geriatric Mental Health Division, Centre for Addiction and Mental Health, U of T; 11 Campbell Institute Research Program, Centre for Addiction and Mental Health, U of T 85. Mouly Rahman; Human Biology Program; Krembil Research Institute Supervisor: Dr. Michael Fehlings THE TEMPORAL EXPRESSION OF PRO-INFLAMMATORY CYTOKINES IN THE CLIP IMPACT-COMPRESSION RAT MODEL OF SPINAL CORD INJURY Rahman MF, 1,2; Chamankhah M, 2; Wang J, 2; Fehlings MG, 2,3,4 1 Department of Human Biology, Faculty of Arts & Science, U of T; 2 Department of Genetics and Development, Krembil Research Institute, University Health Network; 3 Department of Surgery, U of T; 4 Institute of Medical Science, U of T 86. Alborz Rezazadeh Sereshkeh; Institute of Biomaterials and Biomedical Engineering Supervisor: Dr. Tom Chau DEVELOPMENT OF A HYBRID BRAIN COMPUTER INTERFACE BASED ON ELECTROENCEPHALOGRAPHY AND NEAR-INFRARED SPECTROSCOPY Rezazadeh Sereshkeh A 1,2; Chau T 1,2 1 Bloorview Research Institute; 2 Institute of Biomaterials and Biomedical Engineering, U of T 87. Anton Rogachov; Institute of Medical Science Supervisor: Dr. Karen Davis REGIONAL BRAIN SIGNAL VARIABILITY: A NOVEL INDICATOR OF BRAIN HEALTH FOR PAIN SENSITIVITY AND COPING Rogachov A, 1,2; Cheng JC 1,2; Erpelding N, 1; Hemington KS, 1,2; Crawley AP, 1,2; Davis KD, 1,2 1 Krembil Research Institute, Toronto Western Hospital; 2 U of T 88. Parisa Sabetian; Institute of Biomaterials and Biomedical Engineering Supervisor: Dr. Paul Yoo DIRECTIONALLY-SENSITIVE PERIPHERAL NERVE RECORDING: BIPOLAR NERVE CUFF DESIGN Sabetian P 1; Popivic M, 1,2,3; Yoo P 1,2 1 Institute of Biomaterials and Biomedical Engineering, U of T; 2 Department of Electrical and Computer Engineering, U of T; 3 Toronto Rehabilitation Institute- University Health Network 89. Usman Saeed; Institute of Medical Science Supervisor: Dr. Mario Masellis and Dr. Sandra E. Black

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APOLIPOPROTEIN E ϵ4 ASSOCIATES WITH HIPPOCAMPAL VOLUMES AND VERBAL EPISODIC MEMORY PERFORMANCE ACROSS ALZHEIMER’S, LEWY BODY AND MIXED DEMENTIAS: THE SUNNYBROOK DEMENTIA STUDY Saeed U 1,2; Yu Q 1; MacIntosh B 1,3; Herrmann N 1,4; Ramirez J 1; Rogaeva E 5; Black SE 1,2,6; Masellis M 1,2,7 1 Sunnybrook Health Sciences Centre; 2 Institute of Medical Science, Faculty of Medicine, U of T; 3 Department of Medical Biophysics, U of T; 4 Department of Psychiatry, Faculty of Medicine, U of T; 5 Tanz Centre for Research in Neurodegenerative Diseases, Faculty of Medicine, U of T; 6 Brill Chair in Neurology, Department of Medicine, U of T; 7 Department of Neurology, Faculty of Medicine, U of T. 90. Vinoja Sebanayagam; Institute of Medical Science Supervisor: Dr. Jennifer Ryan MULTI-SCALE ENTROPY OF EYE MOVEMENTS AS A MEASURE OF MEMORY IN AGING Sebanayagam V, 1,4; Shen K, 1; Olsen RK, 1; McIntosh AR, 1,2; Ryan JD, 1,2,3 1 Rotman Research Institute, Baycrest hospital; 2 Department of Psychology, U of T; 3 Department of Psychiatry, U of T; 4 Institute of Medical Science, U of T 91. Simon Spichak; Human Biology Program Supervisor: Dr. Donald Mabbott USING DIFFUSION TENSOR IMAGING (DTI) METRICS TO TRACK THE DEVELOPMENT OF U-FIBRES IN HEALTH CHILDREN Spichak S, 1; Mabbott D, 2,3 1 Human Biology Program: Neuroscience, U of T; 2 Department of Neurosciences & Mental Health, Hospital for Sick Children; 3 Department of Paediatrics, U of T 92. Joseph Steinman; Medical Biophysics Supervisor: Dr. John Sled 3D MORPHOLOGICAL ANALYSIS OF THE MOUSE CEREBRAL VASCULATURE: COMPARISON OF IN VIVO AND EX VIVO METHODS J Steinman 1, 2*; M Koletar 3; B Stefanovic 2,3; JG Sled 1,2 1 Mouse Imaging Centre, The Hospital for Sick Children, 25 Orde Street, Toronto, Canada, M5T 3H7; 2 Department of Medical Biophysics, U of T; 3 Sunnybrook Research Institute 93. Filip Stojic; IBBME Supervisor: Dr. Tom Chau A NOVEL EEG-BCI DEPENDENT ON DISCRIMINATION OF IMAGINED STIMULI IN VISUAL FIELD QUADRANTS Stojic F, 1,2; Chau T, 1,2 1 Institute of Biomaterials and Biomedical Engineering, U of T; 2 Holland Bloorview Kids Rehabilitation Hospital 94. Petri Takkala; Institute of Medical Science Supervisor: Dr. Steven Prescott TWO-PHOTON IMAGING OF GABAA RECEPTOR-MEDIATED ANTIDROMIC DISCHARGE IN PRIMARY SOMATOSENSORY NEURONS Takkala P, 1,2; Prescott SA, 1,2,3 1 Institute of Medical Science, U of T; 2 Neurosciences and Mental Health, The Hospital for Sick Children; 3 Physiology, U of T 95.

Steven Tran; Cell & Systems Biology Supervisor: Dr. Robert Gerlai ACTIVATION OF THE DOPAMINERGIC SYSTEM REGULATES ALCOHOL INDUCED LOCOMOTOR ACTIVITY IN ZEBRAFISH Steven T, 1; Facciol A, 2; Chatterjee D, 2; Gerlai R, 1,2 1 Cell & Systems Biology, U of T; 2 Psychology, U of T Mississauga 96. Ekaterina Turlova; Physiology Supervisor: Dr. Hong-Shuo Sun TRANSIENT RECEPTOR POTENTIAL MELASTATIN 7 (TRPM7) REGULATES AXONAL DEVELOPMENT AND MATURATION OF PRIMARY HIPPOCAMPAL NEURONS Turlova E 1,2; Bae CYJ 2; Deurloo M 2; Chen W 1,2; Barszczyk A 2; Horgen FD 5; Fleig A 6; Feng ZP 2; Sun HS 1,2,3,4. Departments of 1 Physiology, 2 Surgery and 3 Pharmacology, 4 Institute of Medical Science, Faculty of Medicine, U of T; 5 College of Natural and Computational Sciences, Hawaii Pacific University, Kaneohe, USA; 6 Center for Biomedical Research, The Queen’s Medical Center, Honolulu, USA 97. Ilan Vonderwalde; Institute of Biomaterials and Biomedical Engineering Supervisor: Dr. Cindi Morshead USING A RODENT MODEL OF STROKE TO TEST THE THERAPEUTIC POTENTIAL OF TRANSPLANTING DIRECTLY REPROGRAMMED HUMAN NEURAL PRECURSOR CELLS WITHIN A HAMC HYDROGEL Vonderwalde I, 1; Nusrat L, 2; Azimi A, 3; Sachewsky N, 4; Morshead CM, 1,2,3,4 1 Institute of Biomaterials and Biomedical Engineering, U of T; 2 Rehabilitation Sciences Institute, U of T; 3 Institute of Medical Science, U of T; 4 Department of Surgery, U of T 98. Paul Wannas; Pharmacology Supervisor: Dr. Laurie Zawertailo EFFECTS OF NICOTINE REPLACEMENT ON fMRI EMOTIONAL CUE REACTIVITY IN TREATMENT SEEKING SMOKERS Wannas P 1,2; Olanbiwonnu T 1,2; Payer D 2; Selby P 1,2; Zawertailo L 1,2 1 U of T; 2 Centre for Addiction and Mental Health 99. Andrew Wong; Institute of Biomaterials and Biomedical Engineering Supervisor: Dr. Tom Chau SYSTEMATIC QUANTIFICATION OF SYSTEMIC BLOOD FLOW IN NEAR INFRARED SPECTROSCOPY BRAIN COMPUTER INTERFACES IN A PEDIATRIC CONTEXT Wong AT, 1,2; Chau T, 1,2 1 Institute of Biomaterials and Biomedical Engineering, U of T; 2 Bloorview Research Institute 100. Julia Young; Psychology Supervisor: Dr. Margot Taylor EARLY WHITE MATTER DEVELOPMENT AND OUTCOMES IN CHILDREN BORN VERY PRETERM Young JM 1,4; Morgan BR 1; Lee W 1; Smith ML 2, 4; Shroff MM 1; Sled JG 3; Taylor MJ 1,4 1 Department of Diagnostic Imaging, 2 Department of Psychology,

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Hospital for Sick Children, Toronto; 3 Department of Medical Biophysics, 4 Department of Psychology, U of T 101. Di Yu; Pharmacology and Toxicology Supervisor: Dr. Walter Swardfager PERIPHERAL INFLAMMATORY BIOMARKERS CORRELATE WITH MICROSTRUCTURAL INTEGRITY IN THE WHITE MATTER HYPERINTENSITIES SEEN FREQUENTLY IN ALZHEIMER’S DISEASE Yu D 1,2; Swardfager W 1,2,3,4,5; Ramirez JE 1,3,4; Szilagyi G 1,3,4; Holmes M 1,3,4; Scott CJ 1,3,4; Scola G 2,6; Chan PC 1; Chen J 1; Chan P 1,2; Sahlas DJ 7; Herrmann N 1; Lanctôt KL 1,2,3,5; Andreazza AC 2,6; Pettersen JA 9; Black SE 1,3,4,8 1 Hurvitz Brain Sciences Program, Sunnybrook Research Institute; 2 Department of Pharmacology & Toxicology, U of T; 3 Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute; 4 LC Campbell Cognitive Neurology Unit, Sunnybrook Research Institute; 5 University Health Network Toronto Rehabilitation Institute; 6 Anxiety and Mood Disorders Department; Centre for Additions and Mental Health; 7 Department of Medicine (Neurology Division), McMaster University; 8 Department of Medicine (Neurology Division), U of T; 9 Department of Medicine (Neurology Division), University of British Columbia, Northern Medical Program

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