NSF DAYS at Binghamton University Directorate for Biological Sciences National Science Foundation

NSF DAYS

at

Binghamton University

Directorate for Biological Sciences

National Science Foundation

Diane M. Witt, PhD.www.NSF.gov

National Science Foundation Director Deputy Director

Directorates• Biological Sciences

• Computer & Information Science & Engineering

• Education & Human Resources• Engineering• Geosciences• Mathematical & Physical Sciences• Social, Behaviorial & Economic Sciences

Offices

• Budget, Finance & Award Management• Information & Resource Management

Office of the Director

• Legislative & Public Affairs

• Equal Opportunity Programs

• General Counsel

• Integrative Activities

• Polar Programs

National Science Board Office of Inspector General

Biological Sciences Directorate

Mission To enable the discoveries for understanding life

Vision Inspiring research and education at the frontiers of the life sciences


ResearchResourcesResearchResources

HumanResourcesHuman

Resources

Division of Biological

Infrastructure(DBI)

Division of Biological

Infrastructure(DBI)

BehavioralSystems

BehavioralSystems

Developmental Systems

Developmental Systems

Neural SystemsNeural Systems

Physiological & Structural SystemsPhysiological &

Structural Systems

Integrative Organismal

Systems(IOS)

Integrative Organismal

Systems(IOS)

Div

ision

sC

luste

rs

Molecular & Cellular

Biosciences(MCB)

Molecular & Cellular

Biosciences(MCB)

BiomolecularSystems

BiomolecularSystems

Cellular SystemsCellular Systems

Genes & GenomeSystems

Genes & GenomeSystems

Population & Evolutionary Processes


Division of Environmental

Biology(DEB)

Division of Environmental

Biology(DEB)

Ecological BiologyEcological Biology

EcosystemScience

EcosystemScience

Systematic Biology &Biodiversity InventoriesSystematic Biology &

Biodiversity Inventories

Emerging Frontiers (EF)Emerging Frontiers (EF)

Div

ision

Division of Biological Infrastructure (DBI)

Supports varied activities that provide the infrastructure for contemporary research in biology

Research Resources Databases Curatorial improvement, computerization of research

collections Living stock collections Major items of multi-user instrumentation Development of new instrumentation Research facilities at biological field stations, marine labs

Human Resources Undergraduate research and mentoring in biology Postdoctoral research fellowships in biology

Integrative Organismal SystemsIOS

Supports research focusing on an integrative understanding of organisms.

• Understand why organisms are structured the way they are and function the way they do.

• Innovative applications of systems biology approaches (i.e., combined experimentation, computation, modeling)

• New conceptual and theoretical insights and predictions that may be experimentally verified

Integrative Organismal Systems IOS

Neural Systems Cluster

Organization

• How do genetics, developmental processes, and experience/environment interact to produce structure and function?

Activation

• Information extraction from the environment and integration within the organism to form a decision, perception, or action

Modulation

• Robust emergent properties that underlie adaptive behavior, learning, and complex social interactions


Developmental Systems ClusterPlant, Fungal, and Microbial Developmental Mechanisms

Animal Developmental Mechanisms

• Understanding how interacting developmental processes lead to emergent properties and complex phenotypes

Evolution of Developmental Systems

• Discovering the developmental processes shared by all organisms and those singular ones that produce diversity


Behavioral Systems Cluster

Animal Behavior

• Social and reproductive behavior

• Behavioral ecology and physiology

• Neural and hormonal mechanisms

• Development, function, and mechanisms

• Evolutionary history


Physiological & Structural Systems

Symbiosis, Defense and Self-recognition• Processes and structures that mediate intimate

interactions between two or more organisms

Organism – Environment Interactions• Structures and processes that affect organismal

performance under routine, changing, or stressful environmental conditions

Processes, Structures and Integrity

• Structural and functional properties and interactions that orchestrate daily existence

Division of Environmental Biology (DEB)

DEB supports fundamental research on: • origins, functions, relationships, interactions, and evolutionary history of populations, species, communities, and ecosystems.

•Scientific emphases include systematic biology, biotic surveys & inventories, molecular genetic and genomic evolution, mesoscale ecology, conservation biology, global change, and restoration ecology.

Environmental Sciences (DEB)

Ecological Biology

Ecosystem Science


Systematic Biology & Biodiversity Inventories

Molecular & Cellular Biosciences (MCB)

Biomolecular Systems

Structure, function, dynamics, interactions, and interconversions of biological molecules

Individual macromolecules to the large-scale integration of metabolic and energetic processes

Development of cutting-edge technologies Mechanistic studies of the regulation and catalysis of

enzymes and RNA Higher-order characterization of the biochemical processes

by which all organisms acquire, transform, and utilize energy from substrates

Cellular Systems (MCB)

Cellular Systems Cluster focuses on the structure, function, and regulation of plant, animal and microbial cells, and their interactions with the environment and with one another.

Areas supported include studies of the structure, function, and assembly of cellular elements, such as the cytoskeleton, membranes, organelles, intracellular compartments, intranuclear structures, and extracellular matrix, including eukaryotic and prokaryotic cell walls and envelopes.

Genes & Genomes Systems (MCB)

Genomes and genetic mechanisms in all organisms, whether prokaryote, eukaryote, phage, or virus.

The structure, maintenance, expression, transfer, and stability of genetic information in DNA, RNA, and proteins and how those processes are regulated.

Genome organization, molecular and cellular evolution, replication, recombination, repair, and vertical and lateral transmission of heritable information.

Processes that mediate and regulate gene expression, such as chromatin structure, epigenetic phenomena, transcription, RNA processing, editing and degradation, and translation.

BIO 2009 Priorities

Life in Transition

Microbial Systems

Synthetic Biology

Adaptive Systems Technology

Funding Opportunities in BIO

Life in Transition (LiT)

OriginsHow, where and when did life on

Earth begin?

How did the biological complexity of life emerge from pre-biotic chemistry and geochemistry?

Open system chemistry

Self-sustaining biochemistry

Basic elements

DNA WorldRNA World

H2 + CO2 => [ HCO ]n

Self-replication

EnergyHow is energy obtained and used by

living systems to sustain life?

Understanding natural energy transduction systems will inspire the development of biology-based technologies capable of delivering sustainable, renewable, efficient energy.

Chloroplasts

Assemble the basics

PS IAu Ag

-/+

photon

e-

e-

e-

e-

Applied

Photosynthes

Barry Bruce (UTN), NSF/EF

Adaptation Transformations and Transitions in

the Story of Life

Understanding life’s resilience and adaptation will reduce uncertainty about the future of life on Earth in response to global climate change.

Changes

DiversityWhat will survive,

and how?

Transdisciplinary

Interdisciplinary

Multi-disciplinary

Disciplinary

Life Sciences In Transition


Microbial Systems in the Biosphere (MSB) Replaces Microbial Observatories and Microbial Interactions and Processes (MO/MIP) Solicitation

Synthetic BiologyWhat are the indispensable

requirements for life?

What are:•The physical rules for cell membrane assembly?

•The minimum gene set required to sustain life?

•The fundamental requirements for genome stability?

?

Membrane Encapsulation

Genome Stability

Are There Alternative Routes to Life?

Microfluidic System RNA

Evolution

Brian Paegel and Gerald Joyce Scripps Research

Inst.

Synthetic Biology

Animal model

The primary source of data and behavioral phenomena

Mathematical model Describes hypothetical

relationships between a selected subset of observations

Computational model

Explores the logical consequences of the hypothetical descriptions

Physical model

Explores the behavioral consequences of a hypothetical neural property operating in the animal’s natural environment

Adaptive Systems Adaptive Systems TechnologyTechnology

Closing the Loop of Theory, Observation, Experimentation, and Technology

D. E. Koditschek, ESE Department, University of

Pennsylvania


Solicitations

Special programs with specific guidelines,deadlines, cycles (annual, biennial), etc.

Selected SolicitationsAssembling the Tree of Life

(AToL) • Constructing a universal Tree of Life for all 1.7 million named species of organisms on earth

• Due Date: March (new solicitation forthcoming)

Selected Solicitations2010 Project (will be phased out as a separate solicitation)• Determine the function of all genes in Arabidopsis thaliana by the year 2010 •Due Date: Feb. 19, 2009 (09-514)

Selected SolicitationsResearch Coordination Networks in

Biological Sciences (RCN)• Encourage and foster interactions among scientists. Create new research directions or advance a field.• Due Date: June 29, 2009 (06-567)

Selected SolicitationsResearch Coordination Networks-

Undergraduate Biology Education (RCN-UBE)• Similar to RCN but focuses on improving Biology Education• Due Date: June 29, 2009 (06-567)

Selected Multidisciplinary Programs

Ecology of Infectious Diseases (BIO, GEO, SBE, NIH)

• Discovery of predictive models and principles governing the transmission dynamics of disease agents. • Due Date: Dec. 10, 2008 (08-601)

•Enhancing undergraduate education and training at the intersection of the biological and mathematical sciences.•Due Date: Feb. 12, 2009 (08-510)

Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences (BIO,EHR,MPS)

Developing Expertise and Broadening Participation

Funding Opportunities in NSF/BIO

Research Assistantships to High SchoolStudents (RAHSS) Supplement (06-027)

High School Students

Developing Expertise andBroadening Participation


Research at Undergraduate Institutions (RUI)Same target date as core programs (announcement 00-144)

Research Experience for Undergraduates (REU) Sites (June 5, 2009) and Supplements (contact PD)(07-569)

Undergraduates

Undergraduate Research and Mentoring in theBiological Sciences (URM)Due Date: March 3, 2009 (06-591)Alan Savitzky ([email protected])

Interdisciplinary Training for Undergraduates inBiological and Mathematical Sciences (UBM)Due Date: Feb. 12, 2009 (08-510)Nancy Huntly ([email protected])

Graduate Students

Graduate Research Fellowships (GRFP)(08-593). Due date: Nov. 7, 2008Education and Human Resources Directorate. NSF-wide program

Doctoral Dissertation Improvement Grants (DDIG)

(08-564). Due date: Third Friday in November. DEB and Behavioral Cluster in IOS([email protected]; [email protected])

Integrative Graduate Education and Research Traineeship (IGERT)

(new solicitation soon). Due date: April, 2009Education and Human Resources Directorate. NSF-wide program


Postdoctoral Fellows

Postdoctoral Research Fellowships in Biology (GRFP)

(07-580). Due date: Nov. 2, 2009Division of Biological Infrastructure

• Broadening Participation of Under-represented Groups in Biology Carter Kimsey ([email protected])• Biological Informatics Peter McCartney ([email protected])


Minority Postdoctoral Research Fellowships and Supporting Activities

(06-586). Due date: First Monday in NovemberBIO and SBEBIO: Carter Kimsey ([email protected])

Faculty and Teachers

Faculty Early Career Development Program (CAREER)

(08-557). Deadline: July 21, 2009 Untenured Assistant ProfessorsMary Chamberlin ([email protected])

Research Initiation Grants to Broaden Participation in Biology (RIG BP)

(09-501) Deadline: Jan. 12, 2009New investigator, new facultyCarter Kimsey ([email protected])

Research Opportunity Awards (ROA)(07-041) Supplement

Research Experience for Teachers (RET)(05-524) Supplement


Realities:

Recent Funding History of NSF BIO DirectorateFY 2001-2009

$300

$350

$400

$450

$500

$550

$600

$650

$700

1 2 3 4 5 6 7 8 9

Fiscal Years

Fu

nd

ing

Lev

el (

in m

illio

ns)

Actual Funding Funding in 2001 Constant Dollars

Funding Realities

2009 Request

Call Your PROGRAM DIRECTOR

Summary and Advice

Read the Grant Proposal Guide

Improve the health of the Nation by conducting and supporting

research:

in the cause, diagnosis, prevention, and cure of human

disease.

National Institutes of Health NIH

______________________

Mission: To promote the progress of science; to advance the national health, prosperity and welfare; to secure national defense (NSF Act 0f 1950).

Vision: Advancing discovery, innovation, and education beyond the frontiers of current knowledge, and empowering future generations in science and engineering.

Proposal Submission

NSF

Online FastLane

15 Pages

Target Dates,deadlines

Suggested Reviewers

FASTLANE

NIH

Grants.gov

25 Pages

3 Deadlines

eCommons

FASTLANE

NSF

Advisory Panels

Ad Hoc Reviews

NIH

Study Sections

Review System________________________

NSF All proposals

discussed

High Priority

Medium Priority

Low Priority

Non-competitive

NIH “Streamlined”

Priority score

Percentile

Funding line

Review System________________________

Merit Review Criteria

Intellectual merit

Broader impacts

Best ideas from the most capable people,

determined by competitivemerit review.

DiscoveriesDiscoveries

TransformativeTransformative

DiscoveriesDiscoveries

Tra ormativeTra ormative

Questions?

NSF DAYS at Binghamton University Directorate for Biological Sciences National Science Foundation

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