Oral Lession Associated COVID-19 : Symptoms or Complications

Drg. Rochman Mujayanto, Sp.PM

PENDIDIKAN : 1. SARJANA KEDOKTERAN GIGI UNIVERSITAS AIRLANGGA SURABAYA LULUS TAHUN 2001 2. PROFESI DOKTER UNIVERSITAS AIRLANGGA SURABAYA LULUS TAHUN 2004 3. SPESIALIS PENYAKIT MULUT UNIVERSITAS AIRLANGGA SURABAYA LULUS TAHUN 2016

PEKERJAAN : 1. 2011 - SEKARANG DOSEN FAKULTAS KEDOKTERAN GIGI UNISSULA, SEMARANG 2. 2011 – SEKARANG RS HERMINA PANDANARAN, SEMARANG 3. 2017 – SEKARANG RSI GIGI & MULUT SULTAN AGUNG SEMARANG 4. 2017 – SEKARANG RS GIGI & MULUT SOELASTRI SURAKARTA

ORGANISASI: 1. PENGURUS PUSAT IKATAN SPESIALIS PENYAKIT MULUT INDONESIA, BIDANG CONTINUING DEVELOPMENT EDUCATION &

PENGABDIAN KEPADA MASYARAKAT, PERIODE TAHUN 2017–20222. WAKIL KETUA PENGURUS IKATAN SPESIALIS PENYAKIT MULUT INDONESIA WILAYAH II (JAWA BARAT, JAWA TENGAH,

YOGYAKARTA, KALIMANTAN, KEPULAUAN RIAU) PERIODE TAHUN 2017-20223. PENGURUS WILAYAH JAWA TENGAH PERHIMPUNAN KONSELOR VCT HIV INDONESIA, BIDANG ORGANISASI DAN HUKUM,

PERIODE TAHUN 2019 - 20244. KEPALA DEPARTEMEN ILMU PENYAKIT MULUT FAKULTAS KEDOKTERAN GIGI UNIVERSITAS ISLAM SULTAN AGUNG5. KETUA TIM HIV/AIDS RUMAH SAKIT ISLAM GIGI & MULUT SULTAN AGUNG6. KONSELOR HIV/AIDS RUMAH SAKIT ISLAM GIGI & MULUT SULTAN AGUNG

Drg. Rochman Mujayanto,Sp.PM

Publikasi : 1. Mujayanto R, Indraswary R. Differential Diagnosis of COVID-19 Enanthema. Eur J Dent. 2020 Dec;14(S 01):S179-S181. doi: 10.1055/s-0040-1719210. Epub 2020 Nov 26. PMID:

33242912; PMCID: PMC7775208.2. Kontributor buku : Panduan Praktik Klinis Ilmu Penyakit Mulut Edisi ke-1 Kolegium Ilmu Penyakit Mulut Indonesia Ikatan Spesialis Penyakit Mulut Indonesia.

DOI: https://doi.org/10.32793/monograph.v1i1.6303. Kontributor buku : Petunjuk Teknis Pelayanan Kesehatan Gigi dan Mulut di Fasilitas Kesehatan Tingkat Pertama Pada Masa Adaptasi Kebiasaaan Baru – Kementerian Kesehatan RI

20214. Mujayanto R. Pencabutan Gigi : Kondisi Kompromis Medis. In: Amalina R, Woroprobosari NR, eds. Pencabutan Gigi Dengan Penyulit. 1st ed. EF Press Digimedia; 2019:1-16.5. Mujayanto R. Komplikasi Diabetes Melitus Pada Mukosa Mulut. In: Amalina R, Septiana L, eds. Diabetes Dental Care. 1st ed. EF Press Digimedia; 2019:17-26.

ORAL LESSION ASSOCIATED COVID-19 : SYMPTOMS OR COMPLICATIONS

DRG. ROCHMAN MUJAYANTO, SP.PM

DENTAL SEMINAR UMS

ZOOM MEETING, JUNE 2TH 2021

Highly Pathogenic HCoV : ReviewZhu, Z., Lian, X., Su, X. et al. From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses.

Respir Res 21, 224 (2020). https://doi.org/10.1186/s12931-020-01479-w

COVID-19 and its Modes of TransmissionKaria, R., Gupta, I., Khandait, H. et al. COVID-19 and its Modes of Transmission. SN Compr. Clin. Med. 2, 1798–1801 (2020).

https://doi.org/10.1007/s42399-020-00498-4

Atukorallaya DS and Ratnayake RK (2021) Oral Mucosa, Saliva, and COVID-19 Infection in Oral Health Care. Front. Med. 8:656926. doi: 10.3389/fmed.2021.656926

Signs & SimptomsCOVID-19

Into Respiratory

Extra Respiratory

•Oral mucosal lesions

•Neurological dysfunctions, (such as loss of smell, loss of taste)

•Headache

•Associated myofascial pain

Atukorallaya DS and Ratnayake RK (2021) Oral Mucosa, Saliva, and COVID-19 Infection in Oral Health Care. Front. Med. 8:656926. doi: 10.3389/fmed.2021.656926

Into Respiratory

• Cough

• Shortness of breath or trouble breathing

Extra Respiratory

• Oral mucosal lesions

• Neurological dysfunctions, (such as loss of smell, loss of taste)

• Headache

• Associated myofascial pain

Iranmanesh, B, Khalili, M, Amiri, R, Zartab, H, Aflatoonian, M. Oral manifestations of COVID‐19 disease: A review article. Dermatologic Therapy. 2021; 34:e14578. https://doi.org/10.1111/dth.14578

Oral Mucosal Lesions of COVID-19

Aphthous-like lesions

•Herpetiform lesions

•Ulcer and erosionWhite/Red

plaques

Erythema/ Enanthem

EM-like lesions

Angina bullosa-like

lesions

Melkerson-Rosenthal syndrome

Vesicles and pustules

Petechiae

Nonspecific lesions

(mucositis)

Atukorallaya DS and Ratnayake RK (2021) Oral Mucosa, Saliva, and COVID-19 Infection in Oral Health Care. Front. Med. 8:656926. doi: 10.3389/fmed.2021.656926

Orofacial Symptoms of

COVID-19

Headache

Myofacialpain

Burning sensation of the oral

mucosa

Loss of taste

Loss of smell

Dry mouth

11

12

13

14

DIFFERENTIAL DIAGNOSIS

ORAL MANIFESTATIONS OF COVID-19

Suspected COVID-19

● Oral herpes (primary or recurrent)

● Herpes zoster

● Varicella

● Herpangina

● Hand Foot & Mouth Diseases

● Measles

Probable COVID-19 (Lost of Taste)● Side effects of drugs

● Nutritional deficiencies

● Diabetes mellitus

● Hypotyrodism

● Perniciosa anemia

● Sjorgen syndrome

● Crohn Diseases

Covid-19 Symptomatic Patients With Oral Lesions

16

Favia G, Tempesta A, Barile G, Brienza N, Capodiferro S, Vestito MC, Crudele L, Procacci V, Ingravallo G, Maiorano E, Limongelli L. Covid-19 Symptomatic Patients with Oral Lesions:

Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification. Journal of Clinical Medicine. 2021; 10(4):757.

https://doi.org/10.3390/jcm10040757

Atukorallaya DS and Ratnayake RK (2021) Oral Mucosa, Saliva, and COVID-19 Infection in Oral Health Care. Front. Med. 8:656926. doi: 10.3389/fmed.2021.656926

Brandini, D.A., Takamiya, A.S., Thakkar, P., Schaller, S., Rahat, R. and Naqvi, A.R. (2021), Covid‐19 and oral diseases: Crosstalk, synergy or association?. Rev Med Virol. https://doi.org/10.1002/rmv.2226

La Rosa GRM, Libra M, De Pasquale R, Ferlito S and Pedullà E (2021) Association of Viral Infections With Oral Cavity Lesions: Role of SARS-CoV-2 Infection. Front. Med. 7:571214. doi: 10.3389/fmed.2020.571214

Immunopathogenesis

Gupta, A., Madhavan, M.V., Sehgal, K. et al. Extrapulmonary manifestations of COVID-19. Nat Med 26, 1017–1032

(2020). https://doi.org/10.1038/s41591-020-0968-3

cytokine release syndrome (CRS)

Guo, M., Tao, W., Flavell, R.A. et al. Potential intestinal infection and faecal–oral transmission of SARS-

CoV-2. Nat Rev Gastroenterol Hepatol 18, 269–283 (2021). https://doi.org/10.1038/s41575-021-00416-6

Oral Lession Associated COVID-19 : Symptoms or Complications ?

An association between oral

diseases and SARS-CoV-2 infection is still unclear and currently poorly

investigated

The appearance of such lesions could be related to the direct or indirect action of SARS-CoV-2

over the oral mucosa cells, coinfections, immunity

impairment, and adverse drug reactions

The oral signs and symptoms presented by patients with

Covid‐19 are a direct result of SARS‐CoV‐2 infection or

secondary disorders facilitated by systemic damage, alterations

in the immune system, or adverse effects of treatment and

require further investigation with larger cohort sizes

La Rosa GRM, Libra M, De Pasquale R, Ferlito S and Pedullà E (2021) Association of Viral Infections With

Oral Cavity Lesions: Role of SARS-CoV-2 Infection. Front. Med. 7:571214. doi:10.3389/fmed.2020.571214

La Rosa GRM, Libra M, De Pasquale R, Ferlito S and Pedullà E (2021) Association

of Viral Infections With Oral Cavity Lesions: Role of SARS-CoV-2 Infection.

Front. Med. 7:571214. doi:10.3389/fmed.2020.571214

Brandini, D.A., Takamiya, A.S., Thakkar, P., Schaller, S., Rahat, R. and

Naqvi, A.R. (2021), Covid‐19 and oral diseases: Crosstalk, synergy or

association?. Rev Med Virol. https://doi.org/10.1002/rmv.2226

CONCLUSION

Always ask about the symptoms of ageusia & anosmia

The SARS-COV-2 PCR examination is the standard standard

Teleconsultation with Oral Medicine specializes

THANK YOUROCHMANMUJAYANTO

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