Review the

BiopharmaceuticsandPharmacokinetics1(0520431)

Dr.QutaibaAhmedAlAgaAssistantProfessorFacultyofPharmacyPhiladelphiaUniversity-Jordan

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§ Coursemoduledescriptionandobjectives:§ Thiscourse isdevotedtotheexplorationandexaminationof thephysical and physicochemical behavior of drugs, dosage forms,and drug delivery systems in physiological milieu and theirimplications for pharmaceutical care. Drug absorption processes,bioavailability, and bioequivalence will be highlighted.Pharmacokinetic and Pharmacodynamic concepts, includingabsorption kinetics, volume of distribution, and compartmentalmodels,willbeintroducedtothestudent.

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Review the following: §  Mathematical fundamentals in

Pharmacokinetics

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Review of rates and order of reaction: §  Zero- order and 1st order. §  Practice problem

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One compartment mathematical open model: §  IV bolus administration: §  Elimination rate constant §  Apparent volume of distribution §  Clearance §  Area under the curve §  Calculation from plasma §  Practice problem

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Multiple compartment model: §  IV bolus administration: §  Tow compartment model §  Elimination rate constant §  Apparent volume of distribution §  Clearance §  Area under the curve §  Calculation from plasma §  Practice problem

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Revision and first examination

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Drugeliminationandclearance

1)Renaldrugexcretion2)Drugclearancei)DeterminationofrenalclearanceiiDeterminationofhepaticclearance

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PHARMACOKINETICS

§ Drugeliminationandclearance:Practiceproblems

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Multipledosingregimen:

§ Drugaccumulation.§ RepetitiveIVinjection.§ loadingdose,schedulingofdosageregimen

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§ Multipledosing:Practiceproblems§ Revisionandsecondexamination

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§ Bioavailabilityandbioequivalence:relativeandabsolutebioavailabilily,methodsofassessingbioavailabilily,shortoverviewofbioequivalenccstudies§ practiceproblems

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§ Revisionandfinalexamination13

§ Learningoutcomes:§ Attheendofthismodule,studentwillbeableto:§ Understandthecompartmentalmodelingandit’ssignificance§ Understanddrugabsorption,distributionandelimination§ Understand drug clearance including (total, renal and hepaticclearance)

§ Understand pharmacokinetics and biopharmaceutics after I.Vbolus,I.Vinfusion,andoraladministrationofdrugs.

§ Understandproteinbindinganditseffects§ Understandbioavailabilityandbioequivalence§ UnderstandMultipledosageregimen§ Haveaknowledgeonbiopharmaceuticsconsiderations indosageformdesign

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AllocationofMarksAssessmentinstruments Mark

FirstExam 20%

SecondExam 20%

Assignment/seminar/quizzes

20%

FinalExam 40%

Total 100%

RecommendedBooks

ü  Applied Biopharmaceutics and Pharmacokinetics., Shargel and A.B.C. Yu., Appleton & Lange/MacGraw-Hill, New York., 4th edition 1999. ISBN 0-8385-0129-X

ü  Applies clinical pharmacokinetics, Bauer, Larry A. Appleton & Lange/MacGraw-Hill, New York., 2nd edition 2008. 10.1036/0071476288

ü  ClinicalPharmacokineticsConceptsandApplications.MALCOlMROWlANDandTHOMASN.TOZER.,1994,3rdedition.LIpPINCOTTWILLIAMS&WILKINS

Thankyouforlistening

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