P. D. HINDUJA NATIONAL HOSPITAL AND MEDICAL HOSPITAL AND MEDICAL

RESEARCH CENTRE S C C NMUMBAI

Research DepartmentResearch Department1

RESEARCH DEPARTMENT

The Research section of the hospital wasThe Research section of the hospital was established in the year 1987

The section is actively involved in conductingThe section is actively involved in conducting basic research, clinical research, and drug trials

It i i d b M b i U i it f thIt is recognized by Mumbai University for the degrees of MSc & PhD by research in January 19931993.

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RESEARCH DEPARTMENTRESEARCH DEPARTMENT

Our Laboratory Is fully accredited by the CollegeOur Laboratory Is fully accredited by the College of American Pathologists [ CAP ]

Registration with Central Plan Schemes of theRegistration with Central Plan Schemes of the Government of India, under Controller General of Accounts (CGS) Indiaof Accounts (CGS), India.

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ORGANIZATION CHARTORGANIZATION CHART

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ETHICS & SCIENTIFIC COMMITTEEETHICS & SCIENTIFIC COMMITTEE

Clinical Research Ethics Committee (CREC) :

Institutional Review Board (IRB)

National Advisory Committee

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ETHICS & SCIENTIFIC COMMITTEEETHICS & SCIENTIFIC COMMITTEE

CREC & IRB:Formulated as per ICMR guidelinesEach EC meets once in two months (alternate (months)Meet additionally if required

Institutional Review board (IRB) registered with Office for Human Research Protections (OHRP) , US & Federal Wide Assurance approval from OHRPFederal Wide Assurance approval from OHRP New SOP’s formulated as per ICMR guidelines as well as OHRP (US) guidelines.as OHRP (US) guidelines.

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•There are 16 MSc/PhD seats. Students do high quality research for their University degree.q y y g

•So far 55 students have registered for MSc and gPhD of Mumbai University.

•Of these 20 have obtained MSc degree, 11 have obtained PhD. 9 have submitted synopsis/thesis.

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S f l 584 j h b b i d d f hSo far total 584 projects have been submitted and many of them have significantly contributed to our knowledge base.

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STUDIES SUPPORTED BY NATIONAL AGENCIESSTUDIES SUPPORTED BY NATIONAL AGENCIES

1. Lady Tata Memorial Trust (LTMT)y ( )

2. Baba Atomic Research Center (BARC)

3. Center for Cellular & Molecular Biology, (CCMB)3. Center for Cellular & Molecular Biology, (CCMB) Hyderabad.

4. Department of Biotechnology (DBT)p gy ( )

5. ICMR : Dr. Manoj Chadha

6. Bombay Orthopedic Society: Dr Vikas Agashe 6. Bombay Orthopedic Society: Dr Vikas Agashe

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INTERNATIONAL COLLABORATIONS INTERNATIONAL COLLABORATIONS

National Institute Of Health (NIH) , U.S government, ( ) , g ,Health and Human Services (HHS)Oxford University, UKUniversity college, LondonJapanese Cardiology AssociationAmerican Heart AssociationCanadian AssociationFIND DiagnosticsMc gill universityg y

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PARTICIPATION IN INTERNATIONAL STUDIESPARTICIPATION IN INTERNATIONAL STUDIES

Dr Jatin Kothari with American Heart Association grant on d f Bi k f kid i j f distudy of Biomarkers of kidney injury after cardiac surgery.

Dr. Z.F.Udwadia, with Imperial college London, UK for 'Biomarkers for immunity to MTB infection in exposed but un infected healthcare workers'Dr.F.N.Kapadia : inditiated by Ethics section of the European Society of Intensive Care Medicine coordination with yWelpicus project on 'Consensus guidelines for world wide End of Life Practice for patients in Intensive care units‘.Dr Z F Udwadia with Menssana Research,Inc., New Jersey forDr Z F Udwadia with Menssana Research,Inc., New Jersey for “Can a point‐of‐care breath test be used to diagnose active pulmonary tuberculosis?”

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PARTICIPATION IN INTERNATIONAL STUDIESPARTICIPATION IN INTERNATIONAL STUDIES

Dr C Rodrigues with Prof Tony Catanzaro, University of California, San Diego, Rapid tests for drug resistance to detect extensively drug resistant tuberculosis, NIH, USA grant.Dr C Rodrigues with FIND diagnostics, Geneva, Switzerland for g g , ,“Evaluation of the FIND / Cepheid Xpert MTB assay for the detection of pulmonary TB in sputum of symptomatic adults”.Dr C Rodrigues with Dr Madhukar Pai McGill UniversityDr C Rodrigues with Dr.Madhukar Pai, McGill University, Canada for 'Evaluation of LED microscopy for TB diagnosis in high incidence settings'.Co ordination by the Canadian Intensive care association to Co ordination by the Canadian Intensive care association to study patterns of weaning patients from invasive mechanical ventilation – across the world by Dr F N Kapadia

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PARTICIPATION IN INTERNATIONAL STUDIESPARTICIPATION IN INTERNATIONAL STUDIES

Dr C Rodrigues : with Prof Lazerange, University of St Louis, Paris, on study of diagnosis of tuberculosis by ESAT6, CFP10, PGL Antigen for diagnosis of Tuberculosis.Dr T F Ashavaid : Accurex India Pvt Ltd in collaboration withDr. T.F.Ashavaid : Accurex India Pvt Ltd in collaboration with Daiichi Pure Chemicals (Tokyo, Japan) Dr Asha Pherwani collaborated with ISAAC-International study of Asthma & Allergies in childhoodDr Alan Almeida: 'Global renal information database'. The GRID‐CKD project 'Evaluation of chronic kidney diseaseGRID CKD project. Evaluation of chronic kidney disease practice patterns through the global information database (GRID)

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PROPOSED INTERNATIONAL STUDIESPROPOSED INTERNATIONAL STUDIES

Dr C Rodrigues with Prof Dalia Goletti, EuropeanDr C Rodrigues with Prof Dalia Goletti, European Union, to develop test to differentiate active from latent TBfrom latent TB

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AREAS OF RESEARCH & DEVELOPMENTAREAS OF RESEARCH & DEVELOPMENT

A - Basic Sciences• Molecular Biology• Genetics• Biochemistry• Biochemistry• Microbiology ‐ Infectious diseases – TB, HCV, HIV, HBV, etc• Hematology, transfusion medicinegy

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AREAS OF RESEARCH & DEVELOPMENTAREAS OF RESEARCH & DEVELOPMENTB - Clinical Sections

• Critical Care Medicine • Pediatrics• Oncology• Endocrinology and diabetics• Chest Medicine

Pediatrics

• Neurosurgery

• Orthopedics

• Infectious diseases• Rheumatology• Gastroenterology• Nephrology

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Infectious diseases

• Cardiology

• ENT

• Ophthalmology• Imaging• Neurology (including pediatric neurology)

Ophthalmology

C - Clinical Trials ..Phase II & III studies.

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