Post on 11-Jan-2016
description
NSF DAYS
at
Binghamton University
Directorate for Biological Sciences
National Science Foundation
Diane M. Witt, PhD.www.NSF.gov
National Science Foundation Director Deputy Director
Directorates• Biological Sciences
• Computer & Information Science & Engineering
• Education & Human Resources• Engineering• Geosciences• Mathematical & Physical Sciences• Social, Behaviorial & Economic Sciences
Offices
• Budget, Finance & Award Management• Information & Resource Management
Office of the Director
• Legislative & Public Affairs
• Equal Opportunity Programs
• General Counsel
• Integrative Activities
• Polar Programs
National Science Board Office of Inspector General
Biological Sciences Directorate
Mission To enable the discoveries for understanding life
Vision Inspiring research and education at the frontiers of the life sciences
Directorate for Biological Sciences
ResearchResourcesResearchResources
HumanResourcesHuman
Resources
Division of Biological
Infrastructure(DBI)
Division of Biological
Infrastructure(DBI)
BehavioralSystems
BehavioralSystems
Developmental Systems
Developmental Systems
Neural SystemsNeural Systems
Physiological & Structural SystemsPhysiological &
Structural Systems
Integrative Organismal
Systems(IOS)
Integrative Organismal
Systems(IOS)
Div
ision
sC
luste
rs
Molecular & Cellular
Biosciences(MCB)
Molecular & Cellular
Biosciences(MCB)
BiomolecularSystems
BiomolecularSystems
Cellular SystemsCellular Systems
Genes & GenomeSystems
Genes & GenomeSystems
Population & Evolutionary Processes
Population & Evolutionary Processes
Division of Environmental
Biology(DEB)
Division of Environmental
Biology(DEB)
Ecological BiologyEcological Biology
EcosystemScience
EcosystemScience
Systematic Biology &Biodiversity InventoriesSystematic Biology &
Biodiversity Inventories
Emerging Frontiers (EF)Emerging Frontiers (EF)
Div
ision
Division of Biological Infrastructure (DBI)
Supports varied activities that provide the infrastructure for contemporary research in biology
Research Resources Databases Curatorial improvement, computerization of research
collections Living stock collections Major items of multi-user instrumentation Development of new instrumentation Research facilities at biological field stations, marine labs
Human Resources Undergraduate research and mentoring in biology Postdoctoral research fellowships in biology
Integrative Organismal SystemsIOS
Supports research focusing on an integrative understanding of organisms.
• Understand why organisms are structured the way they are and function the way they do.
• Innovative applications of systems biology approaches (i.e., combined experimentation, computation, modeling)
• New conceptual and theoretical insights and predictions that may be experimentally verified
Integrative Organismal Systems IOS
Neural Systems Cluster
Organization
• How do genetics, developmental processes, and experience/environment interact to produce structure and function?
Activation
• Information extraction from the environment and integration within the organism to form a decision, perception, or action
Modulation
• Robust emergent properties that underlie adaptive behavior, learning, and complex social interactions
Integrative Organismal Systems IOS
Developmental Systems ClusterPlant, Fungal, and Microbial Developmental Mechanisms
Animal Developmental Mechanisms
• Understanding how interacting developmental processes lead to emergent properties and complex phenotypes
Evolution of Developmental Systems
• Discovering the developmental processes shared by all organisms and those singular ones that produce diversity
Integrative Organismal Systems IOS
Behavioral Systems Cluster
Animal Behavior
• Social and reproductive behavior
• Behavioral ecology and physiology
• Neural and hormonal mechanisms
• Development, function, and mechanisms
• Evolutionary history
Integrative Organismal Systems IOS
Physiological & Structural Systems
Symbiosis, Defense and Self-recognition• Processes and structures that mediate intimate
interactions between two or more organisms
Organism – Environment Interactions• Structures and processes that affect organismal
performance under routine, changing, or stressful environmental conditions
Processes, Structures and Integrity
• Structural and functional properties and interactions that orchestrate daily existence
Division of Environmental Biology (DEB)
DEB supports fundamental research on: • origins, functions, relationships, interactions, and evolutionary history of populations, species, communities, and ecosystems.
•Scientific emphases include systematic biology, biotic surveys & inventories, molecular genetic and genomic evolution, mesoscale ecology, conservation biology, global change, and restoration ecology.
Environmental Sciences (DEB)
Ecological Biology
Ecosystem Science
Population & Evolutionary Processes
Systematic Biology & Biodiversity Inventories
Molecular & Cellular Biosciences (MCB)
Biomolecular Systems
Structure, function, dynamics, interactions, and interconversions of biological molecules
Individual macromolecules to the large-scale integration of metabolic and energetic processes
Development of cutting-edge technologies Mechanistic studies of the regulation and catalysis of
enzymes and RNA Higher-order characterization of the biochemical processes
by which all organisms acquire, transform, and utilize energy from substrates
Cellular Systems (MCB)
Cellular Systems Cluster focuses on the structure, function, and regulation of plant, animal and microbial cells, and their interactions with the environment and with one another.
Areas supported include studies of the structure, function, and assembly of cellular elements, such as the cytoskeleton, membranes, organelles, intracellular compartments, intranuclear structures, and extracellular matrix, including eukaryotic and prokaryotic cell walls and envelopes.
Genes & Genomes Systems (MCB)
Genomes and genetic mechanisms in all organisms, whether prokaryote, eukaryote, phage, or virus.
The structure, maintenance, expression, transfer, and stability of genetic information in DNA, RNA, and proteins and how those processes are regulated.
Genome organization, molecular and cellular evolution, replication, recombination, repair, and vertical and lateral transmission of heritable information.
Processes that mediate and regulate gene expression, such as chromatin structure, epigenetic phenomena, transcription, RNA processing, editing and degradation, and translation.
Directorate for Biological Sciences
BIO 2009 Priorities
Life in Transition
Microbial Systems
Synthetic Biology
Adaptive Systems Technology
Funding Opportunities in BIO
Life in Transition (LiT)
OriginsHow, where and when did life on
Earth begin?
How did the biological complexity of life emerge from pre-biotic chemistry and geochemistry?
Open system chemistry
Self-sustaining biochemistry
Basic elements
DNA WorldRNA World
H2 + CO2 => [ HCO ]n
Self-replication
EnergyHow is energy obtained and used by
living systems to sustain life?
Understanding natural energy transduction systems will inspire the development of biology-based technologies capable of delivering sustainable, renewable, efficient energy.
Chloroplasts
Assemble the basics
PS IAu Ag
-/+
photon
e-
e-
e-
e-
Applied
Photosynthes
Barry Bruce (UTN), NSF/EF
Adaptation Transformations and Transitions in
the Story of Life
Understanding life’s resilience and adaptation will reduce uncertainty about the future of life on Earth in response to global climate change.
Changes
DiversityWhat will survive,
and how?
Transdisciplinary
Interdisciplinary
Multi-disciplinary
Disciplinary
Life Sciences In Transition
Funding Opportunities in BIO
Microbial Systems in the Biosphere (MSB) Replaces Microbial Observatories and Microbial Interactions and Processes (MO/MIP) Solicitation
Synthetic BiologyWhat are the indispensable
requirements for life?
What are:•The physical rules for cell membrane assembly?
•The minimum gene set required to sustain life?
•The fundamental requirements for genome stability?
?
Membrane Encapsulation
Genome Stability
Are There Alternative Routes to Life?
Microfluidic System RNA
Evolution
Brian Paegel and Gerald Joyce Scripps Research
Inst.
Synthetic Biology
Animal model
The primary source of data and behavioral phenomena
Mathematical model Describes hypothetical
relationships between a selected subset of observations
Computational model
Explores the logical consequences of the hypothetical descriptions
Physical model
Explores the behavioral consequences of a hypothetical neural property operating in the animal’s natural environment
Adaptive Systems Adaptive Systems TechnologyTechnology
Closing the Loop of Theory, Observation, Experimentation, and Technology
D. E. Koditschek, ESE Department, University of
Pennsylvania
Funding Opportunities in BIO
Solicitations
Special programs with specific guidelines,deadlines, cycles (annual, biennial), etc.
Selected SolicitationsAssembling the Tree of Life
(AToL) • Constructing a universal Tree of Life for all 1.7 million named species of organisms on earth
• Due Date: March (new solicitation forthcoming)
Selected Solicitations2010 Project (will be phased out as a separate solicitation)• Determine the function of all genes in Arabidopsis thaliana by the year 2010 •Due Date: Feb. 19, 2009 (09-514)
Selected SolicitationsResearch Coordination Networks in
Biological Sciences (RCN)• Encourage and foster interactions among scientists. Create new research directions or advance a field.• Due Date: June 29, 2009 (06-567)
Selected SolicitationsResearch Coordination Networks-
Undergraduate Biology Education (RCN-UBE)• Similar to RCN but focuses on improving Biology Education• Due Date: June 29, 2009 (06-567)
Selected SolicitationsResearch Coordination Networks-
Undergraduate Biology Education (RCN-UBE)• Similar to RCN but focuses on improving Biology Education• Due Date: June 29, 2009 (06-567)
Selected Multidisciplinary Programs
Ecology of Infectious Diseases (BIO, GEO, SBE, NIH)
• Discovery of predictive models and principles governing the transmission dynamics of disease agents. • Due Date: Dec. 10, 2008 (08-601)
•Enhancing undergraduate education and training at the intersection of the biological and mathematical sciences.•Due Date: Feb. 12, 2009 (08-510)
Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences (BIO,EHR,MPS)
Developing Expertise and Broadening Participation
Funding Opportunities in NSF/BIO
Research Assistantships to High SchoolStudents (RAHSS) Supplement (06-027)
High School Students
Developing Expertise andBroadening Participation
Developing Expertise andBroadening Participation
Research at Undergraduate Institutions (RUI)Same target date as core programs (announcement 00-144)
Research Experience for Undergraduates (REU) Sites (June 5, 2009) and Supplements (contact PD)(07-569)
Undergraduates
Undergraduate Research and Mentoring in theBiological Sciences (URM)Due Date: March 3, 2009 (06-591)Alan Savitzky (asavitzk@nsf.gov)
Interdisciplinary Training for Undergraduates inBiological and Mathematical Sciences (UBM)Due Date: Feb. 12, 2009 (08-510)Nancy Huntly (nhuntly@nsf.gov)
Graduate Students
Graduate Research Fellowships (GRFP)(08-593). Due date: Nov. 7, 2008Education and Human Resources Directorate. NSF-wide program
Doctoral Dissertation Improvement Grants (DDIG)
(08-564). Due date: Third Friday in November. DEB and Behavioral Cluster in IOS(ddig-deb@nsf.gov; ddig-ios@nsf.gov)
Integrative Graduate Education and Research Traineeship (IGERT)
(new solicitation soon). Due date: April, 2009Education and Human Resources Directorate. NSF-wide program
Developing Expertise andBroadening Participation
Postdoctoral Fellows
Postdoctoral Research Fellowships in Biology (GRFP)
(07-580). Due date: Nov. 2, 2009Division of Biological Infrastructure
• Broadening Participation of Under-represented Groups in Biology Carter Kimsey (ckimsey@nsf.gov)• Biological Informatics Peter McCartney (pmccartn@nsf.gov)
Developing Expertise andBroadening Participation
Minority Postdoctoral Research Fellowships and Supporting Activities
(06-586). Due date: First Monday in NovemberBIO and SBEBIO: Carter Kimsey (ckimsey@nsf.gov)
Faculty and Teachers
Faculty Early Career Development Program (CAREER)
(08-557). Deadline: July 21, 2009 Untenured Assistant ProfessorsMary Chamberlin (mchamber@nsf.gov)
Research Initiation Grants to Broaden Participation in Biology (RIG BP)
(09-501) Deadline: Jan. 12, 2009New investigator, new facultyCarter Kimsey (ckimsey@nsf.gov)
Research Opportunity Awards (ROA)(07-041) Supplement
Research Experience for Teachers (RET)(05-524) Supplement
Developing Expertise andBroadening Participation
Realities:
Recent Funding History of NSF BIO DirectorateFY 2001-2009
$300
$350
$400
$450
$500
$550
$600
$650
$700
1 2 3 4 5 6 7 8 9
Fiscal Years
Fu
nd
ing
Lev
el (
in m
illio
ns)
Actual Funding Funding in 2001 Constant Dollars
Funding Realities
2009 Request
Call Your PROGRAM DIRECTOR
Summary and Advice
Read the Grant Proposal Guide
Improve the health of the Nation by conducting and supporting
research:
in the cause, diagnosis, prevention, and cure of human
disease.
National Institutes of Health NIH
______________________
Mission: To promote the progress of science; to advance the national health, prosperity and welfare; to secure national defense (NSF Act 0f 1950).
Vision: Advancing discovery, innovation, and education beyond the frontiers of current knowledge, and empowering future generations in science and engineering.
Proposal Submission
NSF
Online FastLane
15 Pages
Target Dates,deadlines
Suggested Reviewers
FASTLANE
NIH
Grants.gov
25 Pages
3 Deadlines
eCommons
FASTLANE
NSF
Advisory Panels
Ad Hoc Reviews
NIH
Study Sections
Review System________________________
NSF All proposals
discussed
High Priority
Medium Priority
Low Priority
Non-competitive
NIH “Streamlined”
Priority score
Percentile
Funding line
Review System________________________
Merit Review Criteria
Intellectual merit
Broader impacts
Best ideas from the most capable people,
determined by competitivemerit review.
DiscoveriesDiscoveries
TransformativeTransformative
DiscoveriesDiscoveries
Tra ormativeTra ormative
Questions?