Post on 16-Jul-2015
Probiotics
Defined as the daily administration of
certain live microorganisms in amounts
adequate to confer a health benefit on
the host.
Oragenics’ Probiotic Cocktail
S. oralis KJ3
S. uberis KJ2
S. rattus JH145
The Problem
• Adults have an average
of 23 decayed and filled
tooth surfaces
• 5 billion people affected
worldwide
• Expenditures for dental care in the US, 2004:
$66 billion
• Most of these costs are associated with dental
caries
Cariogenicity of Parent
and Mutant Strains
• Decay caused by lactic
acid-producing S.
mutans
• Lactic acid dissolves
the mineral in teeth
and the dextran
capsule traps the acid
next to the tooth
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x
x
x
x
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Cariogenicity of Parent
and Mutant Strains
• Rat infected with
acid-producing
wild-type strain
• Rat infected with
JH145
The Problem• Three out of four American adults
have some form of periodontal disease
• Periodontal disease causes over 70% of tooth loss in adults over the age of 35
• The American Dental Association has estimated the spending on professional periodontal treatment to be nearly $12 billion per year
• 6-8 species of bacteria cause the disease(S)
Dental-videos.com
http://www.perio.org/consumer/2a.html
Healthy Diseased
S. oralis S. uberis
Basis for the Negative Interaction
• The mechanism of
inhibition by S. oralis
is production of
hydrogen peroxide.
Safety
• Confirmed in laboratory animals and humans
• All three strains are sensitive to all front-line
antibiotics
• JH145 (ldh) reversion frequency is
unmeasurably low
Efficacy: BID for Four Weeks
Cosmetic Benefits
• The peroxide also provides
a whitening effect
• Decreased production of
volatile sulfur-containing
compoundsTea and chlorhexidine-stained ceramic
chips treated with probiotic or untreated
control
treated
Current Status
• Adult formulation (EvoraPlus) – Gum and Tooth
• Children’s formulation (EvoraKids) – Tooth health
• Companion pet formulation (Teddy’s Pride) - Gums
Oragenics
INNOVATIVE HEALTH SOLUTIONS