Post on 04-Jun-2018
8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
1/9
TEST PAPER - Microbiology, Disease, Organisms &TEST PAPER - Microbiology, Disease, Organisms &AntibioticsAntibiotics
Marks Marks 8080
Time Time ! mins"! mins"
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
#"$" Tick t%e rig%t anser 'Eac% carry one mark(1. Microbiology is
a) Study of plants b) Study of animals c( St)*y o+ microorganism d) All of the above.
2. Shape of a cocci will be
a( Ro)n* b) Rod shaped c) Spiral d) oma
!. ross infection in hospitals is called as
a) Secondary "nfection b) #atent "nfection c) ommunity Ac$uired "nfection *( osocomial n+ection
%. hemical substances produced by one species of organism that arecapable of
suppressing the growth or destroying the other organism are called
as
a( Antibioticsb) Antibacterialc) Antigensd) &one of the above
8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
2/9
'. A laboratory method of determining the susceptibility of antibiotics
is calledthe a( Sensiti.ity test"b) (iochemical testc) rease testd) Staining test
*. +hich of the following is atypical bacterium, a) Staphylococcus aureus b) Streptococcus pneumonae c( /egionella ne)mo%illa
d) -seudomonas
. Aminoglycoside antibiotics such as gentamicin /
a) Acts on the cell membrane to cause cell lea0age b( Acts on t%e 10S ribosomes to in%ibit rotein synt%esis c) Acts on the bacterial cell wall to inhibit cell wall synthesis d) Acts on &A gyrase to inhibit cell replication
. A facultative anaerobic organism is an organism3 usually abacterium
a) -seudomonas aeruginosa45ram/negative) b) &ocardia45ram/positive) c) Mycobacterium tuberculosis4acid/fast)
*( Sta%yloccoc)s, Esc%eric%ia coli, an* /isteria secies
#"2 3ill in t%e blanks 4 ' Eac% blank carry $ mark (
1. a) 5oncentration Deen*ent6illing means ,
7issue concentration or A also called as 8 6ill Ratio 7
M" acterici*alPoer
b) Time Deen*ent 6illing means ,
79 M" or M( 8 time above the M" or M( should remain
longer than %:/ ': ; of the time between two dosing internal.
http://en.wikipedia.org/wiki/Organismhttp://en.wikipedia.org/wiki/Bacteriumhttp://en.wikipedia.org/wiki/Pseudomonas_aeruginosahttp://en.wikipedia.org/wiki/Nocardiahttp://en.wikipedia.org/wiki/Gram-positivehttp://en.wikipedia.org/wiki/Mycobacterium_tuberculosishttp://en.wikipedia.org/wiki/Acid-fasthttp://en.wikipedia.org/wiki/Organismhttp://en.wikipedia.org/wiki/Bacteriumhttp://en.wikipedia.org/wiki/Pseudomonas_aeruginosahttp://en.wikipedia.org/wiki/Nocardiahttp://en.wikipedia.org/wiki/Gram-positivehttp://en.wikipedia.org/wiki/Mycobacterium_tuberculosishttp://en.wikipedia.org/wiki/Acid-fast8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
3/9
Post Antibiotic ample isMycobacteri)m t)berc)losis3 the causative agent of tuberculosis
andMycobacteri)m lerae3 the causative agent of leprosy.
%. 7here are of two types resistance, ntrinsic resistance
Ac9)ire* resistance
'. 7ypes of Antibiotics , a) at)ral
b) Syntheticc) Semi-Synt%etic
*. acterial resistancemeans , A state of insensitivity or decreasedsensitivity
to drugs that ordinarily cause growth inhibition or cell death.
7. Sepsis is a serious medical condition characterised by a whole/bodyinflammatorystate caused by infection. Seticaemiais considered
a subsetof sepsis3 is a serious acute condition, rapidly progressive, life-threateninginfection.
. 7yphoid fever3 also 0nown as enteric fever3 is an illness caused bythe
bacteriumSalmonella ty%i. ommon worldwide3 it is transmittedby
ingestion of food or water contaminated with fecesfrom an infectedperson
?. eta-lactamaseis a type of en@yme produced by some bacteriathat is
http://en.wikipedia.org/wiki/Inflammationhttp://en.wikipedia.org/wiki/Infectionhttp://en.wikipedia.org/wiki/Bacteriumhttp://en.wikipedia.org/wiki/Salmonella_typhihttp://en.wikipedia.org/wiki/Salmonella_typhihttp://en.wikipedia.org/wiki/Feceshttp://en.wikipedia.org/wiki/Enzymehttp://en.wikipedia.org/wiki/Inflammationhttp://en.wikipedia.org/wiki/Infectionhttp://en.wikipedia.org/wiki/Bacteriumhttp://en.wikipedia.org/wiki/Salmonella_typhihttp://en.wikipedia.org/wiki/Feceshttp://en.wikipedia.org/wiki/Enzyme8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
4/9
responsible for their resistanceto beta/lactam antibioticsli0epenicillins3
cephalosporins3 cephamycinsand carbapenems.
1:. 7he most common type of 7" is a bladder infection which is also
oftencalled cystitis. Another 0ind of 7" is a 0idney infection3 0nown asyelone%ritis3 and is much more serious.
11. 7he mechanism of action of the macrolides is by inhibition ofbacterial
Protein synthesis by binding reversibly to the subunit ':S of thebacterial
ribosome
12. Aminoglycosi*esare useful primarily in infections involvingaerobic3
negative bacterias3 such as -seudomonas3 Acinetobacter3 andpress beta/
lactamase andwould normally degrade the antibiotic.
1*. (acteria can e>change genetic information by Trans*)ction3Trans+ormationand 5on
8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
5/9
8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
6/9
d) "atrogenic infection is patient induced infection due to therapeutic3diagnostic3 or investigative procedures 4 3alse ).
e) Sub/clinical infection means whose clinical signs and symptoms areclearly
visible 4 3alse).
f) Secondary infection, means a host whose resistance is lowered by a
pre/e>isting disease3 a new parasite sets up an infection 4usually
complicates the disease). 4Tr)e).
g) B lactams antibiotic inhibits the cell wall synthesis of the bacteria 4
Tr)e).
h) Meningitis is the inflammationof the protective membranescovering the
central nervous system4 Tr)e )
i) "n adults3 recently developed Aminoglycosides such as levoflo>acinand
mo>iflo>acinare often used to provide empiric coverage for patientswith
pneumonia due to S. pneumoniae 4 3alse).
C) hronic obstructive pulmonary disease 4D-)3 is a group ofdiseases
characteri@ed by limitation of airflow in the airwaythat is not fullyreversible.
4Tr)e)
#>" Matc% t%e stages o+ n+ectio)s Disease 4 '! marks(
A 1. "ncubation a. "ntroduction of microorganisms into the
tissues.
http://en.wikipedia.org/wiki/Inflammationhttp://en.wikipedia.org/wiki/Central_nervous_systemhttp://en.wikipedia.org/wiki/Levofloxacinhttp://en.wikipedia.org/wiki/Moxifloxacinhttp://en.wikipedia.org/wiki/Diseasehttp://en.wikipedia.org/wiki/Airwayhttp://en.wikipedia.org/wiki/Inflammationhttp://en.wikipedia.org/wiki/Central_nervous_systemhttp://en.wikipedia.org/wiki/Levofloxacinhttp://en.wikipedia.org/wiki/Moxifloxacinhttp://en.wikipedia.org/wiki/Diseasehttp://en.wikipedia.org/wiki/Airway8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
7/9
2. linical "llness b. -eriod in which hostFs defense
mechanisms
overcome and eliminate bacteria from
the
tissues3 and the host recovers.!. -rodrome c. -eriod in which characteristic signs and
symptoms of the disease begin to be
specific
and identifiable.%. "nfection d. -hase in which non/specific signs and
symptoms of disease begin to appear.'. Resolution e.-eriod in which bacteria multiply without
causing signs or symptoms of disease.
Answers : (1- e), (2- c ), (3- d ), (4- a), (5- b )
#"?" Matc% t%e Organisms 4 '> marks(
A a) Staphylococcus. spp. 1. 5ram -ositive coccib) lostridium spp. 2. 5ram &egative coccic)
8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
8/9
A
a) -neumonia 1. 7emp. 9 ! D with Absolute&eutrophil
ount of 9':: Hcmmb) Acute &ecroti@ing
-ancreatitis
2. evelops due to ".I. drug users in
patients prosthetic heart valves3patient
presents with sudden heart murmurs3septic emboli.
c) Gebrile &eutropenia !. "nfectious disease of Cointsd) Sepsis %. Superficial vesiculopustular lesione)
8/13/2019 Microbiology Disease Organism & Antibiotics Majesta - Test Paper-A
9/9
#"@ Matc% t%e +olloing Antibiotics it% t%eir Mo*e o+ Action
Ansers 4 '1- e (, '2- a (, '! - b (, '% - c (, '' - * (" '> - +(
JJJJJJJJJJJJJJJJJJJJJJJJJJJJJ
A (1. 5lycopeptides E (eta/lactams
a. inhibits ':S ribosomes to inhibit proteinsynthesis
2. Macrolides b. &A 5yrase E 7opoisomerase "I
!. Gluro$uinolones c. affects cell membrane permeability
%. olistin E -olymycin d. inhibits bacterial folic acid synthesis
'. o/trimo>a@ole e. inhibits cell wall synthesis
*.D>a@olidinones f. inhibits the initiation comple> formation inprotein
synthesis