Probiotics

Defined as the daily administration of

certain live microorganisms in amounts

adequate to confer a health benefit on

the host.

Oragenics’ Probiotic Cocktail

S. oralis KJ3

S. uberis KJ2

S. rattus JH145

The Problem

• Adults have an average

of 23 decayed and filled

tooth surfaces

• 5 billion people affected

worldwide

• Expenditures for dental care in the US, 2004:

$66 billion

• Most of these costs are associated with dental

caries

Cariogenicity of Parent

and Mutant Strains

• Decay caused by lactic

acid-producing S.

mutans

• Lactic acid dissolves

the mineral in teeth

and the dextran

capsule traps the acid

next to the tooth

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Cariogenicity of Parent

and Mutant Strains

• Rat infected with

acid-producing

wild-type strain

• Rat infected with

JH145

The Problem• Three out of four American adults

have some form of periodontal disease

• Periodontal disease causes over 70% of tooth loss in adults over the age of 35

• The American Dental Association has estimated the spending on professional periodontal treatment to be nearly $12 billion per year

• 6-8 species of bacteria cause the disease(S)

Dental-videos.com

http://www.perio.org/consumer/2a.html

Healthy Diseased

S. oralis S. uberis

Basis for the Negative Interaction

• The mechanism of

inhibition by S. oralis

is production of

hydrogen peroxide.

Safety

• Confirmed in laboratory animals and humans

• All three strains are sensitive to all front-line

antibiotics

• JH145 (ldh) reversion frequency is

unmeasurably low

Efficacy: BID for Four Weeks

Cosmetic Benefits

• The peroxide also provides

a whitening effect

• Decreased production of

volatile sulfur-containing

compoundsTea and chlorhexidine-stained ceramic

chips treated with probiotic or untreated

control

treated

Current Status

• Adult formulation (EvoraPlus) – Gum and Tooth

• Children’s formulation (EvoraKids) – Tooth health

• Companion pet formulation (Teddy’s Pride) - Gums

Oragenics

INNOVATIVE HEALTH SOLUTIONS