Acutely Toxic Gas: Carbon Monoxide · Acutely Toxic Gases Chemical Class Standard Operating...

AcutelyToxicGasesChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

AcutelyToxicGas:CarbonMonoxideH220H280H331H360H372

ThisSOPisnotasubstituteforhands-ontraining.PrintacopyandinsertintoyourlaboratorySOPbinder.

Department: Chemistry

DateSOPwaswritten: Tuesday,March28,2017

DateSOPwasapprovedbyPI/labsupervisor: Friday,March24,2017

PrincipalInvestigator:Name:F.Fischer

Signature:______________________________

InternalLabSafetyCoordinatororLabManager:Name:StephenvonKugelgen

LabPhone:510.301.1058

OfficePhone:510.642.8252

EmergencyContact: Name:StephenvonKugelgen

PhoneNumber:510.301.1058Location(s)coveredbythisSOP: HildebrandHallD61

1. Purpose

ThisSOPcoverstheprecautionsandsafehandlingproceduresfortheuseofCarbonMonoxide,anAcutelyToxicGas(ATG).ForalistofATGscoveredbythisSOPandtheiruse(s),seethe“ListofChemicals”.ProceduresdescribedinSection12applytoallmaterialscoveredinthisSOP.Ifyouhavequestionsconcerningtheapplicabilityofanyrecommendationorrequirementlistedinthisprocedure,contactthePrincipalInvestigator/LaboratorySupervisororthecampusChemicalHygieneOfficeratucbcho@berkeley.edu.

2. AcutelyToxicGasesInformation

BeforeworkingwithanyAcutelyToxicGases(ATGs),reviewtheUC-BerkeleyEH&SpublicationToxicGasProgramontheEH&Swebsite.IfyouhavequestionsaboutToxicGasProgramrequirements,contactEH&Sat642-3073.

Rev.Date:2017-03-28

3. PotentialHazards/Toxicity

Toxicgasesaregasesthatmaycausesignificantacutehealtheffectsatlowconcentrations.Healtheffectsmayincludesevereskinoreyeirritation,pulmonaryedema,neurotoxicity,orotherpotentiallyfatalconditions.TheGloballyHarmonizedSystemofClassificationandLabelingofChemicals(GHS)designatesATGsbyoneormoreofthefollowingHcodes:

H280Containsgasunderpressure;mayexplodeifheatedH330FatalifinhaledH331ToxicifinhaledH332HarmfulifinhaledH333Maybeharmfulifinhaled

ATGsmayalsohaveotherhazardouspropertiesinadditiontoacutetoxicity(e.g.corrositivity,pyrophoricity).Safeuserequiresassessingallpotentialhazards.

ItisthePrincipal Investigator’s responsibility toensureactivity-specific laboratoryproceduresand/orprocessesaretakenintoaccountwhenusingthisChemicalClassSOP.

Please,reviewtheSDSofanychemicalbeforeuse(seeSection11–SDSLocation).ThefollowinginformationisnotintendedtoreplacetheSDS.

SpecificHazards/ToxicityforCarbonMonoxide

H220-extremelyflammablegasH280-containsgasunderpressure;mayexplodeifheatedH331-toxicifinhaledH360-maydamagefertilityortheunbornchildH372-causesdamagetoorgans(centralnervoussystem)throughprolongedorrepeatedexposure

Itisacolorless,odorless,poisonousandextremelyflammablegas.CarbonMonoxideisachemicalasphyxiantandmaybefatalifinhaled.ExposuretoCarbonMonoxidecancausenausea,dizziness,headaches,andcollapse.CarbonMonoxideposesaseriousfirehazardwhenitisaccidentallyreleased.FlameorhightemperatureimpingingonalocalizedareaofthecylinderofCarbonMonoxidecancausethecylindertoexplodewithoutactivatingthecylinder’sreliefdevices.Provideadequatefireprotectionduringemergencyresponsesituations.

Themostsignificantrouteofover-exposureforCarbonMonoxideisbyinhalation.INHALATION:Carbonmonoxideisclassifiedasachemicalasphyxiant,producingatoxicactionbycombiningwiththehemoglobinofthebloodandreplacingtheavailableoxygen.Throughthisreplacement,thebodyisdeprivedoftherequiredoxygen,andasphyxiationoccurs.Sincetheaffinityofcarbonmonoxideforhemoglobinisabout200-300timesthatofoxygen,onlyasmallamountofCarbonMonoxidewillcauseatoxicreactiontooccur.CarbonMonoxideexposuresinexcessof50ppmwillproducesymptomsofpoisoningifbreathedforasufficientlylongtime.Othereffectsofexposurecanbesummarizedasfollows:

CONCENTRATIONOFGASOBSERVEDEFFECTAllexposurelevels:Over-exposuretoCarbonMonoxidecanbeindicatedbythelipsandfingernailsturningbrightred.

Rev.Date:2017-03-28

200ppm:Slightsymptoms(headache,discomfort)afterseveralhoursofexposure.400ppm:Headacheanddiscomfortexperiencedwithin2-3hoursofexposure.1,000-2000ppm:Within30minutes,slightpalpitationsoftheheartoccur.Within1.5hours,thereisatendencytostagger.Within2hours,thereismentalconfusion,headache,andnausea.2000-2500ppm:Unconsciousnesswithin30minutes.>2500ppm:Potentialforcollapseanddeathbeforewarningsymptomsareproduced.NOTE:Athighaltitudes,individualsmaybemoresusceptibletoCarbonMonoxideover-exposures.Developmentofsymptomsmayalsooccurmorerapidlyifindividualsaredoingphysicallydemandingtasks.Individualswhohaveheartconditionsmayexperienceamorerapidonsetofsymptoms.Duringrecovery,victimscanexperienceheadaches,visionproblems,andmemoryloss.

HEALTHEFFECTSORRISKSFROMEXPOSURE:Over-exposuretoCarbonMonoxidemaycausethefollowinghealtheffects:ACUTE:CarbonMonoxideisatoxicgas.SymptomsofCarbonMonoxidepoisoningcandevelopgradually,orcanarisesuddenly,dependingontheconcentrationanddurationofexposure.Lipsandfingernailswillturnbrightred,whichisasignificantsignofCarbonMonoxideover-exposure.Othersymptomsofover-exposurecanincludeheadache,shortnessofbreath,wheezing,dizziness,indigestion,andnausea.Athighconcentrationsunconsciousnessordeathmayoccur.Symptomscanincludeblurredvisionandmemoryloss.CHRONIC:ClinicalstudiesindicatethatthereisarelationshipbetweenexposuretoCarbonMonoxideinspecificoccupations(i.e.,fire-fighters,foundryworkers)andanincreasedincidenceofcardiovascularproblems.CarbonMonoxideisareproductivetoxin.RefertoSection11ofthisMSDSforfurtherinformation.TARGETORGANS:Respiratorysystem,circulatorysystem,cardiovascularsystem,reproductivesystem.

4. EngineeringControls

Usetheengineeringcontrolslistedbelowunlessotherlab-specificinformationisincludedintheProtocol/Proceduresection.

• WorkwithATGsmustbeconductedinafumehoodunlessothercontrolsaredesignatedinthelab-specificProtocol/Proceduresection.Sashheightmustbekeptlowtoavoidescapingfumesandprovideaphysicalbarrier.

• Indoorstorageofallgascylindersinthisprogrammustbeinamechanicallyventilated,lockablearea.Examplesofmechanicalventilatedareasincludeexhaustedgascabinets,fumehoods,andspecialfirecodecompliantgasstoragerooms.

• Allcylindersandgascabinetsmustbeclearlylabeledwithcontentandhazardinformation.• Allregulators,valves,piping,tubingandfittingsmustbechemicallycompatiblewiththegases

beingused.Regulatorsmustbecompatiblewiththesizeandtypeofgascylinderbeingusedandratedforfullcylinderpressure.Consultyourgassupplierforapprovedregulators,valves,piping,tubing,andfittings.

• Cylindersmustbestoredupright,withtankvalvessecurelyclosedandvalveprotectioncapinplace,andfirmlysecuredtopreventfallingorbeingknockedover.

• SomeATGshavepoorwarningproperties.IfaparticularATGfallsintothiscategoryandworkwiththisgaswillbedoneroutinelyorlargerquantitieswillbeemployed,installacontinuouselectronicwarningsensorwithalarmifavailable.Insurethatthefumehoodisoperating

Rev.Date:2017-03-28

properlyandkeepthesashaslowaspossibleatalltimes.Aventilationmonitorisrequiredonthehood.

5. PersonalProtectiveEquipment

Ataminimum,thefollowingPPEmustbewornatalltimes.

EyeandFaceProtectionA. ANSIZ87.1-compliantsafetyglasseswithsideshields,orchemicalsplashgoggles.

• Ordinary prescription glasses will NOT provide adequate protection unless they alsomeetANSIstandardandhavecompliantsideshields.

B. Ifthepotentialforexplosion/splashingexists,andadequatecoverageisnotprovidedbythehoodsash,afaceshieldmustbeworn.

SkinandBodyProtection1. Glovesarerequiredwhenhandlinghazardouschemicals.

• RefertospecificchemicalSDSforinformationongloveselection.• Foradditionalinformationongloveselection,goto:

http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-and-usage.html2. Labcoatsarerequiredwhenhandlinghazardouschemicalsinthelab.Selectthetypeoflabcoat

accordingtothehazardsatthespecificworkplace.3. Longpants,closed-toe/closed-heelshoes,coveredlegs,andankles.

RespiratoryProtectionRespiratoryprotectionisnormallynotrequiredforUCBerkeleylaboratoryactivities.AnylabpersonnelconsideringtheuseofarespiratormustcontactEH&Sforaworkplaceassessment.

6. FirstAidProceduresandMedicalEmergencies

Intheeventofaninjury,notifyyoursupervisorimmediatelyandEH&Swithin8hours.

GototheOccupationalHealthFacility(TangHealthCenter,oncampus); ifafterhours,gotothenearestemergencyroom(AltaBates,2450AshbyAveinBerkeley);or

Call911(fromacellphone:510-642-3333)if:

• itisalifethreateningemergency;or

• younotareconfidentinyourabilitytofullyassesstheconditionsoftheenvironmentand/orthe condition of the contaminated/injured person, or you cannot be assured of your ownsafety;or

• thecontaminated/injuredpersonisnotbreathingorisunconscious.

Please remember to provide a copy of the appropriate manufacturer SDS (if available) to theemergency responders or physician. At a minimum, be ready to provide the identity/name of anyhazardousmaterialsinvolved.

Incaseofskincontact

Rev.Date:2017-03-28

Ifskincontactoccurs,and/orskinorclothingareonfire,immediatelydrenchinthesafetyshowerwithcopiousamountsofwaterfornolessthan15minutestoremoveanyremainingcontaminants.Ifpossibletodosowithoutfurtherinjury,removeanyremainingjewelryorclothing.IncaseofeyecontactRinsethoroughlywithplentyofwaterusinganeyewashstationforatleast15minutes,occasionallyliftingtheupperandlowereyelids.Removecontactlensesifpossible.IfinhaledMoveintofreshair.

7. SpecialHandling,Storage,andDisposalRequirements

Lab-specificinformationonhandlingandstoragemaybeincludedintheProtocol/Proceduresection.Precautionsforsafehandling

• Donotdrag,roll,slideordropcylinders.Asuitablehandtruck,towhichthecylinderissecured,mustbeusedforcylindermovement.

• Whentransportinggasesoutsidethelab,theprotectivecapmustbeinplaceandmustcoverthevalve.

• Neverattempttoliftacylinderbyitscap.• Securecylindersatalltimeswhileinuseandduringtransport.• Oncecylinderhasbeenconnectedtoprocess,openvalveslowlyandcarefully.Ifexperiencing

difficultyopeningcylindervalve,discontinueuseandcontactsupplier.Donotattempttoforcefreeing“frozen”orcorrodedvalves.

• Regulatorsandvalvesmustbekeptfreeofmoisture.Systemsmustbepurgedwithdryinertgas(e.g.helium,nitrogen,argon,etc.)beforetheproductisintroducedandwhensystemisoutofservice.

Conditionsforsafestorage• ItisessentialthatallATGsbestoredseparatelyfromallchemicalswithwhichtheymayreact.

EnsuresegregationofincompatiblechemicalsperguidancewithinEH&Sguidelines.Also,followanysubstance-specificstorageguidanceprovidedinSafetyDataSheet(SDS)documentation.

• Allcompressedgascylindersmustbestoreduprightwithvalvecovercapsinplace.Damagetoavalvecancausethecylindertobecomeadangerousprojectile.Cylindersmustbeproperlysecuredwithtwonon-combustiblerestraintstopreventthemfromfallingatalltimes.

Disposal

• Allemptygascylindersmustbelabeledasempty;however,emptycylindersmaystillcontainsometoxicgas,somustremaininexhaustedenclosuresorfirecodecompliantgasstoragerooms.Depletedgascylindersmustbereturnabletothevendoraccordingtotheirguidelines.

8. ChemicalRelease

ChemicalReleaseDial911• AccidentalRelease–Helpcontaminatedorinjuredpersons.Ifconditionsandtimepermit,close

anyopenvalve.Evacuatethereleasearea.Avoidbreathingvapors.Eliminatesourcesof

Rev.Date:2017-03-28

ignition.Keepothersfromenteringthisarea(e.g.,usecautiontape,barriers,etc.).NotifysupervisorandEH&Simmediately.

• Contactwithbodyorclothes–Removeclothingandrinsebodythoroughlyinemergencyshowerforatleast15minutes.Seekmedicalattention.NotifysupervisorandEH&Simmediately.

• ContactwithEyes–Immediatelyrinseeyeballsandinnersurfaceofeyelidwithwaterfor15minutesusinganeyewashstationbyforciblyholdingtheeyeopen.Seekmedicalattention.NotifysupervisorandEH&Simmediately.

9. CleaningandDecontamination

Lab-specificinformationondecontaminationmaybeincludedintheProtocol/Proceduresection.Alllinesorductscarryingpurgedorexhaustedemissionsofgasesmustbeconnectedtoamechanicalexhaustsystemthatdischargestoasafelocation(i.e.,presentsnopotentialforre-entrainmentintoanybuildingsupplyairintakeoroccupiedarea).Constructionoftheexhaustductsmustbechemicallyresistanttodegradationbythegasinuse.Significantemissionsofcorrosiveortoxicgasesrequireanemissioncontroldevice(e.g.,scrubber,flaredevice,adsorbent)beforethepurgedgascanbeventedintotheexhaustductsystem.RefertoToxicGasProgram.

10. HazardousWasteDisposal

LabelWaste• Allemptygascylindersshallbelabeledasempty

DisposeofWaste• Depletedgascylindersshouldbereturnabletothevendoraccordingtotheirguidelines.• ContactEH&Sat642-3073ifyouneedassistance.

11. SafetyDataSheet(SDS)LocationSDScanbeaccessedonlineathttp://ucsds.com

Rev.Date:2017-03-28

12.Protocol/Procedure–AcutelyToxicGases(ATGs)

Procedure/Use Scale EngineeringControls/Equipment

PPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions

1.UseforSTM/ncAFMtippreparation.

Uptoalecturebottle.

ConductalloperationsinthedesignatedspaceinHildebrandHallD61.Useonlythepermanentlyinstalledandapprovedequipmentandlines.SetupaCOmonitorwheneverthelecturebottleisinuse.

Usewithadequateventilation.Providenaturalorexplosion-proofventilationadequatetoensureCarbonMonoxidedoesnotreachitslowerflammabilitylimitof12.5%.Openflamesandpossiblesparkingandstaticelectricitymustbeavoided

Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.

Faceprotection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.

Handprotection:ConfirmthecompatibilityoftheglovesyouusewiththespecificATG.Generalguidance(unlessotherwisespecifiedinthespecificSDS):ataminimum,8milminimumnitrileglovesmustbeusedtopreventincidentalcontact.Forgasreleaseorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Removeglovesimmediatelyuponcontamination.Washanddryhandsafteruse.

Clothing:Wearlabcoat;fulllengthpantsorequivalent;andclose-toed,close-heeledshoes.

ThedepositionofcarbonmonoxideutilizesaleakvalvethatconnectstheUHVchamberandasmallcarbonmonoxidecylinder.TheUHVsystemshouldhavegoodventilationduringthedepositionprocess:theturbopumpandtheroughingpumponthesystemshouldbeturnedon,andtheroughingpumpshouldbeconnectedtothebuildingventilationsystem.

Beawareofanysignsofdizzinessorfatigue;exposurestofatalconcentrationsofCarbonMonoxidecouldoccurwithoutanysignificantwarningsymptoms.Non-sparkingtoolsshouldbeused.Donotattempttorepair,adjust,orinanyotherwaymodifythecylinderscontainingCarbonMonoxide.MakesuretheCarbonMonoxidedetectorworksnormally.

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.

Rev.Date:2017-03-28

13-DocumentationofTraining(signatureofallusersisrequired)

• PriortoconductinganyworkwithATGs,designatedpersonnelmustprovidetrainingtohis/her

laboratorypersonnelspecifictothehazardsinvolvedinworkingwiththissubstance,workarea

decontamination,andemergencyprocedures.

• ThePrincipalInvestigatormustprovidehis/herlaboratorypersonnelwithacopyofthisSOPanda

copyoftherelevantSDSsprovidedbythemanufacturer.

IhavereadandunderstandthecontentofthisSOP:

Name Signature Identifier Date

Rev.Date:2017-03-28

Appendix–ListofAcutelyToxicGases(non-exhaustivelist)

ChemicalName/Formula CAS# ChemicalName/Formula CAS#AmmoniaNH3 7664-41-7 ArsenicpentafluorideAsF5 7784-36-3

ArsineAsH3 7784-42-1 BorontrichlorideBCl3 10294-34-5

BorontrifluorideBF3 7637-07-2 CarbonmonoxideCO 630-08-0

CyanogenC2N2 460-19-5 CyanogenchlorideNCCl 506-77-4

ChlorineCl2 7782-50-5 DiazomethaneH2CN2 334-88-3

DiboraneB2H6 19287-45-7 FluorineF2 7782-41-4

GermaneGeH4 7782-65-2 Hexaethyltetraphosphate

C12H30O13P4

757-58-4

HydrogenbromideHBr 10035-10-6 HydrogenChlorideHCl 7647-01-0

HydrogenfluorideHF 7664-39-3 HydrogensulfideH2S 7783-06-4

HydrogenselenideH2Se 7783-07-5 MethylmercaptanCH3SH 74-93-1

NitricoxideNO 10102-43-9 NitrogendioxideNO2 10102-44-0

NitrogentetroxideN2O4 10544-72-6 OxygendifluorideOF2 7783-41-7

PhosgeneCOCl2 75-44-5 PhosphinePH3 75-45-5

PhosphorouspentafluoridePF5 7641-19-0 SeleniumhexafluorideSeF6 7783-79-1

StibineSbH3 7803-52-3 SulfurtetrafluorideSF4 7783-60-0

Trimethylsilyldiazomethane(CH3)3SiCHN2 18107-18-1

Rev.Date:2017-03-28

ListofChemicals

Chemical(s) Chemical(s) Chemical(s)

Carbonmonoxide

Acutely Toxic Gas: Carbon Monoxide · Acutely Toxic Gases Chemical Class Standard Operating...

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