By: Kendra Iverson & Sarah Bender

• Muscle- fibrous tissue with the ability to contract, producing movement in or maintaining the position of an animal body

• System- organized arrangement; network….

• Set of connected fibrous tissue that work together to produce movement

• Provide muscle tone• Propel body fluids and food• Generate the heartbeat• Distribute heat throughout the body

• Skeletal muscle•Moves majority of the body

• Smooth muscle•Helps most with digestive system

• Cardiac muscle•Controls the heartbeat

• Location: all skeletal muscles- attach to bones

• Function: movement of bones at joints and maintaining posture

• Voluntary• Contracts and relaxes quickly• Transverse tubule system is well-

developed

• Composed of:•skeletal muscle tissue •nervous tissue•blood•connective tissue

• Fascia- layers of fibrous connective tissue•covers and separates each muscle surface

• Epimysium- lies beneath the fascia• Perimysium- surrounds individual bundles of fibers (fascicles)

• Endomysium- connective tissue layer that separates individual muscle fibers

• Cells that contract in response to stimulation and then relax after the stimulation ends

• Thin and elongated cylinders with rounded ends

• Can extend full length of a muscle

• Sarcolemma- muscle fiber membrane↓

• Sarcoplasm- cytoplasm↓

• Myofibrils- protein filaments which lie parallel and play great role in contraction• Types: Myosin- thicker, called A bands (dark)Actin- thinner, called I bands (light)

↓

• Sarcomere- space from center of one I band to the next I band

• Sarcoplasmic Reticulum- network of membranous channels that surround each myofibril and run parellel

• Transverse Tubules (T tubules)- network of membranous channels between sarcoplasm that open outside

• Both- activate muscle contraction mechanism when the fiber is stimulated

• Site where the motor neuron and muscle fiber meet

• Muscle fiber is specialized to form a motor end plate

• End branches, has many mitochondria and contains synaptic vesicles that store chemicals

• Neurotransmitter stimulates muscle fibers to release acetylcholine

• Travels down a motor neuron axon and stimulates muscle fiber contraction

• Includes one motor neuron and several muscle fibers•The motor neuron transmits an impulse, which allows all the linked muscle fibers to contract at the same time

• Sarcomeres shorten and the muscle is pulled against its attachments

• Sliding Filament Model• Myosin cross-bridge attaches to the binding site on the actin filament and bends, causing a pull on the actin filament

• Myosin releases and attaches to the next binding site on the actin, causing a pull• ATP converts to ADP

• Repeats this cycle as long as the energy source ATP is available and the muscle fiber is stimulated to contract

• Stimulated by acetylcholine (neurotransmitter)

• Motor neuron releases acetylcholine into the synaptic cleft to initiate contraction

• Motor end plate has protein receptors which detect acetylcholine

• Muscle impulse travels over sarcolemma surface and into T tubules, reaching the sarcoplasmic reticulum

• Stored calcium ions in the sarcoplasmic reticulum get released into the sarcoplasm

• Troponin and tropomyosin (proteins associated with actin) move to expose the myosin binding sites on the actin filaments due to the concentration of calcium

• Muscle shortens because myosin binds and pulls on actin

• After received- acetylcholinesterase breaks down acetylcholine, calcium returns to sarcoplasmic reticulum, and myosin and actin links break

• ATP molecules provides the energy•Must be regenerated because it has a limited supply

• Creatine phosphate•Energy can be transferred to ADP molecules, converting them back ATP molecules as ATP is decomposing

• Cellular respiration makes a few ATP molecules in early phases

• Muscles require oxygen • Glucose in broken down completely in

mitochondria • Blood carries oxygen, bound to the

pigment hemoglobin• The pigment myoglobin stores the

oxygen in muscle tissue

• The amount of oxygen that liver cells need to convert lactic acid into glucose, and the amount muscle cells must have to recreate the original concentration of ATP and creatine phosphate

• Develops during strenuous activity•Pyruvic acid builds up during anaerobic respiration and diffuses out of muscle cells into the liver

• May take hours to repay

• When a muscle can no longer contract

• Usually from a build up of lactic acid in the muscle, which lowers pH and results in muscle fibers to not respond to stimulation

• Cramps- a muscle has a sustained involuntary contraction

• More than half of energy released in cellular respiration becomes heat

• All active cells generate heat, but muscle cells make up a large majority of a bodies total mass

• Blood moves heat from muscle to other tissues, maintaining body temperature

• Location: walls of hollow internal organs, blood vessels

• Function: to move food through the digestive system and constrict blood vessels

• Involuntary• Contracts and relaxes slowly• Rhythmic• No transverse tubules

• Major types:• Multiunit: muscle fibers are separate

• Usually contract in response to stimulation by certain hormones or motor nerve impulses

• Visceral: organized in sheets • Are found in walls of hollow organs• Can stimulate others, displaying rhythmically• Responsible for involuntary wavelike motion

called peristalsis

• Reactions of actin and myosin• Triggered by membrane impulses and

increased intracellular calcium ions• Uses energy from ATP • Neurotransmitters are acetylcholine

and norepinephrine• Affected by hormones• Fibers can change length without

changing tension

• Location: wall of the heart ONLY• Function: pumping action of the heart• Involuntary• Network of cells contract as a unit• Rhythmic• Transverse tubule system is well-

developed• Intercalated discs separating

adjacent cells

• Intercalated discs communicate a muscle impulse throughout entire heart•Allows the hearts muscle fibers to beat as a single unit

• Network responds in an all-or-none manner

• Threshold Stimulus- the minimal strength required to cause a contraction•Muscle fibers remain unresponsive until reached

• All-or-None Response- if a muscle fiber contracts at all, it contracts fully

• There is no partial contraction• Once threshold stimulus is reached,

fiber responds to fullest contraction

• Recording a Muscle Contraction:•Myogram- the pattern resulting from a movement when connected to a device

•Twitch- a single contraction that lasts only a fraction of a second

•Latent period- the delay between the time of stimulation and the time the fiber responds

(a) Series of twitches

(b) Summation

(c) Tetanic Contraction

• Summation- when the stimulus of the next series arrives before the muscle fiber can completely relax

• Tetanic Contraction- when a forceful, sustained contraction lacks any relaxation

• Recruitment of Motor Units:•Recruitment- the number of motor units activated as a result of a higher intensity of stimulation• The addiction of muscle fibers to take part in a contraction

• Sustained Contractions:•Produced by summation and recruitment together

• Increasing strength•Muscle tone- fibers undergo some sustained contraction even when muscles appear to be relaxed• Keeps posture maintained

• Muscular hypertrophy: muscles enlarging in size and strength due to forceful exercise

• Muscular atrophy: muscles decreasing in size and strength due to lack of exercise

• Size is relative to strength•Capillary networks, actin and myosin filaments, and number of mitochondria

• Slow twitch fibers: lower intensity and able to resist fatigue, but may not increase muscle size•Running or swimming

• Fast twitch fibers: higher intensity and increase muscle size, but are fatigable•Lifting weights

• Variety of movements• Movement depends on:

•The kind of joint•How the muscle attaches

• Origin: the immovable end of a muscle• Insertion: the movable end of a muscle• The insertion is pulled towards the

origin when contraction occurs• Flexion and extension tell about the

angle between bones that meet at a joint

• Almost always function in groups• Must will movement to occur and

nervous system allows correct muscles to stimulate

• Prime Mover/Agonist: muscle responsible for a particular movement

• Synergist: muscles that contract and assist the prime mover

• Antagonists: muscles that resist the action of the prime mover

• Tendinitis- a tendon (attaches muscle to bone) becomes inflamed and swollen after injury or repeated stress during activity

• Muscle strain- connective tissues are overstretched and the degree of damage and seriousness varies

• Botulinum toxin- blocks stimulation of muscle fibers, paralyzing muscles•“Botox” to temporarily smooth wrinkles by not allowing to move facial muscles

• Steroids- (+) increase muscular strength and used for medical purposes, (-) cause changes of opposite sex and damage internal organs

• Muscular Dystrophies• Missing proteins

• Muscles weaken and degenerate

• Charcot-Marie-Tooth Disease• A duplicate gene

• Weakens hands and feet, and tendon reflexes

• Myotonic Dystrophy• An extending gene

• Muscle weakness and irregular heartbeats

• Hereditary Idiopathic Dilated Cardiomyopathy• A glitch

• Rare form of heart failure in actin

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