Post on 16-Jan-2016
description
MCMP 407
Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS
Cholinergic Receptors
Nicotinic Muscarinic
Ganglionic Skeletal
Muscle
Neuronal
CNS
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Nicotinic ReceptorsNicotinic Receptors
ACH ACHNa+
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Nicotinic ReceptorsNicotinic Receptors
ACH ACHNa+
NH3
COOH
MCMP 407
Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS
Cholinergic Receptors
Nicotinic Muscarinic
M1 M5M3 M4M2
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic receptors are 7 transmembrane domain, G-protein Muscarinic receptors are 7 transmembrane domain, G-protein coupled receptorscoupled receptors
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic receptorsMuscarinic receptors(M(M11, M, M33, M, M55))
NH3
COOH
Gq
Phospho -lipase C
(+)
PIP2
IP3 Diacylglycerol
Increase Ca2+ Activate ProteinKinase C
Response
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic ReceptorsMuscarinic Receptors
(M2 and M4)NH3
COOH
GI
(-)
ATP cAMP
Reduce cAMP-DependentProtein Kinase Activity
Response
Adenylate Cyclase
X(+)K+
MCMP 407
Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS
Adrenergic Receptors
1A
1 2
1B 1D 2A 2B 2C 1 2 3
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: 11-Adrenergic-Adrenergic
ReceptorsReceptors
NH3
COOH
Gq
Phospho-lipase C
(+)
PIP2
IP3 Diacylglycerol
Increase Ca2+ Activate ProteinKinase C
Response
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: 22-Adrenergic-Adrenergic
ReceptorsReceptors
GI
(-)
ATP cAMP
Reduce cAMP-DependentProtein Kinase Activity
Response
Adenylate Cyclase
X(+)K+
NH3
COOH
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: -Adrenergic-AdrenergicReceptorsReceptors
GS
(+)
ATP cAMP
Increase cAMP-DependentProtein Kinase Activity
Response
Adenylate Cyclase
NH3
COOH
MCMP 407
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Heart Rate of Contraction Increase 1 Decrease M2
Force of Contraction Increase Decrease M2
Functional Responses Mediated by the ANS
1,
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Arteries (most) Vasoconstriction 1 ---------- --Veins Vasoconstriction 2 ---------- --Skeletal Muscle Vasodilation 2 ---------- --Endothelium ---------- -- Release EDRF M3
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
LungBronchiolar
smooth muscle
Bronchodilation Bronchoconstriction M32
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Bladder wall Relaxation 2 Contraction M3
Ureter Contraction 1 Relaxation M3
Sphincter Contraction 1 Relaxation M3
Uterus (pregnant) Relaxation 2 Variable
Penis/vas deferens Ejaculation
Genitourinary, smooth muscle
Contraction M311 M3
Erection
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Salivary Glands Increase secretion 1 Increase secretionSmooth Muscle:
Relaxation 2 ,2 M3
Sphincters Contraction 1 Relaxation M3
Secretion ---------- -- Increase secretion M3
Gastrointestinal Tract
M3
Walls Contraction
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Hair follicles,Smooth muscle
Contraction,Piloerection
1 -------------- --
Sweat glandsThermoregulation Increase secretion
Skin
----------------M3
Increase secretion 1Apocrine (stress) ----------------
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
IrisRadial muscle Contraction
Eye
----------------1
-------------Circular muscle M3Contraction--
Ciliary muscle [Relaxation M3Contraction2]
Ciliary epithelium Increase secretionof aqueous humor
----------------2
MCMP 407
Physiology of the eyePhysiology of the eye
LensIris
Radial muscle (1)
Circular muscle (M3)
Canal of Schlemm
Trabecularmeshwork
Ciliary muscle (M3)
Ciliaryepithelium (2)
MCMP 407
Physiology of the eyePhysiology of the eye
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Circular muscle
(M3 Receptors)
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Contraction of circular
muscle leads to
miosis
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Contraction of circular
muscle leads to
miosis
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Radial Muscle
( 1 Receptors)
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Contraction of radial
muscle leads to
mydriasis
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Liver Glycogenolysis -------------- --
Fat cells Lipolysis -------------- --
Kidney Increase reninsecretion
1 -------------- --
Pancreas Decrease insulinrelease
Metabolic functions
----------------
1, 3
2
Gluconeogenesis1, 2