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ANNUAL REPORT 2013/14
< ONLY REVERSE OUT OF PHC BLUE, BLACK AND PHC OCHREANTIMICROBIAL STEWARDSHIP PROGRAM
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The Providence Health Care Antimicrobial Stewardship Program would not have been possible without the contribution of many groups and individuals.
Thank you to the groups who have made time for us, modified work processes to accommodate us, and engaged in dialogue around antimicrobial use:
• Clinical pharmacists• Medical microbiology
technologists• Physicians, residents and
medical students• Nurse practitioners• Infectious diseases physicians• Medical microbiologists• Vancouver Coastal Health’s
Antimicrobial Stewardship team (ASPIRES)
In addition, we would like to thank the following individuals for their unique contributions to building our program and acting as champions for antimicrobial stewardship:
• Salomeh Shajari• Michael Mulder• Felice Kwo• David Lee• Sharon Leung• Ron Wall• Dr. David Patrick• Dr. Jock Reid• BJ Paproski• Leah Shapera• Dr. Anna Rahmani
ACKNOWLEDGEMENTS
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Executive Summary
Introduction Clinical Activities
Education Guidelines Research TeamMetrics Financials
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AKNOWLEDGEMENTS 2
EXECUTIVE SUMMARY 4
INTRODUCTION 6
CLINICAL ACTIVITIES 9
EDUCATION 15
GUIDELINES 20
RESEARCH 22
METRICS & FINANCIALS 23
TEAM 30
TABLE OF CONTENTS
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In response to the growing public health threats of antimicrobial resistance and antimicrobial overuse, we established the Providence Health Care (PHC) Antimicrobial Stewardship Program (ASP) on April 1, 2013.
Our goals were to optimize antimicrobial utilization at PHC and engage prescribers in dialogue around “Bugs and Drugs.”
To accomplish these broad program goals, we successfully implemented the following financially sustainable initiatives:
• Prospective audit of antimicrobial use and feedback to prescribers, with 1386 interventions and an 85 per cent acceptance rate. The majority of recommendations led to discontinuation of antibiotics.
• Collaboration with the Medical Microbiology Division to expedite
optimal treatment of bloodstream infections.
• Partnership with Infection Prevention and Control to minimize the use of concurrent antibiotics for patients with Clostridium difficile infection.
• Effective communication with Wound Care Nursing Team to manage complex wounds.
• Broad education and teaching designed to improve antimicrobial therapeutics knowledge and heighten awareness of antimicrobial resistance
• Accessible, locally relevant, concise and evidence-informed treatment guidelines for common infections
• System improvements in selection and delivery of perioperative antimicrobial prophylaxis.
EXECUTIVE SUMMARY
EXECUTIVE SUMMARY
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In the first year of our program, we built the foundations for a coordinated and systematic approach to support optimal antimicrobial treatment outcomes. We saved $487,231 in antimicrobial expenditures. We also helped other hospitals in British Columbia to develop similar programs in their institutions.
We are very fortunate to have the engagement and support of many individuals and teams in the PHC community. We would like to thank all prescribers at PHC. Together we can delay the post-antibiotic era by improving prescribing behaviour.
Sincerely,
Antimicrobial Stewardship Program
EXECUTIVE SUMMARY
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INTRODUCTION
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BACKGROUND | VISION | MISSION
ASP is a systematic, coordinated and multifaceted approach to improve and measure the use of antimicrobials. Our program focuses on engaging prescribers in dialogue about antimicrobial resistance and therapy. We target inappropriate antimicrobial use by establishing programs to improve education, clinical documentation and care transitions.
In the era of increasing antimicrobial resistance, prescribers need to be well informed when selecting antimicrobials. Treatment needs to be effective and minimize harm from adverse effects such as disruption of human microbiome, development of antimicrobial resistance and superinfections, and drug interactions and toxicities.
We have an opportunity to optimize patient outcomes and potentially delay the post-antibiotic era by improving antimicrobial prescribing.
VISION
Use innovative evidence-informed strategies to transform the way antimicrobials are prescribed.
MISSION
Ensure that every patient and resident at Providence Health Care receives timely, safe and effective antimicrobial therapy.
1.1 INTRODUCTION
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1326
2013
Interventions by the ASP audit and feedback
pro
gram |
Year PHC Antimicrobial Stewardship Pro
gram
est
ablis
hed |
$487,371
Savings in antim
icrobial expendi
ture
s |
85%
Acceptance rate of ASP recom
men
datio
ns |
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CLINICAL ACTIVITIES
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2.1 AUDIT AND FEEDBACK
AUDIT AND FEEDBACK | BACTEREMIA/FUNGEMIA ALERTS | CLOSTRIDIUM DIFFICILE MANAGEMENT | URINARY TRACT INFECTIONS AND ASYMPTOMATIC BACTERIURIA IN RESIDENTIAL CARE | WOUND CARE COLLABORATION
Ongoing audit and feedback are core clinical activities of our ASP. All patients receiving targeted antimicrobials are assessed for potential interventions including:
• Changing antimicrobials to target a syndrome or known pathogen
• Discontinuing antimicrobials • Transitioning to oral antimicrobials• Establishing duration of therapy
We make recommendations based on review of medical and nursing notes, diagnostic test results, published guidelines and local epidemiology. In complicated cases, we recommend consultation with the Infectious Diseases service.
We always attempt to contact the physician team to discuss our recommendations. Our goal is to
provide timely, accessible and clinically relevant recommendations. All suggestions are left in the interdisciplinary notes and tracked in our database.
We understand that departures from clinical guidelines are necessary. Ultimately, the decision to accept or reject our recommendations rests with the most responsible physician. We never write orders without explicit approval by the most responsible medical or surgical team.
did you know?
This year, we made 1326 audit and feedback interventions with an acceptance rate of 85%.
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2.2 BACTEREMIA/FUNGEMIA ALERTS
AUDIT AND FEEDBACK | BACTEREMIA/FUNGEMIA ALERTS | CLOSTRIDIUM DIFFICILE MANAGEMENT | URINARY TRACT INFECTIONS AND ASYMPTOMATIC BACTERIURIA IN RESIDENTIAL CARE | WOUND CARE COLLABORATION
We implemented an ongoing collaborative process with the Medical Microbiology laboratory where the ASP physician or pharmacist participates in blood culture rounds. This ensures patients with positive blood cultures (bacteremia/fungemia) receive the most timely and appropriate treatment.
We have been using the new rapid identification system (MALDI-TOF) directly from blood cultures in conjunction with direct antimicrobial susceptibility testing. The PHC Medical Microbiology laboratory is leading the implementation of this innovative technology. We are fortunate to have this collaboration.Review of MALDI-TOF results for rapid identification of
pathogen directly from blood cultures
Preparing for rapid identification using MALDI-TOF
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2.3 CLOSTRIDIUM DIFFICILE MANAGEMENT
AUDIT AND FEEDBACK | BACTEREMIA/FUNGEMIA ALERTS | CLOSTRIDIUM DIFFICILE MANAGEMENT | URINARY TRACT INFECTIONS AND ASYMPTOMATIC BACTERIURIA IN RESIDENTIAL CARE | WOUND CARE COLLABORATION
Clostridium difficile infection (CDI) is the most common form of infectious diarrhea in hospitalized patients. Antimicrobial use is a key driver of CDI and we know that patients diagnosed with CDI recover more slowly if they are on antimicrobials for other possible infections.
In collaboration with Infection Prevention and Control, we implemented a process where the ASP physician and pharmacist receive real time phone alerts of all new C. difficile cases (“War on the Spore” program). The goal is to assess whether concurrent antimicrobials can be stopped.
In fiscal year 2014/15, ASP will start reviewing all inpatient cases of C. difficile infection. In addition to assessing the need for concurrent antimicrobials, the ASP team will be assessing adherence to regional CDI management guidelines.
Real time phone alerts for newly diagnosed C. difficile cases
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2.4
ASP collaborated with Infection Prevention and Control and St. Vincent’s Langara to implement a pilot prospective audit and review of urine cultures submitted from residents at Langara. The goal was to reduce inappropriate collection of urine cultures and unnecessary antibiotic treatment for asymptomatic bacteriuria. The project was successful in reducing overall antibiotic prescriptions for presumed urinary tract infections and the number of urine cultures collected from patients. In fiscal 2014/15, we will explore opportunities to implement this prototype in other residential care facilities at PHC.
URINARY TRACT INFECTIONS AND ASYMPTOMATIC BACTERIURIA IN RESIDENTIAL CARE
AUDIT AND FEEDBACK | BACTEREMIA/FUNGEMIA ALERTS | CLOSTRIDIUM DIFFICILE MANAGEMENT | URINARY TRACT INFECTIONS AND ASYMPTOMATIC BACTERIURIA IN RESIDENTIAL CARE | WOUND CARE COLLABORATION
Residential Care UTI Guideline
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2.5 WOUND CARE COLLABORATION
AUDIT AND FEEDBACK | BACTEREMIA/FUNGEMIA ALERTS | CLOSTRIDIUM DIFFICILE MANAGEMENT, URINARY TRACT INFECTIONS AND ASYMPTOMATIC BACTERIURIA IN RESIDENTIAL CARE | WOUND CARE COLLABORATION
Patients with complicated wounds are often prescribed antibiotics for presumed infection. However, wounds which are appropriately cleaned by wound care nurse specialists will frequently show no residual signs of infection. In collaboration with the Wound Care Team, we implemented a process where ASP is alerted when antibiotics are prescribed for wounds with no clear signs of infection. The goal of the program is to avoid unnecessary antibiotics.
Educational dialogue between ASP pharmacist and wound care nurse specialist
did you know?Inappropriate wound culture collection is a primary driver of unnecessary antibiotic use. The next time you want to obtain a wound culture, consult the Wound Care Nursing Team for advice.
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EDUCATION
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3.0
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3.1 EDUCATION
ROUNDS | JOURNAL CLUBS | POINT OF CARE EDUCATION | ROTATIONS FOR TRAINEES | KNOWLEDGE DISSEMINATION
We have held many interdisciplinary education sessions to enhance dialogue around antimicrobial stewardship at Providence Health Care.
ROUNDS
We implemented monthly ASP teaching for residents and medical students at St. Paul’s Hospital. ASP noon rounds were also held bimonthly for the Clinical Teaching Unit.
In the next fiscal year, we will be expanding clinical rounds to the General Surgery service and the Intensive Care Unit at St. Paul’s Hospital.
ASP rounds in the ICU
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3.2 JOURNAL CLUBS
ROUNDS | JOURNAL CLUBS | POINT OF CARE EDUCATION | ROTATIONS FOR TRAINEES | KNOWLEDGE DISSEMINATION
EVENING JOURNAL CLUBS
To promote physician, pharmacist and specialized nursing engagement, ASP organized six evening journal clubs this year.
Topics included febrile neutropenia, intra-abdominal infections, cardiac surgical site infections and implantable cardiac device infections, cellulitis and chronic venous insufficiency, and diabetic foot infections.
With the support of unrestricted educational grants from pharmaceutical companies, we engaged approximately 150 physicians, pharmacists and nurse specialists at Providence Health Care through evidence-informed education and dialogue.
Physician performs appropriate hand hygiene while considering the optimal antimicrobial to prescribe
In a Piperacillin-tazobactam (PZ) use evaluation, PZ was prescribed inappropriately in 41% of skin/soft tissue infections and 38% of lower respiratory tract infections.
did you know?
Executive Summary
Introduction Clinical Activities
Education Guidelines Research TeamMetrics Financials
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POINT OF CARE EDUCATION
The ASP physician and pharmacist were available to discuss and provide advice on antimicrobial treatment choices. These discussions often occured on the hospital wards during clinical rounds. Dialogue helps provide learning opportunities for prescribers and our team.
ROTATIONS FOR TRAINEES
We have provided supervision to trainees in the University of British Columbia Pharmacy, Infectious Diseases and Medical Microbiology residency programs. We will continue to offer rotations for trainees in the UBC Infectious Diseases and Medical Microbiology residency programs. Shorter rotations will be offered to PharmD candidates. Eventually, we hope to provide this rotation to other trainees.
3.3 EDUCATION
ROUNDS | JOURNAL CLUBS | POINT OF CARE EDUCATION | ROTATIONS FOR TRAINEES | KNOWLEDGE DISSEMINATION
ASP physician and pharmacist review audit and feedback recommendations.
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KNOWLEDGE DISSEMINATION
We accepted invitations to speak at two forums sponsored by the BC Patient Safety and Quality Council. We shared our experience in developing a leading Antimicrobial Stewardship Program with other health organizations in British Columbia.
3.3 EDUCATION
ROUNDS | JOURNAL CLUBS | POINT OF CARE EDUCATION | ROTATIONS FOR TRAINEES | KNOWLEDGE DISSEMINATION
Executive Summary
Introduction Clinical Activities
Education Guidelines Research TeamMetrics Financials
Empiric Antimicrobial Therapy for Febrile Neutropenia
with no Apparent Focus of Infection
IDENTIFY PATIENTS WITH FEBRILE NEUTROPENIA
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INVESTIGATE FOR A SOURCE OF INFECTION
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Empiric treatment should be started immediately after basic investigations
Cefepime 2g IV Q8H
EVALUATE FOR RESPONSE TO THERAPY
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NOTES on Antimicrobials
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GUIDELINES & RESEARCH
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4.1
The Antimicrobial Stewardship Subcommittee is actively involved in developing and revising clinically relevant treatment guidelines for common infections seen at PHC. We produced six new guidelines, which were posted on our website. These guidelines are reviewed and endorsed by our sub-specialty colleagues at PHC and treatment recommendations consider local epidemiology.
PERIOPERATIVE ANTIMICROBIAL PROPHYLAXIS AND ORDER SETS
In collaboration with physicians in the Department of Surgery, we have been revising antimicrobials on pre-printed perioperative orders. Revisions are submitted to the local Pharmacy and Therapeutics Committee for approval. We have also been working closely with our antimicrobial
stewardship colleagues at Vancouver Coastal Health to develop a regional document for perioperative antimicrobial prophylaxis. Next fiscal year, ASP will be working closely with order sets for the Clinical Systems Transformation project.
GUIDELINES AND PATHWAYS | PERIOPERATIVE ANTIMICROBIAL PROPHYLAXIS AND ORDER SETS
GUIDELINES AND PATHWAYS
Clinical pharmacist checks ASP guidelines on the Internet
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DRUG UTILIZATION | RESEARCH FELLOWSHIPS
DRUG UTILIZATIONWe believe that our program will significantly decrease overall antimicrobial utilization at Providence Health Care. However, our antiquated pharmacy information system limits simple data extraction. We anticipate that with information system upgrades coming in the next fiscal year, the study of drug utilization will be much easier. The drug utilization analysis will be done in collaboration with the provincial “Do Bugs Need Drugs?” program.
RESEARCH FELLOWSHIPSASP will be involved in co-supervising an infectious diseases fellow for the AMMI Canada (Association of Medical Microbiology and Infectious Disease Canada) Post-Residency Research Fellowship.
The project will start next fiscal year. The objective is to examine the clinical impacts of rapidly identifying pathogens causing bacteremia in hospitalized patients followed by prospective audit and feedback.
RESEARCH4.2
Provincial “Do Bugs Need Drugs?” program
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1000
200
400
800
600
0
DISCONTINUE
INITIATE IN
DICATED ANTI-EFFECTIVE
MODIFY ROUTE
MODIFY DURATION
980 517 81
52
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INTERVENTIONS | DRUG UTILIZATION
6.0 INTERVENTIONS
The standard for clinical outcome metrics for antimicrobial stewardship programs is an ongoing area of research. In the first year of our program, we were able to track the number and types of interventions we made through our prospective audit and feedback based on targeted antimicrobials. Process measures will
be further refined in the next few years to better understand where audit and feedback has the most impact.
The types of interventions and the indications for the interventions are summarized in Tables 1-2 and Figure 1.
NUMBER
NUMBER OF INTERVENTIONS 1326
ACCEPTANCE PROPORTION NUMBER (PERCENTAGE)
ACCEPTED 780 (85.4%)
NOT ACCEPTED 133 (14.6%)
UNKNOWN 413
TABLE 1. TOTAL NUMBER OF INTERVENTIONS BY THE ANTIMICROBIAL STEWARDSHIP TEAM
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INTERVENTIONS6.1
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INTERVENTIONS | DRUG UTILIZATION
TABLE 2. TOTAL NUMBER OF INTERVENTIONS BY THE ASP TEAM BY SITE
NUMBER OF INTERVENTIONS
ACCEPTED (%) NOT ACCEPTED (%)
UNKNOWN
SPH 1,249 742 (86.8%) 113 (13.2%) 394
MSJ 77 38 (65.5%) 20 (34.5%) 19
1200
1000
200
400
800
600
0DISCONTINUE MODIFY
ANTIMICROBIALMODIFY ROUTE MODIFY DURATION MODIFY DOSE
980
517
8152 23
FIGURE 1A. TYPES OF INTERVENTION SUGGESTIONS BY ANTIMICROBIAL STEWARDSHIP PROGRAM
INTE
RVEN
TIO
N
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INTERVENTIONS | DRUG UTILIZATION
6.2 DRUG UTILIZATION
DRUG UTILIZATION
The pharmacy information system has been undergoing upgrades to permit more efficient extraction of drug utilization data. During the first year of our program, resources were not available to examine the
changes in antimicrobial utilization after our antimicrobial stewardship program was implemented. After the information system upgrades, our plan is to review drug utilization for targeted antimicrobials. The metric used for each antimicrobial will be Daily Defined Dose/10,000 patient days.
FIGURE 1B. ANTIMICROBIALS MOST OFTEN DISCONTINUED
PIPERACILLIN-TAZOBACTAM IV
CEFTRIAXONE IV
VANCOMYCIN
METRONIDAZOLE IV
CIPROFLOXACIN IV
325
140
162
5343
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ANTIMICROBIAL EXPENDITURE SAVINGS | FINANCIAL STATEMENT
6.3 FINANCIALS
ANTIMICROBIAL EXPENDITURES
Although financial savings are not the primary objectives of our antimicrobial stewardship program, we know that implementation of ASP can decrease antimicrobial expenditures.
This occurs through more judicious
use of antimicrobials when they are needed, better determination of antimicrobial therapy duration and improved selection of pathogen directed antimicrobials and routes of administration. This year expenditures decreased by $487,371.
ANNUAL ANTIMICROBIAL EXPENDITURES
ACTUAL EXPENDITURES
BUDGET
$2,500,000
$500,000
$1,000,000
$2,000,000
$1,500,000
02009 - 10
FISCAL YEAR
$3,000,000
2010 - 11 2011 - 2012 2012 - 13 2013 - 14* 2014 - 15*
FY 13 - 14 antibiotic budget ↓ $174K
FY 14 - 15 antibiotic budget ↓ $208K
↓ ↓
EXPE
NDI
TURE
S ($
)
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ANTIMICROBIAL EXPENDITURE SAVINGS | FINANCIAL STATEMENT
6.4
CUMULATIVE ANTIMICROBIAL EXPENDITURES 2013-2014
ACTUAL EXPENDITURES
BUDGET
ANTIMICROBIAL EXPENDITURE SAVINGS
$2,500,000
$500,000
$1,000,000
$2,000,000
$1,500,000
01 2 3 4 5 6 7 8 9 10 11 12 13
FISCAL PERIODS
EXPE
NDI
TURE
S ($
)
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ANTIMICROBIAL EXPENDITURE SAVINGS | FINANCIAL STATEMENT
FINANCIAL STATEMENT 2013-2014
6.5 FINANCIALS
ACTUAL BUDGET VARIANCELABOURASP PHYSICIAN (0.5 FTE)
$163,292 $163,292 $ =
ASP PHARMACIST (1.0 FTE)
$94,396 $122,715 $28,319
ANALYST $ - $41,768 $41,768CLERK $ - $4,849 $4,849TOTAL LABOUR $257,688 $332,624 $74,936
NON LABOURPDA $571 $300 ($271)CONFERENCE $712 $ - ($712)CONSULTANTS $1,020 $ - ($1,020)MEMBERSHIP FEES $201 $ - ($201)SUNDRY $10,000 $6,500 ($3,500)COMPUTER FEES $2,095 $ - ($2,095)TOTAL NON-LABOUR $14,599 $6,800 ($7,799)
TOTAL EXPENSES $272,286 $339,424 $67,137
ACTUAL BUDGET VARIANCEDRUGS - ANTIBIOTICS $1,749,899 $2,063,712* $313,813
* The 2013/14 budget was reduced by $173,558 to fund the program
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CLINICAL TEAM7.0
CLINICAL TEAM | OPERATIONAL TEAM | ANTIMICROBIAL STEWARDSHIP SUBCOMMITTEE | RESEARCH TEAM
ASP Physician lead
Dr. Victor Leung
CLINICAL TEAM
The clinical team consists of the ASP physician (Dr. Victor Leung) and pharmacists (Allison Kirkwood, Dr. Daljit Ghag). We work closely with clinical pharmacists, physicians and nurses at Providence Health Care to conduct the daily activities of the program. The clinical team is responsible for engaging prescribers and are the champions for the project by ensuring appropriate visibility of the project across the organization and to other organizations as appropriate.
ASP Pharmacist
Allison Kirkwood
Interim ASP Pharmacist
Dr. Daljit Ghag
ANNUAL REPORT 2013/14
Executive Summary
Introduction Clinical Activities
Education Guidelines Research TeamMetrics Financials
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OPERATIONAL TEAM7.1
CLINICAL TEAM | OPERATIONAL TEAM | ANTIMICROBIAL STEWARDSHIP SUBCOMMITTEE | RESEARCH TEAM
OPERATIONAL TEAM
The operational team consists of our Vice President Executive Sponsor (David Thompson) and Project Sponsor (Luciana Frighetto). They provide overall direction and senior level decisions required by the project including confirmation and approval of project scope, timeline and budget. They provide support to ensure that the required resources are available and are accountable for ensuring the Senior Leadership Team and Providence Health Care board committees and external stakeholders are updated on the overall status of the project.
Vice President, Seniors Care and Clinical Support Services
David Thompson
Pharmacy Director, PHC Acute Care & Medication Use Evaluation
Luciana Frighetto
ANNUAL REPORT 2013/14
Executive Summary
Introduction Clinical Activities
Education Guidelines Research TeamMetrics Financials
33
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ANTIMICROBIAL STEWARDSHIP SUBCOMMITTEE7.2
CLINICAL TEAM | OPERATIONAL TEAM | ANTIMICROBIAL STEWARDSHIP SUBCOMMITTEE | RESEARCH TEAM
ANTIMICROBIAL STEWARDSHIP SUBCOMMITTEE
The subcommittee is chaired by Dr. Glen Brown and reports to the Pharmacy and Therapeutics Committee. Members provide direct input into key decisions and resolution of critical issues throughout the project. The subcommittee meets monthly.
Clinical Pharmacist, Intensive Care
Dr. Marc Romney
Physician and Head, Division of Medical Microbiology.Medical Director, Infection Prevention and Control
Dr. Glen Brown
Physician, Division of Medical Microbiology
Dr. Sylvie Champagne
Physician and Head, UBC Division of Infectious Diseases
Dr. Peter Phillips
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ANNUAL REPORT 2013/14
Executive Summary
Introduction Clinical Activities
Education Guidelines Research TeamMetrics Financials
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ANTIMICROBIAL STEWARDSHIP SUBCOMMITTEE7.3
CLINICAL TEAM | OPERATIONAL TEAM | ANTIMICROBIAL STEWARDSHIP SUBCOMMITTEE | RESEARCH TEAM
Physician, Division of AIDS and Infectious Diseases
Dr. Mark Hull
Physician, Division of Hematology
Dr. Chantal Leger
ANNUAL REPORT 2013/14
Right to left: Dr. Marc Romney, Allison Kirkwood, Dr. Victor Leung, Dr. Chantal Leger, Dr. Glen Brown. (Missing: Dr. Peter Phillips, David Thompson, Luciana Frighetto, Dr. Sylvie Champagne, Dr. Mark Hull, Dr. TC Yang, Dr. Rob Stenstrom, Dr. Daljit Ghag)
Executive Summary
Introduction Clinical Activities
Education Guidelines Research TeamMetrics Financials
ANNUAL REPORT 2013/14
< ONLY REVERSE OUT OF PHC BLUE, BLACK AND PHC OCHREANTIMICROBIAL STEWARDSHIP PROGRAM