SHMT

Purines

5. 10Methylene THF

serine

glycine

Thymidinesynthesis

dUMP

THF

Yasko Methylation Pathway© Content and diagrams may not be reproduced without express permission from NRI and HHI

VDR

MTHFR

MTR

DHPRNOS

MAO A

COMT

COMT

G6PDH

GAD

SOD

GST

OTC

ACAT

MTRRBHMT

MAT

AHCY

CBS

SUOXACE

Tryptophan Tyrosine

Kreb’sCycle

Arginine

Ornithine

UREA

Citrulline + NO

taurine

5 MethylTHF

NeuronalDamage

MicroglialActivation

Peroxynitrite

Super Oxide

glutamate gaba

Serotonin Dopamine

mercurylead

BH4

AMMONIA LEADBH2

ALUM

NorEpSAMe

SAHHIAA

VMA

B12

0 B

H4

1 B

H4

2 B

H4

SAH

HVA

Methionine

Homocysteine

cystathionine

Cysteine + , α-ketobutyrate

glutathione

Guanido AC

adenosine

SAMe

SAH

methylationDMG

TMG SAH

Angiotensin I Angiotensin II

cortisol

AMMONIA

DNA, RNAProtein, lipids

“When the need is for energy and not forcysteine, homocysteine is metabolized to

Alpha-Ketobutyrate, NH3 and H2S.”Text of Biochemistry with Clinical Correlations, Devlin 2002

Creatine Creatinine

glycine

α-ketoglutarate

NADH/FADH

fumarate

succinate

aspartateoxaloacetate

Acetyl CoA

citrate

isocitrate

Pyruvate