COURSE DESCRIPTION

TIN 330

Bioindustrial Technology

3(2-3)

Course Description

• Knowledge on cultivation process design which covers environmental factors in effect of microbial growth and enzymatic processes , bioreactors and instrument, cultivation process, downstream process and techno-economy bioprocess aspects.

• Holistic understanding on bioindustrial technology and how to develop bioindustrial product

Textbook• Aiba,S., A.E humprey, dan N.F. Milis.1973. Biochemical

Engineering., Second Edition. Academic Press, New York• Belter, P.A.,E.L. Cutsler dan H.Wei-Shou.1988. bioseparations :

Downstream Processing for Biotechnology. A Wiley-interscience Publ., New York

• crueger, W and A. Crueger.1984. Biotechnology : A Textbook of Industrial Microbiology. Science tech., Inc., Madison

• Rehm, H.Z and G. Reed.1985. Biotechnology Vol 9.1995. Biotechnology : Enzyme, Biomass, Food and Feed, VCH Verlagsgeselshaft mbH,Weinheim

• Scragg, A.H.1991.Bioreactors in Biotechnology : A Practical Approach>Ellis Horword, New york

• Stanbury, P.F and A. Whitaker.1989.Principles of Fermentation technology. Pergamon Press.Oxford

• Wang, D.I., C.L.Cooney, A.L.Demain,P.Dunnil,A.E.humprey and M.D.Lilly.1979.Fermentation and Enzyme Technology.John Willey and Sons, new york

Textbook• Prave,P.,U.Faust,W.Sittg and D.A.Sukatsch.1987.Fundamentals

of Biotechnology.VCH Verlagsgeselshaft mbH,Weinheim• Bailley,J.E and D.F.Ollis.1986. Biochemical Engineering

Fundamentals.Second Edition.McGraw-Hill Co., New York• Chaplin,M.F and C.Bucke.1990. Enzyme Technology>Cambridge

university Press, Cambride• Demain,A.L. and N.A. Solomon.1986.Manual of Industrial

Microbiology and Biotechnology. American Societyfor Microbiology.Washington

• Margaritis,A. and J.B. Wallace.Novel Bioreactor System and their Application.J.of Biotechnology.May,1984

• Pirt,S.J.1985.Principles of Microbe and Cell Cultivation.blackwell Sci., Oxford

• Rehm,H.Z and G.Reed.1985.Biotechnology vol 2 : Fundamentals of Biochemical Engineering. VCH Verlagsgeselshaft mbH,Weinheim

Other references

• L.Hartoto and I.Sailah.1992. Sistem Bioreaktor.Pusat Antar Universitas Bioteknologi.IPB, Bogor

• Judoamidjojo,R.M.,E.G.Sa’id dan L.Hartoto.1989.Biokonversi. Pusat Antar Universitas Bioteknologi,IPB

• Mangunwidjaja,D. and A.Suryani.1994. Teknologi Bioproses. Penebar Swadaya, Jakarta

Course Outcomes• Understand scope range and how important to study bioindustrial

technology• Understand cultivation technique and downstream application on

bioindustry• Understand type of bioreactor and its application to many

production process• Understand free enzyme application and immobile to many

production process• Understand many kind of plants and animal cell and it’s

application to bioindustry• Understand techno-economy aspects in bioindustry• Understand microbes application for many kind of products made

with optimal cultivation condition, bioreactor uses and efficient downstream process

• Collaborate in a team work• Demonstrate effective communication orally and in writing

Lecturer Team

1. MRH (Mulyorini Rahayuningsih) – coordinator

2. IKS (Khaswar Syamsu)

3. PUR (Purwoko) – laboratory practices coordinator

4. Rini Purnawati and Egnawati Sari – laboratory practices

Major Topics Covered in the CourseWeek Major Topics Lecturer

1 Introduction IKS

2-3Cultivation technique and downstream application process IKS

4 Type of bioreactors and example application to many processes IKS

5 Scale up of bioprocess IKS

6Free and immobile enzyme application to many production processes IKS

7 Bioetanol production technology IKS

10 Biopolymer (gum xanthan, pullulan, gellan, dextran, etc ) production technology MRH

11 ARA production technology MRH

12 Bioinsecticides, microbial vitamins production technology MRH

13 Organic acids production technology MRH

14 Microbial Enzymes production technology MRH

15 Antibiotics and vaccines production technology MRH

16 Techno economy aspects in bioindustry MRH

Laboratory practices

Week Topics Lecturer

1 GLP in Microbiology Lab PUR

2-3 Kinetics of Enzymatic Processes PUR

4-5 Production of Lipase Enzymes PUR

6-7 Production of bioetanol : Immobilized cells and free cells PUR

10-11 Production of citric acid : submerged cultivation and solid substrates cultivation

MRH

12-13-14 Bioinsecticides production semi solid and submerged cultivation

MRH

15-16 Scale up technique IKS/Rini P

Assessment

• Mid exam (UTS ) – 30 %

• Final exam (UAS) – 30 %

• Laboratory Practices (performance and report) – 30 %

• Paper – 10 %