Post on 20-Mar-2016
description
Bioinformatics: Science that derives information from computer analysis of biological data
Data:1) Information from genomes / genetic code2) Biochemical results, patient statistics, etc.3) Scientific literature
Information flow:Input Storage Retrieval
Data analysis
Concepts of computational science, statistics,mathematics, linguistics, biological sciences...
Hypothesis
Data
Deductiveprocess
Inductiveprocess
Bioinformatics refers to the creation and advancement of algorithms, computational and statistical techniques, and theory to solve formal and practical problems posed by or inspired from the management and analysis of biological data.
Computational biology refers to hypothesis-driven investigation of a specific biological problem using computers, carried out with experimental and simulated data, with the primary goal of discovery and the advancement of biological knowledge
Diego Sánchez
Instituto de Biologia y Genética MolecularUniversidad de Valladolid-CSICC/Sanz y Forés s/n47003 Valladolid
Tfno: 983-184814Fax: 983-184800E-mail: lazarill@ibgm.uva.es
Databases (raw and curated-annotated data)
Sequence and structure databases (DNA and proteins):Sequence and structure databases (DNA and proteins):
General DB: GenBank, Protein structure (PDB), SwissProt, ESTdb, SNPs…Genome DB: Human Genome; Mouse…Organism-specific: Flybase; ACEDB; Zebrafish…
Scientific literature:Scientific literature: Pubmed, Medline
Zoology:Zoology: Taxonomy, Tree of life
Relational DB: HomoloGene; CDD; Prosite...
Global and relational DBGlobal and relational DB:: Entrez; Ensembl; GOdb…
Web-based analysis platforms
NCBI; ExPASy; EBI…
chFGF2chFGF2chFGF7chFGF7
rFGF2rFGF2rFGF7rFGF7
Genes-proteins relationships:Orthology, homology, paralogy, analogy and xenology
rFGF2 and chFGF2 are orthologsrFGF2 and rFGF7 are paralogsfFGF and chFGF7 are homologs
75 My
Time
chFGF2chFGF2chFGF7chFGF7fFGFfFGF rFGF2rFGF2
rFGF7rFGF7
350 My