Post on 07-Aug-2015
ASSINGMENT WORK
STUDENT NAME :- SAURABH VERMA DEPARTMENT :- PHARMACOINFORMATIC INSTITUTE :- NIPER, KOLKATA SUBJECT :- (DATABASE MANAGEMENT) ( SYSTEM)
STUDENT NAME :- SAURABH VERMA DEPARTMENT :- PHARMACOINFORMATIC INSTITUTE :- NIPER, KOLKATA SUBJECT :- (DATABASE MANAGEMENT) ( SYSTEM)
To get the protien sequence and observe structure and superimpose with ligand,get the pi
value and mol.wt of that sequence and Glycosylation
Assignment Work
• >3E63:A|PDBID|CHAIN|SEQUENCE• RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGE
VVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCY• SAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLT• KVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWS
FGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHL• IELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFR
DLALRVDQIRDNMA
Fragment-based discovery of JAK-2 inhibitors
Molecular Description
• Classification: Transferase • Structure Weight: 34888.05• Molecule: Tyrosine-protein kinase JAK2• Polymer: 1 • Type: protein• Length: 293• Chains: A• EC#: 2.7.10.2 3.1.13.2 • Organism: Homo sapiens • UniProtKB: Search PDB | O60674• PDB Display Files :-3E63
Sequence Display
3E63.txt3E63.txt
SEQUENCE
3D- VIEW
LIGAND PROTIEN INTERACTION
5-phenyl-1H-indazol-3-amine(5-B2)
RESULT OF MOTIF FINDERIN SEQUENCE
1 MOTIF
2-MOTIF
Database of protein domains, families and functional sites
PROTIEN SITE
PROTIEN SITE
MOLECULAR WEIGHT
• The Sequence Manipulation Suite: Protein Molecular WeightResults for 293 residue sequence "3E63:A|PDBID|CHAIN|SEQUENCE" starting "RDPTQFEERH".The protein weighs 34.47 kilodaltons
CALCULATE THE PI VALUE OF PROTIEN SEQUENCE
PI- TABLE
NetOGlyc 4.0 ServerThe NetOglyc server produces neural network predictions of mucin type GalNAc O-
glycosylation sites in mammalian proteins.
OUTPUT DESCRIPTION
END
THANKU