Hematopoietic System- 1 Bone Marrow Hematopoiesis Linda F. Cunningham, MD January 2, 2003.
2003-2004 Hematopoiesis Pharmacology Review 28 August 2015 7:22 AM.
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Transcript of 2003-2004 Hematopoiesis Pharmacology Review 28 August 2015 7:22 AM.
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2003-2004Hematopoiesis
Pharmacology Review
April 19, 202310:05 AM
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Abciximab
Antiplatelet
Anti-GPIIb/IIIa receptor antibody
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Acetaminophen
Analgesic, Antipyretic
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Adalimumab
TNF inhibitor
Anti-TNF antibodyUsed in rheumatoid arthritis
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Alemtuzumab
Antineoplastic
Anti-CD52 antibody
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Allopurinol
AntigoutAntineoplastic (supporting
agent)
Folic acid analogueXanthine oxidase inhibitor
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Aminocaproic acid (EACA)
Procoagulant
Inhibitor of plasminogen activation
(decreases fibrinolysis)
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Aminoglutethimide
AntineoplasticImmunosuppressive
Glucocorticoid antagonistAromatase inhibitor
(decreases steroid synthesis)
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Angiostatin
Antineoplastic
Angiogenesis inhibitor
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Anistreplase
Thrombolytic
Streptokinase + plasminogen
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Anti-thymocyte globulin
Immunosuppressive
Anti-T cell antibody
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Aprotinin
Procoagulant
Fibrinolytic inhibitorSerine protease inhibitor
(“serpin”)Streptokinase inhibitor
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Argatroban
Anticoagulant
Direct thrombin inhibitor
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L-asparaginase
Antineoplastic
Protein synthesis inhibitor
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Aspirin(Acetylsalicylic acid, ASA)
NSAID (acetylsalicylate)Analgesic, Anti-inflammatory
Antipyretic, Antiplatelet
Irreversible cyclooxygenase inhibitor
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Azathioprine
ImmunosuppressiveAntineoplastic
Antimetabolite(“pseudofeedback inhibition” of
HGPRT and PRP)
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Basiliximab
Immunosuppressive
Anti-CD25 (interleukin 2 receptor)
Organ transplant (antirejection)
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Betamethasone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidNot by inhalation
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Bivalirudin
Anticoagulant
Direct thrombin inhibitor
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Bortezomib
Antineoplastic
Proteosome inhibitor
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Bradykinin
Inflammatory mediator
Plasma, hypotension, pain
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C3a, C5a
Inflammatory mediators
Anaphylatoxins Low molecular weight
complement cleavage products
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Celecoxib
NSAIDAnti-inflammatory
Cyclooxygenase 2 (COX-2) inhibitor
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Cetirizine
Antihistamine
H1 antagonist Non-sedating
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Chlorpheniramine
Classical antihistamine
H1 antagonist
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Clopidogrel
Antiplatelet
ADP receptor antagonist
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Cobalamin(cyanocobalamin, hydroxocobalamin)
Vitamin
Treatment forvitamin B12 deficiency
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Cortisol (Hydrocortisone)
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroid
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Cyclosporine
ImmunosuppressiveAntineoplastic
Binds cyclophilinInhibits calcineurin
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Cytarabine (AraC)
Antineoplastic
Antimetabolite
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Daclizumab
Immunosuppressive
Anti-CD25 (interleukin 2 receptor) antibody
Organ transplant (anti-rejection)
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Dalteparin
Anticoagulant
LMW HeparinATIII activator
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Desmopressin acetate
Synthetic analogue ofarginine vasopressin
Used in treatment of bleeding disorders
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Dexamethasone
AdrenocorticosteroidGlucocorticoidAntineoplastic
Antiemetic
Anti-inflammatory steroidNot by inhalation
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Diflunisal
NSAIDAnalgesic, Anti-inflammatory
Antipyretic
Cyclooxygenase inhibitor
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Diphenhydramine
Classical antihistamineAntiemetic
H1 antagonist
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Dipyridamole
Antiplatelet
Phosphodiesterase inhibitor(increases cAMP)
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Drotrecogin alfa(Activated Protein C)
Anticoagulant
Many actionsTreatment for septic shock
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Edrecolomab
Antineoplastic
Anti-17-1A antibody
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Enoxaparin
Anticoagulant
LMW HeparinATIII activator
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Eptifibatide
Antiplatelet
GPIIb/IIIa antagonist
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Erythropoietin (EPO)
Cytokine
Primary regulator of RBC synthesis
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Etanercept
TNF inhibitor
Tumor necrosis factor receptor+ Fc portion of IgG
Used in rheumatoid arthritis
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Fexofenadine
Antihistamine
H1 antagonistNon-sedating
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5-Fluorouracil
Antineoplastic
AntimetaboliteThymidylate synthase inhibitor
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Folic acid
Vitamin
Treatment for folicacid deficiency
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Gefitinib
Antineoplastic
MiscellaneousTyrosine kinase inhibitor
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Gemcitabine
Antineoplastic
Antimetabolite
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Gemtuzumab
Antineoplastic
Anti-CD33 antibody
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Heparin
Anticoagulant
ATIII activator
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Hirudin
Anticoagulant
Direct thrombin inhibitor(DTI)
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Histamine
Inflammatory mediator
Stored in mast cells and basophils
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Hydrocortisone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroid
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4-Hydroxycoumarin
Oral anticoagulant
Vitamin K synthesis inhibitor
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Hydroxyurea
Antineoplastic
MiscellaneousRibonucleotide reductase
inhibitor
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Hydroxyzine
Classical antihistamine
H1 antagonist
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Ibritumomab
Antineoplastic
Anti-CD20 antibody
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Ibuprofen
NSAIDAnalgesic, Anti-inflammatory
Antipyretic
Reversible cyclooxygenase inhibitor
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Imatinib
Antineoplastic
MiscellaneousTyrosine kinase inhibitor
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Indomethacin
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitorTocolytic
Uterine relaxant
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Infliximab
TNF inhibitor
Anti-TNF monoclonal antibodyTreatment of IBD
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Interferon alpha
Antiviral for hepatitisAntineoplastic
Cytokine
Anti-angiogenesis
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Interleukin 2
Cytokine Antineoplastic
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Interleukin 11
Cytokine Antineoplastic (supporting
agent)
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Interleukin 12
Cytokine Antineoplastic (supporting
agent)
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Kallidin
Inflammatory mediator
Plasma, hypotension, pain
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Ketoprofen
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
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Lepirudin
Anticoagulant
Direct thrombin inhibitor (DTI)
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Leucovorin
Antineoplastic (supporting agent)
Folic acid analogue(used in methotrexate rescue)
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Leukotriene B4 (LTB4)
Inflammatory mediator
Lipoxygenase productof arachidonate metabolism
Chemotactic
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Leukotrienes C4, D4, E4
(LTC4, LTD4, LTE4)
Inflammatory mediators
Cysteinyl leukotrienesPeptidyl leukotrienes
SRS-ALipoxygenase products ofarachidonate metabolism
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Loratidine
Antihistamine
H1 antagonistNon-sedating
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Meclofenamate
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
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6-Mercaptopurine
Antineoplastic
Antimetabolite(“pseudofeedback inhibition” of
HGPRT and PRP – purine synthesis)
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Methotrexate
ImmunosuppressiveAntineoplastic
Folic acid antagonistDihydrofolate reductase
inhibitor
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Methylprednisolone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidNot by inhalation
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Montelukast
Leukotriene inhibitor
LTR1 and LTD4 antagonistAsthma treatment
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Muromonab-CD3
Immunosuppressive
Mouse monoclonal anti-CD3 antibody
Organ transplant (anti-rejection)
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Mycophenolate
Immunosuppressive
Inhibits inosine monophosphate dehydrogenase activity
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Naproxen
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
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Non-steroidalAnti-inflammatory Drugs
(NSAIDs)
Analgesic, Anti-inflammatory, Antipyretic
Cyclooxygenase inhibitors
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Omalizumab
Anti-asthma
Anti-IgE antibody
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Palivizumab
Antiviral
Monoclonal antibody againstthe surface of
respiratory syncytial virus
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Pentostatin
Antineoplastic
MiscellaneousEnzyme inhibitor
(blocks purine synthesis)
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Phytonadione
Vitamin K
Warfarin antagonist
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Piroxicam
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
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Platelet Activating Factor (PAF)
Inflammatory mediator
LipidHypotensive
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Prednisone
AdrenocorticosteroidGlucocorticoid Antineoplastic
Anti-inflammatoryNot by inhalation
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Promethazine
Classical antihistamineAntipsychotic
Antiemetic
H1 antagonist
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Prostaglandin D2 (PGD2)
Bronchoconstrictor
Cyclooxygenase product of arachidonate metabolism
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Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)
Oxytocic prostaglandinInflammatory mediator
Cyclooxygenase product of arachidonate metabolism
Uterine stimulantCervical ripener
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Prostaglandin F2 (PGF2)
Inflammatory mediator
Cyclooxygenase product of arachidonate metabolism
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Prostaglandin I2 (PGI2)
Inflammatory mediator
Inhibits platelet aggregation
Cyclooxygenase product of arachidonate metabolism
Prostacyclin
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Protamine Sulfate
Heparin antagonist
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Rituxumab
Antineoplastic
Anti-CD20 antibody
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Rofecoxib
NSAIDAnti-inflammatory
Cyclooxygenase 2 (COX-2) inhibitor
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Sargramostim(GM-CSF)
Colony stimulating factor
WBC (granulocyte and macrophage)
stimulant
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Sirolimus
Immunosuppressive
Binds FKBP, inhibits mTOR (mammalian kinase target of
rapamycin) & cell cycle progression
Rapamycin
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Streptokinase
Thrombolytic
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Sulindac
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
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Tacrolimus
ImmunosuppressiveAntineoplastic
Binds FKBP (FK506 binding protein)
Inhibits calcineurin
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Thalidomide
AntineoplasticLeprosy treatment
Anti-angiogenicAnti-TNF
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6-Thioguanine
Antineoplastic
Antimetabolite (“pseudofeedback inhibition” of
HGPRT and PRP – purine synthesis)
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Thromboxane A2 (TXA2)
Autacoid
Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism
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Ticlopidine
Antiplatelet
ADP receptor antagonist
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Tissue plasminogen activators
Thrombolytics
alteplase, reteplase, tenecteplase
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Tositumomab
Antineoplastic
Anti-CD20 antibody
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Trastuzumab
Antineoplastic
Anti-HER2 antibody
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Tripelennamine
Classical antihistamine
H1 antagonist
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Tumor necrosis factor
CytokineAntineoplastic
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Urokinase
Thrombolytic
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Warfarin
Anticoagulant
Vitamin K synthesis inhibitor
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Zafirlukast
Leukotriene inhibitor
LTR1 and LTD4 antagonistAsthma treatment
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Zileuton
Leukotriene inhibitor
5-lipoxygenase inhibitorUsed in asthma