Post on 21-Jan-2016
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UNIMIX - Vacuum processing units
Scale-up Basics
Rainer Liebig
Project Manager Sales EKATO SYSTEMS GmbH
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Agenda
Vacuum Processing Plant UNIMIX – Features Design Aspects Parameters for Scale-up
Tip speed of PARAVISC Mixing time of PARAVISC Tip speed of Homogeniser BTO – Batch Turn Over
Summary
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Vacuum Processing Plant EKATO UNIMIX
Features: Vacuum processing Heating/cooling Agitation with PARAVISC High Sheer Homogenizer S-Jet Raw material charging into
homogenizer Internal/external homogenisation
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sInnovation for your process
Professional scale-up calculation of Newtonian and non-Newtonian fluids.
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sScale-up calculation
EKATO SYSTEMS is unique with the possibility to calculate the scale-up parameters to maximize the quality and
quantity for our customer!
Important Design Aspects
Tip speed of Homogenizer – 27 m/s
Tip speed of PARAVISC agitator – 2.5 m/s
Vessel design: ratio H / Ø = 1 : 1
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sScale up calculation - Parameters
Tip speed of PARAVISC agitator
Mixing time PARAVISC
Tip speed of Homogenizer
BTO’s (Batch Turn Over’s) at homogeniser
Product transfer in case of pre-phase vessels
Tip speedRotor (homogenisator)
Tip speed PARAVISC
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Scale up calculation – Tip Speed PARAVISC
C = π * n/s * ddSRT25 = 0,284 m dSRC1000 = 0,976 m
nSRT25 = 120 rpm nSRC1000 = ? rpm
CSRT25 = 3,14* 120/60s * 0,284 = 1,78 m/sec
CSRC1000= 3,14 * X /60s * 0,401 = 1,78 m/secA
BX =2* 0,284 / 0,976 = 0,581 * 60 = 34,8 rpm
3,14 * 120/60s * 0,284 = 3,14 * X/60s * 0,976 = 34,8 rpm
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Scale up calculation – Mixing Time PARAVISC
tSRC1000 = (nSRT25 * tSRT25) / nSRC1000
tSRT25 = 2 min tSRC1000 = ? min
nSRT25 = 120 rpm nSRC1000 = 34,8 rpm
tip speed = 1,78 m/s tip speed = 1,78 m/s
tSRT1000 = (120SRT25 * 2SRT25) / 34,8SRC1000 = 6:53 min
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Scale up calculation – Tip Speed Homogeniser
C = π * n/s * ddSRT25 = 0,060 m dSRC1000 = 0,166 m
nSRT25 = 6000 rpm nSRC1000 = ? rpm
CSRT25 = 3,14 * 6000/60s * 0,060 = 18,8 m/sec
CSRC1000= 3,14 * x /60s * 0,166 = 18,8 m/secA
B 3,14 * 6000/60s* 0,060 = 3,14 * X/60s * 0,166 = 2164 rpm
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sScale up calculation – BTO (Batch Turn Over) at Homogeniser
25 L
1000 L
S-jet 100
S-jet 1000
= 100 L/min H2O
= 1000 L/min H2O
100 / 25 * 2:00 = 8 BTO‘s
* = all with same tip speed of 18,8 m/sec
tSRT25 = 2:00 min = 8 BTO’s tSRC1000 = ? min = 8 BTO’s
1000/1000
* 8 BTO‘s = 8:00
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sSummary
REMEMBER
In order to succeed in the scale-up calculation, the following information need to be established:
Tip speed of PARAVISC agitator
Mixing time PARAVISC
Tip speed of Homogenizer
BTO’s (Batch Turn Over’s) at homogeniser
Thank you for your attention!
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