CONTRIBUTORS - Springer978-0-306-48523-7/1.pdfCONTRIBUTORS *Presenting authors ... Agoram, Balaji...
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CONTRIBUTORS *Presenting authors to whom correspondence should be addressed. Almon, Richard R. State University of New York at Buffalo School of Pharmacy and Pharmaceutical Sciences Department of Biological Sciences 565 Hochstetter Hall, North Campus Buffalo, NY 14260 (716) 645-2888 [email protected] Andersson, Borje S. The University of Texas Department of Blood and Marrow Transplantation M. D. Anderson Cancer Center Houston, Texas 77030 (713) 794-5743 [email protected] Bauer, Robert J.* XOMA (US) LLC 2910 Seventh Street Berkeley, CA 94710 (510) 204-7562 [email protected] Danhof, Meindert * Leiden/Amsterdam Center for Drug Research Leiden University Einsteinweg 55 P.O. Box 9502 2300RA Leiden THE NETHERLANDS +31 71 5276211 [email protected]
Transcript of CONTRIBUTORS - Springer978-0-306-48523-7/1.pdfCONTRIBUTORS *Presenting authors ... Agoram, Balaji...
CONTRIBUTORS*Presenting authors to whom correspondence should be addressed.
Almon, Richard R.State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Biological Sciences565 Hochstetter Hall, North CampusBuffalo, NY 14260(716) [email protected]
Andersson, Borje S.The University of TexasDepartment of Blood and Marrow TransplantationM. D. Anderson Cancer CenterHouston, Texas 77030(713) [email protected]
Bauer, Robert J.*XOMA (US) LLC2910 Seventh StreetBerkeley, CA 94710(510) [email protected]
Danhof, Meindert *Leiden/Amsterdam Center for Drug ResearchLeiden UniversityEinsteinweg 55P.O. Box 95022300RA LeidenTHE NETHERLANDS+31 71 [email protected]
296
D’Argenio, David Z. *University of Southern CaliforniaBiomedical Engineering3650 McClintock AvenueOlin Hall 500Los Angeles, CA 90089-1451(213) [email protected]
DuBois, Debra C.State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Pharmaceutical Sciences &Department of Biological Sciences117 Hochstetter HallBuffalo, NY 14260(716) 645-2363 [email protected]
Egorin, Merrill J.University of Pittsburgh Cancer Institute5117 Centre AvenueG27E Hillman Research PavilionPittsburgh, PA 15213-1863(412) [email protected]
Eiseman, Julie L.University of Pittsburgh Cancer Institute5117 Centre AvenueG27B Hillman Research PavilionPittsburgh, PA 15213-1863(412) [email protected]
Granneman, Rick G.Abbott LaboratoriesGlobal Pharmaceutical Research & Development100 Abbott Park RoadAbbott Park, IL 60064-6104(847) [email protected]
297
Guzy, SergeXOMA (US) LLC2910 Seventh StreetBerkeley, CA 94710(510) [email protected]
Harrold, John M.University of PittsburghSchool of EngineeringDepartment of Chemical and Petroleum Engineering1249 Benedum HallPittsburgh, PA 15261(412) [email protected]
Hsu, Ann*Impax Laboratories30831 Huntwood Ave.Hayward, CA 94544(510) [email protected]
Huang, YangxinUniversity of Rochester School of Medicine and DentistryDepartment of Biostatistics and Computational Biology601 Elmwood Avenue, Box 630Rochester, NY 14642(585) [email protected]
Jin, Jin. Y.State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Pharmaceutical Sciences565 Hochstetter Hall, North CampusBuffalo, NY 14260(716) 645-2842 ext. [email protected]
298
Joseph, ErinUniversity of Pittsburgh Cancer InstituteMolecular Therapeutics and Drug Discovery ProgramPittsburgh, PA 15213(412) [email protected]
Jusko, William J.*State University of New York at BuffaloSchool of Pharmacy and Pharmaceutical SciencesDepartment of Pharmaceutical Sciences565 Hochstetter Hall, North CampusBuffalo, NY 14260(716) 645-2855 ext. [email protected]
Kang, Dongwoo *ALZA CorporationClinical Pharmacology1950 Charleston Road M11-4089Mountain View, CA 94043(650) [email protected]
Kang, WonkuInje UniversityCollege of MedicinePharmacogenomics Research Center633-165, Gaegum-Dong, Jin-GuBusanSOUTH [email protected]
Madden, TimothyDivision of PharmacyThe University of TexasM. D. Anderson Cancer CenterHouston, Texas 77030(713) [email protected]
299
Müller, PeterThe University of TexasDepartment of BiostatisticsM. D. Anderson Cancer CenterHouston, Texas 77030(713) [email protected]
Pang, K. Sandy *University of TorontoDepartment of Pharmaceutical SciencesFaculty of Pharmacy19 Russell StreetToronto, Ontario M5S 2S2CANADA(416) [email protected]
Park, KyungsooD-quarto#201Daeshin-dong 126-36Seoul, [email protected]
Parker, Robert S. *University of PittsburghSchool of EngineeringDepartment of Chemical and Petroleum Engineering1249 Benedum HallPittsburgh, PA 15261(412) [email protected]
Poland, BillPharsight Corporation800 W. El Camino Real, Suite 200Mountain View, CA 94040(650) [email protected]
300
Ramanathan, Murali *State University of New York at BuffaloDepartment of Pharmaceutical Sciences543 Cooke HallBuffalo, NY 14260-1200(716) 645-2842 ext. [email protected]
Rodman, John H.St. Jude Children’s Research HospitalPharmaceutical Department332 North Lauderdale, MS 150Memphis, TN 38105-2794(901) [email protected]
Robbins, Brian L.St. Jude Children’s Research HospitalPharmaceutical Department332 North LauderdaleMemphis, TN 38105-2794(901) 495-3686
Rosner, Gary L. *The University of TexasDepartment of BiostatisticsM. D. Anderson Cancer Center1515 Holcombe BoulevardHouston, Texas 77030(713) [email protected]
Schumitzky, AlanUniversity of Southern CaliforniaDepartment of MathematicsDRB 262Los Angeles, CA 90089-1113(213) [email protected]
301
Strychor, SandraUniversity of Pittsburgh Cancer InstituteMolecular Therapeutics and Drug Discovery ProgramPittsburgh, PA 15213(412) [email protected]
Sun, EugeneAbbott LaboratoriesGlobal Pharmaceutical Research & Development200 Abbott Park Road, Dept. R435, Bldg. LFCP4-4Abbott Park, IL 60064-6229(847) [email protected]
Tang, FengThe University of TexasDepartment of BiostatisticsM. D. Anderson Cancer CenterHouston, Texas 77030(713) [email protected]
van der Graaf, Piet H.Pfizer Ltd.Discovery Biology IPC 619Sandwich, KentC13 9NJUNITED KINGDOM+44 1304 648 [email protected]
Verotta, DavideUniversity of California, San FranciscoSchool of MedicineDepartment of Biopharmaceutical Sciences513 ParnassusSan Francisco, CA 94143-0446(415) [email protected]
302
Visser, Sandra A.G.Astra Zeneca R&D SödertäljeDMPK & BAC, PK/PDS-15185 SödertäljeSWEDEN+ 46 8 553 [email protected]
Wada, RussPharsight Corporation800 W. El Camino Real, Suite 200Mountain View, CA 94040(650) [email protected]
Weiss, Michael *Martin Luther University Halle-WittenbergDepartment of PharmacologySection of PharmacokineticsD-06097 Halle/SaaleGERMANY+49 [email protected]
Wu, Hulin *University of Rochester School of Medicine and DentistryDepartment of Biostatistics and Computational Biology601 Elmwood Avenue, Box 630Rochester, NY 14642(585) [email protected]
Xu, LuNovartis Institute of Biomedical Research400 Technology Square 7-130Cambridge, MA 02138(617) [email protected]
303
Zamboni, William C.University of PittsburghSchool of PharmacyDepartment of Pharmaceutical SciencePittsburgh, PA 15261(412) [email protected]
Zhang, AidongState University of New York at BuffaloDepartment of Computer Science and EngineeringBell HallBuffalo, NY 14260(716) 645-3180 ext. [email protected]
Zhang, LiState University of New York at BuffaloDepartment of Computer Science and EngineeringBell HallBuffalo, NY 14260(716) 645-3180 ext. [email protected]
Zhou, ZexunUniversity of Southern CaliforniaBiomedical Engineering3650 McClintock AvenueOlin Hall 500Los Angeles, CA [email protected]
Zuideveld, Klaas P.F. Hoffmann-La RocheClinical PharmacologyPDMP, 15/1.030Grenzacherstrasse 124CH-4070 BaselSWITZERLAND+ 41 61 688 [email protected]
PARTICIPANTS
Agoram, BalajiAmgen, Inc.1 Amgen Center DriveMS 30-E-0BThousand Oaks, CA [email protected]
Al-Huniti, NidalUniversity of IowaCollege of PharmacyS232 Pharmacy BuildingIowa City, IA [email protected]
Ariano, RobertSt. Boniface General HospitalDepartment of Pharmacy409 Tache AvenueWinnipeg, Manitoba R2H [email protected]
Balan, GuhanCovance Clinical Research Inc.309 W. Washington AvenueSuite #4EMadison, WI [email protected]
Balius, Trent521 N. Main StreetGreensburg, PA 15601
Beringer, PaulUniversity of Southern CaliforniaSchool of Pharmacy1985 Zonal AvenueLos Angeles, CA [email protected]
Best, BrookieUC, San DiegoPediatric Pharm. Res. Unit9500 Gilman Drive MC 0979La Jolla, CA [email protected]
Bies, Robert R.University of Pittsburgh805 N Salk HallSchool of PharmacyPittsburgh, PA [email protected]
Bigos, Kristin L.University of Pittsburgh806 Salk HallPittsburgh, PA [email protected]
Blanchard, Marie SuzetteFrontier Science Foundation1244 Boylston Street, Suite 303Chestnut Hill, MA [email protected]
Bourne, DavidUniversity of OklahomaHealth Sciences CenterCollege of Pharmacy1110 N. Stonewall AvenueOklahoma City, OK [email protected]
Brundage, Richard C.University of MinnesotaCollege of Pharmacy, WDH 7-151308 Harvard Street, SEMinneapolis, MN [email protected]
306
Brundage, DiannePark Nicollet Health ServicesMethodist Hospital Pharmacy6500 Excelsior BoulevardMinneapolis, MN [email protected]
Burckart, GilbertUniversity of Southern CaliforniaSchool of Pharmacy1985 Zonal Avenue, PSC-100Los Angeles, CA [email protected]
Capparelli, EdmundUC, San DiegoPediatric Pharmacology ResearchUnit9500 Gilman Drive, M/C 0979La Jolla, CA [email protected]
Chan, Kenneth K.The Ohio State UniversityCollege of Pharmacy308 Comp. Cancer Center410 West 12th AvenueColumbus, OH [email protected]
Charusanti, PepUCLABiocybernetics Dept.405 Hilgard Ave.Los Angeles, CA [email protected]
Chen, DannyPurdue Pharma44 Rosemere AvenueFairfield, CT [email protected]
Chen, CliffBristol-Myers Squibb Co.Rt.206 with ProvincelineF1.3103Princeton, NJ [email protected]
Chen, GraceProcter and GamblePharmaceuticals8700 Mason Montgomery RoadMason, OH [email protected]
Chittenden, JasonSimulations Plus, Inc.1220 W. Avenue J.Lancaster, CA [email protected]
Csajka, Chantal1318 7th AvenueSan Francisco, CA [email protected]
Danhof, MeindertLeiden UniversityLeiden/Amsterdam Center forDrug ResearchEinsteinweg 55P.O. Box 95022300RA [email protected]
Dao, Le N.Genentech, Inc.1 DNA WayMail Stop 70South San Francisco, [email protected]
307
D’Argenio, David Z.University of Southern CaliforniaBiomedical EngineeringOlin Hall 500Los Angeles, CA [email protected]
Desai, AmitUniversity of Pacific, Stockton504 Northbank Cts, #129Stockton, CA [email protected]
DiStefano III, Joseph9878 Easton DriveBeverly Hills, CA [email protected]
Doshi, SameerAmgen, Inc.1 Amgen Center DriveThousand Oaks, CA [email protected]
Ducharme, Murray P.MDS Pharma Services2350 Cohen StreetMontreal, Quebec H4R [email protected]
Eiseman, Julie L.UPCI Research PavilionThe Hillman Cancer Center5117 Center Avenue, G27bPittsburgh, PA [email protected]
Eisenberg, Marisa1435 El Miradero AvenueGlendale, CA [email protected]
Endrenyi, LaszloUniversity of TorontoDepartment of PharmacologyMedical Sciences BuildingToronto, Ontario M5S [email protected]
Eppler, SteveGenentech, Inc.1 DNA WaySouth San Francisco, CA [email protected]
Erlandsen, MogensUniversity of AarhusDepartment of BiostatisticsVennelyst Boulevard 6Aarhus C [email protected]
Fabian, Tanya J.University of Pittsburgh806 Salk HallPittsburgh, PA [email protected]
Feng, YanUniversity of Pittsburgh904 Salk HallPittsburgh, PA [email protected]
Ferl, Gregory Z.6130 Coldwater Cyn. Avenue, #9North Hollywood, CA [email protected]
308
Floares, AexandruOncological InstituteStr. Republicii, Nr. 34-363400, [email protected]
Florian, JeffUniversity of PittsburghChemical Engineering Department1249 Benedum HallPittsburgh, PA [email protected]
Forrest, AlanSUNY-Buffalo School ofPharmacyDepartment of Pharmacy Practice233 Cooke HallBuffalo, NY [email protected]
Frye, Reginald F.University of PittsburghSchool of Pharmacy807 Salk HallPittsburgh, PA [email protected]
Fuller, Tova1921 Beloit Avenue #1Los Angeles, CA [email protected]
Gastonguay, Marc R.Gastonguay Consulting LLC3 Winterset LaneSimsbury, CT [email protected]
Geary, RichardISIS Pharmaceuticals2292 Faraday AvenueCarlsbad, CA [email protected]
Gershman, Jason AndrewRice UniversityDepartment of StatisticsMS-138Houston, TX [email protected]
Grenier, JulieMDS Pharma Services2350 Cohen StreetMontreal, Quebec H4R [email protected]
Guzy, SergeXoma (US) LLC2910 Seventh StreetBerkeley, CA [email protected]
Han, Emily2123 N. Rodney Drive #312Los Angeles, CA [email protected]
Harrell, RoyAmgen, Inc.1 Amgen Center DriveThousand Oaks, CA [email protected]
Harrold, JohnUniversity of Pittsburgh1249 Benedum HallPittsburgh, PA [email protected]
309
Heatherington, Anne C.Amgen Inc.One Amgen Center DriveMS 30E-O-BThousand Oaks, CA [email protected]
Hirankarn, Sarapee4107 Chester Avenue, #2JPhiladelphia, PA [email protected]
Hori, SharonUCLABiomedical EngineeringLos Angeles, CA [email protected]
Houk, Brett E.Amgen Inc.1 Amgen Center DriveMail stop 1-1-AThousand Oaks, CA [email protected]
Hoyo-Vadillo, CarlosFarmacologia, Cinvestav, IPNDept. of PharmacologyAv. IPN 2508PO BOX 14100Mexico City [email protected]
Hsiai, Tzung K.University of Southern CaliforniaBiomedical Engineering3650 McClintock AvenueOlin Hall 530ALos Angeles, CA [email protected]
Hsu, Joy C.University of Southern CaliforniaPO Box 7004Los Angeles, CA [email protected]
Hsu, AnnIMPAX Labs30831 Huntwood AvenueHaywood, CA [email protected]
Huang, YangxinFrontier Science & TechnologyResearch Foundation1244 Boylston Street, Suite 303Chestnut Hill, MA [email protected]
Huang, FengleiBoehringer IngelheimPharmaceuticals, Inc.P.O. Box 368900 Ridgebury RoadRidgefield, CT [email protected]
Jumbe, Nelson L.XenoPort Inc.3410 Central ExpresswaySanta Clara, CA [email protected]
Jusko, William J.University at Buffalo/SUNYDepartment of PharmaceuticalSciences565 Hochstetter HallBuffalo, NY [email protected]
310
Kaila, NitinUniversity of MinnesotaDepartment of Experimental andClinical Pharmacology308 Harvard St. SE7-192 WDHMinneapolis, MN [email protected]
Kambhampati, PrasadMDS Pharma Services621 Rose StreetLincoln, NE [email protected]
Kang, DongwooALZA CorporationClinical Pharmacology1950 Charleston RoadMountain View, CA [email protected]
Kern, Steven E.University of UtahDepartment of Pharmaceutics421 Wakara Way, Suite 318Salt Lake City, UT [email protected]
Kiffer, Carlos R.V.University of So PauloDepartment of Infectious DiseasesAlameda dos Guaicanas 984 -Planalto PaulistaSo Paulo [email protected]
Kuchimanchi, KameshAmgen Inc.One Amgen Center DriveM/S 30E-0-BThousand Oaks, CA [email protected]
Labbe, LineUC, San FranciscoNONMEM Group521 ParnassusRoom C-255, Box 0626San Francisco, CA [email protected]
Landaw, Elliot M.UCLASchool of MedicineDepartment of Biomathematics10833 Le Conte Avenue Box951766Los Angeles, CA [email protected]
Lavigne, JeanMDS Pharma Services2350 Cohen StreetMontral, Qubec H4R [email protected]
Lee, Jason515 Kelton Avenue #326Los Angeles, CA [email protected]
311
Lee, Kyoung-JuneChoongwae Pharma Corp.146-141, Annyung-Ri, Tae-Ub,Hwasung-SiKyunggi-DoHwasung, Kyunggi [email protected]
Levi, MichaUC, San FranciscoBox 0626San Francisco, CA [email protected]
Lin, Jane Marie1921 Beloit Avenue, Apt. 1Los Angeles, CA [email protected]
Luo, F. RogerBristol-Myers Squibb CompanyP.O. Box 4000Princeton, NJ [email protected]
Luu, Kenneth T.University of the Pacific2191 Piccardo CircleStockton, CA [email protected]
Magee, MindyGlaxoSmithKline709 Swedeland Road, UW27-10King of Prussia, PA [email protected]
Mager, Donald E.National Institute on AgingGerontology Research Center5600 Nathan Shock DriveBaltimore, MD [email protected]
McCune, JeannineUniversity of WashingtonDepartment of Pharmacy1959 NE Pacific Street H361EBox 357630Seattle, WA [email protected]
Mendes, CaioFleury Medical Diagnostic CenterRua Domingos Fernandes 230apto 41Sao Paulo [email protected]
Mills, Jonathan A.Symyx Therapeutics, Inc.3100 Central ExpresswaySanta Clara, CA [email protected]
Nasser, Azmi2924 Bywater DriveRichmond, VA [email protected]
Newman, Edward M.Beckman Research InstituteCity of Hope1450 East Duarte RoadFox North Room 2000Duarte, CA [email protected]
312
Ng, CheeGenentech1400 GrandviewMail stop 70South San Francisco, CA [email protected]
Nguyen, Linh ThuyAmgen Inc.Department of Pharmacokineticsand DrugMetabolismOne Amgen Center DriveThousand Oaks, CA [email protected]
Panetta, John CarlSt. Jude Children’s ResearchHospitalDept. of Pharmaceutical Sci.332 North Lauderdale StreetMemphis, TN [email protected]
Pang, K. SandyUniversity of TorontoFaculty of Pharmacy19 Russell StreetToronto Ontario M5S [email protected]
Park, SunwonKorea Advanced Institute ofScience and TechnologyDepartment of Chemical andBiomolecular Engineering373-1 Guseong-dong, Yuseong-guDaejeon 305-701SOUTH [email protected]
Parker, Robert S.University of PittsburghDepartment of Chemical andPetroleum Engineering1249 Benedum HallPittsburgh, PA [email protected]
Pelsor, Francis R.Food & Drug Administration5600 Fishers LaneHFD-880Rockville, MD [email protected]
Persky, Adam M.University of North Carolina5111-103 Copper Ridge DriveDurham, NC [email protected]
Peterson, Mark C.Amgen Inc.One Amgen Center Drive , MS30E-0-BThousand Oaks, CA [email protected]
Raber, SusanPfizer Global Research &Development11085 Torreyana RoadSan Diego, CA [email protected]
Racine-Poon, AmyNovartis Pharma Inc.WSJ 27 1013Basel CH [email protected]
313
Ramanathan, MuraliUniversity at Buffalo/SUNYDepartment of PharmaceuticalSciences543 Cooke HallBuffalo, NY [email protected]
Rhee, Sarah1536 Via Del ReySouth Pasadena, CA [email protected]
Rodman, JohnSt. Jude Children’s ResearchHospitalPharmaceutical Department332 North LauderdaleMS 150Memphis, TN [email protected]
Rodvold, Keith A.University of Illinois at ChicagoCollege of Pharmacy, M/C 886833 South Wood Street, Room 164Chicago, IL [email protected]
Rosner, Gary L.M.D. Anderson Cancer CenterUniversity of TexasDepartment of Biostatistics1515 Holcombe Blvd., #447Houston, TX [email protected]
Rovetti, Robert J.511 S. El Molino #1Pasadena, CA [email protected]
Sale, MarkGlaxoSmithKline5 Moore DriveResearch Triangle Park, NC [email protected]
Sawchuk, Ronald J.University of MinnesotaDepartment of PharmaceuticsWeaver-Densford Hall, Room9-143308 Harvard St., SEMinneapolis, MN [email protected]
Song, IvyGlaxoSmithKline5 Moore DriveMail stop 17.1354C.1CResearch Triangle Park, NC [email protected]
Song, Daniel5640 Andrus AvenueTorrance, CA [email protected]
Steinbach, Joseph H.UC, San DiegoHillcrest Medical Center 8414200 W. Arbor DriveSan Diego, CA [email protected]
Synold, Timothy W.City of Hope Medical Center1500 East Duarte RoadDuarte, CA [email protected]
314
Tabrizi, MohammadAbgenix Inc.6701 Kaiser Drive Ms 23Fremont, CA [email protected]
Tam, Vincent H.University of HoustonCollege of Pharmacy1441 Moursund StreetHouston, TX [email protected]
Teja-Isavadharm, PaktiyaArmed Forces Research Instituteof Medical Sciences315/6 Rajvithi RoadPhayathaiBangkok [email protected]
Tibbitts, JayXOMA LLC2910 Seventh StreetBerkeley, CA [email protected]
Tretriluxana, Jarugool3828 Ingraham Street #322Los Angeles, CA [email protected]
Tretriluxana, Suradej3828 Ingraham Street #322Los Angeles, CA [email protected]
Uchizono, JimUniversity of the PacificTJ Long School of Pharmacy751 Brookside RoadStockton, CA [email protected]
Veng-Pedersen, PeterUniversity of IowaCollege of PharmacyRoom 118Iowa City, IA [email protected]
Venitz, JurgenVirginiaCommonwealthUniv.Department of PharmaceuticsSchool of PharmacyRoom 450B, R.B. Smith Building410 N 12th StreetP.O. 980533Richmond, VA [email protected]
Wang, Xiaoning1210 W. 28th Street #16Los Angeles, CA [email protected]
Weiss, MichaelMartin Luther UniversityHalle-WittenbergDepartment of PharmacologySection of PharmacokineticsD-06097 Halle/[email protected]
315
Whitfield, LloydPfizer Global Research andDevelopment2800 Plymouth RoadBuilding 50/M345Ann Arbor, MI [email protected]
Williams, Paul JamesUniversity of the PacificSchool of Pharmacy3601 Pacific AvenueStockton, CA [email protected]
Woodworth, James R.Vertex Pharmaceuticals130 Waverly StreetCambridge, MA [email protected]
Wu, BenjaminGenentech Inc.1 DNA WayMail Stop 70South San Francisco, CA [email protected]
Wu, HulinFrontier Science & TechnologyResearch Foundation, Inc.1244 Boylston Street, Suite 303Chestnut Hill, MA [email protected]
Xiao, JimOhio State UniversityCollege of Pharmacy500 W 12th AvenueColumbus, OH [email protected]
Xu, LuNovartis Institute of BiomedicalResearch400 Technology Square7-130Cambridge, MA [email protected]
Xu, Christine R.Ribapharm Inc.3300 Hyland AvenueCosta Mesa, CA [email protected]
Yang, Bing-BingAmgen Inc.One Amgen Center DrivePharmacokinetics and DrugMetabolism30E-0-BThousand Oaks, CA [email protected]
Yang, ZhengBristol-Myers Squibb Co.Rt. 206 and Province Line RdP.O. Box 4000Princeton, NJ [email protected]
Yu, ZhilingAllergan, Inc.2525 Dupont Drive, RD-2BIrvine, CA [email protected]
Yu, RosieISIS Pharmaceuticals2292 Faraday AvenueCarlsbad, CA [email protected]
316
Zelenitsky, SherylUniversity of ManitobaFaculty of PharmacyManitobaWinnipeg R3T [email protected]
Zheng, Hong XiaUniversity of Southern CaliforniaSchool of Pharmacy1985 Zonal Avenue, PSC-100Los Angeles, CA [email protected]
Zhou, ZexunUniversity of Southern CaliforniaBiomedical EngineeringOlin Hall 500Los Angeles, CA [email protected]
INDEX
3TC, 33–35, 37
adenosine agonists, 57adherence, 211adherence model, 214adherence rates, 216antiretroviral treatment, 221
Bayesian, 166, 225Bayesian decision theory, 240, 247, 251Bayesian inference, 105, 106, 128Bayesian MCMC, 174Bayesian nonparametric model, 242Bayesian optimal design, 247bone marrow transplantation, 240
cardiac glycosides, 67cell-cycle model, 271chemotherapy, 239, 255cluster, 92cluster analysis, 85covariates, 241CYP3A, 5CYP3A4, 10
deconvolution, 165Dirichlet process, 243Discrete Fourier Transform, 198, 204dosage design, 257dose-individualization, 251drug absorption, 3drug resistance, 221, 222drug-receptor complex, 91
Efficacy Index, 222efflux transporters, 4enterocytes, 4expectation maximization, 135exposure response, 49
GABAA agonists, 59gastrointestinal motility, 10geldanamycin, 106gene expression, 197
genomic effects, 87glucocorticoid receptor, 85
HAART, 211, 224heat shock protein, 107, 119hepatic metabolism, 117heterogeneous receptor, 71hierarchical, 241high-dose chemotherapy, 251HIV, 211HIV dynamics, 221HIV therapy, 218HIV virions, 223homeostatic feedback, 54HSP auto-regulation, 127
importance sampling, 140inhibitory quotients, 212intestinal enzymes, 8intestinal metabolism, 9intestinal modeling, 11intestinal segments, 8intestinal transporters, 3, 6, 7intrinsic activity, 51intrinsic clearance, 118, 125intrinsic clearances, 18
kinases, 36, 45
lamivudine, 33, 45ligand-receptor, 71linear system, 165linearized approximation, 138loss function, 247
Markov chain Monte Carlo, 165, 225Mct1, 5mean residence time, 17metropolis-hastings, 166microarray, 100microarray study, 89microsomes, 117mixed-effect model, 222mixture of normals, 242
318
model-based adjustment, 256model-based optimization, 273Monte Carlo, 135Monte Carlo integration, 139mRNA measurements, 87MRP2, 4, 6MRP3, 5, 6MRP4, 46multi-modal distributions, 241multidrug transporter, 4mutation, 218
non-compliance, 221nucleoside, 211nucleoside analog, 33
opioid receptor agonists, 57optimal dose, 240oral drug absorption, 4
P-glycoprotein, 4, 6, 11107, 121
p53, 107perfusion-limited, 110pharmacogenomics, 85, 86phosphorylation, 33, 36, 43–45population pharmacokinetic, 135postreceptor events, 71, 77predictive distribution, 247protease inhibitors, 212, 221
Raf-1, 107, 119, 121, 127receptor density, 53receptor heterogeneity, 67, 76
receptor occupation, 70receptor subtypes, 81receptor theory, 50, 52, 61resistance, 211, 218reverse transcriptase inhibitor, 221
scaled-up, 67segregated flow model, 13, 14, 16self-organizing maps, 206serotonin receptor agonists, 60set-point model, 55small intestine, 4sodium pump, 71stem-cell transplantation, 251steroid membrane receptors, 97system pharmacology, 100systemic exposure, 240
T cells, 214tolerance, 54transcriptional activity, 122transcriptional control, 86transducer function, 51treatment schedule design, 272triphosphates, 40, 41tumor growth, 256tumor xenograft, 126
viral dynamics, 214viral load, 218virological response, 221, 235visualization, 197
zidovudine, 33
