BME 130 – Genomes
Lecture 1
History of Genomics
Administrivia
Course policies
Grading
Assignments
Readings
Charles DarwinOn the Origin of Species1859
Gregor MendelExperiments in PlantHybridisation1866
Francis GaltonStatistical genetics, law of ancestral heridity (basis ofeugenics)1876
WalterSutton
TheodorBoveri
Propose that hereditary factors reside on chromosomes and are inherited by Mendellian laws (1902)
Archibald GarrodAlkaptonuria is not caused by bacterial infection, but is inherited (recessive), 1908
Thoman Hunt MorganExperimental validation of chromosomal theory of inheritance, established fruit fly as model genetic organism, 1910
James Watson and Francis Crick describe a model for
the structure of DNA, 1953;Crick enunciates central
dogma of molecular biology 1957
Marshall NirenbergCracks the genetic code by translating (first) poly-U, 1961
Paul BergCreates first recombinant DNA molecules, 1972
Herber Boyer and Stan CohenClone DNA into foreign cells; birth of recombinant DNA technology, 1973
Walter Gilbert and Fred SangerDevelop methods to sequence DNA, 1977
Kary MullisInvents the polymerase-chain reaction for DNA amplification, 1983
Scheibye-Alsing et al. (2009),Comp. Biology & Chemistry 33(2):121
Genomes!
1995 Hemophilus influenzae1996 yeast1998 worm1999 fruit fly2001 human2002 mouse2004 rat
http://www.genomenewsnetwork.org/