Post on 08-Jan-2018
description
HUMAN PAPILLOMA
VIRUS(HPV)
By,Acchaya Bajracharya & Veronika
Putzenlechner
INTRODUCTION HPV = Human Papilloma Virus More than 170 types of HPV Transferred via skin on skin contact Can lead to cancer Some types show symptoms, others do
not
WHAT IS IT? Non-enveloped DNA Virus Family: Papillomavirus family Establish only on basal keratinocytes of
skin/mucous membrane HPV types 6 and 11: cause genital warts HPV types 16 and 18: may progress to
precancerous lesions and invasive cancer
ETHIOLOGY (CAUSES AND TRANSMISSION) generally skin contact:
perinatalgenital infectionshandsshared objects (toys)bloodsurgery
SYMPTOMS Cancer Respiratory papillomatosis Immuno-comprimised Genital wart Skin warts
Types of warts: Common skin warts plantar warts subungual or periungual warts flat warts
CANCER
Incidence of HPV associated cancers in USA (2004-2008)
DEMOGRAPHY Estimated global prevalence = 11.7%
(women) Sub-Saharan Africa = 24% Eastern Europe = 21.4% Latin America = 16.1%
Highest percentage of cases of HPV in women
Type of cancer Deaths/year in US
Percentage due to HPV
Deaths/year in US due to HPV
anus 950 91% 870
cervix 4020 91% 3600
penis 320 63% 200
vagina 880 85% 750
vulva 1030 69% 710
total 7200 6130
Estimated deaths since 2014:• Worldwide = 536019• United States = 11139
PREVENTION Vaccine: Gardasil Gardasil 9 Cervarix
Education Social mobilization Screening Papillative care Use & promotion of safe sex – condoms Male circumcision
Protection against HPV types: 6, 11, 16 & 18
Protection against HPV types: 16 & 18
TREATMENT Currently no specific treatment for
HPV Virus normally clears by itself – within
2 years Genital warts:
Physical ablation – e.g. Excision, cryosurgery, etc.
Topical agents – e.g. 0.15–0.5% podophyllotoxin solution
Cancer: chemotherapy
FUTURE DRACO drug = early stages Alferon N = drug to treat genital warts Lopinavir = antiretroviral – of the
protease inhibitor class
BIBLIOGRAPHY https://en.wikipedia.org/wiki/Genital_wart https://en.wikipedia.org/wiki/Human_papillomavirus http://jid.oxfordjournals.org/content/202/12/1789.full http://www.cancer.gov/about-cancer/causes-preventi
on/risk/infectious-agents/hpv-fact-sheet#q4 http://www.who.int/immunization/topics/hpv/en/ http://www.nhs.uk/chq/Pages/2611.aspx http://www.kegel.com/hpv/deaths/
https://en.wikipedia.org/wiki/Papillomaviridae https://en.wikipedia.org/wiki/Human_papillomavirus http://www.who.int/mediacentre/factsheets/fs380/en/