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Pearcy, Mark, Woodruff, Mia, Xiao, Yin, Klein, Travis, Crawford, Ross, Izatt,Maree, Langton, Christian, Hutmacher, Dietmar, & Schuetz, Michael(2013)Orthopaedics and Trauma Queensland Annual Report 2012.
Orthopaedics and Trauma Queensland, Australia.
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http://www.ihbi.qut.edu.au/about/researchover/medicaldevice/orthopaedicsTrauma.jsp
Orthopaedics and Trauma QueenslandA Centre for reseArCh And eduCAtion in MusCuloskeletAl disorders
IncorporatIng:
› BIomaterIals and tIssue morphology group
› Bone group
› cartIlage regeneratIon laBoratory
› northsIde spIne research group
› orthopaedIc research group
› paedIatrIc spIne research group
› QuantItatIve BIomedIcal ImagIng and characterIsatIon research group
› regeneratIve medIcIne group
› trauma research group
A N N U A L R E P O R T 2 0 1 2
HeadingContents
inTrOducTiOn inside front
direcTOr’s message inside front
research Overview 1
selecTed PrOjecT highlighTs 1
research FaciliTies 9›› institute of health and Biomedical
innovation (ihBi) 9›› science and engineering Faculty 9›› medical engineering research
Facility (merF) 9
FacTs and Figures 9
naTiOnal cOmPeTiTive granTs 10
OTher granTs 11
PuBlicaTiOns 13›› Books 13›› Book chapters 13›› journal articles 13
sTaFF 17
adjuncT PrOFessOrial sTaFF 19
higher degree research sTudenTs 20›› new students 20›› continuing students 20›› completions 22›› Overseas visiting students 22
awards, Prizes and cOmmuniTy service 23
acknOwledgemenTs 24
for further inforMAtion PhOne +61 7 3138 6000 Fax +61 7 3138 6030 email orthotraumaqld@qut.edu.auwww.ihbi.qut.edu.au/research/medical_device.jsp
introduCtion
Orthopaedics and Trauma Queensland, the centre for research and education in
musculoskeletal disorders, is an internationally recognised research group that continues
to develop its reputation as an international leader in research and education. it provides a
stimulus for research, education and clinical application within the international orthopaedic
and trauma communities.
Orthopaedics and Trauma Queensland develops and promotes the innovative use of
engineering and technology, in collaboration with surgeons, to provide new techniques,
materials, procedures and medical devices. its integration with clinical practice and strong
links with hospitals ensure that the research will be translated into practical outcomes
for patients.
The group undertakes clinical practice in orthopaedics and trauma and applies core
engineering skills to challenges in medicine. The research is built on a strong foundation
of knowledge in biomedical engineering, and incorporates expertise in cell biology,
mathematical modelling, human anatomy and physiology and clinical medicine in
orthopaedics and trauma. new knowledge is being developed and applied to the full range
of orthopaedic diseases and injuries, such as knee and hip replacements, fractures and
spinal deformities.
doMAin leAder’s MessAge
welcome to the 2012 Orthopaedics and Trauma Queensland (O&TQ) annual report.
The review of QuT’s institute of health and Biomedical innovation (ihBi) conducted in 2012 is
leading to a re-organisation of the structure of research groups in ihBi. The completion of the
restructure was delayed with the executive director, Professor ross young, leaving to take
on the role of executive dean in the Faculty of health at QuT. a new executive director is
expected to begin in september 2013 with the new structure commencing in 2014.
Orthopaedics and Trauma Queensland is taking the opportunity of this delay to develop a
more comprehensive strategy for its transition into a centre recognised internationally for its
leadership in the area of the group’s central theme of advancing orthopaedic and trauma
surgery for improved treatment of musculoskeletal disorders and disease. Because of the
restructuring of ihBi for 2014 i have included a summary in the Facts and Figures section
of our performance from 2006 showing that over the seven years we have graduated 44
Postgraduate students, received $23.27million in research funding and published 387
journal papers; all significant achievements.
This year our research in orthopaedic implants, biomaterials and innovative scaffold
development, bone biology, spinal deformity and other spinal disorders has continued
to develop and provide clinically relevant outcomes. Our international links continue to
develop with Professor yin xiao cementing a formal link with chinese colleagues while our
other international links continue to flourish.
Please enjoy this report of our activities in 2012.
Professor Mark Pearcy Bsc, Phd, deng, fieAust, CPeng (Biomed)medical device domain leader, institute of health and Biomedical innovation, QuT
R e s e a R C h O v e R v i e w [ 1 ]
Research Overview
reseArCh overview
The research of Orthopaedics and Trauma
Queensland seeks to solve problems in a
broad range of areas focussed on issues
encountered in clinical practice, including:
›› Biomaterials and bone substitutes
›› cartilage biomechanics
›› cell biology›› cell biomechanics›› clinical research›› epidemiology›› Fracture healing›› lubrication›› mathematical
modelling›› mechanical
testing
›› Osteoarthritis›› Osteoporosis›› regenerative
medicine›› spinal deformity›› spinal disease›› surgical
complications›› surgical implants›› Tissue engineering›› Tissue mechanics›› wound healing
seleCted ProjeCt highlights
1. Biomaterials and tissue Morphology group
The Biomaterials and Tissue morphology
(BTm) group at ihBi, led by associate
Professor mia woodruff has taken on
several new members during 2012,
including the recruitment of research
associate dr giles kirby from the uk,
who undertook his Phd with collaborator
Professor kevin shakesheff at the
university of nottingham, and research
assistants kristofor Bogoevski and Flavia
savi. several publications arose during
the year including a Materials Today article
detailing histological assessment of long-
term bone regeneration using resorbable
scaffolds plus progenitor cells, in a pre-
clinical model (Figure 1).
Figure 1. Resorbable medical grade polycaprolactone scaffolds with and without the addition of bone marrow stromal cells implanted within a critical-sized porcine cranial defect for two years (Woodruff et al, publication: 74).
The BTm group continues to work closely
with the medical engineering research
Facility (merF) where several large
animal models are underway testing
new scaffolds in bone repair including
bioactive composites and novel growth
factor delivery strategies. The histology
capacity at ihBi continues to grow via
income from several equipment grants
and, with the resin embedding techniques
enabling large bone defect analysis, is
strengthening to become one of the
most equipped in the country. The BTm
group and the regenerative medicine
group, led by Professor hutmacher,
are also building capacity in the area of
biofabrication with a focus on custom
made, bioactive resorbable scaffolds for
patient specific implantation. we are also
developing growth factor delivery strategies
aimed at reducing clinical doses and
associated costs, (Figure 2); (which shows
microspheres containing growth factors
immobilised onto electrospun meshes
and demonstrates excellent bone-cell
interactions with the particles).
Figure 2. a) Electrospun porous meshes immobilized with protein eluting biodegradable particles. b) Precursor osteoblasts attaching and spreading on microparticles (Bock et al, publication: 8).
The paraffin and resin histology laboratory,
housed at ihBi , provides both QuT
academic project support and contract-
research services to external industry
[ 2 ] R e s e a R C h O v e R v i e w
clients and universities (Figure 3). services
include tissue processing, embedding
(paraffin and resin), sectioning, staining,
imaging/scanning and histomorphometrical
analysis – please contact us if you would
like further information on using these
services: mia.woodruff@qut.edu.au
Figure 3. Histology service provision at IHBI. For information please contact mia.woodruff@qut.edu.au.
2. Bone groupThe research of this group focuses on the
changes that osteocytes exhibit in osteo-
arthritis (Figure 4).
Figure 4. Pathological changes of osteocytes in osteoarthritis (OA).
Developing novel bone substitute
materials for bone repair and regeneration
low oxygen tension (hypoxia) plays a
pivotal role in the body by coupling blood
vessel and bone formation. it does this
by triggering a process of progenitor cell
recruitment and differentiation. The aim
of this project involves using materials-
based strategies to design scaffolds,
which activate the hypoxia pathway for the
purpose of developing and regenerating
skeletal tissue. This project will be a
catalyst to develope new treatment
strategies for large bone defects and has
the potential greatly to improve clinical
outcomes for patients. currently the market
for bone substitutes in australia alone is
estimated at a$400 million per annum.
Titanium implants and bone integration
Titanium implants are widely used in
dentistry and orthopaedics to replace
teeth and joints. modifying the implant
surface has been shown to improve
bone formation around titanium implants
under ‘normal’ conditions. however, their
success is reduced in compromised bone
such as that encountered in osteoporosis.
This study investigates the effect of
surface roughness and chemistry on bone
integration in osteoporotic conditions
and determine the associated biological
mechanisms. The determination of the
biological mechanisms will improve our
understanding of bone-implant interaction,
especially in difficult clinical situations such
as osteoporosis. This will lead to improved
outcomes of implants in osteoporotic
conditions.
Mesenchymal stem cell characterization
and tissue forming capacity
cell-based therapy has emerged as
one of the most promising therapeutic
approaches for tissue repair and
regeneration due to the inherent
characteristics of mesenchymal stromal
cells (mscs) in respect to their self-renewal
capacity and multipotent differentiation
potential. however, there has not been
a universal understanding of which
expansion conditions are optimal for the
manufacture of mscs intended for bone
repair and regeneration. more interestingly,
recent experimental evidence suggests
that implanted mscs have a close
communication with host cells, and the
contribution of donor cells is beyond their
direct conversion into bone forming cells.
The group is working on the molecular and
cellular interactions during the process
of new bone formation. The knowledge
developed will provide a scientific rationale
for the development of novel therapeutic
strategies in the treatment of bone defects.
3. Cartilage regeneration laboratoryThe cartilage regeneration laboratory
(crl) is led by associate Professor
Travis klein. The goal of the crl is to
develop long-term regenerative therapies
for treating cartilage defects, including
osteoarthritis. To help understand the
processes of cartilage formation and joint
pathologies, the group is developing model
systems combining human cells with
functionalised biomaterials and mechanical
stimulation techniques. The crl is
also working in the emerging area of
biofabrication, where biomaterials and cells
are combined in a computer-controlled
manner to form three-dimensional
structures suitable for in-vitro or in-vivo
studies.
crl research is funded by the australian
research council (arc) through the
Future Fellowship and discovery Project
schemes, as well as the national health
and medical research council (nhmrc)
through a Project grant (in collaboration
with associate Professor yin xiao and
Professor ross crawford). associate
Professor klein and Professor dietmar w
hutmacher are also named investigators
on a large european union grant that
was awarded in 2012. This project,
hydrozOnes, is a major collaborative
effort with 16 partners from around europe
that aims to develop tissue-engineered
cartilage constructs using advanced
biomaterial and biofabrication technologies
over the next five years. additionally, the
crl was successful in its bid for an ihBi
collaboration grant with dr Tony Parker
from ihBi and the Faculty of health. This
grant aims to help our understanding of
the interactions between the angiogenic
system and loading in osteoarthritis.
Heading
R e s e a R C h O v e R v i e w [ 3 ]
The crl currently consists of one
postdoctoral researcher, dr karsten
schrobback, 3 Phd students, and several
additional higher degree research (hdr)
students who are co-supervised in the
group. One of the major developments of
the year was june jeon’s completion of
her Phd, entitled ‘development of zonal
cartilage constructs: effects of chondrocyte
subpopulation, compressive stimulation,
and culture models.’ dr jeon did an
excellent job during her Phd and continues
to play a role in the crl as a post-doc in
the regenerative medicine group. daniela
Paul, and christoph meinert completed
their master’s and Bachelor’s degrees,
respectively, at the university of applied
sciences darmstadt (germany) after
successful research projects in the crl.
christoph has decided to re-join the crl
for a Phd at QuT, starting in 2013.
in 2012, the crl published work in leading
journals including Osteoarthritis and
Cartilage, Tissue Engineering –
Part A, the Journal of Tissue Engineering
and Regenerative Medicine, Cell
and Tissue Research, the Journal of
Biophotonics, and Progress in Polymer
Science. The article in the Journal of
Biophotonics describes novel imaging
techniques for cartilage, which were
developed during marieke Pudlas’ (first
author) research visit to the crl, and
was chosen as the cover article.
The group presented their work in 2012
at the world Biomaterials congress
(chengdu, china), including a special
symposium on zonal cartilage tissue
engineering chaired by associate
Professor klein; the world congress of
the international cartilage repair society
(montreal, canada); the Tissue engineering
and regenerative medicine international
society world congress (vienna, austria);
and annual meetings of the matrix
Biology society of australia and new
zealand. They further took part in the first
australian Osteoarthritis summit, in which
stakeholders including research leaders,
funding bodies and people suffering
from Oa discussed the priorities for
osteoarthritis research.
4. northside spine research groupThis group bases its activities around
the clinical practice of dr Paul licina and
examines the outcomes of surgery for
degenerative spinal disorders. in particular
the group is looking at comparison
of fusion rates with bone substitute.
investigations into anterior alone anterior
lumber interbody fusion with plate and
rhBPm-2 were completed and material
is being prepared for publication.
Presentation of ‘actifuse is comparable
with infuse in achieving fusion’ at the
spine society of australia annual scientific
meeting 2013 was well received with an
aim of future publication of these results.
Presentation of ‘Patient expectations,
outcomes and satisfaction: related, relevant
or redundant?’, at the international society
for the study of the lumbar spine (issls)
spine week meeting in amsterdam 2012
was followed by publication in the evidence
Based spine journal (eBsj). Future
collaboration with ihBi and the centre
for accident research and road safety,
Queensland (carrs-Q) investigating
fitness to drive following spinal surgery is
in progress.
5. orthopaedic research groupThe Orthopaedic research group directed
by Professor ross crawford is directly
involved in the supervision and training
of the next generation of doctors and
surgeons. each year medical students from
around the world participate in traineeships
with the group’s post-doctoral researchers
who try to impart research skills to further
the students’ careers. The projects that the
students participate in are part of the larger
research program that the Orthopaedic
group is involved in. an overseas
orthopaedic surgeon spends
12 months with the group developing
surgical and research skills. To date
fourteen surgeons, from countries as
diverse as india, canada, The netherlands
and the uk, have completed this training.
Professor crawford is involved in clinical
research at The Prince charles hospital
including research projects exploring the
relationship between obesity and outcome
following total joint replacement; minimising
complications post surgery; the efficacy
of new techniques and instrumentation;
economic evaluation of infection prevention
in total hip replacement; and risk factors
and outcome following hip fracture.
Professor crawford and his team also
have strong collaborative links with the
exeter hip unit in exeter, uk and liaise on
many clinical and developmental projects
surrounding hip replacement.
Professor crawford and dr lance wilson
have been investigating the causes and
clinical treatment of periprosthetic femoral
fractures. These fractures, that directly
involve the existing femoral implant, are
rare and difficult to treat. Our team of
orthopaedic surgeons, engineers and
students approached the problem with
two aims: to generate the same type of
fractures seen clinically in the laboratory
and to assess the performance of different
fracture repair techniques. The study has
generated two additions to the field of
orthopaedic research: an in-vitro model for
periprosthetic fracture generation and the
validation of cement-in-cement revisions
for periprosthetic fractures.
Biomechanical studies into the design and
behaviour of femoral stems used in total hip
replacement have been instrumental in the
development of a new design of implant
that will be released globally in 2014. in
Heading
[ 4 ] R e s e a R C h O v e R v i e w
addition to the scientific achievements,
the team has trained medical students
and orthopaedic surgeons in the use of
biomechanics as related to orthopaedics.
On the reverse side biomedical engineering
students are able to work with surgeons on
projects that are clinically applicable.
6. Paediatric spine research groupThe QuT/mater Paediatric spine research
group (Psrg) is a collaboration between
QuT Biomedical engineering researchers
and spinal Orthopaedic surgeons at the
mater children’s hospital in Brisbane,
australia. The group was established in
2002 to undertake research into spinal
deformities and other spine disorders to
improve the understanding and treatment
of these conditions. scoliosis, the most
common spinal deformity affecting children
and adolescents, results in the spine
curving sideways and twisting, leading to
an obvious hump on one side of the back
(Figure 5).
Figure 5. A 13-year-old girl suffering from progressive scoliosis requiring surgical stabilization.
scoliosis affects 2–4% of the population
and can appear during infancy, childhood
or the teenage years. The cause remains
unknown. about 500 australian children
each year require surgical correction and
stabilisation of their progressing scoliosis
using screws and rods. a world first study,
currently underway by Psrg researchers,
involves the sampling of vertebral bone
from the spinal column of adolescents with
scoliosis. The bone samples are taken by
the Orthopaedic spinal surgeon during
anterior scoliosis correction surgery in the
operating theatres at the mater children’s
hospital (Figures 6 and 7).
Figure 6. Fluoroscope image taken as the sample of vertebral bone is collected prior to the insertion of the vertebral body screw.
Figure 7. Spinal Orthopaedic Surgeons performing surgical stabilisation of progressive idiopathic scoliosis.
several recent studies have established
that teenagers with idiopathic scoliosis
have generalised lower bone mineral
density than their peers without scoliosis,
when measured by conventional imaging
techniques. it is also now understood
that low bone mineral density is a primary
problem of idiopathic scoliosis rather than
secondary to the spinal deformity as it is
present before the deformity develops and
also persists into maturity.
The vertebral bone samples taken in
this study will be analysed for their bone
mineral density as well as the quality of
the bone to see if there are abnormalities
in either bony architecture or the material
mechanical properties of scoliotic bone.
nanoindentation and Quantitative
Backscattered electron imaging (Figure 8)
will be used to analyse the vertebral bone
samples as well as complementary tests
on a sample of the patient’s blood for bone
turnover markers and vitamin d status.
Figure 8. Example of a Quantitative Backscattered Electron image showing mineral variations within adult trabecular bone in a femoral head sample from previous work by Victoria Toal as part of her PhD studies. The current study will analyse adolescent scoliotic vertebral bone for the first time.
This research project will make a
considerable contribution towards an
improved understanding of the quality of
bone in scoliosis sufferers. The findings
will potentially be used as a factor in the
prediction of scoliotic curve progression,
and the treatment approaches employed
for children and adolescents with
scoliosis. as this study is the first ever
to examine scoliotic vertebral bone
using nanoindentation and Quantitative
Backscattered electron imaging, it is
anticipated that there will be significant
international and national interest from both
the scientific and medical community in the
outcomes of this research.
Heading
R e s e a R C h O v e R v i e w [ 5 ]
a novel and topical research project
deviation for the Psrg in 2012 found that
the iPhone is a useful clinical device that
can assist medical staff in the surveillance
and management of young patients
with spinal deformity. The worsening
of spinal deformities in young children
and adolescents has been traditionally
monitored by spinal Orthopaedic surgeons
by measurement of the angles of deformity
on hardcopy x-rays with a protractor
and pencil. The rotation deformity of the
scoliotic spine and ribcage (rib hump)
was measured with a simple hand-held
scoliometer tool (similar to a carpenter’s
level). The iPhone and other smart phones
have the capability to accurately sense
inclination, and can therefore be used to
measure scoliosis deformity angles on
x-rays (or computer screens for digital
x-rays) and the twisting of the patient’s
ribcage (rib hump) (Figures 9 and 10).
Figure 9. iPhone measuring the angle of vertebral tilt on an X-Ray of a patient with scoliosis.
Figure 10. iPhone measuring the angle of trunk rotation (rib hump) on a scoliosis patient.
The research project aimed to quantify
the performance of the iPhone compared
to a standard protractor (scoliosis angles)
and scoliometer (rib humps) to ensure
medical staff could rely on their phones to
provide accurate readings and therefore
make appropriate clinical management
decisions. The x-ray measurement study
and the rib hump measurement study both
confirmed that the iPhone has the potential
to make a significant impact on efficiency
in busy city spinal clinics as well as remote
areas where digital x-ray systems are not
always available. The iPhone was found to
be a clinically equivalent measuring tool to
the traditional protractor and scoliometer
devices, with inter and intra-observer
variability similar to the traditional devices
and also similar to previous studies of
the traditional measurement techniques.
This work resulted in two internationally
peer-reviewed journal papers published
in 2012 as well as an award for the Best
Presentation at the annual scientific
meeting of the spine society of australia
conference and continues to attract
interest from researchers and clinicians
internationally.
7. Quantitative Biomedical imaging and Characterisation research group (Q-BiC)
The Q-Bic research group now
concentrates almost exclusively on
Quantitative ultrasound imaging and
characterisation.
3D/4D Quantitative Ultrasound Imaging
‘flat-Bed’ scanner: although
mammography is an effective way to
detect breast cancer, it is a 2d modality
used to image a 3d structure. image
co-registration with mri of a commercial
phantom is currently being investigated.
we have developed a twin-compartment
scanning tank facilitated via an ultrasonically
transparent membrane. in the lower
compartment a phased-array transducer is
scanned and the subject positioned in the
upper compartment.
robotic tumour targeting: successful
tracking of a tumour volume during
radiation delivery will provide a permanent
record of movement and may serve as
an interrupt. we have developed a twin-
robot dynamic phantom that will enable
the dosimetric consequences of tumour
movement to be quantified.
ultrasound Computed tomography:
utilising two co-axial phased-array
ultrasound transducers with a robotic arm
to facilitate translation and rotation, we
aim to determine both attenuation and
velocity maps for implementation within a
finite element model to predict mechanical
integrity. Potential applications include
paediatric skeletal assessment, bone
fatigue fracture risk in elite athletes, armed
forces personnel and equine laminitis.
another application is characterisation of
radiation dosimetry gels, to be validated
against conventional mri and optical cT.
Tissue Characterisation
langton theory and ultrasound transit
time spectroscopy (utts): langton
has recently proposed that the primary
ultrasound attenuation mechanism in
complex porous composite media such as
cancellous bone is due to phase interference
resulting from variations in propagation transit
time through the test sample as detected
over the phase-sensitive surface of the
receive ultrasound transducer. a Transit Time
spectrum, ranging from tmin to tmax, describing
propagation through entire solid and liquid
respectively, may be defined, from which it is
hypothesised that uTTs will provide accurate
assessment of both the volume fraction and
structure of complex porous composites.
it is envisaged that uTTs will, for the first
time, enable whO osteoporosis criteria to
be applied to ultrasound bone densitometry
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[ 6 ] R e s e a R C h O v e R v i e w
measurements, thereby significantly
increasing both the utility and acceptance.
8. regenerative Medicine groupThe Overarching Philosophy of the
Regenerative Medicine Group:
BiOengineers embrace complexity
BiOengineers design modularity/versatility
and BiOengineers deliver simplicity
The translational pathways for clinical
testing and therapeutic use and the
complexity of engineered tissue constructs,
often containing a combination of scaffolds,
cells, and/or growth factors, creates
challenges not only from a basic science
point of view but also from a translational
research angle. hence, it is necessary to
develop a much more iterative style of
research with low and permeable barriers
and a great deal of interaction between
academic research and industry. Based on
this background the regenerative medicine
group focuses on three major themes:
Biofabrication Technology Platform
The anatomical, physiological and
physiochemical aspects of regenerating or,
as an engineer would define it, rebuilding
tissues from cells in orchestration with
a scaffold and/or matrix are immensely
complicated. we must embrace this
biological complexity, but it cannot
dominate the design of a scaffold-
based concept in the process of clinical
translation. moreover, one size or
formulation cannot fulfill every need, from
cell expansion and delivery of growth
factors for muscle regeneration to creating
a structurally sound and slow degrading
scaffold for large-scale bone defect repair.
we should engineer flexibility, so that a
single suite of approvable materials can be
exploited for multiple physician uses in a
variety of clinical niches.
For regenerative medicine to succeed
as a reality, we must deliver simplicity.
The penetration of new technology into
any market is not determined only by
improvement in patient outcome — the true
limiting factors are cost, familiarity, and ease
of use. we believe that our biofabrication
technology platform technology addresses a
balance between the physiological and the
practical requirement, and that its uses for
clinical, veterinary, and laboratory research
needs will continue to expand in the
decades to come.
additive manufacturing techniques offer
the potential to fabricate tissue constructs
to repair or replace damaged or diseased
human tissues and organs. using these
techniques, spatial variations along multiple
axes with high geometric complexity in
combination with different biomaterials can
be obtained. The level of control offered by
these computer-controlled technologies
to design and fabricate tissues will allow
tissue engineers to better study factors that
modulate tissue formation and function,
yet most importantly discuss which
biomaterials properties are needed to move
the current concepts to practical solutions
and ultimately from bench to bedside.
The current limitations of the classical
tissue and organ printing techniques allow
the rm group to make a strong case that
the field needs to move towards exploring
and applying the full spectrum and the
combination of additive manufacturing
techniques and biomaterials for engineering
of tissues and organs. especially we
advocate that tissue engineers in our group
working on this concept need to interface
and learn from other areas such as material
science, mechatronics, bioengineering and
digital printing.
Bone Tissue Engineering
commonly applied therapies to achieve
bone reconstruction or function
are restricted to the transplantation
of autografts and allografts, or the
implantation of metal devices or
ceramic-based implants. Bone grafts
generally possess osteoconductive and
osteoinductive properties. They are,
however, limited in access and availability
and harvest is associated with donor site
morbidity, hemorrhage, risk of infection,
insufficient transplant integration, and graft
devitalisation. as a result, recent research
focuses on the development of alternative
therapeutic concepts.
available literature indicates that bone
regeneration has become a focus area in
the field of tissue engineering. hence, a
considerable number of research groups
including our own and commercial
entities work on the development of
tissue engineered constructs to aid
bone regeneration. however, bench to
bedside translations are still infrequent
as the process towards approval by
regulatory bodies is protracted and
cost-intensive. approval requires both
comprehensive in-vitro and in-vivo studies
necessitating the utilisation of large
preclinical animal models. consequently,
to allow comparison between different
studies and their outcomes, our group
focuses on the standardization of large
preclincial animal models, fixation devices,
surgical procedures and methods of
taking measurements to produce reliable
data pools as a base for further research
directions in the area of bone tissue
engineering.
Development of 3D disease models
in the future, animal and human donor
cell models may not be the first choice for
understanding mechanisms of disease,
cancer and their treatments. a main factor
is the poor evidence for efficacy of animal
models in humans. in addition, ethical
issues limit the applicability of animal
models due to increasing restrictions
in animal transport from overseas and
cost of higher developed animals such
as primates that would provide in-vivo
resemblance of human tissues. human
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donor tissues are of limited availability and
certain genetic predispositions that remain
undetected impact on the interpretability
of the outcome. In-vitro models, on the
other hand allow systematic repetitive,
in-depth and quantitative studies of
physiological and pathophysiological
processes without having to deal with
complications that are associated with
animal and donor tissues such as keeping
cells in viable conditions for a long period
of time. while most in-vitro models have
been successfully created in the two-
dimensional (2d) ‘monolayer’ medium,
2d models for studying for example
tumour cell growth in plastic dishes have
been compared to “...training for a desert
war in the arctic”. a more complex and
purer approach is to provide a three
dimensional (3d) ‘microenvironment’ to
the cells studied, by resembling the cells’
interstitial fluid and extracellular matrix
(ecm) as they experience these under
in-vivo conditions. The logic behind this
3d approach is that this model allows cells
to crosstalk with their microenvironment,
which may initiate events at cellular and
molecular levels including changes in cell
differentiation, morphogenesis, motility,
secretory function and gene expression.
in a 3d structure, cells can recapitulate
their original structure similar to in-vivo
conditions. it is believed that those ‘cues’
from the microenvironment are necessary
for the cells to differentiate and thus such
3d conditions allow the study of in-vivo
cellular events.
Functional features of ecm-cell niches
arise from the dynamic modulation of
the interplay of specific binding and
physical constraints of different cells.
in consequence, projects within this
programme will have to systematically
study different interactions according to
their relevance for various disease-tissue-
specific niche types. These interactions,
or categories of signals, define the general
outline for experimental approaches to
mimic signals related to disease related cell
microenvironments by using bioengineering
tools and innovative biomaterials.
accordingly, surface and matrix engineering
approaches are employed by the rm
group for the preparation of scaffold
surfaces and matrices with gradated
biochemical and physical characteristics.
as a major challenge of such a research
programme, surfaces and matrices have
to combine several of the above-listed
features according to the hypothesis on
the structural and functional properties
of the particular disease cell niche under
investigation. we envision that experiments
using advanced biomimetic materials
together with progress in modeling of
cellular interactions within the niche
microenvironment will substantially
contribute to the refinement of the
hypotheses on exogenous signals of
the disease cell niche which, in turn, will
provide a base for the development of next
generation of biomaterials research for
disease model bioengineering.
currently, several research groups including
ours have begun to adapt more advanced
3d culture techniques adapted from the
tissue engineering field to create not
only more physiological but also more
clinically relevant disease models; e.g.
tumour biology. in the context of what is
defined today as ‘tumour engineering’,
that is, the construction of complex cell
culture models that recapitulate aspects
of the in-vivo tumour microenvironment
to study the dynamics of tumour
development, progression, and therapy
on multiple scales. Our group provides
examples of fundamental questions that
could be answered by developing such
models, and encourages the continued
collaboration between bioengineers,
physical scientists and life scientists not
only for regenerative purposes, but also to
unravel the complexity that is the tumour
microenvironment.
9. trauma research groupThe Trauma research group brings
together clinical and engineering expertise
to tackle emerging issues in relation to the
management of orthopaedic trauma.
Optimizing the timing of mechanical
stimulation for fracture healing
Building on the adjunct appointment
of Professor claes, 2012 saw the
commencement of the first collaborative
research project between the Trauma
research group and the institute for
Orthopaedic research and Biomechanics
(university of ulm, germany). This project,
supported by an arbeitsgemeinschaft fur
ostesynthesis (aO) Trauma asia Pacific
grant, investigates the influence of the
temporal application of load on the process
of fracture healing.
The study question could be best
addressed using an experimental model
developed by Professor claes’ group. in
February dr ronny Bindl joined dr devakar
epari to complete the first experiments,
and train local students nicole loechel
(Phd) and lidia koval (masters) in the
procedures for ongoing work towards this
project. Preliminary results demonstrating
the benefits of early mechanical stimulation
followed by rigid fixation were presented at
the 1st aO Trauma asia Pacific scientific
congress in hong kong.
Mechanobiology of Bone Healing
dr Tim wehner, from the university of
ulm and known for his expertise in the
numerical modelling of fracture healing,
joined the Trauma research group on a
sixth month visit funded by the german
research council (dFg). dr wehner
is collaborating with dr epari on the
development of a novel experimental
model to investigate the mechanobiology
[ 8 ] R e s e a R C h O v e R v i e w
of bone healing. The experimental
model is intended to provide precise
control of the mechanical environment
thereby providing a platform for further
development and validation of algorithms
for the simulation of bone healing and
regeneration. dr wehner’s visit was timely,
coinciding with the 2012 conference and
workshop on modelling and computation
in musculoskeletal engineering, which
featured plenary lecturers from Professor
lutz claes (ulm), Professor georg duda
(Berlin), dr alf gerisch (darmstadt), and
dr richard weinkamer (Potsdam).
dr vaida glatt joined our Trauma research
group in mid 2012 via the julius wolff
institute in Berlin, germany, where she
undertook a post-doctoral fellowship with
Professor georg duda. dr glatt received
her Phd under the supervision of Professor
chris evans at the center for advanced
Orthopaedic studies, harvard medical
school. dr glatt’s research focus is the
regeneration and repair of orthopaedic
tissues. specifically, her interest lies in the
interaction of biological and mechanical
factors in the healing of large segmental
bone defects. her work is focused on
maximising the regenerative capacity of
bone healing while minimising the dose
of BmP-2 required clinically through
manipulation of the implant stability. soon
after arriving, dr glatt was awarded a
vice-chancellor’s research Fellowship in
recognition of her research achievements.
The Trauma research group has
expanded its presence outside the institute
of health and Biomedical innovation.
dr roland steck took on the additional
role of deputy director of the medical
engineering research Facility on The
Prince charles hospital campus.
dr steck has been invaluable in ensuring
the needs of researchers are being met at
this world-class facility. The Trauma group
also moved into the newly completed
Translational research institute (Tri) on the
Princess alexandra hospital campus. maja
schlittler and esther jacobson are the first
of our group to enjoy the new facilities,
which have become a home for the spinal
Trauma registry and the Trauma database.
in 2012, we celebrated the successful
completion of Phd degrees by two of
our group members. congratulations
dr Pushpanjali krishnakanth and
dr caroline grant. we are pleased that
dr caroline grant will continue her work
and support of the group’s activities as a
post-doctoral researcher.
in addition to visits by Professor claes and
Professor Perren we were fortunate to host
for the first time mr ruebi Frigg. mr Frigg is
the chief development Officer at synthes
and has been responsible for many of
the innovations in trauma implants on the
market today. mr Frigg took time out from
a busy world tour to share his knowledge
and experience with members of the
Trauma research group.
2012 ended with the establishment of the
integrated Trauma centre led by Professor
schuetz as part of the newly formed
diamantina health Partners, Queensland’s
first academic health science centre. with
a holistic view of trauma, the centre brings
together Queensland’s brightest and best
covering pre-hospital and hospital care,
allied health, rehabilitation and prevention.
The goal of the centre is to improve care
for patients in our community by integrating
clinical practice, research and education.
Heading
R e s e a R C h f a C i l i t i e s [ 9 ]
Research facilities
institute of heAlth And BioMediCAl innovAtion (ihBi)
QuT kelvin grove campus
›› laboratories for cell culture, mechanical and materials Testing, Polymer chemistry, Tissue mechanics, instrumentation and histology
›› mechanical and electronics workshop
sCienCe And engineering fACultY
Qut gardens Point Campus›› cell culture and mechanical Testing
laboratories›› rapid Prototyping Facility›› six axis spine Testing robot›› nanoindentation (umis 2000)
MediCAl engineering reseArCh fACilitY (Merf)
the Prince Charles hospital›› Operating Theatres›› anatomical and surgical skills
laboratory›› laboratories for materials Testing,
cell culture and Other Projects›› seminar room
The medical engineering research Facility
(merF) at The Prince charles hospital,
chermside was opened in 2008, and
was built by QuT with assistance from
the Queensland government smart
state Facilities Fund, the industry
partners medtronic and stryker, and
The Prince charles hospital. in 2012 merF
transitioned to a new reporting structure
under the umbrella of the institute of health
and Biomedical innovation (ihBi) within the
QuT organisational chart.
merF has become renowned for providing
the very best in theatres, equipment,
amenities and support to accommodate
surgical skills and allied health training and
education. in addition, merF is one of a few
preclinical research facilities worldwide that
is capable of providing the entire process
chain from concept to completion for the
evaluation of new biomaterials, implants,
medical devices
and surgical techniques at a single site.
facts and figures 2012›› 82 staff ›› 56 postgraduate students (20 commencements and 11 completions)›› $4.31 million research income ›› 83 journal papers, 2 books, 7 book chapters
suMMArY of fACts And figures 2006 - 2012
Orthopaedics and Trauma Queensland - facts and figures for 2006 to 2012
data from the O&TQ annual reports that are available on QuT ePrints
year staff number* staff academic and research**
hdr student number enrolled
hdr student commencing
hdr student completions
income au$ journal Publications
2006 45 22 23 4 5 $2.60m 232007 53 25 31 8 2 $2.30m 452008 86 26 40 10 6 $3.00m 422009 90 28 34 10 6 $3.16m 532010 85 27 54 20 8 $3.80m 752011 83 33 59 16 6 $4.10m 632012 82 36 56 20 11 $4.31m 83
totals 44 $23.27m 384* staff number includes academics, research Only staff, Professional staff, adjunct appointments and clinical Fellows associated
with O&TQ** staff number includes academics, research Only staff, Post-doctoral fellows and research Fellows (but not including
research assistants)
Heading
[ 1 0 ] N a t i O N a l C O m p e t i t i v e g R a N t s
grAnt national health and medical research council
title Bioactive and biodegradable scaffold and novel graft source for the repair of large segmental bone defects
Chief investigAtors dw hutmacher, m schuetz, d epari, m woodruff, r steck
funding $448 838
grAnt national health and medical research council
title a novel mesenchymal stromal cell and biomaterial for corneal reconstruction
Chief investigAtors dw hutmacher
funding $498 799
grAnt australian research council
title Optimisation of functional mesoporous materials for low-abundance biomarkers quantification towards biodiagnostic applications
Chief investigAtors i Prasadam
funding $45 000
grAnt national health and medical research council
title stem cells for periodontal regeneration
Chief investigAtors dw hutmacher
funding $200 617
grAnt australian research council Future Fellowship
title Frontiers in bone and joint regeneration
Chief investigAtors dw hutmacher
funding $931 168
grAnt australian research council Future Fellowship
title regenerating articular cartilage with smart hydrogels and fabrication technologies
Chief investigAtors Tj klein
funding $639 288
National competitive grants
Heading
O t h e R g R a N t s [ 1 1 ]
Other grants
grAnt Queensland government
title smart Futures Phd scholarship: robotic extrusion of intelligent tissue engineering scaffolds
Chief investigAtors m woodruff
funding $36 000
grAnt medtronic australasia Pty ltd
title Biomechanical assessment of a new growth modulation staple for fusionless scoliosis correction
Chief investigAtors c adam
funding $39 198
grAnt Queensland Orthopaedic research Trust – Queensland community Foundation Funds
title student research support
Chief investigAtors mj Pearcy
funding $7200
grAnt The Prince charles hospital Foundation research grant
title developing an injectable drug containing hyaluronic acid (ha) and erk signaling pathway modulators for osteoarthritis treatment.
Chief investigAtors r crawford, y xiao, i Prasadam
funding $73 250
grAnt australian dental research Foundation inc
title investigation of hedgehog signalling pathway during cementum regeneration in rat root wound healing model
Chief investigAtors y xiao
funding $9994
grAnt aO Foundation
title regenerative potential of osteoblasts and mesenchymal stem cells for bone tissue engineering
Chief investigAtors dw hutmacher, a Berner, a anthon
funding $122 743
grAnt mater Foundation
title Psrg synthes research activity support
Chief investigAtors c adam, m Pearcy
funding $475 000
grAnt human health and wellbeing collaborative research development grant scheme (hhwB) – ihBi
title Obesity and bone health: molecular links between obesity and osteoarthristis and therapeutic implications
Chief investigAtors r crawford, y xiao
funding $30 000
grAnt The wesley research institute lTd
title The reconstruction of large segmental bone defects using patient-specific tissue engineered constructs
Chief investigAtors m schuetz, dw hutmacher
funding $89 600
grAnt urB – aTn-daad joint research co-operation scheme
title Osteochondral defect regeneration using novel hybrid scaffolds
Chief investigAtors m woodruff
funding $24 000
[ 1 2 ] O t h e R g R a N t s
grAnt ihBi collaborative research development grant
title chondrocyte production and mechanoregulation of anti-aginogenic factors
Chief investigAtors T klein
funding $29 124
grAnt ihBi collaborative research development grant
title an innovative biomemetic model for studying the pathomechanisms of aging and age-related macular degeneration
Chief investigAtors B Feigl, d harkin, dw hutmacher
funding $30 000
grAnt cells and Tissue collaborative research development grant scheme – ihBi
title The expression and release of damage-associated molecular patterns (damps) following skeletal muscle injury
Chief investigAtors r steck, m woodruff, j Peake
funding $15 000
grAnt ihBi collaborative research development grant
title a novel bioengineered 3d model to study ovarian cancer progression in-vivo
Chief investigAtors F melchels, d loessner, dw hutmacher
funding $19 987
grAnt ihBi collaborative research development grant
title deciphering molecular interactions between prostate cancer cells and bone microenvironment
Chief investigAtors a Taubenberger, dw hutmacher,
funding $10 000
grAnt ihBi collaborative research development grant
title customized polycaprolactone melt electrospun scaffold for periodical regeneration
Chief investigAtors c vaquette, dw hutmacher
funding $10 000
grAnt arthritis australia
title Therapeutic targeting of microrna-23 in osteoarthritis
Chief investigAtors r crawford, y xiao, i Prasadam
funding $30 000
grAnt human health and wellbeing collaborative research development grant scheme (hhwB) – ihBi
title developing intelligent biodegradable polymer micro/nanoparticles encapsulating nicotinic receptor modulator drugs for pulmonary delivery for the treatment of nicotine and alcohol dependancy
Chief investigAtors B goss
funding $29 824
Heading
p u b l i C a t i O N s [ 1 3 ]
Books
1. afara iO, Oloyede a (2012) near infrared spectroscopy evaluation of articular cartilage: decision-making in arthroplasty: real-time assessment of articular cartilage. Lambert Academic Publishing.
2. xiao y. (ed) (2012) Mesenchymal stem cells; Cell Biology research Progress. Nova Science Publishers, New York.
Book ChAPters
1. irawan d, hutmacher dw, kleinTj (2012) Matrices for zonal cartilage tissue engineering. In Khang, G. (Ed.) Handbook of Intelligent Scaffold For Tissue Engineering And Regenerative Medicine. singapore, (p 733–756).
2. little P, adam c (2012) Patient-specific modeling of scoliosis. In Gefen, A. (Ed) Studies in Mechanobiology, Tissue Engineering and Biomaterials Vol 9; Part II Spine, Springer, Berlin, (p 103–131).
3. Prasadam i, chakravorty n, crawford rw, xiao y (2012) Mesenchymal stem cells in osteoarthritis therapy:current status of theory, technology and applications. In Xiao Y (Ed) Mesenchymal Stem Cells. nova science Publishers, new york, (p 163–176).
4. schuetz ma, Berner a, richards rg (2012) implant removal. in Babst, reto, Bavonratanavech, southern, &Pesantez, rodrigo (eds.) Minimally invasive plate osteosynthesis [2nd. Ed.]. aO Publishing, davos, (p 757–767).
5. schuetz ma, kääb mj (2012) distale femurfrakturen. In Haas, Norbert P, Krettek C (Eds). Tscherne unfallchirurgie: Hüfte und Oberschenkel. springer verlag.
6. xiao y, kaur n (2012) overview of mesenchymal stem cells. In Xiao Y (Ed) Mesenchymal Stem Cells. nova science Publishers, new york, (p1–14).
7. yan F, lin m, xiao y (2012) Periodontal regeneration and mesenchymal stem cells. in Xiao Y (Ed) Mesenchymal Stem Cells. nova science Publishers, new york, (p177–196).
journAl ArtiCles
1. adam cj (2012) endogenous musculoskeletal tissue engineering – a focussed perspective. Cell and Tissue Research, 347(3):489–99.
2. afara i, Prasadam i, crawford r, xiao y, Oloyede a (2012) non-destructive evaluation of carticular cartilage defects using near-infrared (nir) spectroscopy in osteoarthritic rat model and its direct relation to Mankin score. Osteoarthritis and Cartilage, 20(11):1367–1373.
3. an s, gao y, ling j, wei x, xiao y (2012) Calcium ions promote osteogenic differentiation and mineralization of human dental pulp cells: implications for pulp capping materials. Journal of Materials Science: Materials in Medicine, 23(3):789–795.
4. an s, ling j, gao y, xiao y (2012) effects of varied ionic calcium and phosphate on the proliferation, osteogenic differentiation and mineralization of human periodontal ligament cells in vitr. Journal of Periodontal Research, 47(3):374–382.
5. Balogh zj, reumann mk., gruen rl, mayer-kuckuk P, schuetz ma, harris ia, gabbe Bj, Bhandari m (2012) Advances and future directions for management of trauma patients with musculoskeletal injuries. The Lancet, 380(958):1109–1119.
6. Berner a, Boerckel jd, saifzadeh s, steck r, ren j, vaquette c, zhang jQ, nerlich m, guldberg re, hutmacher dw, woodruff ma (2012) Biomimetic tubular nanofiber mesh and latelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration. Cell and Tissue Research, 347(3):603–612.
7. Blackwood ka, Bock n, dargavilleTr, woodruff ma (2012) scaffolds for growth factor delivery as applied to bone tissue engineering. International Journal of Polymer Science: 1–25.
8. Bock n, dargavilleTr, woodruff ma (2012) electrospraying of polymers with therapeutic molecules: state of the art. Progress in Polymer Science, 37(11):1510–1551.
9. Bolland Bj, whitehouse sl, Timperley aj. (2012) indications for early hip revision surgery in the uk - a re-analysis of njr data. Hip International, 22 (2):145–52.
10. Bray lj, george ka, hutmacher dw, chirilaTv, harkin dg (2012) A dual-layer silk fibroin scaffold for reconstructing the human corneal limbus. Biomaterials, 33(13):3529–3538.
11. Bray lj, heazlewood cF, atkinson k, hutmacher dw, harkin dg (2012) evaluation of methods for cultivating limbal mesenchymal stromal cells. Cytotherapy, 14(8):936–947.
12. Brew cj, simpson Pm, whitehouse sl, donnelly w, crawford r, hubble mjw (2012) scaling digital radiographs for templating in total hip arthroplasty using conventional acetate templates independent of calibration marker. Journal of Arthroplasty, 27(4):643–647.
13. Brogan k, charity j, sheeraz a, whitehouse sl, Timperley aj, howell jr (2012) revision total hip replacement using the cement-in-cement technique for the acetabular component: technique and results for 60 hips. The Journal of Bone and Joint Surgery; British volume, 94(11):1482–6.
14. Brown cP, Oloyede a, crawford rw, Thomas ger, Price aj, gill hs (2012) Acoustic, mechanical and near-infrared profiling of osteoarthritic progression in bovine joints. Physics in Medicine and Biology, 57(2):547–559.
15. Brown Td, slotosch a, Thibaudeau l, Taubenberger a, loessner d, vaquette c, dalton Pd, hutmacher
publications
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[ 1 4 ] p u b l i C a t i O N s
dw (2012) design and fabrication of tubular scaffolds via direct writing in a melt electrospinning mode. Biointerphases, 7(april):13.
16. cao z, zhang h, zhou x, han x, ren y, gao T, xiao y, de crombrugghe B, somerman mj, Feng jQ (2012) genetic evidence for the vital function of osterix in cementogenesis. Journal of Bone and Mineral Research, 27(5):1080–1092.
17. chakravorty n, ivanovski s, Prasadam i, crawford r, Oloyede a, xiao y (2012) the micrornA expression signature on modified titanium implant surfaces influences genetic mechanisms leading to osteogenic differentiation. Acta Biomaterialia, 8(9):3516–3523.
18. chen g, Fan w, mishra s, el-atem a, schuetz ma, xiaoy (2012) tooth fracture risk analysis based on a new finite element dental structure models using micro-ct data. Computers in Biology and Medicine, 42(10):957–963.
19. chen j, crawford r, xiao y (2012) vertical inhibition of the Pi3k/Akt/mtor pathway for the treatment of osteoarthritis. Journal of Cellular Biochemistry, 114(2):245–9.
20. cipitria a, lange c, schell h, wagermaier w, reichert jc, hutmacher dw, Fratzl P, duda gn (2012) Porous scaffold architecture guides tissue formation. Journal of Bone and Mineral Research, 27(6):1275–1288.
21. darmanis sn, hubble mj, howell jr, whitehouse sl, Timperley aj (2012) Benefits of using modern cementing techniques in the acetabulum: the rim cutter. Journal of Orthopaedic Surgery, hong kong, 20 (3):316–321.
22. doan n, du z, crawford r, reher P, xiao y (2012) is flapless implant surgery a viable option in posterior maxilla? A review. International Journal of Oral and Maxillofacial Surgery, 41(9):1064–1071.
23. drobetz h, weninger O, grant c, heal c, muller r, schuetz ma, steck r (2012) More is not necessarily better. A Biomechanical study on distal screw numbers in volar locking distal radius plates. Injury 44:535–539.
24. Fan w, wu c, han P, zhou y, xiao y (2012) Porous Ca-si-based nanospheres: a potential intra-canal disinfectant-carrier for infected canal treatment. Materials Letters, 81(8):16–19.
25. Fu x, chen j, wu d, du z, lei Q, cai z, schultze-mosgau s (2012) effects of ovariectomy on rat mandibular cortical bone: a study using raman spectroscopy and multivariate analysis. Anayltcal Chemistry, 84(7):3318–23.
26. govaert g, schuetz ma, Peters P (2012) rib fixation for a traumatic ‘stove-in chest’: an option to consider. Anz Journal of Surgery, 82(4):276–277.
27. govaert g, siriwardhane m, hatzifotis m, malisano l, schuetz ma (2012) Prevention of pelvic sepsis in major open pelviperineal injury. Injury, 43(4):533–536.
28. han P, wu c, chang j, xiao y (2012) the cementogenic differentiation of periodontal ligament cells via the activation of wnt/ß-catenin signalling pathway by li + ions released from bioactive scaffolds. Biomaterials, 33(27):6370–6379.
29. heljak mk, wieszkowski w, lam cxF, hutmacher dw, kurzydlowski kj (2012) evolutionary design of bone scaffolds with reference to material selection. International Journal for Numerical Methods in Biomedical Engineering, 28(july):789–800.
30. histing T, klein m, stieger a, stenger d, steck r, matthys r, holstein jh, garcia P, Pohlemann T, menger md (2012) A new model to analyze metaphyseal bone healing in mice. Journal of Surgical Research, 178(2):715–721.
31. hutmacher dw, duda g, guldberg re (2012) endogenous musculoskeletal tissue regeneration. Cell and Tissue Research, 347(3):485–488.
32. hutmacher dw, woodruff ma, shakesheff k, guldberg re (2012) direct fabrication as a patient- targeted therapeutic in a clinical environment. Methods in Molecular Biology, 868:327–340.
33. izatt mT, adam cj, verzin ej, labrom rd, askin gn (2012) Ct and radiographic analysis of sagittal profile changes following thoracoscopic anterior scoliosis surgery. Scoliosis, 7(1):15.
34. izatt mT, Bateman gr, adam cj (2012) evaluation of the iPhone with an acrylic sleeve versus the scoliometer for rib hump measurement in scoliosis. Scoliosis, 7(1):14.
35. jaiprakash a, Prasadam i, Feng jQ, liu y, crawford r, xiao y (2012) Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: A possible pathological role in subchondral bone sclerosis. International Journal of Biological Sciences, 8(3):406–417.
36. jeon j.e, schrobback k, hutmacher dw, klein Tj (2012) dynamic compression improves biosynthesis of human zonal chondrocytes from osteoarthritis patients. Osteoarthritis and Cartilage, 20(8):906–915.
37. leong dT, abraham mc, gupta a, lim Tc, chew FT, hutmacher dw (2012) atf5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells. Journal of Cellular Biochemistry, 113(8):2744–2753.
38. licina P, johnston m, ewing l, Pearcy mj (2012) Patient expectations, outcomes and satisfaction: related, relevant or redundant? Evidence-Based Spinecare Journal, 3(4):13–19.
39. little jP, adam cj (2012) towards determining soft tissue properties
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p u b l i C a t i O N s [ 1 5 ]
for modelling spine surgery: current progress and challenges. Medical and Biological Engineering and Computing, 50(2):199–209.
40. little jP, izatt mT, labrom rd, askin gn, adam cj (2012) investigating the change in three dimenstional deformity for idiopathic scoliosis patients using axially loaded Mri. Clinical Biomechanics, 27(5):415–421.
41. loessner d, Quent vmc, kraemer j, weber ec, hutmacher dw, magdolen v, clements ja (2012) Combined expression of klk4, klk5, klk6, and klk7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance. Gynecologic Oncology, 127(3):569–578
42. lutton c, young yw, williams r, meedeniya acB, mackay-sim a, goss B (2012) Combined vegf and Pdgf treatment reduces secondary degeneration after spinal cord injury. Journal of Neurotrauma, 29(5):957–970.
43. malda j, Benders kem., kleinTj, de grauw jc, kik mjl, hutmacher dw, saris dBF, van weeren Pr, dhert wja. (2012) Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles. Osteoarthritis and Cartilage, 20(10):1147–1151.
44. malekani j, schmutz B, gu y, schuetz ma, yarlagadda Pk (2012) orthopedic bone plates: evolution in structure implementation technique and biomaterial. GSTF Journal of Engineering Technology (JET), 1(1): 135–140.
45. mao x, Tay gh, godbolt Bd, crawford rw (2012) Pseudotumour in a well-fixed Metal-on-Polyethylene uncemented hip Arthroplasty. Journal of Arthroplasty, 27(3):493.e13–493.e17.
46. melchels FPw, domingos man, klein Tj., malda j, Bartolo Pj, hutmacher dw (2012) Additive manufacturing of tissues and organs. Progress in Polymer Science, 37(8):1079–1104.
47. momot, k (2012) Microstructural magnetic resonance imaging of articular cartilage. Biomedical Spectroscopy and Imaging, 1(1): 27–37.
48. momot k i, Takegoshi k (2012) sensitivity of the nMr density matrix to pulse sequence parameters: a simplified analytic approach. Journal of Magnetic Resonance, 221 (1):57–68.
49. moody h, heard c, Frank c, shrive n, Oloyede a (2012) investigating the potential value of individual Parameters of histological grading systems in a sheep model of cartilage damage: the Modified Mankin Method. Journal of Anatomy, 221 (9):47–54.
50. Pawlak z, urbaniak w, gadomski a, yusuf kQ, afara iO, Oloyede a (2012) the role of lamellate phospholipid bilayers in lubrication of joints. Acta of Bioengineering and Biomechanics/Wroclaw University of Tecnology, 14(4):101–106.
51. Pfeifer c, müller m, Prantl l, Berner a, dendorfer s, englert c (2012) Cartilage labelling for mechanical testing in t-peel configuration. International Orthopaedics, 36 (7): 1493–1499.
52. Poole cm, cornelius i, Trapp jv, langton cm (2012) fast tessellated solid navigation in geAnt4. Australasian Physical and Engineering Sciences in Medicine, 35(3): 329–334.
53. Poole c, cornelius i, Trapp jv, langton cm (2012) A CAd interface for geAnt4. Australasian Physical and Engineering Sciences in Medicine, 35(3): 329–334.
54. Poole cm, cornelius i, Trapp jv, langton cm (2012) radiotherapy Monte Carlo simulation using cloud computing technology. Australasian Physical and Engineering Sciences in Medicine, 35(4):497–502.
55. Prasadam i, crawford r, xiao y (2012) Aggravation of AdAMts and matrix metalloproteinase production and role of erk1/2 pathway in the interaction of
osteoarthritic subchondral bone osteoblasts and articular cartilage chondrocytes – Possible pathogenic role in osteoarthritis. Journal of Rheumatology, 39(3):621–634.
56. Prasadam i, mao x, wang y, shi w, crawford r, xiao y (2012) inhibition of p38 pathway leads tooA-like changes in a rat animal model. Rheumatology, 51(5):813–823.
57. Pull Ter gunne aF, hosman ajF, cohen dB, schuetz ma, habil d, van laarhoven cjhm, van middendorp jj.(2012) A methodological systematic review on surgical site infections following spinal surgery. Part 1: risk factors. Spine, 37(24):2017–2033.
58. rath sn, arkudas a, lam cx, Olkowski r, Polykandroitis e, chró cicka a, Beier jP, horch re, hutmacher dw, kneser u (2012) development of a pre-vascularized 3d scaffold-hydrogel composite graft using an arterio-venous loop for tissue engineering applications. Journal of Biomaterials Applications, 27(3):277–289.
59. reichert jc, epari dr, wullschleger me, Berner a, saifzadeh s, nöth u, dickinson ic, schuetz ma, hutmacher dw (2012) Bone tissue engineering. reconstruction of critical sized segmental bone defects in the ovine tibia. Knochen-tissue-engineering Rekonstruktion segmentaler knochendefekte kritischer größe in der schafstibia, 41(4):280–287.
60. ruutu m, Thomas g, steck r, degli-esposti ma, zinkernagel ms, alexander k, velasco j, strutton g, Tran a, Benham h, rehaume l, wilson rj, kikly k, davies j, Pettit ar, Brown ma, mcguckin ma, Thomas r (2012) glucan triggers spondylarthritis and Crohn’s disease-like ileitis in skg mice. Arthritis and Rheumatism, 64(7):2211–2222.
61. schantz jT, woodruff ma, lam cxF, lim Tc, machens hg, Teoh sh, hutmacher dw (2012) differentiation
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[ 1 6 ] p u b l i C a t i O N s
potential of mesenchymal progenitor cells following transplantation into calvarial defects. Journal of the Mechanical Behavior of Biomedical Materials, 11(jul):132–142.
62. schon B, schrobback k, van der ven m, stroebel s, hooper gj, woodfield TB (2012) validation of a high-throughput microtissue fabrication process for 3d assembly of tissue engineered cartilage constructs. Cell and Tissue Research, 347( 3): 629–642.
63. schrobback k, klein Tj, crawford r, upton z, malda j leavesley di (2012) effects of oxygen and culture system on in-vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes. Cell and Tissue Research, 347(3):649–663.
64. schrobback k, malda j, crawford rw, upton z, leavesley di, klein Tj (2012) effects of oxygen on zonal marker expression in human articular chondrocytes. Tissue Engineering, 18(Oct):920–933.
65. shaw m, adam cj, izatt mT, licina P, askin gn (2012) use of the iPhone for Cobb angle measurement in scoliosis. European Spine Journal, 21(6):1062–1068.
66. sieh s, Taubenberger av, rizzi sc, sadowski m, lehman ml, rockstroh a, an j, clements ja, nelson cc, hutmacher dw (2012) Phenotypic Characterization of Prostate Cancer lnCaP Cells Cultured within a Bioengineered Microenvironment. PLoS ONE, 7(9).
67. sugiyama s, wullschleger m, wilson k, williams r, goss B (2012) reliability of clinical measurement for assessing spinal fusion: An experimental sheep study. Spine, 37(9):763–768.
68. van middendorp jj, Barbagallo g, schuetz ma, hosman ajF (2012) design and rationale of a Prospective, observational european Multicenter study on the efficacy of acute surgical decompression after traumatic
spinal Cord injury: the sCi-PoeM study. Spinal Cord, 50(9):686–694.
69. van middendorp jj, Pull Ter gunne aF, schuetz ma, habil d, cohen dB, hosman ajF, van laarhoven cjhm (2012) A methodological systematic review on surgical site infections following spinal surgery: Part 2: Prophylactic treatments. Spine, 37(24):2034–2045.
70. van middendorp jj, schuetz ma (2012) likelihood of tetraplegia after Ct clearance of the cervical spine in obtunded blunt trauma patients. Journal of Neurotrauma, 29(8):1714–1715.
71. vaquette c, Fan w, xiao y, hamlet s, hutmacher dw, ivanovski s (2012) A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone/periodontal ligament complex. Biomaterials, 33(22):5560–5573.
72. vijaysegaran P, coulter sa, coulter c, crawford rw (2012) Blood Cultures for Assessment of Postoperative fever in Arthroplasty Patients. journal of Arthroplasty, 27(3):375–377.
73. wilson lj, roe ja, Pearcy mj, crawford rw (2012) shortening cemented femoral implants. An in-vitro investigation to quantify exeter femoral implant rotational stability vs simulated implant length. Journal of Arthroplasty, 27(6):934–939.
74. woodruff ma, lange c, reichert j, Berner a, chen F, Fratzl P, schantz jT, hutmacher dw (2012) Bone tissue engineering: from bench to bedside. Materials Today, 15(10):430–435.
75. wu c, Fan w, zhou y, luo y, gelinsky m, chang j, xiao y (2012) 3d-printing of highly uniform Casio 3 ceramic scaffolds: Preparation, characterization and in-vivo osteogenesis. Journal of Materials Chemistry, 22(24):12288–12295.
76. wu c, zhou y, Fan w, han P, chang j, yuen j, zhang m, xiao y (2012) hypoxia-mimicking mesoporous
bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterial, 33(7):2076–2085.
77. wu c, Fan w, chang j, xiao y (2012) Mesoporous bioactive glass scaffolds for efficient delivery of vascular endothelial growth factor. Journal of Biomaterials Applications, 28(3) pp367–374.
78. wu c, zhou y, lin c, chang j, xiao y (2012) strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering. Acta Biomaterialia, 8(10): 3805–3815.
79. yao jw, xiao y, lin F (2012) effect of various ph values, ionic strength, and temperature on papain hydrolysis of salivary film. European Journal of Oral Sciences, 120(2):140–146.
80. yong mrnO, izatt mT, adam cj, labrom rd, askin gn (2012) secondary curve behavior in lenke type 1C adolescent idiopathic scoliosis after thoracoscopic selective anterior thoracic fusion. spine, 37(23):1965–1974.
81. zhang m, wu c, li h, yuen j, chang j, xiao y (2012) Preparation, characterization and in-vitro angiogenic capacity of cobalt substituted -tricalcium phosphate ceramics. Journal of Materials Chemistry, 22(40):21686–21694.
82. zhang m, wu c, lin k, Fan w, chen l, xiao y, chang j (2012) Biological responses of human bone marrow mesenchymal stem cells to sr-M-si (M 5 Zn, Mg) silicate bioceramics. Journal of Biomedical Materials Research Part A, 100a(11):2979–2990.
83. zhou y, wu c, xiao y (2012) the stimulation of proliferation and differentiation of periodontal ligament cells by the ionic products from Ca 7si 2P 2o 16 bioceramics. Acta Biomaterialia, 8(6):2307–2316.
s t a f f [ 1 7 ]
nAMe title
BrisBAne sPine grouP
dr richard williams centre director
dr Ben goss research Fellow
dr Fatemeh chehrehasa lecturer, human anatomy
dr alexander gibson spinal Fellow
dr hamish deverall spinal Fellow
dr stephen morris spinal Fellow
mrs rachel luton-goggins administration Officer
BioMAteriAls And tissue MorPhologY grouP
associate Professor maria woodruff leader, Biomaterials and Tissue morphology group
dr keith Blackwood Postdoctoral research Fellow
miss alyssa morris research assistant
mr kristofor Bogoevski research assistant
ms Flavia medeiros savi research assistant
mr edward ren research assistant
Bone BiologY grouP
Professor yin xiao leader, Bone research group
dr chengtie wu Postdoctoral Fellow
dr indira Prasadam Postdoctoral research Fellow
dr jiezhong chen Postdoctoral research Fellow
mr samuel Perry research assistant
ms wei shi research assistant
dr kai luo visiting Fellow
dr zhibin du visiting Fellow
CArtilAge regenerAtion lABorAtorY
associate Professor Travis klein vice-chancellor’s research Fellow
dr karsten schrobback Postdoctoral research Fellow
northside sPinAl reseArCh grouP
dr Paul licina spinal Orthopaedic surgeon
Professor mark Pearcy Professor of Biomedical engineering
ms michelle johnston clinical research nurse
orthoPAediC reseArCh grouP
Professor ross crawford chair in Orthopaedic research, director merF
Professor kunle Oloyede leader, cartilage Biomechanics group
dr yufeng zhang Postdoctoral Fellow
dr lance wilson research Fellow
dr sarah whitehouse research Fellow
dr david Farr navigation & arthroplasty Fellow
dr craig hughes navigation & arthroplasty Fellow
ms louise Tuppin clinical data manager
ms sue grice clinical research nurse
dr Takkan morishima visiting Fellow
mr Thor Friis research assistant
miss jessica Thompson research assistant
miss jenna lyon research assistant
miss monica warzywoda administration coordinator
staff
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[ 1 8 ] s t a f f
PAediAtriC sPine reseArCh grouP
dr geoff askin spinal Orthopaedic surgeon
associate Professor clayton adam Principal research Fellow
dr robert labrom spinal Orthopaedic surgeon
mrs maree izatt Project coordinator
Professor mark Pearcy Professor of Biomedical engineering
dr Paige little Postdoctoral research Fellow
dr alan carstens clinical spinal Fellow
dr mark Quick clinical Fellow
dr nabeel sunni clinical Fellow
dr mostyn yong clinical researcher
mr Brendon evans research assistant
mr Beau Brooker research assistant
QuAntAtive BioMediCAl iMAging And ChArACterisAtion reseArCh grouP And MediCAl PhYsiCs
Professor christian langton leader, Quantative Biomedical imaging and characterisation research group
dr konstantin momot senior lecturer, experimental Physics
dr mark wellard magnetic resonance Facility coordinator
regenerAtive MediCine grouP
Professor dietmar w hutmacher chair in regenerative medicine
dr anna Taubenberger visiting Fellow
dr Ferry melchels visiting Fellow
ms stephanie alexander visiting Fellow
dr cedryck vaquette research Fellow
mr Tobias Fuhrmann Postdoctoral research Fellow
dr siamak saifzadeh veterinary research scientist
dr christina Theodoropoulos senior research assistant
mrs nicole Benson labratory Technician
trAuMA reseArCh grouP
Professor michael schuetz chair in Trauma
dr devakar epari leader, Trauma research group
dr roland steck deputy director merF, senior research Fellow
dr Beat schmutz senior research Fellow
dr vaida glatt Postdoctoral research Fellow
dr joost van middendorp Postdoctoral research Fellow
ms maya schlittler Postdoctoral research Fellow
dr caroline grant research Fellow
dr david Theile senior research Fellow
ms esther jacobson spinal database manager
dr ronny Bindl visiting Fellow
dr Timothy wehner visiting Fellow
mrs nadine krueger research assistant
mrs rebecca Bibby administration coordinator
MediCAl deviCe doMAin of ihBi inCorPorAting o&tQ
Professor mark Percy leader
mrs joanne richardson administration Officer
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a d j u N C t p R O f e s s O R i a l s t a f f [ 1 9 ]
MediCAl PhYsiCs›› PrOFessOr james POPe
northside sPinAl reseArCh grouP›› dr Paul licina
PAediAtriC sPinAl reseArCh grouP›› dr geOFFrey askin ›› dr jOhn earwaker ›› PrOFessOr jOhn evans ›› dr rOBerT laBrOm›› dr PeTer BOys
regenerAtive MediCine grouP›› PrOFessOr rOBerT e guldBerg ›› dr Paul dalTOn ›› dr sasO ivanOvski›› dr anThOny lynham›› dr Tim wOOdField›› dr jOhannes malda›› PrOFessOr geOrg duda›› dr PaOlO BarTOlO
trAuMA›› PrOFessOr luTz claes ›› PrOFessOr nOrBerT haas ›› dr herwig drOBerTz›› PrOFessOr sTePhan Perren
Finite element simulations: (top) of a rat ulna compression model, which is used for studying stress fracture healing; (bottom) to predict correctly the location of the stress fracture.
adjunct professorial staff
[ 2 0 ] h i g h e R d e g R e e R e s e a R C h s t u d e N t s
new students
doctor of Philosophy
nAMe ProjeCt
Bartnikowski, michal development and optimisation of scaffolds for Osteochondral regeneration
chen, zetao regulating the immune response to bone substitute materials to improve osteogenesis
chhaya, mohit additive tissue manufacturing for breast reconstruction; combining computer aided design and manufacturing with adipose tissue engineering
du, zhibin Osseointergration in osteoporosis subject using ovariectomized rat model
Farnaghi, saba Obesity and osteoarthritis: a new insight in understanding the role of leptin-induced osteocytes in osteoarthritis pathogenesis.
henkel, jan evaluation of the efficacy of a novel ria/mPcl-TcP scaffold system in repairing ciritical-sized segmental bone defects compared to the gold standard autograft treatment in an ovine large animal model.
kashani, jamal an innovative computational framework for simulating articular cartilage biomechanics and degeneration
keenan, Bethany mechanobiology of growth in the scoliotic spine
loechel, nicole The effect of inverse dynamization on bone healing: a mechanobiological investigation
refshauge, sacha augmented reality taining tool for a c-arm fluoroscopy unit
ren, jiongyu use of strontium subsituted bioactive glass (srBg) and Polycaprolactone (Pcl) to develop melt electrospun scaffolds for bone repair
Tadimalla, sirisha mr micro-imaging of articular cartilage: studies based on T1ρ and T2 relaxation
Tourell, monique a magnetic resonance investigation into articular cartilage fibre microstructure.
Tufekci, Pelin development of a novel experimental model to investigate the influence of mechanics on bone healing
Master of engineering
nAMe ProjeCt
afrin, sadia a novel 3-dimensional in-vitro model to study immune cell-renal cell interactions
Fountain, stephanie characterising the mechanical conditions within a critical size bone defect when treated with a tissue engineered bone scaffold.
koval, lidia relationship between the stiffness of the internal fixation and metaphyseal fracture healing in mice.
ikin, nicole Finite element modelling of self-expanding abdominal aortic stents
meek, john racial difference in morphology of the distal humerus
mark, Quick multi-segmental analysis of growth modulation implants
Continuing students
doctor of Philosophy
nAMe ProjeCt
alsulami, abdullah ali Quantitative 3d ultrasound characterisation of tissues
amarathunga arachchige, jayani P Quantitative fit assessment of tibial nail designs during the insertion
Barani lonbani, zohreh characterising closed soft tissue trauma to investigate the reciprocal healing effects with bone fractures
Berner, arne Quantitative and qualitative assessment of the regenerative potential of osteoblasts versus bone marrow derived mesenchymal stem cells in the reconstruction of critical sized segmental tibial bone defects in a large animal model
Bock, nathalie combining electrospun scaffolds with biodegradable microspheres for sustained delivery of growth factors
Brown, Toby melt electrospinning writing
chakravorty, nishant role of micro-rnas in improved osteogenicity of modified titanium implant surfaces
higher degree research students
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h i g h e R d e g R e e R e s e a R C h s t u d e N t s [ 2 1 ]
clarke, amy w an investigation of tooth impact biomechanics to develop a test methodology for mouthguard effectiveness
couzens, greg The role of wrist motors in carpal stability
doan, nghiem v an evaluation of clinical procedures used in dental implant treatment in posterior maxilla using flapless technique
Fairhurst, helen an experimental and finite element investigation of the biomechanical outcomes of scoliosis correction surgery
Friis, Thor-einar The OP1 implant device – a study of osteogenic induction and bone formation in an orthotopic implant model in sheep
han, Pingping The regulation of wnt canonical signalling pathway during cementum regeneration
harith, hazreen haizi The automation of implant fitting for a distal tibial plate
heidarkhan Tehrani, ashkan Biomechanical and structural investigation of collagenous membranes: creating transplantable bioinspired scaffod for cartilage regeneration.
khoei, shadi multi-modality 3d quantitative imaging of radiation dosimetry gels
kuaha, kunnika driving zonal chondrogenesis of mesenchymal stem cells
levett, Peter a development of novel hydrogels and hydrogel constructs for repair of articular cartilage
malekani, javad a novel and innovative technique for deformation of pre-contoured fracture fixation plates in orthopaedic surgery
markwell, Timothy s 3d reconstruction from limited 2d data sets in radiotherapy
mcmeniman, Timothy j Fixation methods in impaction bone grafting of the acetabulum in revision total hip arthroplasty: an in-vitro study
mohd radzi, shairah development of a method to assess the quality of ankle joint reduction in 3d
moody, hayley r using near infrared spectroscopy to adapt histopathology ranking for surgical assessment of articular cartilage
Poh, su Ping Patrina melt extrusion of bioactive scaffolds comprising polycaprolactone (Pcl) and strontium-substituted bioactive glass (srBg) for bone regeneration
Powell, sean k investigations of water dynamics in anisotropic biophysical structures
Thibaudeau, laure Tissue engineered bone construct applied to an in-vivo breast cancer bone metastasis model
Toal, victoria r The mechanics of microdamage and microfracture in trabaecular bone
Tumkur jaiprakash, anjali Osteocytes in the development and progression of osteoarthritis
wille, marie luise ultrasound transit time spectral analysis of complex porous media
zhang, xufang Pro-angiogenic and anti-angiogenic factors in the degeneration of osteoarthritic cartilage
zhou, yinghong interactions between undifferentiated and osteogenic differentiated mesenchymal stromal cells during osteogenesis
Master of engineering
nAMe ProjeCt
calabro, lorenzo improving in-vivo models of fracture fixation associated osteomyelitis
jones, Brendan establishment of ovine model for tissue engineering constructs in critical sized mandibular defects
kim, margaret experimental and clinical evaluation of a tissue engineering strategy in the reconstruction of critical sized mandibular bony defects
sunni, nabeel a biomechanical investigation of fusionless growth modulation implants for spinal scoliosis treatment
vijaysegaran, Praveen an analysis of variables affecting the quality of orthopaedic laminar airflow systems
mostyn yong Polycaprolactone-based scaffold plus rhBmP-2 versus autograft in an ovine model of thoracoscopic anterior spinal fusion
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[ 2 2 ] h i g h e R d e g R e e R e s e a R C h s t u d e N t s
CoMPletions
doctor of Philosophy
name PrOjecT
afara, isaac Oluwaseun near infrared spectroscopy for non-destructive evaluation of articular cartilage
grant, caroline a mechanical testing and modelling of bone-implant construct
jeon, june evelyn development of zonal cartilage constructs: effects of chondrocyte subpopulation, compressive stimulation, and culture models
Poole, christopher m Faster monte carlo simulation of radiotherapy geometries
reichert, verena maria charlotte application of a human bone engineering platform to an in-vitro and in-vivo breast cancer metastasis model
roe, john a how important is length?: mechanical testing and measurement of a cemented, polished, tapered femoral implant
young, yun wai Pro-inflammatory growth factors reduce secondary degeneration after traumatic spinal cord injury
yusuf, kehinde Quasim an exploratory study of the potential of resurfacing articular cartilage with synthetic phospholipids
Master of engineering
nAMe ProjeCt
asgarifar, hajarossadat application of high voltage, high frequency pulsed electromagnetic field on cortical bone tissue
kalhor, ali effects of hyperbaric oxygen and inducible nitric oxide inhibitor treatment on femoral head osteonecrosis in a rat model
yuen, jones Preparation, characterisation and in-vivo osteogenesis of mesoporous bioactive glasses
overseAs visiting students
nAMe universitY
antille, melanie swiss Federal institute of Technology, lausanne
Boom, koen eindhoven university of Technology
chan, kai university of Otago, new zealand
dunker, urip rwTh aachen university, germany
jungst, Thomas julius-maximilians university, wϋrzburg
kammerer, elke university of darmstadt, germany
kirby, giles university of nottingham, uk
standfest, marco university of applied sciences regensburg, germany
Taher, amad radbound university nijmegen medical centre, The netherlands
wang, jun The second xiangya hospital of central south university, china
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a w a R d s , p R i z e s a N d C O m m u N i t y s e R v i C e [ 2 3 ]
awards, prizes and community service
›› Professor dietmar hutmacher received the 2012 australasian society for Biomaterials and Tissue engineering (asBTe) award for research excellence, and made Fellow of the international union of societies for Biomaterials science and engineering. he was also awarded a Founding Fellowship (FTerm) by the Tissue engineering and regenerative medicine society, which recognises Professor hutmacher as a distinguished global leader within the tissue engineering and regenerative medicine field
›› QuT Biomedical engineering graduate michal Bartnikowski was awarded a smart state Phd scholarship to develop robotically extruded intelligent scaffolds for osteochondral defect repair
›› dr mia woodruff received a highly commended 2012 Biotech rising star award at the 2012 women in Technology awards
›› Professor yin xiao was invited to give an expert opinion on a nature paper about a protein with dual benefits for bone health
[ 2 4 ] a C K N O w l e d g e m e N t s
› acknOwledgemenTs
orthopaedics and trauma Queensland gratefully
acknowledges the significant financial and
collaborative support of:
›› aO Foundation
›› australian research council
›› depuy synthes spine
›› golden casket research Foundation
›› holy spirit northside hospital
›› institute of health and Biomedical innovation
›› mater Foundation
›› mater health services Brisbane ltd
›› medtronic sofamor danek
›› national health and medical research council
›› Osteosynthesis and Trauma care (OTc) Foundation, switzerland
›› Princess alexandra hospital
›› Queensland health
›› Queensland Orthopaedic research Trust
›› Queensland university of Technology
›› Queensland x-ray
›› royal australasian college of surgeons
›› stryker
›› The Prince charles hospital
›› The Prince charles hospital Foundation
›› The wesley research institute
© QuT 2013 19870 cricOs no. 00213j