07 Endokrini sistem
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Transcript of 07 Endokrini sistem
-
8/4/2019 07 Endokrini sistem
1/7
Handout 07/ 08
1
.
: , , , ,- .
(
,
,
)
(-
, , -,
). 1.
1.
.
,
-
.
( 1)
.
.
(, ,
, ),
(.
,, ;
, ).
/
. (
)
. (
)
.
(10-10 10-12).
1.
.
. ()
(SHBG--
, CBG-
),
(TBG-
),
().
:
-
8/4/2019 07 Endokrini sistem
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Handout 07/ 08
2
:
(
)
( ,
)
-
-
3.
2. -
-
(3-7
)
(1-
4 )
-:
1.
2.
3.
4.
.
-
.
:::
,
-
:
1. cAMP-
2. cGMP-
3. IP3
4. DAG -
5. 6. () 2.
cAMP-
()
cAMP-
cAMP-
(
)
:
P-a ,
,
( cAMP-
)
:
ACTH
TSH
FSH
LH ADH
-
8/4/2019 07 Endokrini sistem
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Handout 07/ 08
3
,
.
cGMP
.
,cGMP ,
,
.
.
IP3 DAG
4,5
IP3 DAG-
IP3 Ca++
Ca++
DAG
:
IP3 :ADH
TRH
GnRH
,
:
:
(
,
, )
2.
D
.
.
/ /
,
. 3.
:-
(
)
-
8/4/2019 07 Endokrini sistem
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Handout 07/ 08
4
3.
3.
3.
1. -
GH (SH) ,
,
,
-,
, ,
GHRH,
GHIH
:
-TSH
4 3
TRH
-ACTH
ACTH-RH (CRH)
(PRH I PIH)
PIH
PRH
-FSH
,
GnRH
-LH
, , ,
GnRH
2. -
-
- ADH
,
4.
-
8/4/2019 07 Endokrini sistem
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Handout 07/ 08
5
4.
-
(
,
,
), (
,
, )
,
TSH
,
-
-
-
()
-
-
(
)
, ,,
,
,
-
-
,
,
ACTH
,
,
,
,
II
-
,
,
, (
, , ,
ACTH
(,,
-
8/4/2019 07 Endokrini sistem
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Handout 07/ 08
6
)
,
,
,
)
(
)
,
,
, ,
, ,
,
.
.
.
:
( GHRH,
GHIH-, TRH, GnRH,
PIH, ACTH-RH CRH
)
( STH, TSH,
FSH, LH, ACTH,
;
- ,
,
,
-
)
: (down up
)
( -
)
.
LH
.
(,
...)
.
:
,
, .
.
.
.
-
8/4/2019 07 Endokrini sistem
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Handout 07/ 08
7
.
.
(, ,
) .
.
