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Winning at Weight LossWinning at Weight Loss

Fatless®

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Fatless®Honi l

Carbohydrates and Weight Gain

• Carbohydrate consumption has increased over the years as fat intake has decreased.

• Obesity and diabetes rates have risen along with carbohydrate consumption.

• A typical Western diet provides:– 200-300g carbohydrates/day

– 900-1350 calories

– 49% of total calories from carbohydrates

• Blocking the conversion of carbohydrates into glucose can reduce fat storage and promote weight loss.

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Fatless®Honi l

“Potatoes, eaten in large quantities

by a population increasingly

sedentary and overweight, may be

a major contributor to America’s

alarming rates of heart disease and diabetes.”

Time Magazine, Jan. 21, 2002

“10 Foods That Pack A Wallop”

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Fatless®Honi l

“This is not just a potato

problem. It’s also a

problem with white bread,

bagels, and most white rice.”

Time Magazine, Jan. 21, 2002

“10 Foods That Pack A Wallop”

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Fatless®Honi l

Carbohydrates and Weight Gain

Pancreas produces alpha amylase,a starch-digesting enzyme

Alpha amylase converts starchinto glucose (sugar)

Sugar calories are burned or stored as fat cells

Stomach

Pancreas

LiverLiver

SmallIntestineSmallIntestine

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Fatless®Honi l

Foods Containing Starchy Carbohydrates

• Potatoes• Pasta• Bread • Rice• Grain

Refined and processed grains have a high glycemic index

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Fatless®Honi l

Health Risks of Obesity

• Hypertension• Hyperlipidemia• Coronary Artery Disease and Stroke• Type 2 Diabetes• Respiratory Disease (sleep apnea)• Osteoarthritis• Gallbladder disease• Cancer (breast, prostate, colon)• Premature Death!

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Fatless®Honi l

Why Is The Incidence Rising?

• Lack of physical activity

• Poor dietary choices (convenience foods)– Fast food, processed food, and sugar rather than whole

grains and vegetables

• Increased caloric intake– Increased consumption of grains, soft drinks (sugar)

and alchohol1

Center for Nutrition Policy and Promotion, USDA, 2001

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Fatless®Honi l

Many People Need A Kick Start

• Lifestyle Coach

• Dietitian

• Nutritional Supplements

• Prescriptions Drugs (for severe cases)

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Fatless®Honi l

• The first clinically studied starch neutralizer

• Standardized extract made from a portion of the white kidney bean

• Fatless® may bind with alpha amylase, “neutralizing” starch calories and preventing the conversion into glucose (sugar)

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Fatless®Honi l

In Vitro Studies

• One gram of Fatless® will “neutralize the starch calories of 1 lb. pasta or 1 loaf bread

• High Activity Fatless® : 5,000 – 6,000 units/gNon-standardized bean "starch blocker”:0-540 units/g

• No trypsin/protein inhibitor activity detected

• Survives undiluted gastric and intestinal solutions (68-80% retention of activity)

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Fatless®Honi l

Human Studies1. “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind

Placebo-Controlled Study with Normal Human Subjects.” Joe A. Vinson, PhD, University of Scranton, September/2001

2. “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind Placebo-Controlled Study with Normal College-Age Subjects.” Joe A. Vinson, PhD, University of Scranton, November/2001

3. “Evaluation of the Safety and Efficacy of a Food Supplement for Weight Control Through the Reduced Calories Intake from Carbohydrates vs Placebo (Double Blind Test).” Dr. R. Ballerini, EVIC Italia, November/2001

4. “Dose-Response Pilot Study of PHASEOUT efficacy as an inhibitor of glucose absorption with a Full Meal.” Joe A. Vinson, PhD, University of Scranton, May 2002.

5. “Phaseolamin 2250™ (Phaseolus vulgaris) for the Treatment of Obesity.” Jay Udani, MD, Northridge Hospital, 2002

6. “Dose Response Human Study of Amylase Inactivator with Normal Subjects Given a Full Meal.” Joe A. Vinson, PhD, University of Scranton, 2002

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Fatless®Honi l

• 60 subjects, ages 25-45 (male & female, 5-15 kg overweight, stable for 30 days prior to study)

• Double-blind, placebo-controlled study for 30 days

• Recommended diet with daily consumption of complex carbohydrates during one of the principal meals

• Experimental: Placebo plus 500 mg of a Fatless® containing product.

• Changes in weight; fat and lean body mass (bioelectric impedance); waist, hip, and thigh circumference

Dr. R. Ballerini, EVIC, Milan, Italy, November/2001

Weight Loss Study

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Fatless®Honi l

Results – Ballerini Study

Fatless® Placebo

Weight -2,933 kg -0.348 kg

-6.45 lbs -0.76 lbs

-3.96% TBW -0.47%

TBW

Fat Body Mass -10.45% -1.30%

Lean Body Mass 0.0% 0.0%

Hip Circumference -1.39% -0.10%

Thigh Circumference -1.44% -0.39%

Waistline Circumference -3.44% -0.53%

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Fatless®Honi l

NORTHRIDGE HOSPITAL

• Randomized, Double-Blind, Placebo Controlled• 50 Patients

– Obese (35 > BMI > 30)– Age < 50– Based on Statistical Effect Size Calculation

• 8 week active study• 1500mg of Fatless® or Placebo

Approved by Human Use and Research Committee

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Fatless®Honi l

Overall Results

Fatless®

• 3.8 pounds• 1.5 inches off waist• 26 point drop TG• 13% energy• Reduced hunger

Placebo• 1.1 pounds• No loss of inches• 8 point drop TG• No effect on energy or

hunger

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Fatless®Honi l

• Natural, standardized extract with the first demonstration of effectiveness in human studies

• Safe, non-stimulant carbohydrate control mechanism that blocks carbohydrate conversion to sugar calories

• Reduces starch absorption by an average of 57%

• Produces weight loss by reduction of body fat mass

• No known adverse side effects or drug interactions

• Reasonable effective doses (500-1,500 mg/meal)

Summary

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The bottom line…

Healthy eating and physical activity are essential for weight management.