Animism All objects derive their special characteristics from a spirit contained within objects If...
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AnimismAll objects derive their special
characteristics from a spirit contained within objects
If a plant contains a spirit, eating the plant transfers that spirit to the person who eats it
Shaman – medicine man/womanSpecialist in harvesting and utilizing
plants for medicinal properties
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PhantasticaDrugs that create a world of
fantasy in our mindsOther names used over the years
Psychedelic (mind manifester) Psychotomimetics(mimics psychosis) Entheogen (creating spirit or divine within) Entactogen (touching within) Empathogen (empathy creator) Hallucinogen (creating hallucinations)
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Classifying Hallucinogens Chemical Structures (e.g., Indole, Catechol, Other) Pharmacological Effects (e.g., 5-HT agonists, NMDA
glutamate antagonists, anticholinergics) Effects on Conscious Awareness (e.g., visual
perception, body awareness) Classical Phantastica
Capable of altering perceptions while allowing one to remain conscious of surroundings Individual is simultaneously aware of both
fantasy and reality Later memory for experience is relatively
clear. They produce little acute physiological
toxicity In contrast, dissociative anesthetics and
anticholinergics produce physiological toxicity and impair memory.
Two chemical classes of classical phantastica Indole hallucinogens (Serotonin-Like) Catechol hallucinogens (Dopamine-Like)
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Images obtained fromhttp://www.nida.nih.gov/ResearchReports/Hallucinogens/Structure.jpg
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d-lysergic acid diethylamide (LSD) Psilocybin
Mushrooms Ololiuqui
Morning Glory seeds (lysergic acid amide)
Argyreia nervosa Hawaiian baby woodrose seeds
Dimethyltryptamine (DMT) Several plant substances
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LSD is not found in natureFirst synthesized from grain fungus
Ergotism (St. Anthony’s fire)—Condition experienced from eating bread made from fungus infected grain
LSD discovery and early research Synthesized in 1938 by Albert Hoffman,
Sandoz First experience from accidental absorption,
1943 Extensive medical use in U.S., 1953 to 1966 Turned over to government in 1966
Secret Army/CIA research with LSD
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Physical properties of LSD In pure form - colorless, odorless, tasteless
Absorption from GI system rapid Metabolism and Elimination
Half-life approx. 3 hours > 90% is excreted within 24 hours Subjective effects can last 2-12 hours
Cellular Tolerance develops rapidly Repeated daily doses become ineffective
within a few days No evidence for Physical Dependence
with LSD
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Acute Physiological EffectsSympathomimetic effects
Pupil dilation, increased body temp., heart rate, and blood pressure
Parasympathetic effects salivation and nausea
Mechanism of ActionSerotonin Agonist (5-HT2A receptor
agonist)
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Altered senses/perceptions Synesthesia Body distortions
Adverse Reactions Panic Flashbacks
Some beliefs about LSD Creativity Therapy
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Varieties of psychoactive mushrooms Psilocybe mexicana Psilocybe cubensis
Effects Hallucinogenic effects similar to
LSD Similar autonomic effects to LSD Cross tolerance occurs among
psilocybin, LSD, and mescaline Clinical Benefits of Entheogens
Recent studies by Griffiths et al. at Johns Hopkins.
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Dimethyltryptamine (DMT) A short-acting hallucinogen (duration less than
an hour) Found in seeds of certain leguminous trees and
prepared synthetically No effects when taken orally, taken as snuff or
smoked Ayahuasca (vine of the soul)
Religious sacrament in South American tribes Contains:
Banisteriopsis caapi vine (contains harmaline, an MAO inhibitor)
Psychotria viridis leaves (contains DMT) Neither plant has psychoactive effects when
ingested alone
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Mescaline (Peyote) Structurally similar to amphetamine, but
effects are more like those of LSD. Mescaline is the most active drug in peyote; it
induces intensified perception of colors and euphoria.
Effects include dilation of the pupils, increase in body temperature, anxiety, visual hallucinations, and alteration of body image, vomiting, muscular relaxation, and in very high doses may cause death.
Street samples are rarely authentic.
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Chemically related to amphetamines Varying degrees of hallucinogenic and
CNS stimulant effects Phenylethylamines that predominantly:
Release serotonin are dominated by their hallucinogenic effects
Release dopamine are dominated by their stimulant effects
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2,5-Dimethoxy-4-methylamphetamine (DOM or STP)
3,4-Methylenedioxyamphetamine (MDA)
3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)
“Designer” amphetamines 2-CB, 2-C-T7, TMA
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Phencyclidine (PCP) Developed as an intravenous anesthetic, but
found to have serious adverse side effects. NMDA Glutamate Antagonist Effects differ from those of other traditional
hallucinogens It is a general anesthetic in high doses It causes incredible strength and extreme violent
behavior Management of the severe psychological
reactions requires drug therapy
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Physiological effects Hallucinogenic effects, stimulation,
depression, anesthesia, analgesia Large doses can cause coma,
convulsions, and death Psychological effects
Feelings of strength, power, invulnerability, perceptual distortions, paranoia, violence, psychoses
Other PCP-like drugs Ketamine
Veterinary anesthetic Dextromethorphan at high doses
Synthetic derivative of codeine, OTC cough suppressant
Nitrous Oxide
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Belladonna Mandrake Henbane Datura These products contain the
anticholinergic agents, atropine and scopolamine.
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Amanita Muscaria Red and white speckled mushroom found in
forests in many parts of the world Active ingredient once thought to be muscarine, a
cholinergic agonist 1960s, ibotenic acid and muscimol found in
significant amounts Muscimol is a GABA agonist: produces confusion,
disorientation, sensory disturbances, muscle twitches, fatigue, sleep
Salvia Divinorum “Magic Mint”, “Diviners sage” Religious sacrament among Mazatec people of
Oaxaca, Mexico Only recently used in U.S. and Europe, considered
legal hallucinogen, not currently listed as a controlled substance
Kappa opioid agonist
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Drug Discrimination All hallucinogens are capable of establishing
discriminative stimulus control and the discrimination appears to be specific to a particular drug’s mechanism of action. Animals trained to discriminate LSD will
generalize to other indole hallucinogens as well as mescaline, but not to catechol hallucinogens (MDMA) , the dissociative anesthetics (PCP, ketamine), or the anticholinergics (atropine, scopolamine).
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Self Administration in Nonhumans Hallucinogens that ARE self administered
MDMA, PCP, ketamine Hallucinogens that are NOT self-administered
LSD, psilocybin, mescaline However, a recent study showed that monkeys
with a history of MDMA self-administration may self administer psilocybin and mescaline (Fantegrossi et al., 2004).