D ETOXIFICATION & M ETHYLATION Dr. Jeff Thomas. H EALTH C OACH 7 M ETHYLATION W EBINAR S ERIES T IME...
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Transcript of D ETOXIFICATION & M ETHYLATION Dr. Jeff Thomas. H EALTH C OACH 7 M ETHYLATION W EBINAR S ERIES T IME...
DETOXIFICATION & METHYLATIONDr. Jeff Thomas
HEALTHCOACH7 METHYLATION WEBINAR SERIESTIME: 4-430PM PST
1. July 7th Metabolism and Methylation2. July 14th Immunity and Methylation3. July 21st Inflammation and Methylation4. July 28th Detoxification and Methylation5. August 4th Hormones and Methylation6. August 11th Brain and Methylation7. August 18th SNPs and Methylation8. August 25th Gut and Methylation9. September 1st Allergies and Methylation10. September 8th Methylation and Autism11. September 15th Methylation and Cancer12. September 22nd Methylation and Lyme Disease13. September 29th Methylation and Weight Concerns14. October 6th Methylation and POTS / EDS
** All webinars we be recorded and available for your listening pleasure.
OVERVIEW
What is detoxification? How do methylation and detoxification
relate? Where does our body perform detoxification? How does our liver perform detox? How does detoxification become impaired? Complications of impairment? Genetic mutations and detoxification Detox Treatment Recommendations
WHAT IS DETOXIFICATION?
Process by which our liver alters various harmful substances that come from outside and inside our bodies, into a form your body can safely eliminate.
METHYLATION & DETOXIFICATION
Source: http://www.hindawi.com/journals/aurt/2013/963697.fig.002.jpg
ORGANS THAT PERFORM DETOXIFICATION
Source: http://www.lytnyc.com/wp-content/uploads/2012/04/CNA-9_112.jpg
LIVER DETOXIFICATION
Source: http://www.tuberose.com/Graphics/liver-detox-pathway2.jpg
VARIOUS WAYS LIVER DETOXIFICATION CAN BECOME IMPAIRED
Source: http://nourishholisticnutrition.com/wp-content/uploads/Liver.png
SYMPTOMS OF IMPAIRED DETOXIFICATION
Lethargy, fatigue (especially upon rising) Insomnia, difficulty falling asleep Headaches, migraines Skin issues: acne, boils, rashes Digestive: bloating, gas, nausea, abdominal pain Cognitive: poor concentration and memory, brain
fog General lack of well-being, malaise Excessive storage of adipose tissue, fatty liver,
gallstones Moodiness, irritability, depression, anxiety Poor physical balance and fine motor skills,
trembling
GENOMIC MEDICINE & DETOXIFICATION
INTERACTION BETWEEN GENE/SNP VARIANTS AND PHASE 1 & 2 DETOXIFICATION
Phase 1: CYP1/CYP2. These genes can be either increased or
decreased based on SNP variations.
Clinical Concerns: Increased lipid peroxidation. Think of it as free
radicals reeking havoc leading to cell damage. Consequences can alter DNA synthesis and/or be
carcinogenic.
PHASE 1 & 2 RELATED SNPS
Phase 1: CYP1 CYP2
Phase 2: GPX3 GSTM1 (Glutathione transferases) GSTP1 NAT 1/2 (Acetylation) SOD 2/3 (Superoxide dismutase) PON1 (Paraoxonases)
GENES INVOLVED IN DETOXIFICATION
Source: www.genecards.org
HEALTHCOACH7 PERSONALIZED GENETIC REPORT
METHYLATION & DETOXIFICATION PATHWAYS
Source: www.consultdra.com
TREATMENT APPROACHES
“Can’t supplement a shitty diet.” Assess/Optimize Pillars of Health
Nutrition Physical activity Stress Management Hydration Sleep
Optimize pathways of elimination Depuration Therapies
Nutritional Support Outside-In approach Well-balanced
ORDER OF PRIORITIES
“A.L.T.O.S” ASSESS Sn/Sx and SNP’s Start LOW and work up Treat the patient not just the SNP’s. Treat from the OUTSIDE in. Monitor SNS/SX to adjust therapy.
REFERENCES Chan, K., X.-D. Han, and Y. W. Kan. "An Important Function of Nrf2 in
Combating Oxidative Stress: Detoxification of Acetaminophen." Proceedings of the National Academy of Sciences 98.8 (2001): 4611-616. Web
http://geneticgenie.org/blog/2013/02/02/why-support-methylation-and-detoxification-our-ancestors-didnt-need-to/
http://phoenixrising.me/research-2/glutathione-depletionmethylation-blockades-in-chronic-fatigue-syndrome/glutathione-depletion-methylation-cycle-block-a-hypothesis-for-the-pathogenesis-of-chronic-fatigue-syndrome-by-richard-a-van-konynenbury-ph-d
Polymorphisms in Genes Encoding Drugs and Xenobiotic Metabolizing Enzymes, DNA Repair Enzymes, and Response to Treatment of Childhood Acute Lymphoblastic LeukemiaMaja Krajinovic, Damian Labuda, Geraldine Mathonnet, Marcin Labuda, Albert Moghrabi, Josette Champagne, and Daniel SinnettClin Cancer Res March 2002 8:802-810
Shimada, Tsutomu. "Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons." Drug metabolism and pharmacokinetics 21.4 (2006): 257-276.
Crinnion, Walter J. "Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant-induced and other chronic health problems." Alternative medicine review: a journal of clinical therapeutic 16.3 (2011): 215-225.
Muthusamy, Ramya Chellemmal. "DNA Repair." Journal of Pharmaceutical Sciences and Research 5.11 (2013): 213-15. Web.
QUESTIONS??
Source: https://tstoaddicts.files.wordpress.com/2013/08/simpsons-questions.gif
HEALTHCOACH7 METHYLATION WEBINAR SERIESTIME: 4-430PM PST
1. July 7th Metabolism and Methylation2. July 14th Immunity and Methylation3. July 21st Inflammation and Methylation4. July 28th Detoxification and
Methylation5. August 4th Hormones and Methylation6. August 11th Brain and Methylation7. August 18th SNPs and Methylation8. August 25th Gut and Methylation9. September 1st Allergies and Methylation10. September 8th Methylation and Autism11. September 15th Methylation and Cancer12. September 22nd Methylation and Lyme Disease13. September 29th Methylation and Weight Concerns14. October 6th Methylation and POTS / EDS
** All webinars we be recorded and available for your listening pleasure.
HEALTHCOACH 7
Website: www.healthcoach7.com Ph: 1.425.877.0616 Fax: 425.892.2548 Email: [email protected]
Address: 6016 NE Bothell Way Suite G Kenmore, WA 98028 Hours: Mon-Fri 0900-1700
CBS PATHWAYSource: http://www.nature.com/ejcn/journal/v59/n6/fig_tab/1602138f1.html
CBS