Acutely Toxic Gas: Carbon Monoxide · Acutely Toxic Gases Chemical Class Standard Operating...
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Acutely Toxic Gases Chemical Class Standard Operating Procedure Rev. Date: 2017-03-28 Acutely Toxic Gas: Carbon Monoxide H220 H280 H331 H360 H372 This SOP is not a substitute for hands-on training. Print a copy and insert into your laboratory SOP binder. Department: Chemistry Date SOP was written: Tuesday, March 28, 2017 Date SOP was approved by PI/lab supervisor: Friday, March 24, 2017 Principal Investigator: Name: F. Fischer Signature: ______________________________ Internal Lab Safety Coordinator or Lab Manager: Name: Stephen von Kugelgen Lab Phone: 510.301.1058 Office Phone: 510.642.8252 Emergency Contact: Name: Stephen von Kugelgen Phone Number: 510.301.1058 Location(s) covered by this SOP: Hildebrand Hall D61 1. Purpose This SOP covers the precautions and safe handling procedures for the use of Carbon Monoxide, an Acutely Toxic Gas (ATG). For a list of ATGs covered by this SOP and their use(s), see the “List of Chemicals”. Procedures described in Section 12 apply to all materials covered in this SOP. If you have questions concerning the applicability of any recommendation or requirement listed in this procedure, contact the Principal Investigator/Laboratory Supervisor or the campus Chemical Hygiene Officer at [email protected]. 2. Acutely Toxic Gases Information Before working with any Acutely Toxic Gases (ATGs), review the UC-Berkeley EH&S publication Toxic Gas Program on the EH&S website. If you have questions about Toxic Gas Program requirements, contact EH&S at 642-3073.
Transcript of Acutely Toxic Gas: Carbon Monoxide · Acutely Toxic Gases Chemical Class Standard Operating...
AcutelyToxicGasesChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
AcutelyToxicGas:CarbonMonoxideH220H280H331H360H372
ThisSOPisnotasubstituteforhands-ontraining.PrintacopyandinsertintoyourlaboratorySOPbinder.
Department: Chemistry
DateSOPwaswritten: Tuesday,March28,2017
DateSOPwasapprovedbyPI/labsupervisor: Friday,March24,2017
PrincipalInvestigator:Name:F.Fischer
Signature:______________________________
InternalLabSafetyCoordinatororLabManager:Name:StephenvonKugelgen
LabPhone:510.301.1058
OfficePhone:510.642.8252
EmergencyContact: Name:StephenvonKugelgen
PhoneNumber:510.301.1058Location(s)coveredbythisSOP: HildebrandHallD61
1. Purpose
ThisSOPcoverstheprecautionsandsafehandlingproceduresfortheuseofCarbonMonoxide,anAcutelyToxicGas(ATG).ForalistofATGscoveredbythisSOPandtheiruse(s),seethe“ListofChemicals”.ProceduresdescribedinSection12applytoallmaterialscoveredinthisSOP.Ifyouhavequestionsconcerningtheapplicabilityofanyrecommendationorrequirementlistedinthisprocedure,contactthePrincipalInvestigator/LaboratorySupervisororthecampusChemicalHygieneOfficeratucbcho@berkeley.edu.
2. AcutelyToxicGasesInformation
BeforeworkingwithanyAcutelyToxicGases(ATGs),reviewtheUC-BerkeleyEH&SpublicationToxicGasProgramontheEH&Swebsite.IfyouhavequestionsaboutToxicGasProgramrequirements,contactEH&Sat642-3073.
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3. PotentialHazards/Toxicity
Toxicgasesaregasesthatmaycausesignificantacutehealtheffectsatlowconcentrations.Healtheffectsmayincludesevereskinoreyeirritation,pulmonaryedema,neurotoxicity,orotherpotentiallyfatalconditions.TheGloballyHarmonizedSystemofClassificationandLabelingofChemicals(GHS)designatesATGsbyoneormoreofthefollowingHcodes:
H280Containsgasunderpressure;mayexplodeifheatedH330FatalifinhaledH331ToxicifinhaledH332HarmfulifinhaledH333Maybeharmfulifinhaled
ATGsmayalsohaveotherhazardouspropertiesinadditiontoacutetoxicity(e.g.corrositivity,pyrophoricity).Safeuserequiresassessingallpotentialhazards.
ItisthePrincipal Investigator’s responsibility toensureactivity-specific laboratoryproceduresand/orprocessesaretakenintoaccountwhenusingthisChemicalClassSOP.
Please,reviewtheSDSofanychemicalbeforeuse(seeSection11–SDSLocation).ThefollowinginformationisnotintendedtoreplacetheSDS.
SpecificHazards/ToxicityforCarbonMonoxide
H220-extremelyflammablegasH280-containsgasunderpressure;mayexplodeifheatedH331-toxicifinhaledH360-maydamagefertilityortheunbornchildH372-causesdamagetoorgans(centralnervoussystem)throughprolongedorrepeatedexposure
Itisacolorless,odorless,poisonousandextremelyflammablegas.CarbonMonoxideisachemicalasphyxiantandmaybefatalifinhaled.ExposuretoCarbonMonoxidecancausenausea,dizziness,headaches,andcollapse.CarbonMonoxideposesaseriousfirehazardwhenitisaccidentallyreleased.FlameorhightemperatureimpingingonalocalizedareaofthecylinderofCarbonMonoxidecancausethecylindertoexplodewithoutactivatingthecylinder’sreliefdevices.Provideadequatefireprotectionduringemergencyresponsesituations.
Themostsignificantrouteofover-exposureforCarbonMonoxideisbyinhalation.INHALATION:Carbonmonoxideisclassifiedasachemicalasphyxiant,producingatoxicactionbycombiningwiththehemoglobinofthebloodandreplacingtheavailableoxygen.Throughthisreplacement,thebodyisdeprivedoftherequiredoxygen,andasphyxiationoccurs.Sincetheaffinityofcarbonmonoxideforhemoglobinisabout200-300timesthatofoxygen,onlyasmallamountofCarbonMonoxidewillcauseatoxicreactiontooccur.CarbonMonoxideexposuresinexcessof50ppmwillproducesymptomsofpoisoningifbreathedforasufficientlylongtime.Othereffectsofexposurecanbesummarizedasfollows:
CONCENTRATIONOFGASOBSERVEDEFFECTAllexposurelevels:Over-exposuretoCarbonMonoxidecanbeindicatedbythelipsandfingernailsturningbrightred.
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200ppm:Slightsymptoms(headache,discomfort)afterseveralhoursofexposure.400ppm:Headacheanddiscomfortexperiencedwithin2-3hoursofexposure.1,000-2000ppm:Within30minutes,slightpalpitationsoftheheartoccur.Within1.5hours,thereisatendencytostagger.Within2hours,thereismentalconfusion,headache,andnausea.2000-2500ppm:Unconsciousnesswithin30minutes.>2500ppm:Potentialforcollapseanddeathbeforewarningsymptomsareproduced.NOTE:Athighaltitudes,individualsmaybemoresusceptibletoCarbonMonoxideover-exposures.Developmentofsymptomsmayalsooccurmorerapidlyifindividualsaredoingphysicallydemandingtasks.Individualswhohaveheartconditionsmayexperienceamorerapidonsetofsymptoms.Duringrecovery,victimscanexperienceheadaches,visionproblems,andmemoryloss.
HEALTHEFFECTSORRISKSFROMEXPOSURE:Over-exposuretoCarbonMonoxidemaycausethefollowinghealtheffects:ACUTE:CarbonMonoxideisatoxicgas.SymptomsofCarbonMonoxidepoisoningcandevelopgradually,orcanarisesuddenly,dependingontheconcentrationanddurationofexposure.Lipsandfingernailswillturnbrightred,whichisasignificantsignofCarbonMonoxideover-exposure.Othersymptomsofover-exposurecanincludeheadache,shortnessofbreath,wheezing,dizziness,indigestion,andnausea.Athighconcentrationsunconsciousnessordeathmayoccur.Symptomscanincludeblurredvisionandmemoryloss.CHRONIC:ClinicalstudiesindicatethatthereisarelationshipbetweenexposuretoCarbonMonoxideinspecificoccupations(i.e.,fire-fighters,foundryworkers)andanincreasedincidenceofcardiovascularproblems.CarbonMonoxideisareproductivetoxin.RefertoSection11ofthisMSDSforfurtherinformation.TARGETORGANS:Respiratorysystem,circulatorysystem,cardiovascularsystem,reproductivesystem.
4. EngineeringControls
Usetheengineeringcontrolslistedbelowunlessotherlab-specificinformationisincludedintheProtocol/Proceduresection.
• WorkwithATGsmustbeconductedinafumehoodunlessothercontrolsaredesignatedinthelab-specificProtocol/Proceduresection.Sashheightmustbekeptlowtoavoidescapingfumesandprovideaphysicalbarrier.
• Indoorstorageofallgascylindersinthisprogrammustbeinamechanicallyventilated,lockablearea.Examplesofmechanicalventilatedareasincludeexhaustedgascabinets,fumehoods,andspecialfirecodecompliantgasstoragerooms.
• Allcylindersandgascabinetsmustbeclearlylabeledwithcontentandhazardinformation.• Allregulators,valves,piping,tubingandfittingsmustbechemicallycompatiblewiththegases
beingused.Regulatorsmustbecompatiblewiththesizeandtypeofgascylinderbeingusedandratedforfullcylinderpressure.Consultyourgassupplierforapprovedregulators,valves,piping,tubing,andfittings.
• Cylindersmustbestoredupright,withtankvalvessecurelyclosedandvalveprotectioncapinplace,andfirmlysecuredtopreventfallingorbeingknockedover.
• SomeATGshavepoorwarningproperties.IfaparticularATGfallsintothiscategoryandworkwiththisgaswillbedoneroutinelyorlargerquantitieswillbeemployed,installacontinuouselectronicwarningsensorwithalarmifavailable.Insurethatthefumehoodisoperating
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properlyandkeepthesashaslowaspossibleatalltimes.Aventilationmonitorisrequiredonthehood.
5. PersonalProtectiveEquipment
Ataminimum,thefollowingPPEmustbewornatalltimes.
EyeandFaceProtectionA. ANSIZ87.1-compliantsafetyglasseswithsideshields,orchemicalsplashgoggles.
• Ordinary prescription glasses will NOT provide adequate protection unless they alsomeetANSIstandardandhavecompliantsideshields.
B. Ifthepotentialforexplosion/splashingexists,andadequatecoverageisnotprovidedbythehoodsash,afaceshieldmustbeworn.
SkinandBodyProtection1. Glovesarerequiredwhenhandlinghazardouschemicals.
• RefertospecificchemicalSDSforinformationongloveselection.• Foradditionalinformationongloveselection,goto:
http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-and-usage.html2. Labcoatsarerequiredwhenhandlinghazardouschemicalsinthelab.Selectthetypeoflabcoat
accordingtothehazardsatthespecificworkplace.3. Longpants,closed-toe/closed-heelshoes,coveredlegs,andankles.
RespiratoryProtectionRespiratoryprotectionisnormallynotrequiredforUCBerkeleylaboratoryactivities.AnylabpersonnelconsideringtheuseofarespiratormustcontactEH&Sforaworkplaceassessment.
6. FirstAidProceduresandMedicalEmergencies
Intheeventofaninjury,notifyyoursupervisorimmediatelyandEH&Swithin8hours.
GototheOccupationalHealthFacility(TangHealthCenter,oncampus); ifafterhours,gotothenearestemergencyroom(AltaBates,2450AshbyAveinBerkeley);or
Call911(fromacellphone:510-642-3333)if:
• itisalifethreateningemergency;or
• younotareconfidentinyourabilitytofullyassesstheconditionsoftheenvironmentand/orthe condition of the contaminated/injured person, or you cannot be assured of your ownsafety;or
• thecontaminated/injuredpersonisnotbreathingorisunconscious.
Please remember to provide a copy of the appropriate manufacturer SDS (if available) to theemergency responders or physician. At a minimum, be ready to provide the identity/name of anyhazardousmaterialsinvolved.
Incaseofskincontact
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Ifskincontactoccurs,and/orskinorclothingareonfire,immediatelydrenchinthesafetyshowerwithcopiousamountsofwaterfornolessthan15minutestoremoveanyremainingcontaminants.Ifpossibletodosowithoutfurtherinjury,removeanyremainingjewelryorclothing.IncaseofeyecontactRinsethoroughlywithplentyofwaterusinganeyewashstationforatleast15minutes,occasionallyliftingtheupperandlowereyelids.Removecontactlensesifpossible.IfinhaledMoveintofreshair.
7. SpecialHandling,Storage,andDisposalRequirements
Lab-specificinformationonhandlingandstoragemaybeincludedintheProtocol/Proceduresection.Precautionsforsafehandling
• Donotdrag,roll,slideordropcylinders.Asuitablehandtruck,towhichthecylinderissecured,mustbeusedforcylindermovement.
• Whentransportinggasesoutsidethelab,theprotectivecapmustbeinplaceandmustcoverthevalve.
• Neverattempttoliftacylinderbyitscap.• Securecylindersatalltimeswhileinuseandduringtransport.• Oncecylinderhasbeenconnectedtoprocess,openvalveslowlyandcarefully.Ifexperiencing
difficultyopeningcylindervalve,discontinueuseandcontactsupplier.Donotattempttoforcefreeing“frozen”orcorrodedvalves.
• Regulatorsandvalvesmustbekeptfreeofmoisture.Systemsmustbepurgedwithdryinertgas(e.g.helium,nitrogen,argon,etc.)beforetheproductisintroducedandwhensystemisoutofservice.
Conditionsforsafestorage• ItisessentialthatallATGsbestoredseparatelyfromallchemicalswithwhichtheymayreact.
EnsuresegregationofincompatiblechemicalsperguidancewithinEH&Sguidelines.Also,followanysubstance-specificstorageguidanceprovidedinSafetyDataSheet(SDS)documentation.
• Allcompressedgascylindersmustbestoreduprightwithvalvecovercapsinplace.Damagetoavalvecancausethecylindertobecomeadangerousprojectile.Cylindersmustbeproperlysecuredwithtwonon-combustiblerestraintstopreventthemfromfallingatalltimes.
Disposal
• Allemptygascylindersmustbelabeledasempty;however,emptycylindersmaystillcontainsometoxicgas,somustremaininexhaustedenclosuresorfirecodecompliantgasstoragerooms.Depletedgascylindersmustbereturnabletothevendoraccordingtotheirguidelines.
8. ChemicalRelease
ChemicalReleaseDial911• AccidentalRelease–Helpcontaminatedorinjuredpersons.Ifconditionsandtimepermit,close
anyopenvalve.Evacuatethereleasearea.Avoidbreathingvapors.Eliminatesourcesof
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ignition.Keepothersfromenteringthisarea(e.g.,usecautiontape,barriers,etc.).NotifysupervisorandEH&Simmediately.
• Contactwithbodyorclothes–Removeclothingandrinsebodythoroughlyinemergencyshowerforatleast15minutes.Seekmedicalattention.NotifysupervisorandEH&Simmediately.
• ContactwithEyes–Immediatelyrinseeyeballsandinnersurfaceofeyelidwithwaterfor15minutesusinganeyewashstationbyforciblyholdingtheeyeopen.Seekmedicalattention.NotifysupervisorandEH&Simmediately.
9. CleaningandDecontamination
Lab-specificinformationondecontaminationmaybeincludedintheProtocol/Proceduresection.Alllinesorductscarryingpurgedorexhaustedemissionsofgasesmustbeconnectedtoamechanicalexhaustsystemthatdischargestoasafelocation(i.e.,presentsnopotentialforre-entrainmentintoanybuildingsupplyairintakeoroccupiedarea).Constructionoftheexhaustductsmustbechemicallyresistanttodegradationbythegasinuse.Significantemissionsofcorrosiveortoxicgasesrequireanemissioncontroldevice(e.g.,scrubber,flaredevice,adsorbent)beforethepurgedgascanbeventedintotheexhaustductsystem.RefertoToxicGasProgram.
10. HazardousWasteDisposal
LabelWaste• Allemptygascylindersshallbelabeledasempty
DisposeofWaste• Depletedgascylindersshouldbereturnabletothevendoraccordingtotheirguidelines.• ContactEH&Sat642-3073ifyouneedassistance.
11. SafetyDataSheet(SDS)LocationSDScanbeaccessedonlineathttp://ucsds.com
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12.Protocol/Procedure–AcutelyToxicGases(ATGs)
Procedure/Use Scale EngineeringControls/Equipment
PPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions
1.UseforSTM/ncAFMtippreparation.
Uptoalecturebottle.
ConductalloperationsinthedesignatedspaceinHildebrandHallD61.Useonlythepermanentlyinstalledandapprovedequipmentandlines.SetupaCOmonitorwheneverthelecturebottleisinuse.
Usewithadequateventilation.Providenaturalorexplosion-proofventilationadequatetoensureCarbonMonoxidedoesnotreachitslowerflammabilitylimitof12.5%.Openflamesandpossiblesparkingandstaticelectricitymustbeavoided
Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.
Faceprotection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.
Handprotection:ConfirmthecompatibilityoftheglovesyouusewiththespecificATG.Generalguidance(unlessotherwisespecifiedinthespecificSDS):ataminimum,8milminimumnitrileglovesmustbeusedtopreventincidentalcontact.Forgasreleaseorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Removeglovesimmediatelyuponcontamination.Washanddryhandsafteruse.
Clothing:Wearlabcoat;fulllengthpantsorequivalent;andclose-toed,close-heeledshoes.
ThedepositionofcarbonmonoxideutilizesaleakvalvethatconnectstheUHVchamberandasmallcarbonmonoxidecylinder.TheUHVsystemshouldhavegoodventilationduringthedepositionprocess:theturbopumpandtheroughingpumponthesystemshouldbeturnedon,andtheroughingpumpshouldbeconnectedtothebuildingventilationsystem.
Beawareofanysignsofdizzinessorfatigue;exposurestofatalconcentrationsofCarbonMonoxidecouldoccurwithoutanysignificantwarningsymptoms.Non-sparkingtoolsshouldbeused.Donotattempttorepair,adjust,orinanyotherwaymodifythecylinderscontainingCarbonMonoxide.MakesuretheCarbonMonoxidedetectorworksnormally.
Notes AnydeviationfromthisSOPrequiresapprovalfromPI.
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13-DocumentationofTraining(signatureofallusersisrequired)
• PriortoconductinganyworkwithATGs,designatedpersonnelmustprovidetrainingtohis/her
laboratorypersonnelspecifictothehazardsinvolvedinworkingwiththissubstance,workarea
decontamination,andemergencyprocedures.
• ThePrincipalInvestigatormustprovidehis/herlaboratorypersonnelwithacopyofthisSOPanda
copyoftherelevantSDSsprovidedbythemanufacturer.
IhavereadandunderstandthecontentofthisSOP:
Name Signature Identifier Date
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Appendix–ListofAcutelyToxicGases(non-exhaustivelist)
ChemicalName/Formula CAS# ChemicalName/Formula CAS#AmmoniaNH3 7664-41-7 ArsenicpentafluorideAsF5 7784-36-3
ArsineAsH3 7784-42-1 BorontrichlorideBCl3 10294-34-5
BorontrifluorideBF3 7637-07-2 CarbonmonoxideCO 630-08-0
CyanogenC2N2 460-19-5 CyanogenchlorideNCCl 506-77-4
ChlorineCl2 7782-50-5 DiazomethaneH2CN2 334-88-3
DiboraneB2H6 19287-45-7 FluorineF2 7782-41-4
GermaneGeH4 7782-65-2 Hexaethyltetraphosphate
C12H30O13P4
757-58-4
HydrogenbromideHBr 10035-10-6 HydrogenChlorideHCl 7647-01-0
HydrogenfluorideHF 7664-39-3 HydrogensulfideH2S 7783-06-4
HydrogenselenideH2Se 7783-07-5 MethylmercaptanCH3SH 74-93-1
NitricoxideNO 10102-43-9 NitrogendioxideNO2 10102-44-0
NitrogentetroxideN2O4 10544-72-6 OxygendifluorideOF2 7783-41-7
PhosgeneCOCl2 75-44-5 PhosphinePH3 75-45-5
PhosphorouspentafluoridePF5 7641-19-0 SeleniumhexafluorideSeF6 7783-79-1
StibineSbH3 7803-52-3 SulfurtetrafluorideSF4 7783-60-0
Trimethylsilyldiazomethane(CH3)3SiCHN2 18107-18-1
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ListofChemicals
Chemical(s) Chemical(s) Chemical(s)
Carbonmonoxide
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