Post on 20-Mar-2016
description
Supplementary figure 1
a b
e i
h-V
U-D
IPG
-3m
-VU
-DIP
G-3
h-V
U-D
IPG
-5m
-VU
-DIP
G-5
c d
f
g h
j
k l
**
Supplementary figure 2
a c
b
e
d
m-VU-DIPG-3 h-SU-DIPG-VI
m-VU-DIPG-5 m-CNMC-D1
m-CNMC-D1
Supplementary figure 3
a bHuman platform Murine platform
Supplementary table 1
Patient h-SU-DIPG-I h-SU-DIPG-III h-SU-DIPG-V h-SU-DIPG-VII h-SU-DIPG-VIII
Age (years) 5 14 12 10 10
Sex M M F M M
Histological diagnosisat autopsy
Anaplatic astrocytoma(WHO grade III) GBM GBM GBM Astrocytoma
(WHO grade III)
Supplementary table 2
Gene Forward Reverse
Human
H3F3A GGGCAGGAGCCTCTCTTAAT ACCAAGTAGGCCTCACAAGC
Hist1H3b AAGCAGAGGCTGACCAATCC TCCTTGGGCATGATGGTGAC
PI3KCA H1047R/L GCTCCAAACTGACCAAACTGT AATCGGTCTTTGCCTGCTGA
PI3KCA E542K CATCTGTGAATCCAGAGGGGA ACATGCTGAGATCAGCCAAA
Murine
H3f3a GTGTCCTTACCATGGCTCGT CAGCAGTTAAGAGCACTAGTTGA
Hist1h3b AAGCAGAGGCTGACCAATCC TCCTTGGGCATGATGGTGAC
Pi3ka H1047R/L ACTAGCAGCTCACTGACCAGA GCTATCAAACCCTGCTTGCG
Pi3ka E542K TCTTCCCCTTCGCCAAGTCTA ACAGGAAGAAGGTCCCTCGG
Supplementary table 3
AMEL CSF1PO1 D13S317 D16S539 D21S11 D5S818 D7S820 TH01 TPOX vWa
h-SU-DIPG-VI Cortex Control X/X 10/11 11/ 8/13 29/31 10/12 8/9 7/8 8/11 17/18