Yasko Methylation Cycle
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SHMT Purines 5. 10 Methylene THF serine glycine Thymidine synthesis dUMP THF Yasko Methylation Pathway © Content and diagrams may not be reproduced without express permission from NRI and HHI VDR MTHFR MTR DHPR NOS MAO A COMT COMT G6PDH GAD SOD GST OTC ACAT MTRR BHMT MAT AHCY CBS SUOX ACE Tryptophan Tyrosine Kreb’s Cycle Arginine Ornithine UREA Citrulline + NO taurine 5 Methyl THF Neuronal Damage Microglial Activation Peroxynitrite Super Oxide glutamate gaba Serotonin Dopamine mercury lead BH4 AMMONIA LEAD BH2 ALUM NorEp SAMe SAH HIAA VMA B12 0 BH4 1 BH4 2 BH4 SAH HVA Methionine Homocysteine cystathionine Cysteine + , α-ketobutyrate glutathione Guanido AC adenosine SAMe SAH methylation DMG TMG SAH Angiotensin I Angiotensin II cortisol AMMONIA DNA, RNA Protein, lipids “When the need is for energy and not for cysteine, homocysteine is metabolized to Alpha-Ketobutyrate, NH3 and H2S.” Text of Biochemistry with Clinical Correlations, Devlin 2002 Creatine Creatinine glycine α-ketoglutarate NADH/FADH fumarate succinate aspartate oxaloacetate Acetyl CoA citrate isocitrate Pyruvate
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Here is the updated diagram of the methylation cycle that I utilize in the program. For additional information about the cycle go to the Methylation and Mutation DVDs on www.dramyyasko.com/resources. For specific questions I suggest going to the chat group at www.ch3nutrigenomics.com.With love and hope, Dr. Amy© Content and diagrams may not be reproduced without express permission from NRI and HHI
Transcript of Yasko Methylation Cycle
SHMT
Purines
5. 10Methylene THF
serine
glycine
Thymidinesynthesis
dUMP
THF
Yasko Methylation Pathway© Content and diagrams may not be reproduced without express permission from NRI and HHI
VDR
MTHFR
MTR
DHPRNOS
MAO A
COMT
COMT
G6PDH
GAD
SOD
GST
OTC
ACAT
MTRRBHMT
MAT
AHCY
CBS
SUOXACE
Tryptophan Tyrosine
Kreb’sCycle
Arginine
Ornithine
UREA
Citrulline + NO
taurine
5 MethylTHF
NeuronalDamage
MicroglialActivation
Peroxynitrite
Super Oxide
glutamate gaba
Serotonin Dopamine
mercurylead
BH4
AMMONIA LEADBH2
ALUM
NorEpSAMe
SAHHIAA
VMA
B12
0 B
H4
1 B
H4
2 B
H4
SAH
HVA
Methionine
Homocysteine
cystathionine
Cysteine + , α-ketobutyrate
glutathione
Guanido AC
adenosine
SAMe
SAH
methylationDMG
TMG SAH
Angiotensin I Angiotensin II
cortisol
AMMONIA
DNA, RNAProtein, lipids
“When the need is for energy and not forcysteine, homocysteine is metabolized to
Alpha-Ketobutyrate, NH3 and H2S.”Text of Biochemistry with Clinical Correlations, Devlin 2002
Creatine Creatinine
glycine
α-ketoglutarate
NADH/FADH
fumarate
succinate
aspartateoxaloacetate
Acetyl CoA
citrate
isocitrate
Pyruvate
