-Y’

NOTICE OF MAILING CHANGE 0 Check here ifyou wish t o

discontinue receiving this publication

US. DEPARTMENT OF HE3ITI-I AND HUMAN SERVICES

OFFICIALBLISINESS Penalty for Private Use, $300

The NIH Guide announces scientific initiativesand provides policy and administrativeinformation to indivi­duals and organizationswho need to be kept informed ofopportunities, requirements, and changes in extra-mural prognms administered by the National Institutesof Health.

0 Check here ifyour address has changed and you wish to con­tinue receiving this publication. Make corrections below and mail this page to:

NIH Guide Printing & Reproduction Branch National Institutes of Health Room B4BN08, Building 31 Bethesda, Maryland 20892

First Class Mail Postages & Fees Paid

PHS/NIH/OD Permit No. G-291

Vol. 20, No. 18 May 3, 1991

N I H G U I D E - Vol. 20, No. 18, May 3, 1991

NOTICES

REVIEW PROCEDURES FOR PROGRAM PROJECT GRANT APPLICATIONS . . . . . . . . . . . . . . . . . . . 1 National I n s t i t u t e of Chi ld Health and Human DevelopmentIndex: CHILD HEALTH, HUMAN DEVELOPMENT

NOTICES OF A V A I L A B I L I T Y (RFPs AND RFAs)

E V A L U A T I O N OF N I H IMPLEMENTATION OF SECTION 491 OF THE PUBLIC HEALTH SERVICE ACT, MANDATING A PROGRAM OF PROTECTION FOR RESEARCH SUBJECTS (RFP) . 2 National I n s t i t u t e s of Heal th Index: N A T I O N A L INSTITUTES OF HEALTH

PROSTATE, LUNG, COLORECTAL, AND OVARIAN CANCER SCREENING TRIAL -SCREENING CENTERS (RFP) .................................................... 2 National Cancer I n s t i t u t e Index: CANCER

ADULT AIDS CLINICAL TRIALS UNITS (RFA AI-91-07) ............................ 3 National I n s t i t u t e of Allergy and I n f e c t i o u s Diseases Index: ALLERGY, INFECTIOUS DISEASES

COOPERATIVE NETWORK FOR MOLECULAR GENETIC AND CYTOGENETIC STUDIES OF PROSTATE CANCER (RFA CA-91-10) ............................................. 6 National Cancer I n s t i t u t e Index: CANCER

STATE SERVICE SYSTEMS IMPROVEMENT THROUGH CONSUMER AND FAMILY SUPPORT ACTIVITIES (RFA MH-91-13) .................................................. 7 National I n s t i t u t e of Mental Heal th Index: MENTAL HEALTH

COOPERATIVE NETWORK FOR EVALUATION OF PROGNOSTIC MARKERS OF URINARY BLADDER CANCER (RFA CA-91-09) .............................................. 9 National Cancer I n s t i t u t e Index: CANCER

ADAMHA SMALL INSTRUMENTATION PROGRAM (RFA AA-91-03) ........................ 10 Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion Index: ALCOHOL, DRUG ABUSE, MENTAL HEALTH

NOTICES

REVIEW PROCEDURES FOR PROGRAM PROJECT GRANT APPLICATIONS

P.T. 34; K.W. 1014006

National I n s t i t u t e of Chi ld Heal th and Human Development

E f f e c t i v e f o r t h e June 1 , 1991 r e c e i p t d a t e , program p r o j e c t (POI)a p p l i c a t i o n s assigned t o t h e Nat ional I n s t i t u t e of Child Heal th and Human Development ( N I C H D ) w i l l no longer be r o u t i n e l y s i t e - v i s i t e d . These a p p l i c a t i o n s w i l l be considered by t h e r e l e v a n t I n i t i a l Review Group ( I R G ) without i n t e r a c t i o n with t h e a p p l i c a n t . The I R G w i l l have t h e op t ion of d e f e r r i n g an a p p l i c a t i o n f o r a s i t e v i s i t , a l though t h i s w i l l be t h e except ion r a t h e r t han s tandard p r a c t i c e .

A s a r e s u l t of t h i s change, N I C H D PO1 a p p l i c a n t s must ensure t h a t t h e d e s c r i p t i o n of t h e proposed r e sea rch f o r each component p ro jec t / co re f a c i l i t y is thorough and complete (no t t o exceed 20 pages) , pe rmi t t i ng d i r e c t eva lua t ion by t h e rev iewers .

Unless o therwise ind ica t ed , NICHD Center Core (P30) Grant and Spec ia l i zed Center (P50) Grant a p p l i c a t i o n s w i l l cont inue t o r ece ive s i t e v i s i t s as a p a r t of t h e review process .

Programatic ques t ions about t h i s announcement should be d i r e c t e d t o :

Laurance S . Johnston, Ph .D . Acting Di rec to r , Div is ion of S c i e n t i f i c Review N IC H D I N I H Executive Plaza North, Room 520 Bethesda, MD 20892 Telephone: (301) 496-1696

N I H G U I D E - Vol. 20, No. 18, May 3, 1991 Page 1

Grants management ques t ions should be d i r e c t e d t o :

Donald Clark Chief, Office of Grants and Cont rac ts National I n s t i t u t e of Child Health and Human DevelopmentExecutive Plaza North, Room 501 Bethesda, MD 20892

w' Telephone: (301) 496-5001

NOTICES OF AVAILABILITY (RFPs AND RFAs)

EVALUATION OF N I H IMPLEMENTATION OF SECTION 491 OF THE PUBLIC HEALTH SERVICE ACT. MANDATING A PROGRAM OF PROTECTION FOR RESEARCH SUBJECTS

RFP AVAILABLE: NIH-OD-91-12

P.T. 34; K.W. 0783005

Nat ional I n s t i t u t e s of Heal th

The Office of Extramural Programs, Office of Extramural Research, Of f i ce of t h e Di rec to r , Nat ional I n s t i t u t e s of Health, has a requirement t o eva lua te t h e n a t i o n a l program of p r o t e c t i o n f o r r e sea rch s u b j e c t s a t i n s t i t u t i o n s engagedi n r e sea rch funded by t h e Department of Health and Human Se rv ices pursuant t o Sec t ion 491 of t h e PHS A c t . This eva lua t ion w i l l examine t h e e x t e n t t o which t h e program is meeting t h i s o b j e c t i v e while cont inuing t o f ac i l i t a t e needed r e sea rch t o improve t h e na t ion ' s h e a l t h . Prel iminary cons ide ra t ions suggestf o u r broad c a t e g o r i e s of measurement: outcome measures focus ing on adequacyof consent procedures , r i s k assessment and sub jec t s e l e c t i o n ; ou tput measures,inc luding workload and caseload measures from i n s t i t u t i o n a l records ; p rocess measures explor ing v a r i a t i o n s i n i n s t i t u t i o n a l procedures and deployment of t h e program i n new s e t t i n g s and i n use of innovat ive in t e rven t ions ; and resource measures of personnel , t i m e , e f f o r t and c o s t s . The c o n t r a c t o r must have t h e p ro fes s iona l c a p a b i l i t i e s and f a c i l i t i e s t o eva lua te government programs of n a t i o n a l scope and comparable complexity with major imp l i ca t ionsf o r Federal h e a l t h sc i ences po l i cy , government-university r e l a t i o n s , and t h e broad pub l i c . The r e s u l t s of t h e s tudy w i l l be t h e b a s i s f o r recommendations t o ensure responsiveness t o r a p i d l y changing r e sea rch oppor tun i t i e s while maintaining appropr i a t e sa feguards f o r i nd iv idua l s involved as s u b j e c t s of

-' r e sea rch . It is expected t h a t t h e c o n t r a c t w i l l have a two- (2 ) yea r per iodof performance. Any r e spons ib l e o f f e r o r may submit a proposal t h a t w i l l be considered by t h e Government.

The issuance d a t e of t h e RFP w i l l be on o r about May 31, 1991, and proposa ls w i l l be due by t h e c l o s e of bus iness 50 days a f t e r i s suance .

Requests f o r t h e RFP must be d i r e c t e d t o :

Valerie P i c k e t t Research Cont rac ts Branch Divis ion of Contrac ts and Grants Office of t h e Di rec to r National I n s t i t u t e s of Heal th Building 31, Room 1B44 9000 Rockvi l le Pike Bethesda, MD 20892

PROSTATE. LUNG. COLORECTAL. AND OVARIAN CANCER SCREENING TRIAL - SCREENING CENTERS

RFP AVAILABLE: NCI-CN-15342-04

P.T. 34; K.W. 0715035, 0745020, 0755015

Nat ional Cancer I n s t i t u t e

The Nat ional Cancer I n s t i t u t e ( N C I ) , Div is ion of Cancer Prevent ion and Control , Ear ly Detect ion Branch, is i n t e r e s t e d i n s o l i c i t i n g proposa ls from organizations f o r Screening Centers f o r t h e P r o s t a t e , Lung, Co lo rec t a l , and Ovarian (PLCO) Cancer Screening T r i a l . Up t o f i f t e e n (15) sc reening Centers w i l l be e s t a b l i s h e d , each r e c r u i t i n g no less than 5,000 s u b j e c t s and 5,000

l.c* c o n t r o l s t o t h e t r i a l . A t o t a l of 148,000 men and women w i l l be r e c r u i t e d t o t h e t r i a l i n approximately equal numbers. Female s u b j e c t s w i l l be screened f o r c o l o r e c t a l , lung, and ovar ian cancers . Male s u b j e c t s w i l l be screened f o r c o l o r e c t a l , lung, and p r o s t a t e cancer . Screening w i l l be annual ly f o r f o u r

N I H G U I D E - Vol. 20, No. 18, May 3, 1991 - Page 2

y e a r s f o r p r o s t a t e , lung, and ovarian cancers and only i n y e a r s one and t h r e e f o r c o l o r e c t a l cance r . Sub jec t s and c o n t r o l s w i l l be followed f o r a t least t e n y e a r s . A Coordinating and Data Management Center w i l l develop and maintain systems and procedures f o r biomedical d a t a management, s tudy coord ina t ion , s t a t i s t i c a l a n a l y s i s , and r e p o r t w r i t i n g . The NCI has s e l e c t e d t h e cancer sites and sc reen ing m o d a l i t i e s . Screening Centers , i n cooperat ion with t h e N C I , w i l l develop screening l o g i s t i c s and d i a g n o s t i c p r o t o c o l s . A pre-proposal conference w i l l be he ld and t h e d a t e w i l l be s p e c i f i e d i n t h e Request f o r Proposals (RFP) .

Requests f o r t h i s RFP must be i n w r i t i n g and r e f e r e n c e RFP No. NCI-CN-15342-04. The RFP w i l l be a v a i l a b l e approximately Apr i l 25, 1991 and w i l l be due approximately June IO, 1991.

Copies of t h e RFP may be obtained by sending a w r i t t e n r e q u e s t t o :

M r . Chris topher B . Myers, Contract S p e c i a l i s t National I n s t i t u t e s of Health National Cancer I n s t i t u t e Research Con t rac t s Branch, PCCS Executive Plaza South, Room 635 9000 Rockvi l le Pike Bethesda, MD 20892 Telephone: (301) 496-8603

ADULT AIDS CLINICAL TRIALS UNITS

RFA AVAILABLE: AI-91-07

P.T. 34; K.W. 0715008, 0755015

National I n s t i t u t e of Allergy and I n f e c t i o u s Diseases

Letter of I n t e n t Receipt Date: June 5 , 1991 Preappl i ca t ion Meetings : June 3, 4 and 5 , 1991 Applicat ion Receipt Date : August 6 , 1991

BACKGROUND

The Nat ional I n s t i t u t e of Allergy and I n f e c t i o u s Diseases ( N I A I D ) announces t h e a v a i l a b i l i t y of a Request f o r Applicat ions (RFA) f o r AIDS C l i n i c a l T r i a l s Un i t s (ACTUS). The purpose of t h i s RFA is t o recompete t h e a d u l t component of t h e AIDS C l i n i c a l T r i a l Group (ACTG) by s o l i c i t i n g a p p l i c a t i o n s from e x i s t i n gACTUs and from new a p p l i c a n t s . Th i s i n i t i a t i v e w i l l u t i l i z e t h e coope ra t ive agreement. The a d u l t component of t h e ACTG is a network of 32 domestic biomedical r e s e a r c h i n s t i t u t i o n s t h a t , i n aggregate , has t h e c a p a b i l i t i e s t o develop new t h e r a p e u t i c i n t e r v e n t i o n s from i n i t i a l c l i n i c a l t r i a l s i n human s u b j e c t s t o t h e i r f i n a l approval by t h e Food and Drug Adminis t ra t ion. The r e sea rch o b j e c t i v e s of t h e ACTG are t o e v a l u a t e t h e s a f e t y and e f f i c a c y of t h e r a p e u t i c i n t e r v e n t i o n s f o r t h e t r ea tmen t of Human Immunodeficiency Virus ( H I V ) i n f e c t i o n , acquired immunodeficiency syndrome (AIDS), and a s s o c i a t e d o p p o r t u n i s t i c c o n d i t i o n s .

HEALTHY PEOPLE 2000

The Pub l i c Health Se rv ice (PHS) is committed t o achieving t h e h e a l t h promotionand d i s e a s e prevent ion o b j e c t i v e s of Healthy People 2000, a PHS-led n a t i o n a l a c t i v i t y f o r s e t t i n g p r i o r i t y areas. This RFA, Recompetition of t h e Adult AIDS C l i n i c a l T r i a l s Un i t s , i s r e l a t e d t o t h e p r i o r i t y area of H I V i n f e c t i o n . P o t e n t i a l a p p l i c a n t s may o b t a i n a copy of "Healthy People 2O0Ot' ( F u l l Report:Stock No. 017-001-00474-0) o r "Healthy People 2000** (Summary Report: Stock No. 017-001-00473-1) through t h e Superintendent of Documents, Government P r i n t i n g Of f i ce , Washington, D . C . 20402-9325 ( te lephone 202-783-3238).

OBJECTIVES

It is t h e i n t e n t of t h e recompeti t ion t o maintain a cooperat ive network of a d u l t ACTUs t h a t has t h e c a p a b i l i t y t o conduct a l l phases of t h e r a p e u t i cc l i n i c a l eva lua t ion t o i d e n t i f y new t h e r a p i e s and t o f a c i l i t a t e t h e t r a n s f e r of i n t e r v e n t i o n s from t h e r e sea rch s e t t i n g t o r o u t i n e p a t i e n t care. Emphasisw i l l be placed on t h e i n c l u s i o n of women, m i n o r i t i e s and substance abuse r s i n t h e c l i n i c a l s t u d i e s so t h a t t h e p a t i e n t s p a r t i c i p a t i n g i n t h e c l i n i c a l t r i a l s network r e f l e c t t h e demographic f e a t u r e s of t h e n a t i o n a l H I V epidemic. This network w i l l be composed of i n v e s t i g a t o r s from a v a r i e t y of d i s c i p l i n e s with demonstrated e x p e r t i s e and experience i n conducting c l i n i c a l t r i a l s e s p e c i a l l y among H I V i n f e c t e d p a t i e n t s . The r e s e a r c h o b j e c t i v e s w i l l be accomplishedthrough t h e development of p r o t o c o l s , a c c r u a l of p a t i e n t s t o ACTG p r o t o c o l s ,

N I H G U I D E - Vol. 20, No. 18, May 3, 1991 - Page 3

-1

submission, a n a l y s i s and p u b l i c a t i o n of d a t a , and by p a r t i c i p a t i o n of t h e ACTU i n v e s t i g a t o r s i n ACTG committees. The r e sea rch agenda and p r i o r i t i e s w i l l be e s t a b l i s h e d by t h e ACTG Executive Committee whose members include t h e Associate D i rec to r of t h e Treatment Research Program, DAIDS. S c i e n t i f i c areas of h ighes t p r i o r i t y inc lude a n t i r e t r o v i r a l therapy and t r ea tmen t of o p p o r t u n i s t i c i n f e c t i o n s a s s o c i a t e d with H I V i n f e c t i o n . S t u d i e s of HIV-associated malignancies and neuro log ica l complicat ions w i l l a l s o be emphasized. The ACTG committees ( S c i e n t i f i c , Resource, and Executive) are composed of i n v e s t i g a t o r s from t h e ACTUs, a N I A I D s t a f f r e p r e s e n t a t i v e , and r e p r e s e n t a t i v e s from p a t i e n t advocacy groups. I n o rde r t o achieve t h e s e o b j e c t i v e s , supplementary r e sources w i l l cont inue t o be provided t o t h e ACTU P r i n c i p a l I n v e s t i g a t o r s by t h e N I A I D through o t h e r funding mechanisms and include: ( 1 ) a S t a t i s t i c a l and Data Analysis Center t h a t assists i n p ro toco ldesign and func t ions as a c e n t r a l d a t a management c e n t e r , ( 2 ) an OperationsOf f i ce t h a t provides t e c h n i c a l and l o g i s t i c a l support f o r t h e development and implementation of p r o t o c o l s , (3) C l i n i c a l S i t e Monitoring t o ensure t h e q u a l i t y of d a t a and conformance with r e g u l a t o r y requirements, and (4) a C l i n i c a l Research Products Repository t h a t provides f o r t h e r e c e i p t ,inventory, and d i s t r i b u t i o n of i n v e s t i g a t i o n a l drugs.

.-

The RFA con ta ins information r e l a t e d to both r equ i r ed and o p t i o n a l components.A l l a p p l i c a n t s must apply f o r t h e ACTU c l i n i c a l co re funding t o be e l i g i b l e t o apply f o r o p t i o n a l components. The c l i n i c a l co re funding w i l l provide t h e r e sources r e q u i r e d t o maintain an i n f r a s t r u c t u r e s u f f i c i e n t t o accrue an agreed upon minimum annual number of new p a t i e n t s on t o p r o t o c o l s . The c l i n i c a l co re funds a l s o w i l l support l a b o r a t o r y c o s t s f o r p ro toco l mandated immunophenotyping. Applicants f o r t h e ACTU c l i n i c a l co re funding w i l l be e l i g i b l e t o apply f o r o p t i o n a l components t h a t include: ( 1 ) p e d i a t r i cc l i n i c a l t r i a l s [ l i m i t e d t o a d u l t ACTUs t h a t have an e x i s t i n g p e d i a t r i ccomponent], ( 2 ) v i ro logy co re l a b o r a t o r y support f o r p ro toco l mandated t e s t i n g , (3) pharmacology co re l a b o r a t o r y support f o r p ro toco l mandated t e s t i n g , (4) developmental r e sea rch i n v i ro logy [ l i m i t e d t o a p p l i c a n t s who apply f o r and are awarded funds f o r (211, ( 5 ) developmental r e sea rch i n pharmacology [ l i m i t e d t o a p p l i c a n t s who apply f o r and are awarded funds f o r (311, ( 6 ) developmental r e sea rch i n immunology, and ( 7 ) developmental r e sea rch i n o t h e r areas of microbiology. An a p p l i c a n t must r e c e i v e an award f o r t h e ACTU c l i n i c a l co re t o be e l i g i b l e f o r funding of t h e o p t i o n a l components.However, funding p r i o r i t i e s f o r t h e o p t i o n a l components w i l l be e s t a b l i s h e d independent of t h e p r i o r i t i e s f o r t h e ACTU c l i n i c a l co re awards. Fundingp r i o r i t i e s f o r t h e ACTU c l i n i c a l co re w i l l no t be a f f e c t e d by t h e presence o r absence of o p t i o n a l components.

SPECIAL INSTRUCTIONS FOR THE INCLUSION OF WOMEN AND MINORITIES I N CLINICAL RESEARCH STUDIES

The fol lowing is a b r i e f s ta tement of t h e N I H and ADAMHA p o l i c y r ega rd ing t h e i n c l u s i o n of women and m i n o r i t i e s i n s tudy popu la t ions . The i n c l u s i o n of women and m i n o r i t i e s should be addressed i n a p p l i c a t i o n s submitted i n response t o t h i s RFA.

For p r o j e c t s involving c l i n i c a l r e s e a r c h , N I H r e q u i r e s a p p l i c a n t s t o g ives p e c i a l a t t e n t i o n t o t h e i n c l u s i o n of women and m i n o r i t i e s i n s tudypopulat ions. I f women o r m i n o r i t i e s are no t included o r adequatelyrep resen ted i n t h e s tudy populat ions f o r c l in i ca l s t u d i e s , a s p e c i f i cj u s t i f i c a t i o n must be provided. Applicat ion without such documentation w i l l no t be accepted f o r review.

MECHANISM OF SUPPORT

Awards w i l l be made as cooperat ive agreements ( U O I ) . The coope ra t ive agreement funding instrument d i f f e r s from t h e t r a d i t i o n a l r e sea rch g r a n t i n t h a t t h e Government awarding component ( N I A I D ) a n t i c i p a t e s s u b s t a n t i a l programmatic involvement du r ing t h e performance. The n a t u r e of N I A I D s t a f f a s s i s t a n c e is desc r ibed i n t h e RFA. However, a p p l i c a n t s must d e f i n e t h e i r own o b j e c t i v e s i n accord with i n d i v i d u a l i n t e r e s t s and approaches t o conductingt h e r e sea rch . The N I A I D a n t i c i p a t e s t h a t $48,000,000 w i l l be a v a i l a b l e f o r t h e i n i t i a l year of funding a p p l i c a t i o n s i n response t o t h i s RFA and t h a t approximately 20-25 a p p l i c a t i o n s w i l l be funded. The award of g r a n t s pursuant t o t h i s RFA is cont ingent on t h e cont inuing a v a i l a b i l i t y of funds f o r t h i s purpose and on t h e r e c e i p t of a s u f f i c i e n t number of a p p l i c a t i o n s of highs c i e n t i f i c m e r i t .

APPLICATION SUBMISSION

E l i g i b i l i t y : Any domestic u n i v e r s i t y , medical c o l l e g e , h o s p i t a l , o r o t h e r .d c l i n i c a l r e sea rch i n s t i t u t i o n is e l i g i b l e . Under t h e terms of t h i s RFA, new

a p p l i c a n t s and e s t a b l i s h e d a d u l t ACTUs are i n v i t e d t o apply. Only domestic

N I H G U I D E - Vol. 20, No. 18, May 3, 1991 - Page 4

organ iza t ions are e l i g i b l e t o apply and t h e a p p l i c a t i o n may no t i nc lude an i n t e r n a t i o n a l component.

Letter of I n t e n t : Prospect ive a p p l i c a n t s are asked t o submit, by June 5,1991, a l e t t e r of i n t e n t t h a t i nc ludes a d e s c r i p t i v e t i t l e and d e s c r i p t i o n of t h e proposed r e sea rch no t t o exceed t h r e e pages. The l e t t e r of i n t e n t is r eques t ed t o provide an i n d i c a t i o n of t h e number and scope of a p p l i c a t i o n s t o be r ece ived and t o promote e a r l y i n t e r a c t i o n between N I A I D s t a f f and t h e a p p l i c a n t . The l e t t e r of i n t e n t does not commit t h e sender t o submit an a p p l i c a t i o n , nor i s it a requirement f o r submission of an a p p l i c a t i o n .

Submission: The r e sea rch g r a n t a p p l i c a t i o n form PHS 398 ( r e v . 10/88,r e p r i n t e d 9/89) must be used i n applying. These forms are a v a i l a b l e a t most i n s t i t u t i o n a l bus iness o f f i c e s and from t h e Divis ion of Research Grants,Nat ional I n s t i t u t e s of Heal th , Westwood Building, Room 449, 5333 Westbard Avenue, Bethesda, MD 20892. To i d e n t i f y responses t o t h i s announcement under I t e m 2 on page 1 of t h e g r a n t a p p l i c a t i o n , check *yes ' and inc lude t h e t i t l e and number of t h e RFA. The RFA l a b e l i n t h e form PHS 398 must be a f f i x e d t o t h e bottom of f a c e page of t h e o r i g i n a l s igned a p p l i c a t i o n . F a i l u r e t o do so could r e s u l t i n delayed processing of t h e a p p l i c a t i o n so t h a t it may n o t r each t h e review committee i n t ime f o r review. Incomplete and nonresponsivea p p l i c a t i o n s w i l l be r e t u r n e d t o t h e a p p l i c a n t without review.

REVIEW PROCEDURES

Comprehensive eva lua t ion of t h e a p p l i c a t i o n s w i l l be conducted by a Spec ia l Review Committee (SRC) c o n s i s t i n g p r i m a r i l y of non-Federal s c i e n t i f i c e x p e r t s . The a d u l t component ( P a r t A ) and p e d i a t r i c component ( P a r t B, i f p r e s e n t ) w i l l be evaluated and scored based on t h e s c i e n t i f i c m e r i t a t one SRC s e s s i o n . Optional components w i l l be forwarded t o a second SRC f o r e v a l u a t i o n . The p r i o r i t y sco re assigned t o t h e a p p l i c a t i o n w i l l be based on t h e s c o r e received f o r P a r t A . The merit of P a r t B and P a r t C components w i l l be used by N I A I D t o guide funding d e c i s i o n s with r e s p e c t t o t h e s e components.

APPLICATION PROCEDURES

Submit by August 6, 1991, a s igned, t y p e w r i t t e n o r i g i n a l of t h e a p p l i c a t i o n , and 6 e x a c t , s i n g l e - s i d e d photocopies ( inc lud ing Appendix) i n one package t o :

Division of Research Grants National I n s t i t u t e s of Health Westwood Building, Room 240 Bethesda, MD 20892**

Submit 17 e x a c t , s i n g l e - s i d e d photocopies of t h e a p p l i c a t i o n i n one packaged i r e c t l y t o :

D r . Al len S t o o l m i l l e r AIDS Review Sec t ion NIAIDIDEAIPPRB Westwood Building, Room 3A-07 5333 Westbard Avenue Bethesda, MD 20892

INQUIRES

The RFA is a v a i l a b l e from and Letters of I n t e n t are t o be s e n t t o :

F.H. Batzold, Ph.D. Division of AIDS National I n s t i t u t e of A l l e ry and I n f e c t i o u s Diseases 6003 Executive Boulevard, Room 208P Rockvil le , MD 20892 Telephone: (301) 496-8214

For budget ques t ions , c o n t a c t :

M s . Mary Kirker Chief, AIDS Grants Management Sect ion Grants Management BranchINIAID Westwood Building, Room 706 Bethesda, MD 20892 Telephone: (301) 496-7075

N I H G U I D E - Vol. 20, No, 18, May 3, 1991 - Page 5

COOPERATIVE NETWORK FOR MOLECULAR GENETIC AND CYTOGENETIC STUDIES OF PROSTATE CANCER

RFA AVAILABLE: CA-91-10

P.T. 34; K.W. 0715035, 1002058, 1002004, 0413001

National Cancer I n s t i t u t ew Letter of I n t e n t Receipt Date: June I O , 1991 Applicat ion Receipt Date: September 6, 1991

The Cancer Diagnosis Branch of t h e Divis ion of Cancer Biology, Diagnosis and Centers (DCBDC) a t t h e National Cancer I n s t i t u t e ( N C I ) i n v i t e s a p p l i c a t i o n sf o r cooperat ive agreements from i n s t i t u t i o n s capable of and i n t e r e s t e d i n p a r t i c i p a t i n g i n a cooperat ive network f o r s t u d i e s of molecular g e n e t i c s and cy togene t i c s of p r o s t a t e cancer . The g o a l s of t h i s Request f o r Applicat ions(RFA) are: 1) t o promote c o l l a b o r a t i o n s and i n t e r a c t i o n s between b a s i c s c i e n t i s t s and c l i n i c i a n s i n o r d e r t o advance p r o s t a t e cancer r e sea rch ; 2 ) t o i d e n t i f y g e n e t i c a l t e r a t i o n s t h a t may d i s t i n g u i s h t h e behavior of c l i n i c a l l ys i l e n t p r o s t a t e cancer from t h a t of c l i n i c a l l y evident cancer; 3 ) t o determine whether t h e r e is a molecular g e n e t i c b a s i s f o r d i f f e r e n c e s i n p r o s t a t e cancer incidence between Blacks and Whites; 4 ) t o explore t h e b i o l o g i c a l basis f o r t h e s t r i k i n g i n c r e a s e i n p r o s t a t e cancer incidence with age. Groupsp a r t i c i p a t i n g i n t h e network w i l l a t tempt t o assess b i o l o g i c a l d i f f e r e n c e s i n p r o s t a t e cancer u s ing molecular g e n e t i c and cy togene t i c approaches with t h e long-term goal of developing a more informative c l a s s i f i c a t i o n system.Cooperative s t u d i e s w i l l f a c i l i t a t e t h e a p p l i c a t i o n of molecular techniques t o p r o s t a t e cancer r e sea rch through t h e e f f i c i e n t use of p r o s t a t e cancer and normal p r o s t a t e t i s s u e .

Awards w i l l be made as cooperat ive agreements t h a t create an a s s i s t a n c e r e l a t i o n s h i p with s u b s t a n t i a l involvement of N C I s t a f f du r ing t h e performanceof t h e p r o j e c t , as o u t l i n e d i n t h e RFA. This mechanism is used when t h e NCI wishes t o s t i m u l a t e i n v e s t i g a t o r i n t e r e s t and proposes t o adv i se o r assist i n an important and opportune area of r e sea rch . Applicants w i l l be r e s p o n s i b l ef o r t h e planning, d i r e c t i o n , and execut ion of t h e proposed p r o j e c t . It is e s s e n t i a l t h a t t h e r e be good l i a i s o n between basic s c i e n t i s t s and c l i n i c i a n s . Each group responding t o t h i s RFA must d e s c r i b e e x i s t i n g and proposedcollaboration/cooperation between b a s i c s c i e n t i s t ( s 1 and c l i n i c i a n ( s 1 .

;91rr The N C I a n t i c i p a t e s making t h r e e t o f i v e awards f o r p r o j e c t pe r iods of up t o f o u r y e a r s . A t o t a l of $1,000,000 is expected t o be set a s i d e f o r t h e i n i t i a l yea r ' s funding. Although t h i s program is provided f o r i n t h e f inanc ia l p l a n sof t h e N C I , t h e award of coope ra t ive agreements pursuant t o t h i s RFA is cont ingent on t h e a v a i l a b i l i t y of funds appropr i a t ed f o r f i sca l yea r 1992.

The Pub l i c Health Se rv ice (PHS) is committed t o achieving t h e h e a l t h promotionand disease prevent ion o b j e c t i v e s of HEALTHY PEOPLE 2000, a PHS-led n a t i o n a l a c t i v i t y f o r s e t t i n g p r i o r i t y areas. This RFA, "Cooperative Network f o r Molecular Genetic and Cytogenetic S t u d i e s of P r o s t a t e Cancer" is r e l a t e d t o t h e p r i o r i t y area of cance r . P o t e n t i a l a p p l i c a n t s may o b t a i n a copy of "Healthy People 2000" ( F u l l Report: Stock No. 017-001-00474-0) or "HealthyPeople 2000" (Summary Report: Stock No. 017-001-00473-1) through t h e Superintendent of Documents, Government P r i n t i n g Office, Washington, D.C . 20402-9325 ( te lephone 202-783-3238).

For p r o j e c t s involving c l i n i c a l r e s e a r c h , N I H r e q u i r e s a p p l i c a n t s t o g ives p e c i a l a t t e n t i o n t o t h e i n c l u s i o n of women and m i n o r i t i e s i n s tudypopu la t ions . While i n c l u s i o n of women is no t r e l e v a n t t o t h i s RFA, s p e c i a lemphasis should be placed on t h e need f o r i n c l u s i o n of m i n o r i t i e s ,p a r t i c u l a r l y b l acks , who are d i s p r o p o r t i o n a t e l y a f f e c t e d , i n s t u d i e s of p r o s t a t e cance r . If m i n o r i t i e s are no t included o r are inadequatelyrep resen ted i n t h e s tudy populat ions f o r c l i n i c a l s t u d i e s , a s p e c i f i cj u s t i f i c a t i o n f o r t h i s exc lus ion o r inadequate r e p r e s e n t a t i o n must be provided. Applicat ions without such documentation w i l l no t be accepted f o r review.

This RFA i s a one-time s o l i c i t a t i o n with a s p e c i f i e d dead l ine of September 6,1991 f o r r e c e i p t of a p p l i c a t i o n s .

A copy of t h e complete RFA d e s c r i b i n g t h e r e sea rch goa l s and scope, t h e coope ra t ive agreement mechanism, t h e review c r i t e r i a , and o t h e r a p p l i c a t i o nrequirements i s a v a i l a b l e from:

N I H G U I D E - Vol. 20, No. 18, May 3, 1991 - Page 6

Roger L. Aamodt, Ph.D. Program Di rec to r f o r Pa thologyXytology Cancer Diagnosis Branch, DCBDC, N C I Room 638, Executive Plaza South 6120 Executive Boulevard Rockvil le , MD 20892-9904 Telelephone: (301) 496-7147 FAX: (301) 496-8656

'I-

I n q u i r i e s concerning t h i s RFA are encouraged and should be d i r e c t e d t o D r . Aamodt a t t h e above addres s and te lephone number.

For f i s c a l and a d m i n i s t r a t i v e matters, c o n t a c t :

Robert E . Hawkins Grants Management S p e c i a l i s t Grants Adminis t ra t ion Branch National Cancer I n s t i t u t e EPS. Room 216 Bethesda, MD 20892 Telephone: (301) 496-7800 e x t . 13

This program is desc r ibed i n t h e Catalog of Federal Domestic Assis tance No. 93.394, Cancer Detect ion and Diagnosis Research. Awards are made under a u t h o r i z a t i o n of t h e Pub l i c Health Se rv ice Act, T i t l e I V , P a r t A (Pub l i c Law 78-410 as amended: 42 USC 241) and adminis tered under PHS g r a n t p o l i c i e s and Federal Regulations 42 CFR P a r t 52 and 45 CFR P a r t 74. This program is no t s u b j e c t t o t h e intergovernmental review requirements of Executive Order 12372 o r Health Systems Agency review.

STATE SERVICE SYSTEMS IMPROVEMENT THROUGH CONSUMER AND FAMILY SUPPORT ACTIVITIES

RFA AVAILABLE: MH-91-13

P.T. 34; K . W . 0730050, 0715095, 0715129, 0403004

National I n s t i t u t e of Mental Health

Applicat ion Receipt Date: June 24, 1991 .-

PURPOSE

The Community Support Program (CSP) of t h e Nat ional I n s t i t u t e of Mental Health ( N I M H ) is i n v i t i n g a p p l i c a t i o n s under t h i s Request f o r Applicat ions (RFA) t o demonstrate and e v a l u a t e s e r v i c e system improvement s t r a t e g i e s t h a t i n t e g r a t e consumers and family members i n t o t h e planning and p rov i s ion of mental h e a l t h and support s e r v i c e s a t S t a t e and l o c a l l e v e l s .

The Pub l i c Health Se rv ice (PHS) is committed t o achieving t h e h e a l t h promotionand d i s e a s e prevent ion o b j e c t i v e s of "Healthy People 2000", a PHS-led n a t i o n a l a c t i v i t y f o r s e t t i n g p r i o r i t y areas. This RFA, "S ta t e Se rv ice SystemsImprovement Through Consumer and Family Support A c t i v i t i e s , * * is r e l a t e d t o t h e p r i o r i t y area of mental h e a l t h . P o t e n t i a l a p p l i c a n t s may o b t a i n a copy of "Healthy People 2000'* ( F u l l Report: Stock No. 017-001-00474-0)o r "HealthyPeople 2000" (Summary Report: Stock No. 017-001-00473-1) through t h e Superintendent of Documents, Government P r i n t i n g Of f i ce , Washington, D . C . 20402-9325 ( te lephone 202-783-3238).

Applicat ions are encouraged t h a t demonstrate and e v a l u a t e s t r a t e g i e s t h a t are d i r e c t e d toward t h e fol lowing programmatic goa l s :

o I n t e g r a t i n g primary consumers and family members i n t o S t a t e and,l o c a l s e r v i c e d e l i v e r y , systems planning, decision-making, and r e s e a r c h a c t i v i t i e s i n o r d e r t o develop mental h e a l t h and supports e r v i c e s t h a t are considered responsive t o consumer and familyneeds and p re fe rences ;

o Improving l i n k a g e s between consumer s e l f - h e l p and family support groups and t h e formal community support , t r ea tmen t , and r e h a b i l i t a t i o n s e r v i c e systems;

o Inc reas ing t h e e f f e c t i v e n e s s of consumers and family members i n i d e n t i f y i n g and f o s t e r i n g needed system, program, and s e r v i c e improvements;

N I H G U I D E - Vol. 20, No. 18, May 3, 1991 - Page 7

o Foster ing p a r t i c i p a t i o n of minori ty ind iv idua l s i n consumer s e l f - h e l p and family support groups as an element of t h e s e r v i c e d e l i v e r y planning and dec i s ion making;

o Increas ing oppor tun i t i e s f o r consumer employment wi th in t h e formal s e r v i c e system.

POPULATION OF CONCERN'41,--

The populat ion of concern f o r CSP g r a n t s inc ludes ind iv idua l s 18 yea r s and over with a severe and p e r s i s t e n t mental d i s o r d e r s t h a t s e r i o u s l y impairfunc t ioning i n primary aspects of d a i l y l i v i n g , such as in t e rpe r sona lr e l a t i o n s , l i v i n g arrangements, and employment. Applicants should paya t t e n t i o n t o t h e unique needs and s p e c i a l concerns of racial and e t h n i c m i n o r i t i e s and women.

SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES I N CLINICAL RESEARCH STUDIES

For p r o j e c t s involv ing c l i n i c a l r e sea rch , N I H r e q u i r e s a p p l i c a n t s t o g ives p e c i a l a t t e n t i o n t o t h e inc lus ion of women and m i n o r i t i e s i n s tudypopula t ions . I f women o r m i n o r i t i e s are no t included i n t h e s tudy popula t ionsf o r c l i n i c a l s t u d i e s , a s p e c i f i c j u s t i f i c a t i o n f o r t h i s exc lus ion must be provided. Appl ica t ions without such documentation w i l l no t be accepted f o r review.

ELIGIBILITY

Only mental h e a l t h a u t h o r i t i e s i n S t a t e s and T e r r i t o r i e s t h a t do no t c u r r e n t l y have a CSP S t a t e Serv ice System Improvement Demonstration Grant o r are i n t h e f i n a l year of a CSP S t a t e Serv ice System Improvement Demonstration Grant f o r genera l community support development a c t i v i t i e s are e l i g i b l e t o apply f o r t h e s e g r a n t s . Each S t a t e and T e r r i t o r y may submit only one a p p l i c a t i o n .

APPLICATION PROCEDURES

A l l a p p l i c a n t s must use form PHS-5161 ( r ev i sed 3/89). Applicat ion k i t s are a v a i l a b l e from : - Grants Management Branch National I n s t i t u t e of Mental H e a l t h Parklawn Building, Room 7C-15 5600 F i she r s Lane Rockvi l le , MD 20857 Telephone: (301) 443-4414

TERMS AND CONDITIONS OF SUPPORT

Period of Support

Support may be reques ted f o r a per iod of up t o t h r e e yea r s . Annual awards w i l l be made sub jec t t o cont inued a v a i l a b i l i t y of funds and progress achieved.

I n F i s c a l Year 1991, it is es t imated t h a t approximately $1 mil l ion w i l l be a v a i l a b l e t o support approximately 10 p r o j e c t s . The expected average amount of an award, f o r d i r e c t c o s t s , i s es t imated t o be $100,000 per year. However, t h e amount of funding a v a i l a b l e w i l l depend on appropr ia ted funds and programp r i o r i t i e s a t t h e t i m e of award.

Allowable Costs

Applicants must inc lude t h e fol lowing agreement i n t h e i r a p p l i c a t i o n s : "(Applicant) agrees t h a t no t more than 10 percent of any r e s u l t a n t g r a n t award w i l l be expended f o r admin i s t r a t ive purposes.w'

Grants are intended t o ass i s t i n meeting t h e c o s t s of planning, developing, and implementing a c t i v i t i e s t o support a t ta inment of t h e p r o j e c t o b j e c t i v e s . Grant funds are t o be a d d i t i v e , n o t s u b s t i t u t i v e ; t hey are no t t o be used t o r ep lace e x i s t i n g r e sources .

Grant funds may be used f o r expenses c lear ly r e l a t e d and necessary t o carry ou t t h e proposed p r o j e c t , inc luding both d i r e c t and i n d i r e c t c o s t s t h a t are s p e c i f i c a l l y i d e n t i f i e d with t h e proposed p r o j e c t .

INQUIRIES 4.

Applicants are encouraged t o con tac t I n s t i t u t e s t a f f before applying f o r an award :

N I H G U I D E - Vol. 20, No. 18, May 3, 1991 - Page 8

Neal Brown, Chief Community Support Sec t ion System Development and Community Support Branch Division of Applied and Se rv ices Research National I n s t i t u t e of Mental Health Parklawn Building, Room 11C-22 5600 F i s h e r s Lane Rockvil le , MD 20857 Telephone: (301) 443-3653

I n q u i r i e s p e r t a i n i n g t o g r a n t s management should be d i r e c t e d t o :

Steven Hudak Chief , Grants ,Management Sec t ion Grants Management Branch National I n s t i t u t e of Mental Health Parklawn Building, Room 7C-23 Rockvil le , MD 20857 Telephone: (301) 443-4456

1 CANCER

RFA AVAILABLE: CA-91-09

P.T. 34; K.W. 0715035, 0785220, 0765033

National Cancer I n s t i t u t e

Letter of I n t e n t Receipt Date: May 31, 1991 Applicat ion Receipt Date: J u l y 31, 1991

The Cancer Diagnosis Branch of t h e Divis ion of Cancer Biology, Diagnosis and Centers a t t h e Nat ional Cancer I n s t i t u t e i n v i t e s a p p l i c a t i o n s f o r coope ra t ive agreements from i n s t i t u t i o n s capable of and i n t e r e s t e d i n p a r t i c i p a t i n g i n t h e ''Cooperative Network f o r Evaluat ion of Prognost ic Markers of Urinary Bladder Cancer." The o b j e c t i v e of t h i s Request f o r Applicat ions (RFA) is t o i n v i t e a p p l i c a t i o n s f o r cooperat ive agreements t o support a network of l a b o r a t o r i e s t o coope ra t ive ly eva lua te promising d i a g n o s t i c and p rognos t i c markers of u r i n a r y bladder cance r . The network w i l l perform c o l l a b o r a t i v e s t u d i e s r e q u i r i n g e x p e r t i s e i n urology, pathology, and/or b a s i c cancer biology t o e v a l u a t e appropr i a t e q u a n t i f i a b l e markers of u r i n a r y bladder cancer and t o d e f i n e r e l e v a n t c l i n i c a l a p p l i c a t i o n s . This network w i l l cont inue and expandt h e c o l l a b o r a t i v e s t u d i e s of u r i n a r y bladder cancer markers c u r r e n t l ysupported by t h e "Marker Network f o r Bladder Cancer."

Awards w i l l be made as cooperat ive agreements t h a t create an a s s i s t a n c e r e l a t i o n s h i p with s u b s t a n t i a l N C I programmatic involvement with t h e r e c i p i e n t sdur ing t h e performance of t h e p r o j e c t , as o u t l i n e d i n t h i s RFA. The coope ra t ive agreement mechanism is used when t h e N C I wishes t o s t i m u l a t e i n v e s t i g a t o r i n t e r e s t and proposes t o assist i n an important and opportune area of r e s e a r c h . Applicants w i l l be r e s p o n s i b l e f o r t h e planning, d i r e c t i o n ,and execut ion of t h e proposed p r o j e c t .

The N C I a n t i c i p a t e s making fou r t o s i x awards f o r p r o j e c t pe r iods of up t o fou r y e a r s . A t o t a l of $950,000 is expected t o be se t a s i d e f o r funding t h e s e a c t i v i t i e s i n t h e i n i t i a l yea r . Although t h i s p r o j e c t is provided f o r i n t h e f i n a n c i a l p l a n s of t h e N C I , t h e award of cooperat ive agreements pursuant t o t h i s RFA is cont ingent on t h e a v a i l a b i l i t y of funds appropr i a t ed i n f i s c a l yea r 1992.

The Pub l i c Heal th Se rv ice (PHS) is committed t o achieving t h e h e a l t h promotionand d i s e a s e prevent ion o b j e c t i v e s of "Healthy People 2000," a PHS-led n a t i o n a l a c t i v i t y f o r s e t t i n g p r i o r i t y areas. This RFA, "Cooperative Network f o r Evaluat ion of Prognost ic Markers of Urinary Bladder Cancer," is r e l a t e d t o t h e p r i o r i t y area of cance r . P o t e n t i a l a p p l i c a n t s may o b t a i n a copy of "HealthyPeople 2000" ( F u l l Report: Stock No. 017-001-00474-0) o r "Healthy People2000" (Summary Report: Stock No. 017-001-00473-1) through t h e Superintendentof Documents, Government P r i n t i n g Of f i ce , Washington, D . C . 20402-9325 ( te lephone 202-783-3238). For p r o j e c t s involving c l i n i c a l r e s e a r c h , N I H r e q u i r e s a p p l i c a n t s t o g ive s p e c i a l a t t e n t i o n t o t h e i n c l u s i o n of women and m i n o r i t i e s i n s tudy popu la t ions . I f women o r m i n o r i t i e s are n o t included o r are inadequately r ep resen ted i n t h e s tudy popu la t ions f o r c l i n i c a l s t u d i e s , a s p e c i f i c j u s t i f i c a t i o n f o r t h i s exc lus ion o r inadequate r e p r e s e n t a t i o n must be provided. Applicat ions without such documentation w i l l no t be accepted f o r review.

N I H G U I D E - Vol. 20, No. 18, May 3 , 1991 - Page 9

This RFA is a one-time s o l i c i t a t i o n with a s p e c i f i e d dead l ine of J u l y 31, 1991 f o r r e c e i p t of a p p l i c a t i o n s .

A copy of t h e complete RFA desc r ib ing t h e r e sea rch goa l s and scope, t h e coopera t ive agreement mechanism, t h e review cr i ter ia , and o t h e r app l i ca t ionrequirements is a v a i l a b l e from:

* u r u ' Roger L . Aamodt Ph.D. Program Di rec to r f o r Pathology and CytologyCancer Diagnosis Branch, DCBDC, NCI Executive P laza South, Room 638 6120 Executive Boulevard Rockvi l le , MD 20892-9904 Telephone: (301) 496-7147 FAX: (301) 496-8656

I n q u i r i e s concerning t h i s RFA o r t h e a c t i v i t i e s of t h e c u r r e n t l y funded marker network are encouraged and should be d i r e c t e d t o D r . Roger L . Aamodt a t t h e above address o r te lephone o r FAX number.

For f i s ca l and admin i s t r a t ive matters, con tac t :

Robert E . Hawkins Grants Management S p e c i a l i s t Grants Adminis t ra t ion Branch National Cancer I n s t i t u t e EPS, Room 216 Bethesda, MD 20892 Telephone: (301) 496-7800 e x t . 13

This program is descr ibed i n t h e Catalog of Federal Domestic Assis tance No. 93.394, Cancer Detect ion and Diagnosis Research. Awards are made under au thor i za t ion of t h e Publ ic Heal th Serv ice A c t , T i t l e I V , P a r t A (Pub l i c Law 78-410 as amended: 42 USC 241) and adminis tered under PHS g r a n t p o l i c i e s and Federal Regulat ions 42 CFR P a r t 52 and 45 CFR P a r t 74. This program is no t sub jec t t o t h e intergovernmental review requirements of Executive Order 12372 o r Health Systems Agency review.

ADAMHA SMALL INSTRUMENTATION PROGRAM I' RFA: AA-91-03

P.T. 34; K.W. 0735000

Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion

Letter of I n t e n t Receipt Date: May 20, 1991 Applicat ion Receipt Date, June 21, 1991

The Alcohol, Drug Abuse, and Mental Health Adminis t ra t ion (ADAMHA) is announcing t h e t h i r d year of t h e ADAMHA S m a l l Ins t rumentat ion Program (ASIP).Th i s program was reauthor ized by Congress f o r FY 1991 i n Sec t ion 501(m) of t h e Publ ic Health Serv ice Act, as added t o by P.L. 100-690, i n response to f i n d i n g s t h a t much of t h e r e sea rch ins t rumenta t ion i n t h e Nation's p r i n c i p a lu n i v e r s i t i e s is e i t h e r obso le t e o r poorly maintained. These f ind ings ,documented i n s e v e r a l r e p o r t s , i d e n t i f i e d t h e need f o r upgrading equipmentc u r r e n t l y i n use . The most s i g n i f i c a n t need w a s f o r r e l a t i v e l y low-cost p i eces of equipment. To address t h i s problem, ADAMHA e s t a b l i s h e d t h e Small Ins t rumenta t ion Program i n FY 1989. Awards are made under a u t h o r i t y of T i t l e s I11 and of t h e PHS A c t as amended. Funds w i l l be provided t o r e sea rch - in t ens ive i n s t i t u t i o n s c u r r e n t l y r ece iv ing ADAMHA r e sea rch suppor t .The ASIP is no t intended t o r ep lace r e q u e s t s f o r equipment i n a p p l i c a t i o n s f o r i nd iv idua l r e sea rch p r o j e c t s . Rather , it is intended t o he lp fund items of equipment t h a t are d i f f i c u l t t o j u s t i f y wi th in t h e contex t of an ind iv idua l r e sea rch p r o j e c t but t h a t w i l l upgrade t h e i n s t i t u t i o n ' s r e sea rch i n f r a s t r u c t u r e .

The ADAMHA program has a similar purpose t o t h e Nat ional I n s t i t u t e s of Health Small Ins t rumenta t ion Program but w i l l ope ra t e s e p a r a t e l y and under s l i g h t l yd i f f e r e n t gu ide l ines because of d i f f e r e n c e s i n t h e i n f r a s t r u c t u r e supportmechanisms a v a i l a b l e t o t h e two agencies .

The ADAMHA program w i l l be funded i n FY 1991 a t $2,402,000. The programd provides awards ranging from $20,000 t o $60,000 t o e l i g i b l e i n s t i t u t i o n s .

E l i g i b l e i n s t i t u t i o n s are those t h a t had f i v e o r more a c t i v e ADAMHA r e sea rch g r a n t s awarded i n FY 1990. The awards must be from t h e fol lowing types of r e sea rch mechanisms: R01, R03, R29, and R37. The amount f o r which an

N I H GUIDE - Vol. 20, No. 18, May 3, 1991 - Page 10

i n s t i t u t i o n may apply w a s c a l c u l a t e d by a formula based on t h e $2,402,000 a v a i l a b l e f o r t h e program t h i s year and on t h e number of ADAMHA-sponsoredawards i n t h e e l i g i b l e mechanisms a t an i n s t i t u t i o n . Each e l i g i b l e i n s t i t u t i o n may submit ONLY ONE a p p l i c a t i o n t h a t i nco rpora t e s a l l appropr i a t e equipment r e q u e s t s from t h a t i n s t i t u t i o n . Thus, it is e s s e n t i a l t h a t i n s t i t u t i o n a l o f f i c i a l s p u b l i c i z e t h e a v a i l a b i l i t y of ASIP funds so t h a t ADAMHA-supported i n v e s t i g a t o r s i n need of small r e sea rch instruments are provided t h e opportuni ty t o i n d i c a t e t h e i r needs f o r such equipment t o t h e appropr i a t e i n s t i t u t i o n a l o f f i c i a l .

The equipment requested must be a v a i l a b l e f o r use by more than one p r o j e c t e i t h e r c u r r e n t l y o r i n t h e f u t u r e . The primary u s e r ( s ) of t h e equipment must be one o r more P r i n c i p a l I n v e s t i g a t o r s of a c t i v e ADAMHA-supported r e s e a r c h g r a n t s , and t h e s p e c i f i c p r o j e c t s must be c i t e d i n t h e a p p l i c a t i o n . No i n d i r e c t c o s t s w i l l be provided and t h e r e w i l l be no f u t u r e yea r funding commitment. The requested funds may be f o r f u l l o r p a r t i a l support of one o r more p i e c e s of equipment I n no case, however, can t h e t o t a l purchase p r i c e of a requested p i e c e of equipment be less than $5 ,000 o r more t h a n $100,000r e g a r d l e s s of t h e sou rce ( s1 of funding. I f t h e t o t a l d o l l a r amount of proposed eguipment purchases exceeds t h e amount f o r which t h e i n s t i t u t i o n is e l i g i b l e , a s ta tement must be submitted i n d i c a t i n g t h e i n s t i t u t i o n w i l l provide t h e d i f f e r e n c e . Support from t h i s psogram cannot be used t o purchase items exceeding $100,000 i n c o s t even i f c o s t s are sha red . The equipmentpurchased must be t h e same as t h a t s p e c i f i e d i n t h e ASlP a p p l i c a t i o n .

Applicat ions must be r ece ived by June 21, 1991, and l e t t e r s of i n t e n t should be r ece ived by May 20, 1991. Deta i l ed a p p l i c a t i o n procedures have been s e n t t o e l i g i b l e i n s t i t u t i o n s . Applicat ions w i l l be pee r reviewed by a s i n g l e ADAMHA-wide committee. The review c r i t e r i a are: Degree of adherence t o t h e terms of t h e l e t t e r of e l i g i b i l i t y and adequacy of t h e j u s t i f i c a t i o n provided f o r t h e equipment r eques t ed . The reviewers w i l l determine whether t h e a p p l i c a t i o n is recommended f o r approval ; no p r i o r i t y sco res w i l l be voted. Applicat ions w i l l be assi ned t o i n d i v i d u a l ADAMHA I n s t i t u t e s f o r cons ide ra t ion by t h e i r Nat ional Advisory Counci ls and for funding. The I n s t i t u t e s expect t o make t h e awards i n September.

Ouestions concerning t h i s program may be d i r e c t e d t o any of t h e following persons :

D r . Charles Sharp Division of P r e c l i n i c a l Research

'WNational I n s t i t u t e on Drus- Abuse Room 10A-31 Telephone: (301) 443-6300

M r . James MoynihanDivision of Basic Brain and Behavioral Sciences National l n s t i t u t e of Mental Health Room 11-95 Telephone: (301) 443-3107

D r . Lesl ie I s a k i Division of Basic Research National I n s t i t u t e on Alcohol Abuse and Alcoholism Room 16C-05 Telephone: (301) 443-4223

Grants Management Contact:

E l s i e M. FlemingChief , Management Review and Assis tance Sec t ion National I n s t i t u t e on Alcohol Abuse and Alcoholism Room 16-86 5600 F i s h e r s Lane Rockvil le , MD 20857 Telephone: (301) 443-4703

**THE M A I L I N G ADDRESS G I V E N FOR SENDING APPLICATIONS TO THE DIVISION OF RESEARCH GRANTS OR CONTACTING PROGRAM STAFF I N THE WESTWOOD B U I L D I N G I S THE CENTRAL M A I L I N G ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHO USE EXPRESS M A I L OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD B U I L D I N G IS:

5333 Westbard Avenue * U.S. G~P.0.:1991-281-826:20044 Bethesda, Maryland 20816

N I H G U I D E - Vol. 20, No. 18, May 3 , 1991 - Page 11