1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0
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A 1. 8 1. 6 1. 4 1. 2 1. 0 0. 8 0. 6 0. 4 0. 2 0 I II III (N=26) (N=18) (N=36) NORE1A mRNA level (NORE1A/GAPDH) P < 0.05 P < 0.05 WD MD PD (N=25) (N=46) (N=9) P < 0.05 P < 0.05 1. 8 1. 6 1. 4 1. 2 1. 0 0. 8 0. 6 0. 4 0. 2 0 I II III (N=26) (N=18) (N=36) NORE1B mRNA level (NORE1B/GAPDH) P < 0.05 WD MD PD (N=25) (N=46) (N=9) P < 0.05 P < 0.05 P < 0.05 B Percentage of specimens (%) 80 70 60 50 40 30 20 10 0 NORE1A level Wild type K-R as Mutant K-Ras 30 Normal Low (N=49) (N=31) 19 20 11 80 70 60 50 40 30 20 10 0 NORE1B level Wild type K-R as Mutant K-Ras 34 Normal Low (N=55) (N=25) 21 16 9
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P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. 1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0. 1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0. NORE1A mRNA level ( NORE1A/GAPDH ). NORE1B mRNA level ( NORE1B/GAPDH ). WD MD PD - PowerPoint PPT Presentation
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A
1.8
1.6
1.4
1.2
1.0
0.8
0.6
0.4
0.2
0 I II III
(N=26) (N=18) (N=36)
NO
RE
1A m
RN
A le
vel (
NO
RE
1A/G
AP
DH
)
P < 0.05
P < 0.05
WD MD PD
(N=25) (N=46) (N=9)
P < 0.05
P < 0.05
1.8
1.6
1.4
1.2
1.0
0.8
0.6
0.4
0.2
0 I II III
(N=26) (N=18) (N=36)
NO
RE
1B m
RN
A le
vel (
NO
RE
1B/G
AP
DH
)
P < 0.05
WD MD PD
(N=25) (N=46) (N=9)
P < 0.05
P < 0.05
P < 0.05
B
Per
ce
nta
ge
of
sp
ecim
en
s (
%) 80
70
60
50
40
30
20
10
0
NORE1A level
Wild type K-RasMutant K-Ras
30
Normal Low(N=49) (N=31)
19
20
11
80
70
60
50
40
30
20
10
0
NORE1B level
Wild type K-RasMutant K-Ras
34
Normal Low(N=55) (N=25)
21
16
9