Post on 09-Jul-2018
Choosing the path of least resistanceHot Melt Extrusion vs. Spray Drying
© 2014 Hovione
Hot Melt Extrusion Spray Drying
Solubilization and Stability
Challenges
Dru
g L
oad
ing
(%
)
Drug Melting Point (ºC)
100
0
25
50
75
100
150 200 250 300
No dependence on
organic solubility
Max
imum
Org
anic
So
lub
ility
(%
)
Drug Melting Point (ºC)
100
0
5
10
15
20
150 200 250 300
Commercial Feasibility
Decreases
Max
imum
Org
anic
So
lub
ility
(%
)
Drug Melting Point (ºC)
100
0
5
10
15
20
150 200 250 300
No drug loading or melting
point limitations related to process
Dru
g L
oad
ing
(%
)
Drug Melting Point (ºC)
100
0
25
50
75
100
150 200 250 300