Post on 12-Apr-2017
DPI 1
Dry powder Inhalers
SUBODH S SATHEESH2ND MPHARM
DEPT OF PHARMACEUTICSECPS
Department of pharmaceutics
DPI 2
Introduction COPDPulmonary dosage formsInhaler technologyPMDIDry powder inhalers
DPI 3
Ideal charactersEasy to useMultiple dosesMoistureAccurate and uniformConsistentMinimize adhesion
DPI 4
Design Capsule opening mechanismAirflowRetention of capsule debrisMouthpiece design
DPI 5
Issues with designSingle dose devicesMultiple dose devices
DPI 6
Mechanism ImpactionDiffusionSedimentationInterceptionElectrostatic precipitation
DPI 7
Drug deliveryInvitroInvivo
DPI 8
Inhalation devicesNebulizersPressurized metered dose inhalersDry powder inhalers
DPI 9
Factors affecting DPI devicesHumidityInterparticulate forcesParticle sizePhysical properties of powdersCarrier and size
DPI 10
characterizationCrystallinityPolymorphismMoisture contentParticle sizeForces of interaction
DPI 11
MicronizationFluid energy millBall millPin mill
DPI 12
Evaluation AppearanceColourSieve analysisMoisture contentSpray patternFlow properties
DPI 13
Current trendsTwisthalerHandihalerTurbuhalersEasyhaler
DPI 14
CONCLUSIONDrug delivery to lungsImproves aerosol delivery systemsHigh patient compatibilityHigh dose carrying capacityTreatment of asthma and COPD
DPI 15
Bibliography Frijilink H W, Dry powder inhaler for pulmonary drug delivery
IJPR 2015; 1(1);67-86.Nithi yadav, Alka lohani, Dry powder inhalers. A review, Indo
global journal of pharmaceutical sciences, 2014;3(2);141-171Newman SP, Evolution of dry powder inhalers formulation and
perfomance. Respiratory care 2013 1209-1223Mark copley, accessing Dry powder inhalers. Copley scientific
2012;(3):1027-1028Sahane SP, Nikhar AK. Dry powder inhalers, IJPC 2011;(3)
1143-1149.
DPI 16
THANKS FOR LISTENING