Compound E

Wt

PSD-95 DCC Overlay

Lack of PS function increases spine density, PSD-95 and DCC clusters. Representative 3D reconstitution confocal images of cortical neurons are taken from 12 stacks. PSD-95 and DCC staining are shown respectively for Wt (top panel) and Wt neurons treated with Compound E (bottom

panel). Synaptic clusters of PSD-95 (green) and DCC (red) are visualized as yellow overlay (left panel).

Figure 1SParent et al.