CONTRIBUTORS*Presenting authors to whom correspondence should be addressed.

Almon, Richard R.State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Biological Sciences565 Hochstetter Hall, North CampusBuffalo, NY 14260(716) 645-2888almon@acsu.buffalo.edu

Andersson, Borje S.The University of TexasDepartment of Blood and Marrow TransplantationM. D. Anderson Cancer CenterHouston, Texas 77030(713) 794-5743bandersson@mdanderson.org

Bauer, Robert J.*XOMA (US) LLC2910 Seventh StreetBerkeley, CA 94710(510) 204-7562bauer@xoma.com

Danhof, Meindert *Leiden/Amsterdam Center for Drug ResearchLeiden UniversityEinsteinweg 55P.O. Box 95022300RA LeidenTHE NETHERLANDS+31 71 5276211m.danhof@lacdr.leidenuniv.nl

296

D’Argenio, David Z. *University of Southern CaliforniaBiomedical Engineering3650 McClintock AvenueOlin Hall 500Los Angeles, CA 90089-1451(213) 740-0341dargenio@bmsr.usc.edu

DuBois, Debra C.State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Pharmaceutical Sciences &Department of Biological Sciences117 Hochstetter HallBuffalo, NY 14260(716) 645-2363 x.114dubois@nsm.buffalo.edu

Egorin, Merrill J.University of Pittsburgh Cancer Institute5117 Centre AvenueG27E Hillman Research PavilionPittsburgh, PA 15213-1863(412) 623-3252egorinmj@msx.upmc.edu

Eiseman, Julie L.University of Pittsburgh Cancer Institute5117 Centre AvenueG27B Hillman Research PavilionPittsburgh, PA 15213-1863(412) 623-3239eisemanj@msx.upmc.edu

Granneman, Rick G.Abbott LaboratoriesGlobal Pharmaceutical Research & Development100 Abbott Park RoadAbbott Park, IL 60064-6104(847) 937-7478rick.g.granneman@abbott.com

297

Guzy, SergeXOMA (US) LLC2910 Seventh StreetBerkeley, CA 94710(510) 204-7476guzy@xoma.com

Harrold, John M.University of PittsburghSchool of EngineeringDepartment of Chemical and Petroleum Engineering1249 Benedum HallPittsburgh, PA 15261(412) 624-9630jmh17@pitt.edu

Hsu, Ann*Impax Laboratories30831 Huntwood Ave.Hayward, CA 94544(510) 476-2016annhsu@impaxlabs.com

Huang, YangxinUniversity of Rochester School of Medicine and DentistryDepartment of Biostatistics and Computational Biology601 Elmwood Avenue, Box 630Rochester, NY 14642(585) 275-0319yhuang@bst.rochester.edu

Jin, Jin. Y.State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Pharmaceutical Sciences565 Hochstetter Hall, North CampusBuffalo, NY 14260(716) 645-2842 ext. 236jinyan@buffalo.edu

298

Joseph, ErinUniversity of Pittsburgh Cancer InstituteMolecular Therapeutics and Drug Discovery ProgramPittsburgh, PA 15213(412) 623-1015erk5@pitt.edu

Jusko, William J.*State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Pharmaceutical Sciences565 Hochstetter Hall, North CampusBuffalo, NY 14260(716) 645-2855 ext. 225wjjusko@buffalo.edu

Kang, Dongwoo *ALZA CorporationClinical Pharmacology1950 Charleston Road M11-4089Mountain View, CA 94043(650) 564-5211dkang@alzus.jnj.com

Kang, WonkuInje UniversityCollege of MedicinePharmacogenomics Research Center633-165, Gaegum-Dong, Jin-GuBusanSOUTH KOREA+82-51-890-6413kang@inje.ac.kr

Madden, TimothyDivision of PharmacyThe University of TexasM. D. Anderson Cancer CenterHouston, Texas 77030(713) 745-3040tmadden@mdanderson.org

299

Müller, PeterThe University of TexasDepartment of BiostatisticsM. D. Anderson Cancer CenterHouston, Texas 77030(713) 745-4937pm@odin.mdacc.tmc.edu

Pang, K. Sandy *University of TorontoDepartment of Pharmaceutical SciencesFaculty of Pharmacy19 Russell StreetToronto, Ontario M5S 2S2CANADA(416) 978-6164pang@phm.utoronto.ca

Park, KyungsooD-quarto#201Daeshin-dong 126-36Seoul, SeodaemooKOREA018-278-6922pkyungs@chollian.net

Parker, Robert S. *University of PittsburghSchool of EngineeringDepartment of Chemical and Petroleum Engineering1249 Benedum HallPittsburgh, PA 15261(412) 624-7364rparker@pitt.edu

Poland, BillPharsight Corporation800 W. El Camino Real, Suite 200Mountain View, CA 94040(650) 314-3841bpoland@pharsight.com

300

Ramanathan, Murali *State University of New York at BuffaloDepartment of Pharmaceutical Sciences543 Cooke HallBuffalo, NY 14260-1200(716) 645-2842 ext. 242murali@acsu.buffalo.edu

Rodman, John H.St. Jude Children’s Research HospitalPharmaceutical Department332 North Lauderdale, MS 150Memphis, TN 38105-2794(901) 495-3686john.rodman@stjude.org

Robbins, Brian L.St. Jude Children’s Research HospitalPharmaceutical Department332 North LauderdaleMemphis, TN 38105-2794(901) 495-3686

Rosner, Gary L. *The University of TexasDepartment of BiostatisticsM. D. Anderson Cancer Center1515 Holcombe BoulevardHouston, Texas 77030(713) 794-1798glr@odin.mdacc.tmc.edu

Schumitzky, AlanUniversity of Southern CaliforniaDepartment of MathematicsDRB 262Los Angeles, CA 90089-1113(213) 740-2392schum@math.usc.edu

301

Strychor, SandraUniversity of Pittsburgh Cancer InstituteMolecular Therapeutics and Drug Discovery ProgramPittsburgh, PA 15213(412) 623-3227sas18@pitt.edu

Sun, EugeneAbbott LaboratoriesGlobal Pharmaceutical Research & Development200 Abbott Park Road, Dept. R435, Bldg. LFCP4-4Abbott Park, IL 60064-6229(847) 938-2421Eugene.Sun@Abbott.com

Tang, FengThe University of TexasDepartment of BiostatisticsM. D. Anderson Cancer CenterHouston, Texas 77030(713) 745-4935ftang@odin.mdacc.tmc.edu

van der Graaf, Piet H.Pfizer Ltd.Discovery Biology IPC 619Sandwich, KentC13 9NJUNITED KINGDOM+44 1304 648 330piet-van-der-graaf@sandwich.pfizer.com

Verotta, DavideUniversity of California, San FranciscoSchool of MedicineDepartment of Biopharmaceutical Sciences513 ParnassusSan Francisco, CA 94143-0446(415) 476-1556davide@areill.ucsf.edu

302

Visser, Sandra A.G.Astra Zeneca R&D SödertäljeDMPK & BAC, PK/PDS-15185 SödertäljeSWEDEN+ 46 8 553 24436sandra.visser@astrazeneca.com

Wada, RussPharsight Corporation800 W. El Camino Real, Suite 200Mountain View, CA 94040(650) 314-3853rwada@pharsight.com

Weiss, Michael *Martin Luther University Halle-WittenbergDepartment of PharmacologySection of PharmacokineticsD-06097 Halle/SaaleGERMANY+49 345-557-1657michael.weiss@medizin.uni-halle.de

Wu, Hulin *University of Rochester School of Medicine and DentistryDepartment of Biostatistics and Computational Biology601 Elmwood Avenue, Box 630Rochester, NY 14642(585) 275-6767hwu@bst.rochester.edu

Xu, LuNovartis Institute of Biomedical Research400 Technology Square 7-130Cambridge, MA 02138(617) 871-3372lu.xu@pharma.novartis.com

303

Zamboni, William C.University of PittsburghSchool of PharmacyDepartment of Pharmaceutical SciencePittsburgh, PA 15261(412) 623-1215zamboniw@pitt.edu

Zhang, AidongState University of New York at BuffaloDepartment of Computer Science and EngineeringBell HallBuffalo, NY 14260(716) 645-3180 ext. 124azhang@cse.buffalo.edu

Zhang, LiState University of New York at BuffaloDepartment of Computer Science and EngineeringBell HallBuffalo, NY 14260(716) 645-3180 ext. 142LiZhang@cse.buffalo.edu

Zhou, ZexunUniversity of Southern CaliforniaBiomedical Engineering3650 McClintock AvenueOlin Hall 500Los Angeles, CA 90089-1451zexunzho@usc.edu

Zuideveld, Klaas P.F. Hoffmann-La RocheClinical PharmacologyPDMP, 15/1.030Grenzacherstrasse 124CH-4070 BaselSWITZERLAND+ 41 61 688 1756klaas.zuideveld@roche.com

PARTICIPANTS

Agoram, BalajiAmgen, Inc.1 Amgen Center DriveMS 30-E-0BThousand Oaks, CA 91320BAgoram@amgen.com

Al-Huniti, NidalUniversity of IowaCollege of PharmacyS232 Pharmacy BuildingIowa City, IA 52242nidal-al-huniti@uiowa.edu

Ariano, RobertSt. Boniface General HospitalDepartment of Pharmacy409 Tache AvenueWinnipeg, Manitoba R2H 2A6CANADArariano@sbgh.mb.ca

Balan, GuhanCovance Clinical Research Inc.309 W. Washington AvenueSuite #4EMadison, WI 53703guhan.balan@covance.com

Balius, Trent521 N. Main StreetGreensburg, PA 15601

Beringer, PaulUniversity of Southern CaliforniaSchool of Pharmacy1985 Zonal AvenueLos Angeles, CA 90089-9121beringer@usc.edu

Best, BrookieUC, San DiegoPediatric Pharm. Res. Unit9500 Gilman Drive MC 0979La Jolla, CA 92093-0979brookie@ucsd.edu

Bies, Robert R.University of Pittsburgh805 N Salk HallSchool of PharmacyPittsburgh, PA 15213biesrr@msx.upmc.edu

Bigos, Kristin L.University of Pittsburgh806 Salk HallPittsburgh, PA 15261klb110@pitt.edu

Blanchard, Marie SuzetteFrontier Science Foundation1244 Boylston Street, Suite 303Chestnut Hill, MA 02467suzette@sdac.harvard.edu

Bourne, DavidUniversity of OklahomaHealth Sciences CenterCollege of Pharmacy1110 N. Stonewall AvenueOklahoma City, OK 73117david-bourne@ouhsc.edu

Brundage, Richard C.University of MinnesotaCollege of Pharmacy, WDH 7-151308 Harvard Street, SEMinneapolis, MN 55455brund001@umn.edu

306

Brundage, DiannePark Nicollet Health ServicesMethodist Hospital Pharmacy6500 Excelsior BoulevardMinneapolis, MN 55426brundd@parknicollet.com

Burckart, GilbertUniversity of Southern CaliforniaSchool of Pharmacy1985 Zonal Avenue, PSC-100Los Angeles, CA 90033burckart@usc.edu

Capparelli, EdmundUC, San DiegoPediatric Pharmacology ResearchUnit9500 Gilman Drive, M/C 0979La Jolla, CA 92093-0979ecapparelli@ucsd.edu

Chan, Kenneth K.The Ohio State UniversityCollege of Pharmacy308 Comp. Cancer Center410 West 12th AvenueColumbus, OH 43210chan.56@osu.edu

Charusanti, PepUCLABiocybernetics Dept.405 Hilgard Ave.Los Angeles, CA 90095pep@chem.ucla.edu

Chen, DannyPurdue Pharma44 Rosemere AvenueFairfield, CT 06825dchen500@yahoo.com

Chen, CliffBristol-Myers Squibb Co.Rt.206 with ProvincelineF1.3103Princeton, NJ 08543cliff.chen@bms.com

Chen, GraceProcter and GamblePharmaceuticals8700 Mason Montgomery RoadMason, OH 45040chen.g.5@pg.com

Chittenden, JasonSimulations Plus, Inc.1220 W. Avenue J.Lancaster, CA 93534jason@simulations-plus.com

Csajka, Chantal1318 7th AvenueSan Francisco, CA 94122chantal@ariel1.ucsf.edu

Danhof, MeindertLeiden UniversityLeiden/Amsterdam Center forDrug ResearchEinsteinweg 55P.O. Box 95022300RA LeidenNETHERLANDSm.danhof@lacdr.leidenuniv.nl

Dao, Le N.Genentech, Inc.1 DNA WayMail Stop 70South San Francisco, CA94080-4990le1@gene.com

307

D’Argenio, David Z.University of Southern CaliforniaBiomedical EngineeringOlin Hall 500Los Angeles, CA 90089-1451dargenio@bmsrs.usc.edu

Desai, AmitUniversity of Pacific, Stockton504 Northbank Cts, #129Stockton, CA 95207adesai@uop.edu

DiStefano III, Joseph9878 Easton DriveBeverly Hills, CA 90210joed@cs.ucla.edu

Doshi, SameerAmgen, Inc.1 Amgen Center DriveThousand Oaks, CA 91320sdoshi@amgen.com

Ducharme, Murray P.MDS Pharma Services2350 Cohen StreetMontreal, Quebec H4R 2N6CANADAmurray.ducharme@mdsps.com

Eiseman, Julie L.UPCI Research PavilionThe Hillman Cancer Center5117 Center Avenue, G27bPittsburgh, PA 15213-1863eisemanj@msx.upmc.edu

Eisenberg, Marisa1435 El Miradero AvenueGlendale, CA 91201mystech@ucla.edu

Endrenyi, LaszloUniversity of TorontoDepartment of PharmacologyMedical Sciences BuildingToronto, Ontario M5S 1A8CANADAl.tothfalusi@utoronto.ca

Eppler, SteveGenentech, Inc.1 DNA WaySouth San Francisco, CA 94080eppler@gene.com

Erlandsen, MogensUniversity of AarhusDepartment of BiostatisticsVennelyst Boulevard 6Aarhus C 8000DENMARKmogens@biostat.au.dk

Fabian, Tanya J.University of Pittsburgh806 Salk HallPittsburgh, PA 15261fabiant@msx.upmc.edu

Feng, YanUniversity of Pittsburgh904 Salk HallPittsburgh, PA 15261yaf2@pitt.edu

Ferl, Gregory Z.6130 Coldwater Cyn. Avenue, #9North Hollywood, CA 91606gzferl@ucla.edu

308

Floares, AexandruOncological InstituteStr. Republicii, Nr. 34-363400, Cluj-NapocaROMANIAalexandru-floares@xnet.ro

Florian, JeffUniversity of PittsburghChemical Engineering Department1249 Benedum HallPittsburgh, PA 15232jaf8@pitt.edu

Forrest, AlanSUNY-Buffalo School ofPharmacyDepartment of Pharmacy Practice233 Cooke HallBuffalo, NY 14260Forrest@Buffalo.edu

Frye, Reginald F.University of PittsburghSchool of Pharmacy807 Salk HallPittsburgh, PA 15261rfrye@pitt.edu

Fuller, Tova1921 Beloit Avenue #1Los Angeles, CA 90025tova@seas.ucla.edu

Gastonguay, Marc R.Gastonguay Consulting LLC3 Winterset LaneSimsbury, CT 06070marc.gastonguay@snet.net

Geary, RichardISIS Pharmaceuticals2292 Faraday AvenueCarlsbad, CA 92008rgeary@isisph.com

Gershman, Jason AndrewRice UniversityDepartment of StatisticsMS-138Houston, TX 77251-1892jgersh@rice.edu

Grenier, JulieMDS Pharma Services2350 Cohen StreetMontreal, Quebec H4R 2N6CANADAjulie.grenier@mdsps.com

Guzy, SergeXoma (US) LLC2910 Seventh StreetBerkeley, CA 94710guzy@xoma.com

Han, Emily2123 N. Rodney Drive #312Los Angeles, CA 90027eehan@usc.edu

Harrell, RoyAmgen, Inc.1 Amgen Center DriveThousand Oaks, CA 91320rharrell@amgen.com

Harrold, JohnUniversity of Pittsburgh1249 Benedum HallPittsburgh, PA 15261jmh17@pitt.edu

309

Heatherington, Anne C.Amgen Inc.One Amgen Center DriveMS 30E-O-BThousand Oaks, CA 91320anneh@amgen.com

Hirankarn, Sarapee4107 Chester Avenue, #2JPhiladelphia, PA 19104shirankarn@hotmail.com

Hori, SharonUCLABiomedical EngineeringLos Angeles, CA 90024seiko24@ucla.edu

Houk, Brett E.Amgen Inc.1 Amgen Center DriveMail stop 1-1-AThousand Oaks, CA 91320bhouk@amgen.com

Hoyo-Vadillo, CarlosFarmacologia, Cinvestav, IPNDept. of PharmacologyAv. IPN 2508PO BOX 14100Mexico City 07360MEXICOcarlos@mail.cinvestav.mx

Hsiai, Tzung K.University of Southern CaliforniaBiomedical Engineering3650 McClintock AvenueOlin Hall 530ALos Angeles, CA 90089-1451hsiai@usc.edu

Hsu, Joy C.University of Southern CaliforniaPO Box 7004Los Angeles, CA 90007joyhsu@usc.edu

Hsu, AnnIMPAX Labs30831 Huntwood AvenueHaywood, CA 94544annhsu@impaxlabs.com

Huang, YangxinFrontier Science & TechnologyResearch Foundation1244 Boylston Street, Suite 303Chestnut Hill, MA 02467huang@fstrf.dfci.harvard.edu

Huang, FengleiBoehringer IngelheimPharmaceuticals, Inc.P.O. Box 368900 Ridgebury RoadRidgefield, CT 06877fhuang@rdg.boehringer-ingelheim.com

Jumbe, Nelson L.XenoPort Inc.3410 Central ExpresswaySanta Clara, CA 95051shasha@xenoport.com

Jusko, William J.University at Buffalo/SUNYDepartment of PharmaceuticalSciences565 Hochstetter HallBuffalo, NY 14260wjjusko@acsu.buffalo.edu

310

Kaila, NitinUniversity of MinnesotaDepartment of Experimental andClinical Pharmacology308 Harvard St. SE7-192 WDHMinneapolis, MN 55455kail0004@umn.edu

Kambhampati, PrasadMDS Pharma Services621 Rose StreetLincoln, NE 68502Prasad.Kambhampati@mdsps.com

Kang, DongwooALZA CorporationClinical Pharmacology1950 Charleston RoadMountain View, CA 94043dongwoo.kang@alza.com

Kern, Steven E.University of UtahDepartment of Pharmaceutics421 Wakara Way, Suite 318Salt Lake City, UT 84108skern@remi.med.Utah.edu

Kiffer, Carlos R.V.University of So PauloDepartment of Infectious DiseasesAlameda dos Guaicanas 984 -Planalto PaulistaSo Paulo 04064-031BRAZILkiffer@uninet.com.br

Kuchimanchi, KameshAmgen Inc.One Amgen Center DriveM/S 30E-0-BThousand Oaks, CA 91320kameshk@amgen.com

Labbe, LineUC, San FranciscoNONMEM Group521 ParnassusRoom C-255, Box 0626San Francisco, CA 94143line@c255.ucsf.edu

Landaw, Elliot M.UCLASchool of MedicineDepartment of Biomathematics10833 Le Conte Avenue Box951766Los Angeles, CA 90095-1766elandaw@biomath.medsch.ucla.edu

Lavigne, JeanMDS Pharma Services2350 Cohen StreetMontral, Qubec H4R 2N6CANADAjean.lavigne@mdsps.com

Lee, Jason515 Kelton Avenue #326Los Angeles, CA 90024virgil@ucla.edu

311

Lee, Kyoung-JuneChoongwae Pharma Corp.146-141, Annyung-Ri, Tae-Ub,Hwasung-SiKyunggi-DoHwasung, Kyunggi 445-976KOREAkjunlee@cwp.co.kr

Levi, MichaUC, San FranciscoBox 0626San Francisco, CA 94143-0626micha@c255.ucsf.edu

Lin, Jane Marie1921 Beloit Avenue, Apt. 1Los Angeles, CA 90025wackjane@ucla.edu

Luo, F. RogerBristol-Myers Squibb CompanyP.O. Box 4000Princeton, NJ 08543rogar.luo@bms.com

Luu, Kenneth T.University of the Pacific2191 Piccardo CircleStockton, CA 95207kennethlu@hotmail.com

Magee, MindyGlaxoSmithKline709 Swedeland Road, UW27-10King of Prussia, PA 19406mindy.2.magee@gsk.com

Mager, Donald E.National Institute on AgingGerontology Research Center5600 Nathan Shock DriveBaltimore, MD 21224magerdo@grc.nia.nih.gov

McCune, JeannineUniversity of WashingtonDepartment of Pharmacy1959 NE Pacific Street H361EBox 357630Seattle, WA 98195-7630jmccune@u.washington.edu

Mendes, CaioFleury Medical Diagnostic CenterRua Domingos Fernandes 230apto 41Sao Paulo 04509-010BRAZILcaio.mendes@fleury.com.br

Mills, Jonathan A.Symyx Therapeutics, Inc.3100 Central ExpresswaySanta Clara, CA 95051jmills@symyx.com

Nasser, Azmi2924 Bywater DriveRichmond, VA 23233anasser@hsc.vcu.edu

Newman, Edward M.Beckman Research InstituteCity of Hope1450 East Duarte RoadFox North Room 2000Duarte, CA 91010-3000enewman@coh.org

312

Ng, CheeGenentech1400 GrandviewMail stop 70South San Francisco, CA 94080cheeng@gene.com

Nguyen, Linh ThuyAmgen Inc.Department of Pharmacokineticsand DrugMetabolismOne Amgen Center DriveThousand Oaks, CA 91320lnguyen@amgen.com

Panetta, John CarlSt. Jude Children’s ResearchHospitalDept. of Pharmaceutical Sci.332 North Lauderdale StreetMemphis, TN 38105-2794carl.panetta@stjude.org

Pang, K. SandyUniversity of TorontoFaculty of Pharmacy19 Russell StreetToronto Ontario M5S 2S2CANADApang@phm.utoronto.ca

Park, SunwonKorea Advanced Institute ofScience and TechnologyDepartment of Chemical andBiomolecular Engineering373-1 Guseong-dong, Yuseong-guDaejeon 305-701SOUTH KOREAsunwon@kaist.ac.kr

Parker, Robert S.University of PittsburghDepartment of Chemical andPetroleum Engineering1249 Benedum HallPittsburgh, PA 15261rparker@pitt.edu

Pelsor, Francis R.Food & Drug Administration5600 Fishers LaneHFD-880Rockville, MD 20877pelsor@cder.fda.gov

Persky, Adam M.University of North Carolina5111-103 Copper Ridge DriveDurham, NC 27707apersky@nc.rr.com

Peterson, Mark C.Amgen Inc.One Amgen Center Drive , MS30E-0-BThousand Oaks, CA 91320markp@amgen.com

Raber, SusanPfizer Global Research &Development11085 Torreyana RoadSan Diego, CA 92121susan.raber@pfizer.com

Racine-Poon, AmyNovartis Pharma Inc.WSJ 27 1013Basel CH 4001SWITZERLANDany.racine@pharma.novartis.com

313

Ramanathan, MuraliUniversity at Buffalo/SUNYDepartment of PharmaceuticalSciences543 Cooke HallBuffalo, NY 14260murali@acsu.buffalo.edu

Rhee, Sarah1536 Via Del ReySouth Pasadena, CA 91030Sarhee@mit.edu

Rodman, JohnSt. Jude Children’s ResearchHospitalPharmaceutical Department332 North LauderdaleMS 150Memphis, TN 38105-2794john.rodman@stjude.org

Rodvold, Keith A.University of Illinois at ChicagoCollege of Pharmacy, M/C 886833 South Wood Street, Room 164Chicago, IL 60612-7230kar@uic.edu

Rosner, Gary L.M.D. Anderson Cancer CenterUniversity of TexasDepartment of Biostatistics1515 Holcombe Blvd., #447Houston, TX 77030glr@odin.mdacc.tmc.edu

Rovetti, Robert J.511 S. El Molino #1Pasadena, CA 91101rrovetti@ucla.edu

Sale, MarkGlaxoSmithKline5 Moore DriveResearch Triangle Park, NC 27614mark.e.sale@gsk.com

Sawchuk, Ronald J.University of MinnesotaDepartment of PharmaceuticsWeaver-Densford Hall, Room9-143308 Harvard St., SEMinneapolis, MN 55455sawch001@umn.edu

Song, IvyGlaxoSmithKline5 Moore DriveMail stop 17.1354C.1CResearch Triangle Park, NC 27709ivy.h.song@gsk.com

Song, Daniel5640 Andrus AvenueTorrance, CA 90503song@ugcs.caltech.edu

Steinbach, Joseph H.UC, San DiegoHillcrest Medical Center 8414200 W. Arbor DriveSan Diego, CA 92103-8414jsteinbach@ucsd.edu

Synold, Timothy W.City of Hope Medical Center1500 East Duarte RoadDuarte, CA 91010tsynold@coh.org

314

Tabrizi, MohammadAbgenix Inc.6701 Kaiser Drive Ms 23Fremont, CA 94555mohammd.tabrizi@abgenix.com

Tam, Vincent H.University of HoustonCollege of Pharmacy1441 Moursund StreetHouston, TX 77030vtam@uh.edu

Teja-Isavadharm, PaktiyaArmed Forces Research Instituteof Medical Sciences315/6 Rajvithi RoadPhayathaiBangkok 10400THAILANDpaktiyat@thai.amedd.army.mil

Tibbitts, JayXOMA LLC2910 Seventh StreetBerkeley, CA 94710tibbitte@xoma.com

Tretriluxana, Jarugool3828 Ingraham Street #322Los Angeles, CA 90005tretrilu@usc.edu

Tretriluxana, Suradej3828 Ingraham Street #322Los Angeles, CA 90005stretril@usc.edu

Uchizono, JimUniversity of the PacificTJ Long School of Pharmacy751 Brookside RoadStockton, CA 95211juchizono@uop.edu

Veng-Pedersen, PeterUniversity of IowaCollege of PharmacyRoom 118Iowa City, IA 52242veng@uiowa.edu

Venitz, JurgenVirginiaCommonwealthUniv.Department of PharmaceuticsSchool of PharmacyRoom 450B, R.B. Smith Building410 N 12th StreetP.O. 980533Richmond, VA 23298-0533jvenitz@vcu.edu

Wang, Xiaoning1210 W. 28th Street #16Los Angeles, CA 90007xiaoninw@usc.edu

Weiss, MichaelMartin Luther UniversityHalle-WittenbergDepartment of PharmacologySection of PharmacokineticsD-06097 Halle/SaaleGERMANYmichael.weiss@medizin.uni-halle.de

315

Whitfield, LloydPfizer Global Research andDevelopment2800 Plymouth RoadBuilding 50/M345Ann Arbor, MI 48105lloyd.whitfield@pfizer.com

Williams, Paul JamesUniversity of the PacificSchool of Pharmacy3601 Pacific AvenueStockton, CA 95211cpkmann@aol.com

Woodworth, James R.Vertex Pharmaceuticals130 Waverly StreetCambridge, MA 02139james-woodworth@vrtx.com

Wu, BenjaminGenentech Inc.1 DNA WayMail Stop 70South San Francisco, CA 94080wube@gene.com

Wu, HulinFrontier Science & TechnologyResearch Foundation, Inc.1244 Boylston Street, Suite 303Chestnut Hill, MA 02467wu@sdac.harvard.edu

Xiao, JimOhio State UniversityCollege of Pharmacy500 W 12th AvenueColumbus, OH 43210xiao.25@osu.edu

Xu, LuNovartis Institute of BiomedicalResearch400 Technology Square7-130Cambridge, MA 02138lu.xu@pharma.novartis.com

Xu, Christine R.Ribapharm Inc.3300 Hyland AvenueCosta Mesa, CA 92626crxu@ribapharm.com

Yang, Bing-BingAmgen Inc.One Amgen Center DrivePharmacokinetics and DrugMetabolism30E-0-BThousand Oaks, CA 91320-1799byang@amgen.com

Yang, ZhengBristol-Myers Squibb Co.Rt. 206 and Province Line RdP.O. Box 4000Princeton, NJ 08543zheng.yang@bms.com

Yu, ZhilingAllergan, Inc.2525 Dupont Drive, RD-2BIrvine, CA 92623-9534yu-steve@allergan.com

Yu, RosieISIS Pharmaceuticals2292 Faraday AvenueCarlsbad, CA 92008ryu@isisph.com

316

Zelenitsky, SherylUniversity of ManitobaFaculty of PharmacyManitobaWinnipeg R3T 2N2CANADAzelenits@ms.umanitoba.ca

Zheng, Hong XiaUniversity of Southern CaliforniaSchool of Pharmacy1985 Zonal Avenue, PSC-100Los Angeles, CA 90033zhenghongxia29@hotmail.com

Zhou, ZexunUniversity of Southern CaliforniaBiomedical EngineeringOlin Hall 500Los Angeles, CA 90089-1451zexunzho@usc.edu

INDEX

3TC, 33–35, 37

adenosine agonists, 57adherence, 211adherence model, 214adherence rates, 216antiretroviral treatment, 221

Bayesian, 166, 225Bayesian decision theory, 240, 247, 251Bayesian inference, 105, 106, 128Bayesian MCMC, 174Bayesian nonparametric model, 242Bayesian optimal design, 247bone marrow transplantation, 240

cardiac glycosides, 67cell-cycle model, 271chemotherapy, 239, 255cluster, 92cluster analysis, 85covariates, 241CYP3A, 5CYP3A4, 10

deconvolution, 165Dirichlet process, 243Discrete Fourier Transform, 198, 204dosage design, 257dose-individualization, 251drug absorption, 3drug resistance, 221, 222drug-receptor complex, 91

Efficacy Index, 222efflux transporters, 4enterocytes, 4expectation maximization, 135exposure response, 49

GABAA agonists, 59gastrointestinal motility, 10geldanamycin, 106gene expression, 197

genomic effects, 87glucocorticoid receptor, 85

HAART, 211, 224heat shock protein, 107, 119hepatic metabolism, 117heterogeneous receptor, 71hierarchical, 241high-dose chemotherapy, 251HIV, 211HIV dynamics, 221HIV therapy, 218HIV virions, 223homeostatic feedback, 54HSP auto-regulation, 127

importance sampling, 140inhibitory quotients, 212intestinal enzymes, 8intestinal metabolism, 9intestinal modeling, 11intestinal segments, 8intestinal transporters, 3, 6, 7intrinsic activity, 51intrinsic clearance, 118, 125intrinsic clearances, 18

kinases, 36, 45

lamivudine, 33, 45ligand-receptor, 71linear system, 165linearized approximation, 138loss function, 247

Markov chain Monte Carlo, 165, 225Mct1, 5mean residence time, 17metropolis-hastings, 166microarray, 100microarray study, 89microsomes, 117mixed-effect model, 222mixture of normals, 242

318

model-based adjustment, 256model-based optimization, 273Monte Carlo, 135Monte Carlo integration, 139mRNA measurements, 87MRP2, 4, 6MRP3, 5, 6MRP4, 46multi-modal distributions, 241multidrug transporter, 4mutation, 218

non-compliance, 221nucleoside, 211nucleoside analog, 33

opioid receptor agonists, 57optimal dose, 240oral drug absorption, 4

P-glycoprotein, 4, 6, 11107, 121

p53, 107perfusion-limited, 110pharmacogenomics, 85, 86phosphorylation, 33, 36, 43–45population pharmacokinetic, 135postreceptor events, 71, 77predictive distribution, 247protease inhibitors, 212, 221

Raf-1, 107, 119, 121, 127receptor density, 53receptor heterogeneity, 67, 76

receptor occupation, 70receptor subtypes, 81receptor theory, 50, 52, 61resistance, 211, 218reverse transcriptase inhibitor, 221

scaled-up, 67segregated flow model, 13, 14, 16self-organizing maps, 206serotonin receptor agonists, 60set-point model, 55small intestine, 4sodium pump, 71stem-cell transplantation, 251steroid membrane receptors, 97system pharmacology, 100systemic exposure, 240

T cells, 214tolerance, 54transcriptional activity, 122transcriptional control, 86transducer function, 51treatment schedule design, 272triphosphates, 40, 41tumor growth, 256tumor xenograft, 126

viral dynamics, 214viral load, 218virological response, 221, 235visualization, 197

zidovudine, 33