DETOXIFICATION & METHYLATIONDr. Jeff Thomas

HEALTHCOACH7 METHYLATION WEBINAR SERIESTIME: 4-430PM PST

1. July 7th Metabolism and Methylation2. July 14th Immunity and Methylation3. July 21st Inflammation and Methylation4. July 28th Detoxification and Methylation5. August 4th Hormones and Methylation6. August 11th Brain and Methylation7. August 18th SNPs and Methylation8. August 25th Gut and Methylation9. September 1st Allergies and Methylation10. September 8th Methylation and Autism11. September 15th Methylation and Cancer12. September 22nd Methylation and Lyme Disease13. September 29th Methylation and Weight Concerns14. October 6th Methylation and POTS / EDS

** All webinars we be recorded and available for your listening pleasure.

OVERVIEW

What is detoxification? How do methylation and detoxification

relate? Where does our body perform detoxification? How does our liver perform detox? How does detoxification become impaired? Complications of impairment? Genetic mutations and detoxification Detox Treatment Recommendations

WHAT IS DETOXIFICATION?

Process by which our liver alters various harmful substances that come from outside and inside our bodies, into a form your body can safely eliminate.

METHYLATION & DETOXIFICATION

Source: http://www.hindawi.com/journals/aurt/2013/963697.fig.002.jpg

ORGANS THAT PERFORM DETOXIFICATION

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LIVER DETOXIFICATION

Source: http://www.tuberose.com/Graphics/liver-detox-pathway2.jpg

VARIOUS WAYS LIVER DETOXIFICATION CAN BECOME IMPAIRED

Source: http://nourishholisticnutrition.com/wp-content/uploads/Liver.png

SYMPTOMS OF IMPAIRED DETOXIFICATION

Lethargy, fatigue (especially upon rising) Insomnia, difficulty falling asleep Headaches, migraines Skin issues: acne, boils, rashes Digestive: bloating, gas, nausea, abdominal pain Cognitive: poor concentration and memory, brain

fog General lack of well-being, malaise Excessive storage of adipose tissue, fatty liver,

gallstones Moodiness, irritability, depression, anxiety Poor physical balance and fine motor skills,

trembling

GENOMIC MEDICINE & DETOXIFICATION

INTERACTION BETWEEN GENE/SNP VARIANTS AND PHASE 1 & 2 DETOXIFICATION

Phase 1: CYP1/CYP2. These genes can be either increased or

decreased based on SNP variations.

Clinical Concerns: Increased lipid peroxidation. Think of it as free

radicals reeking havoc leading to cell damage. Consequences can alter DNA synthesis and/or be

carcinogenic.

PHASE 1 & 2 RELATED SNPS

Phase 1: CYP1 CYP2

Phase 2: GPX3 GSTM1 (Glutathione transferases) GSTP1 NAT 1/2 (Acetylation) SOD 2/3 (Superoxide dismutase) PON1 (Paraoxonases)

GENES INVOLVED IN DETOXIFICATION

Source: www.genecards.org

HEALTHCOACH7 PERSONALIZED GENETIC REPORT

METHYLATION & DETOXIFICATION PATHWAYS

Source: www.consultdra.com

TREATMENT APPROACHES

“Can’t supplement a shitty diet.” Assess/Optimize Pillars of Health

Nutrition Physical activity Stress Management Hydration Sleep

Optimize pathways of elimination Depuration Therapies

Nutritional Support Outside-In approach Well-balanced

ORDER OF PRIORITIES

“A.L.T.O.S” ASSESS Sn/Sx and SNP’s Start LOW and work up Treat the patient not just the SNP’s. Treat from the OUTSIDE in. Monitor SNS/SX to adjust therapy.

REFERENCES Chan, K., X.-D. Han, and Y. W. Kan. "An Important Function of Nrf2 in

Combating Oxidative Stress: Detoxification of Acetaminophen." Proceedings of the National Academy of Sciences 98.8 (2001): 4611-616. Web

http://geneticgenie.org/blog/2013/02/02/why-support-methylation-and-detoxification-our-ancestors-didnt-need-to/

http://phoenixrising.me/research-2/glutathione-depletionmethylation-blockades-in-chronic-fatigue-syndrome/glutathione-depletion-methylation-cycle-block-a-hypothesis-for-the-pathogenesis-of-chronic-fatigue-syndrome-by-richard-a-van-konynenbury-ph-d

Polymorphisms in Genes Encoding Drugs and Xenobiotic Metabolizing Enzymes, DNA Repair Enzymes, and Response to Treatment of Childhood Acute Lymphoblastic LeukemiaMaja Krajinovic, Damian Labuda, Geraldine Mathonnet, Marcin Labuda, Albert Moghrabi, Josette Champagne, and Daniel SinnettClin Cancer Res March 2002 8:802-810

Shimada, Tsutomu. "Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons." Drug metabolism and pharmacokinetics 21.4 (2006): 257-276.

Crinnion, Walter J. "Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant-induced and other chronic health problems." Alternative medicine review: a journal of clinical therapeutic 16.3 (2011): 215-225.

Muthusamy, Ramya Chellemmal. "DNA Repair." Journal of Pharmaceutical Sciences and Research 5.11 (2013): 213-15. Web.

QUESTIONS??

Source: https://tstoaddicts.files.wordpress.com/2013/08/simpsons-questions.gif

HEALTHCOACH7 METHYLATION WEBINAR SERIESTIME: 4-430PM PST

1. July 7th Metabolism and Methylation2. July 14th Immunity and Methylation3. July 21st Inflammation and Methylation4. July 28th Detoxification and

Methylation5. August 4th Hormones and Methylation6. August 11th Brain and Methylation7. August 18th SNPs and Methylation8. August 25th Gut and Methylation9. September 1st Allergies and Methylation10. September 8th Methylation and Autism11. September 15th Methylation and Cancer12. September 22nd Methylation and Lyme Disease13. September 29th Methylation and Weight Concerns14. October 6th Methylation and POTS / EDS

** All webinars we be recorded and available for your listening pleasure.

HEALTHCOACH 7

Website: www.healthcoach7.com Ph: 1.425.877.0616 Fax: 425.892.2548 Email: info@healthcoach7.com

Address: 6016 NE Bothell Way Suite G Kenmore, WA 98028 Hours: Mon-Fri 0900-1700

CBS PATHWAYSource: http://www.nature.com/ejcn/journal/v59/n6/fig_tab/1602138f1.html

CBS