Organ-on-Chip For Personalized Medicine · 2. Create a roadmap for Organ-on-Chip technology 3....

Organ-on-Chip

For Personalized Medicine

Beyond borders

Janny van den Eijnden-van Raaij

Managing Director hDMT

Vlaams-Nederlandse wetenschaps-en innovatiedag

Brussel, 28 October 2019

Organ-on-Chip Technology for Personalized Health Care

The Problem

Lack of drugs

Drug failure

Ineffective Drugs

Fatal side effects

The Solution

Organ-on-Chip

Technology

Benefit for Society

Cheaper Health Care

Business and jobs

Less animal experiments

Benefit for Patients

Personalized Health Care

Benefit for Drug Development

Faster and better

Collaboration

H2020 Future and Emerging Technologies (FET-open-03) program

CSA Coordination and Support Action (2 yr, 0.52M, start 1 October 2017)

ORCHID - ORgan-on-CHip In Development

Goal:1. Build a network/community of

academia, research institutes,

industry, regulatory bodies, patient

organizations, …..

2. Create a roadmap for Organ-on-Chip

technology

3. Raise awareness by dissemination

and communication

This project has received funding from the European Union's Horizon 2020 research and innovation programme

under grant agreement No 766884.

www.H2020-orchid.eu

Specifications Qualification StandardizationProduction &

UpscalingAdoption

Initial

development Applications

Academia

companies

Manufacturing

companies

Pharma

Cosmetics

Environment

Clinic

Academia

Generic and standardized open technology platforms

Ready-to-use OoC devicesReady-to-use OoC

devices

Organ-on-Chip roadmapBuilding blocks

Qualification

Bridging the gap between developers and end users

developersEnd users

Regulatory agencies

(FDA, EMA)

Regulatory agencies

(FDA, EMA)

Testing & Qualification

infrastructure

Testing & Qualification

infrastructure

Unified qualification requirementsUnified qualification requirements

Qualified and

fit-for-purpose

models

All developed models

Stakeholder

communities

Publicly available data

Standardization

Production and upscalingFrom lab to market

Bridging the valley of death

Thank you!

Organ-on-Chip For Personalized Medicine · 2. Create a roadmap for Organ-on-Chip technology 3....

Documents

Transcript of Organ-on-Chip For Personalized Medicine · 2. Create a roadmap for Organ-on-Chip technology 3....

Organ on a chipcc.ee.ntu.edu.tw/~ultrasound/belab/midterm_oral... · Organ on a chip Don Ingber, MD, PhD Founding Director, Wyss Institute at Harvard Reportors: W.-C. Wang, T.-W.

Electroceuticals - Ecsel Ju · 2019. 10. 23. · Organ-on-Chip ECSEL – IMI workshop 5-7-2017 . What is Organ-on-Chip? Create the smallest functional modules of healthy or diseased

20161005 Organ on a chip - SNU OPEN COURSEWARE

Fabrication and validation of an organ-on-chip system with ...€¦ · fabrication.17,22 The organ-on-chip device described in this publication, first applied in an earlier publication,16

Organ on Chip in Development (ORCHID) · 2018-10-09 · Organ on Chip in Development (ORCHID) EU – H2020 project grant agreement no . 766884 (AMD-766884-3) Website: . Deliverable

Organs on a Chip: The Integrated Discrete Multiple … Tox Methods Nov 2005...Organs on a Chip: The Integrated Discrete Multiple Organ Co-culture System (IdMOC) Albert P. Li, Ph. D.

Organs-On-A-Chip, Cardiotoxicity of VX and Fentanyl ... · organ types within a single microfluidic device as an organs-on-a-chip platform. This is necessary because tissues and organs

Tobias Hasenberg Der Multi-Organ-Chip - Giessen · Hasenberg Der Multi-Organ-Chip Ein mikrophysiologisches System für die Substanztestung ... iPS cell banking 1.100 sqm 20 scientists:

Organ on a chip

NIH Tissue Chip Program: Updates€¦ · organ integration DARPA: Organ integration ... Validation • Partnerships • Adoptions of the tech to the community. New Tissue Chip Initiatives

Applications of New Multi-Organ-Chip Tools for Toxicity ... · • Multi-Organ-Chip model to investigate the interaction of skin-and liver-specific metabolism of cosmetics chemicals

MT-0.6081 Microfluidics and BioMEMS Organs-on-a-chip: Microfludic organ models 3.4.2014 Ville Jokinen.

Moore4Medical WP2 Organ-on-Chip

Organ-on-a-chip engineering: Toward bridging the gap ...

Original Article - Harvard Universitydiseasebiophysics.seas.harvard.edu/wp-content/uploads/2017/04/... · Original Article Toward improved myocardial maturity in an organ-on-chip

Organ-on-chip Networking in Europe - ema.europa.eu · hDMT’s dream . Imagine: organ-on-chip models . that mimic any part of the human body, to study human sickness and health, for

Organ-on-a-Chip Technologies Network overview-May2019.pdf · Organ-on-a-Chip Technologies Network Founded August 2018 Leadership Team = Multidisciplinary group working in key research

Multi-organ in vitro Organ-On-Chip models for intestinal ...accurate prediction of drug absorption could improve the time, cost and overallefficiency within the drug development process.

Human Organ Chip Models Recapitulate Orthotopic Lung ...sites.bu.edu/chenlab/files/2017/10/203_Hassell_Cell-Rep_2017.pdf · (organ chip) cell culture technology can be used to create

EP177 v1.0 Basic Organ-Chip Culture Protocol3uyywi3w8psfe6fxn1g4tdb1-wpengine.netdna-ssl.com/... · An Organ-Chip is a living, micro-engineered environment that recreates the natural