Discovering New Drug-Drug InteractionsBy Text-Mining the Biomedical Literature

Beth PerchaCS 224NFinal ProjectMarch 17, 2011

Background

●Americans are on a lot of drugs.

●Drug interactions are bad.

●We don't test for them in clinical trials.

●We need ways to find likely interactions so we can watch out for them.

Methods (I)

Start with indexed version of Medline:17 million abstracts88 million sentences

Two lexicons:Genes (43 VIP genes)Drugs (602; at least one interaction)

AND

Methods (II)

Results (I)

Results (II)

Most likely interactions... Least likely interactions...