Post on 08-Jan-2017
Jeremy J. Mao
Columbia University
3D Printed Materials in Vivo: Healing
by Endogenous Stem Cells
April 11, 2016
New York, NY
§ One in five adults diagnosed of arthritis
§ Half of those 65 or older
§ By 2030, ~67 million Americans (>18)
§ Could 3D printing be a solution for arthritis
§ ~22 people die each day waiting for organ transplants
§ What does 3D printing have to do with organ transplantation
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cgf
Bone
d e
400 µm 200 µm
Cartilage
80 wt% poly-ε-caprolactone (PCL) (Mw ~65,000)
20 wt% of hydroxyapatite (HA)Lee et al. 2010 Lancet Aug 7;376(9739):440-8. PMID: 20692530
Nature Reviews Rheumatology 6, 677-678 (2011)
Daniel A. Grande, Nicholas A. SgaglioneRegenerative medicine: Self-directed articular resurfacing: a new paradigm?
Nati
ve
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TG
F/T
GF
β3-µ
S
Outer Middle Inner
BA
ED
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(100μm)
Scott Rodeo, HSS
Lisa Fortier, Cornell
To Avoid Root Canals, Teeth That Replace
Themselves
Stem-Cell Research Makes Progress in Quest to
Avoid the Dreaded Drill
§ 18 million root canal
patients/yr
§ $22B annual
expenditure
2014
https://www.google.com/search?q=organ+shortage&espv=2&biw=1209&bih=704&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi2wfze2oTMAhVLGT4KHcy5CPMQ_AUIBygC#imgrc=8cEvQPUTai1AvM%3A
3D printing
Organ shortage
3D printing…holds considerable
promise in generating implantable
organ scaffolds that may reduce or
eliminate organ shortage.