BIOPHARMACEUTICS & DRUG DISPOSITION (Biopharm. drug dispos.)

CONTENTS

Volume 6, Issue Nos 1-4

Issue No. 1, January-March

RESEARCH PAPERS

Valproic Acid and Active Unsaturated Metabolite (2-en): Transfer

to Mouse Liver following Human Therapeutic Doses: N. Nau and W. Loscher .

Acute Tolerance Development to the Diuretic Effect of Furosemide in the Rat: M. Hammarlund and L. K. Paalzow

Comparison of Nonlinear Pharmacokinetic Parameters Estimated from the Sinusoidal Perfusion and Venous Equilibrium Models:

J. G. Wagner

Pharmacokinetics of Valproic Acid in Volunteers after a Single Dose Study: M. Bialer, Z. Hussein, I. Raz, O. Abramsky, Y. Herishanu

and F. Pachys

The Effect of Food and Antacid on the emia of iad R. J.

Wills, R. B. Velagapudi, S. K. Puri and G. J. Yakatan.

Relationship between Total Body Clearance of Caffeine and Urine Flow Rate in Elderly Men: J. M. — J. Blanchard, K. A. Conrad

and G. G. Harrison

On Pharmacokinetics in Target Tissues: M. Weiss

Bioavailability Studies with Ciglitazone in Beagles I. Effect of a “Meal

on the Bioavailability of Three Ciglitazone Dosage Forms: S. R. Cox, E. L. Harrington, R. A. Hill, V. J. Capponi and A. C. Shah

Bioavailability Studies with Ciglitazone in Beagles II. Effect of Pro- pantheline Bromide and Metoclopramide HCL on Bioavailability

of a Tablet: S. R. Cox, E. L. Harrington and V. J. Capponi

Adriamycin-loaded Albumin Microspheres: Preparation, Jn Vivo

Distribution and Release in the Rat: N. Willmott, J. Cummings,

J. F. B. Stuart and A. T. Florence

SHORT COMMUNICATIONS Estimation of Number of Receptor Sites: A Misconception: I. M.

Klotz . i : ; : ‘ ‘ ; ; ‘ ‘ . 105

Estimation of Number of Receptor Sites: A Misconception: A Response: J. G. Wagner : ; ‘ : ; ‘ ‘ . 107

Indexed or abstracted by ‘Current Contents’, “Science Citation Index’ and other leading Indexing/ Abstracting Services

BDDID8 6 1-458 (1985) ISSN 0142-2782

VOLUME CONTENTS

Issue No. 2, April-June

RESEARCH PAPERS Pharmacokinetics of Furosemide After Three Different Single Oral Doses: E. S. Waller, J. W. Massarella, M. S. Tomkiw, R. V.

Smith and J. T. Doluisio

Bioequivalence of a Sustained-Release Isosorbide Dinitrate For- mulation at Steady-State: T. Taylor, L. F. Chasseaud, R. M.

Major, F. C. Leaf, R. Bonn, A. Darragh and R. F. Lambe

Lack of Effect of Liver Disease on the Pharmacokinetics of Acebutolol and Diacetolol: A Single Dose Study: R. Zaman, D. B.

Jack, M. R. Wilkins and M. J. Kendall .

The Relationship Between Buspirone Bioavailability and Dose in Healthy Subjects: R. E. Gammans, R. F. Mayol, A. V. Mackenthun and L. F. Sokya

A Pharmacokinetic Comparison of Cephalexin and Cefadroxil

Using HPLC Assay Procedures: P. G. Welling, A. Selen, J. G. Pearson, F. Kwok, M. C. —_ A. Ifan, D. Marrero, W. A. Craig and C. A. Johnson

Concentration-Dependent Clearance of Procainamide in Normal Subjects: J. D. _— H. Boudoulas, J. J. Mackichan and J. J.

Lima .

Effects of scab on the Disposition Kinetics of Phenytoin in Pregnant Rats: P. A. Cleveland and C. T. Ueda

Michaelis-Menten Elimination Kinetics: Areas Under Curves, Steady-State Concentrations, and Clearances for Compartment Models with Different Types of 7 J. G. Wagner, G. J. Szpunar and J. J. Ferry

A Method for Determining the Pharmacokinetics of Endogenous Creatinine Without Exogenous Creatinine Administration: M. S. S. Chow

SHORT COMMUNICATIONS

Amiodarone and Desethylamiodarone Elimination Kinetics Follow- ing Withdrawal of Long-Term Amiodarone Maintenance Ther- apy: D. Marchiset, R. Bruno, P. Djiane, J. P. Cano, M. Benichou and A. Serradimigni

Absorption of Theophylline From Two Sustained Release Formula- tions: A. Selen, C. A. Johnson, M. C. — W.A. _— and P. G. Welling

Butaperazine Pharmacokinetics in Tardive Sesiblneate: M. E. Wolf, J. 1. Javaid, A. D. Mosnaim and J. M. Davis

VOLUME CONTENTS

Presystemic Elimination and Mean Residence Time: D. Brockmeier

ERRATUM

FORTHCOMING MEETING

Issue No. 3, July-September

REVIEW

Analysis, Disposition and Pharmacokinetics of Nitroglycerin: S. H. Curry and S. M. Aburawi

RESEARCH PAPERS First-Pass Elimination of Lidocaine in the Rabbit after Peroral and

Rectal Route of Administration: W. A. Ritschel, H. Elconin, G. J. Alcorn and D.D. Denson . ‘ . ;

Pharmacokinetics of Theophylline in Protein-Calorie Malnutrition: D. Jung : . : , ; eta

Pharmacokinetics and Pharmacodynamics of Bromocriptine in the

Rat: H. F. Schran, F. L. S. Tse and S. 1. Bhuta : :

Comparison of Fitting Methods for the Analysis of Plasma Concentration-Time Data Resulting from Constant Rate In- travenous Infusion: S. L. Johnson and M. Mayersohn

Comparative Physiological Disposition of Some Anthraquinone Glycosides and Aglycones: J. P. Moreau, S. Moreau and S. Skinner : ‘ ‘ ‘

SHORT COMMUNICATIONS A Pharmacokinetic Model for Prednisone after Infusion to Steady-

State in the Rabbit: J. J. Ferry and J. G. Wagner ; :

Theoretical Decrease in Systemic Availability with Decrease in Input Rate at Steady-State for First-Pass Drugs: J. G. Wagner, E. J. Antal, A. T. Elvin, W. R. Gillespie, E. A. Pratt and K. S. Albert

Effect of Variations in Urine pH and Flow Rate on Cimetidine Renal Disposition in Man: A. Somogyi and R. Gugler ; ;

Gastrointestinal Bioavailability: Determination of /n Vivo Release Profiles of Solid Oral Dosage Forms by Deconvolution: W. R. Gillespie and P. Veng-Pedersen

BOOK REVIEW

Issue No. 4, October-December

RESEARCH PAPERS Effect of Dietary Mineral and Vitamin D Content and Para-

thyroidectomy on the Plasma Disappearance Rate of 1 ,25-Dihydroxy-

vitamin D, in Rats: S. K. Paulson and A. D. Kenny

VOLUME CONTENTS

Confidence Intervals for Multiple-dose Concentrations in the One- compartment Open Model with Rapid Intravenous Injection: K. F.

Karpinski

Electron-capture Gas Chromatographic Determination of Loprazolam in Plasma and a Pharmacokinetic Application: F. A. Levasseur, G. Caillé, R. Elie, M. Vézina and L. Lariviére

Selective Incorporation of Asialofetuin into Hepatocyte of Rat: Y. Aramaki, A. Inaba and S. Tsuchiya .

Pharmacokinetic Evaluation of Novel Sustained-release Dosage Forms of Valproic Acid in Humans: M. Bialer, M. Friedman, J. ene I. Raz and O. Abramsky ;

Oral and Rectal Nalbuphine Bioavailability: First-pass Metabolism in Rats and Dogs: B. J. Aungst, G. Lam and E. Shefter

Pharmacokinetics of Prednisolone after High Doses of Prednisolone Hemisuccinate: H. Derendorf, P. Rohdewald, H. Méllmann, J. Rehder, J. Barth and D. Neveling .

Effect of Time of Dosing on the Disposition of Oral Cibenzoline: R. K. Brazzell, K.-C. Khoo and D. W. Schneck

Allopurinol: A Comparative Study of the Bioavailability and Effect on Plasma Uric Acid of Two Products in Tablet Form: P. Nissen and L. Pedersen

Pharmacodynamics of Acute Intranasal Administration of Verapamil: Comparison with IV and Oral Administration: T. H. Arnold, R. L.

Tackett and J. J. Vallner

Author and Key Word Index