Aterosclerose Coronariana e o Papel do Balanço Redox.

Prof. Mário – IBqM - UFRJ

Joseph L. Goldstein e Michael S. Brown

1973-81 : Definição do modelo de transporte de lipídeos por lipoproteínas. Caracterização dos receptores hepático e extrahepáticos de LDL, VLDL e Quilomicron.

Locais de Extravasamento de Superoxido na Mitocondrida

Fukumura et al. Nature Reviews Cancer 6, 521–534 (July 2006) | doi:10.1038/nrc1910

Table 1. Human plasma antioxidants.Antioxidant Concentration (μM) Mechanism of actionWater-soluble antioxidant

Ascorbic acid 35 - 85 Scavenger of lipid peroxyl radical; regeneration of a-tocopherol by one-electron reduction;prevents copper binding to LDL

Uric acid 130 - 450 Scavenger of oxygen radical; metal chelation

Albumin 430 - 680 Major plasma protein with one high affinity copper binding site; inhibitor of ceruloplasmin oxidative activity

Transferrin 26 - 48 Plasma protein with iron binding ability

Lipophilic antioxidantsa-Tocopherol 15 - 45 Scavenger of lipid peroxyl radical

Ubiquinol-10 0.4 - 1 Scavenger of lipid peroxyl radical; regeneration of a-tocopherol

b-Carotenoids 0.19-1.58 Scavenger of singlet oxygen and peroxyl radical (at low oxygen tension)